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Bruce Cronstein, MD, Rheumatology, New York, NY

Bruce N Cronstein MD

Rheumatology•New York, NY

Paul R. Esserman Professor of Medicine Director, NYU-HHC Clin and Translational Science Institute

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  • 435 30th Street4-19New York, NY 10016

  • Phone+1 212-263-6404

  • Fax+1 212-263-1048

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Summary

  • Dr. Bruce Cronstein received his medical degree from University of Cincinnati College of Medicine and underwent further training in Internal Medicine (University of Cincinnati Medical Center and Lenox Hill Hospital) and Rheumatology (NYU School of Medicine). Dr. Cronstein has been primarily involved in research and has carried out NIH funded research since 1987 until his retirement in 2025 at NYU Grossman School of Medicine where he was the Paul Esserman Professor of Medicine. He carried out research on purine metabolism and adenosine receptors and their role in inflammation, fibrosis, skin and liver disease. Dr. Cronstein is the author of over 300 published manuscripts which have been cited nearly 35,000 times (his H factor is 93). He is the founding director of the NYU Clinical and Translational Science Institute which he led for 15 years. Most recently Dr. Cronstein's laboratory discovered that adenosine, acting at A2A receptors, can prevent and reverse the development of Osteoarthritis. This discovery led to the formation of a biotech startup, Regenosine, which is developing adenosine nanoparticles for intraarticular injection for the treatment of Osteoarthritis. Dr. Cronstein is the recipient of the Lee Howley Award for Arthritis Research and the Distinguished Basic Investigator Award of the American College of Rheumatology. Dr. Cronstein was recently inducted into the National Academy of Inventors.

Education & Training

  • New York University School of Medicine
    New York University School of MedicineFellowship, Rheumatology, 1980 - 1983
  • Zucker School of Medicine at Hofstra/Northwell at Lenox Hill Hospital
    Zucker School of Medicine at Hofstra/Northwell at Lenox Hill HospitalResidency, Internal Medicine, 1980
  • NYU Grossman School of Medicine
    NYU Grossman School of MedicineResidency, Pathology-Anatomic and Clinical, 1977 - 1978
  • University of Cincinnati Medical Center/College of Medicine
    University of Cincinnati Medical Center/College of MedicineInternship, Internal Medicine, 1976 - 1977
  • University of Cincinnati College of Medicine
    University of Cincinnati College of MedicineClass of 1976
  • Lake Forest College
    Lake Forest CollegeB.A., 1972

Certifications & Licensure

  • NY State Medical License
    NY State Medical License 1977 - 2018
  • Rheumatology
    American Board of Internal Medicine Rheumatology

Awards, Honors, & Recognition

  • Fellow, National Academy of Inventors National Academy of Inventors, 2025
  • Distinguished Basic Science Investigator American College of Rheumatology, 2019
  • Master American College of Rheumatology, 2016
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Publications & Presentations

PubMed

Journal Articles

  • Regulation of inflammation by adenosine  
    Gyorgy Hasko and Bruce Cronstein, Frontiers in Immunology, 4/1/2013
  • Fibroblasts from methotrexate-sensitive mice accumulate methotrexate polyglutamates but those from methotrexate –resistant mice do not  
    X. You, A. Williams, T. Dervieux, W. He and B.N. Cronstein, Clinical and Experimental Rheumatology, 3/4/2013
  • Mechanistic Aspects of Inflammation and Clinical Management of Inflammation in Acute Gouty Arthritis  
    Bruce N. Cronstein and Prashanth Sunkureddi, Journal of Clinical Rheumatology, 1/1/2013
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Books/Book Chapters

  • Kelley’s Textbook of Medicine 
    Chapter: Acute phase reactants and the concept of inflammation. 
    Saxena, A. and B.N. CronsteinEditors: G.S. Firestein, R.C. Budd, S.E. Gabriel, I.B. MacInnes and J.R. O’Dell.2012
  • Methylxanthines, Handbook of Experimental Pharmacology 
    Chapter: Methylxanthines and Inflammatory Cells 
    Page 457 - 468Gyorgy Hasko and Bruce CronsteinSpringer-Verlag, Berlin Heidelberg2011
  • Pharmacogenomics in rheumatology. Rheumatology, Fifth Edition 
    Chapter: Section 1, The Scientific Basis of Rheumatic Basis of Rheumatic Disease 
    Page 205 - 210Jeffrey D. Greenberg and Bruce N. CronsteinEdition Fift,2010
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Press Mentions

  • COVID-19 in Patients with Systemic Lupus Erythematosus: Lessons Learned from the Inflammatory Disease
    COVID-19 in Patients with Systemic Lupus Erythematosus: Lessons Learned from the Inflammatory DiseaseDecember 19th, 2020
  • Initiating Guideline-Concordant Gout Treatment Improves Arterial Endothelial Function and Reduces Intercritical Inflammation: A Prospective Observational Study
    Initiating Guideline-Concordant Gout Treatment Improves Arterial Endothelial Function and Reduces Intercritical Inflammation: A Prospective Observational StudyJuly 11th, 2020
  • The 2019 ACR Award Winners & Distinguished Fellows
    The 2019 ACR Award Winners & Distinguished FellowsDecember 18th, 2019
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Grant Support

  • Clinical and Translational Science AwardNEW YORK UNIVERSITY SCHOOL OF MEDICINE2015–2025
  • The Pharmacology Of Dermal FibrosisNational Institute Of Arthritis And Musculoskeletal And Skin Diseases2009–2012
  • Purinergic Regulation Of Bone MetabolismNational Institute Of Arthritis And Musculoskeletal And Skin Diseases2008–2012
  • ACR Basic Research ConferenceNational Institute Of Arthritis And Musculoskeletal And Skin Diseases2011
  • Institutional Clinical And Translational Science AwardNational Center For Research Resources2009–2011
  • CTSA Infrastructure For Pediatric ResearchNational Center For Research Resources2009–2011
  • CTSA Infrastructure For Clinical TrialsNational Center For Research Resources2009–2011
  • CTSA Infrastructure For AIDS ResearchNational Center For Research Resources2009–2011
  • Advanced Training In Clinical InvestigationNational Center For Research Resources2005–2008
  • Pharmacology Of Antirheumatic DrugsNational Institute Of Arthritis And Musculoskeletal And Skin Diseases2004–2007
  • Pathogenesis And Treatment Of Alcohol-Induced CirrhosisNational Institute On Alcohol Abuse And Alcoholism2003–2007
  • Pharmacologic Promotion Of Wound HealingNational Institute Of General Medical Sciences1998–2007
  • Testing For Single Nucleotide Polymorphisms Associated With FibromyalgiaNational Center For Research Resources2005
  • Testing For Single Nucleotide Polymorphisms AssociatedNational Center For Research Resources2004
  • Pharmacologic Promotion Of Wound HealingNational Center For Research Resources1998–2002
  • Pharmacology Of Antirheumatic AgentsNational Center For Research Resources1997–2002
  • Pharmacology Of Antirheumatic AgentsNational Institute Of Arthritis And Musculoskeletal And Skin Diseases1996–2002
  • Pharmacology Of Antirheumatic AgentsNational Institute Of Arthritis And Musculoskeletal And Skin Diseases1995
  • Neutrophil Function In The ElderlyNational Institute On Aging1987–1994
  • Inhibition Of Neutrophil Mediated Tissue InjuryNational Institute Of Arthritis And Musculoskeletal And Skin Diseases1986–1989
  • Adenosine: An Endogenous Inhibitor Of Neutrophil Mediated Tissue InjuryNational Center For Research Resources1987
  • Inhibition Of Neutrophil Mediated Tissue InjuryNat Inst Of Arthritis, Diabetes, Digestive &Kidney Diseases1985

Professional Memberships

Industry Relationships

  • Chief Scientific Officer, Regenosine, LLCDr. Cronstein is a founder of Regenosine which is developing adenosine nanoparticles for the treatment of OsteoarthritisDisclosure: Regenosine, LLC2025 - Present
  • Chairman, Scientific Advisory Board, Regenosine, LLC2018 - Present

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