Bruce R Troen MD

PubMed

• Effects of a 6-Week Treadmill Training With and Without Virtual Reality on Frailty in People With Multiple Sclerosis.
  Tobia Zanotto, Irina Galperin, Danya Pradeep Kumar, Anat Mirelman, Shahar Yehezkyahu
  Archives of Physical Medicine and Rehabilitation. 2025-02-01
• 1 citations
  Frailty in multiple sclerosis: A scoping review.
  Nida' Al Worikat, Farzan Molaei, Anna Zanotto, Abbas Tabatabaei, Sharon G Lynch
  Multiple Sclerosis and Related Disorders. 2024-12-01
• 1 citations
  Age-related increase of CD38 directs osteoclastogenic potential of monocytic myeloid-derived suppressor cells through mitochondrial dysfunction in male mice.
  Ramkumar Thiyagarajan, Lixia Zhang, Omar D Glover, Kyu Hwan Kwack, Sara Ahmed
  Aging Cell. 2024-11-01

Journal Articles

• Regulation of cathepsin D gene expression by retinoic acid and calcitriol in HL-60 cells.  
  Atkins, K.B., Troen, B.R, Journal Invest Med
• Clinical and Metabolic Risk Factors Associated with Elevated Fasting Plasma Glucose in Elderly Hispanic Patients from Zulia State, Venezuela.  
  Florez, H., Sulbaran, T.. Silva, E., Calmon, G., Castillo-Florez, S., Ruiz, J., Troen, B., Rodriguez, O., Samos, F.L., Roos, B.A., Goldberg, R, J Am Geriatr Soc
• Estrogen Inhibits Cathepsin K Gene Expression in Osteoclasts Via the JNK/AP-1 Signal Transduction Pathway.  
  Dolgilevich, S., Liu, B., Zhao, J., Troen, B.R, J Am Geriatr Soc
• Dysfunctional Osteoclasts and Osteopetrosis in an ADP-Ribosyl Cyclase (CD38) Null Mouse.  
  Wu, X. Y., Adebanjo, O. A., Moonga, B., Zhou, A., Wu, X.B., Bevis, P.J.R., Jepsin, K., Schaffler, M., Kimmel, D., Inzerillo, A., Epstein, S., Troen, B.R., Abe, E., Bl..., J Bone Miner Res
• Regulation of Cathepsin K Promoter Activity.  
  Gyda, M., Troen, B.R, J Bone Miner Res
• Cytokine Effects Upon Osteoclastogenesis and Cathepsin K Gene Expression.  
  Corisdeo, S., Gyda, M., Troen, B.R, J Am Geriatr Soc
• Cytokine Effects Upon Osteoclastogenesis and Cathepsin K Gene Expression.  
  Corisdeo, S., Gyda, M., Troen, B.R, J Bone Miner Res
• Novel insights in the regulation of mature osteoclasts by osteoprotegerin (OPG) and Osteoprotegerin-Ligand (OPG-L).  
  Moonga, B.S., Sun, L., Corisdeo, S., Adebanjo, O.A., Bevis, P.J.R., Koval, A., Sodam, B.R., Blair, H.C., Epstein, S., Troen, B.R., Zaidi, M, J Bone Mineral Res
• Effect of Ovariectomy and Dietary Restriction on Bone Mineral Density in Two Aging Rat Models.  
  Corisdeo, S., Kimmel, D.B., Eskin, B.A., Masarachia, P.J., Troen, B.R, J Bone Mineral Res
• Differentiating agents regulate cathepsin B gene expression in HL-60 cells.  
  Troen, B.R., Berquin, I.B., Yan, S., Katiyar, K., Sloane, B.F, FASEB Journal 13
• Regulation of cathepsin B expression in HL-60 promyelocytic leukemia cells: effect of differentiating agents.  
  Berquin, I.B., Huang, L., Troen, B.R, Journal Invest Med
• Regulation of interleukin 8 gene expression by calcitriol and prostaglandin in monocytic cells.  
  Atkins, K.B., Troen, B.R, Journal Invest Med
• Gender Differences in Reaching the Low Density Lipoprotein Cholesterol Level Targeted for the High Coronary Heart Disease Risk Category in Elderly Hispanic Patients ...  
  Florez, H., Sulbaran, T.. Silva, E., Calmon, G., Castillo-Florez, S., Ruiz, J., Troen, B., Rodriguez, O., Samos, F.L., Goldberg, R., Roos, B.A, J Am Geriatr Soc
• Tyrosine kinase dependence of the TPA regulated cathepsin L expression in U937 cells.  
  Atkins, K.B., Troen, B.R, FASEB Journal 7
• p53 induces cathepsin L gene transcription.  
  Troen, B.R., Chang, M.Y, J Cell Biochem Supplement 16B
• Domain analysis of the induction of the mouse cathepsin L promoter by cAMP.  
  Chang, M.Y., Troen, B.R, J Cell Biochem Supplement
• Phorbol ester stimulation of the Cathepsin L promoter is mediated by elements downstream of the transcription initiation site.  
  Troen, B.R., Chauhan, S.S., Gottesman, M.M, J Cell Biochem - Supplement
• Regulation of the phorbol ester-responsive promoter for cathepsin L, a transformation-sensitive protease that is secreted.  
  Troen, B.R., Gottesman, M.M, J Cell Biochem -Supplement
• Isolation of the phorbol ester- and cAMP-responsive promoter for cathepsin L, a secreted protease regulated by transformation.  
  Troen, B.R., Gottesman, M.M, J. Cell Biology
• Structure and regulation by malignant transformation of the gene for MEP: A secreted lysosomal protease.  
  Troen, B.R., Gottesman, M.M, J Cell Biochem - Supplement
• Function and regulation of MEP: an acid protease secreted by malignant cells.  
  Troen, B.R., Gal, S., Gottesman, M.M, J Cell Biochem - Supplement
• Structure and regulation by malignant transformation of the gene for MEP, a secreted lysosomal protease.  
  Troen, B.R., Gottesman, M.M, J Cell Biol
• Isolation of the transformation-sensitive promoter for a lysosomal protease.  
  Troen, B.R., Gottesman, M.M, J Cell Biol
• Expression and cloning of a transformation-regulated lysosomal protein.  
  Troen, B.R., Rabin, M., Doherty, P., Gottesman, M.M, J Cell Biol
• Age Modifies the Impact of Vitamin D3 Supplementation on the 25-OH Vitamin D/ Parathyroid Hormone Ratio.  
  Florez, H.J., Cherniack, E. P., Gómez-Marín, O., Roos, B. A., Levis, S., Troen, B.R, J Bone Miner Res
• Join now to see all

Books/Book Chapters

• Geripause. 
  Chapter: The Geripause: Medical Management 
  Page 3 - 10Troen, B.REditors: Eskin & Troen.Parthenon, New York
• Expression of tissue proteinases and regulation of protein degradation as related to meat quality. 
  Chapter: Cathepsin genes: structure, expression and regulation. 
  Page 29 - 46Troen, B.REditors: Ouali, A., Demeyer, D.I., & Smulders, F.J.M.Audet Tijdschriften bv, Nijmegen, The Netherlands
• The Gene Construction Kit: DNA Sequence Analysis and Presentation 
  Chapter: Sequence Data Analysis Guidebook 
  Troen, B.REditors: Swindell, S.Humana Press, New Jersey
• Biological Mechanisms of Aging. 
  Chapter: Geriatrics Review Syllabus 
  Page 5 - 10Troen, B.R. and Cristofalo, V.JEditors: Cobbs, E.L, Duthie, E.H., & Murphy, J.B.Kendall/Hunt, Dubuque, IowaEdition 4th,
• The Geripause. 
  Chapter: The Menopause: Comprehensive Management 
  Page 23 - 32Troen, B.REditors: Eskin, B.A.The Parthenon Publishing Group, New YorkEdition 4th,
• Cell and Molecular Aging. 
  Chapter: Principles and Practice of Geriatric Surgery 
  Page 8 - 23Troen, B.R. and Cristofalo, V.JEditors: Rosenthal, Zenilman, & Katlic.Springer-Verlag, New York
• Biological Mechanisms of Aging. 
  Chapter: Geriatrics Review Syllabus 
  Page 1 - 8Jurivich, D.A. and Troen, B.REditors: Cobbs, E.L, Duthie, E.H., & Murphy, J.B.Blackwell Publishing, Malden, MAEdition 5th,
• Molecular and Clinical Pharmacology of Calcitonin. 
  Chapter: Principles of Bone Biology 
  Page 1423 - 1440Zaidi, M., Inzerillo, A.M., Troen, B. Moonga, B.S., Abe, E., and Burckhardt, PEditors: Bilezikian, Raisz, & Rodan.Academic Press, San Diego, CAEdition 2nd,
• Osteoporosis. 
  Chapter: The Geripause: Medical Management 
  Page 135 - 150Troen, B.R., Inzerillo, A., Zaidi, MEditors: Eskin & Troen.Parthenon, New York
• Vitamin D, cognitive function, and mental health. 
  Chapter: Lifetime nutritional influences on cognition, behaviour and psychiatric illness 
  Page 420 - 432Cherniack, E.P. and Troen, B.REditors: Benton, D.Cambridge, UK: Woodhead Publishing, Ltd
• Approach to the Geriatric Patient, 1998. 
  Chapter: The Geripause: Medical Management 
  Page 79 - 82Troen, B.REditors: Eskin & Troen.Parthenon, New York
• Skeletal Fragility in the Elderly. 
  Chapter: Geriatric Medicine 
  Inzerillo, A., Iqbal, J., Meier, D., Troen, B.R., and Zaidi, MEditors: Cassel, Leipzig, Cohen, Larson, & Meier.Springer-Verlag, New YorkEdition 4th,
• Biology of Aging, 2001 
  Chapter: Geriatrics Review Syllabus 
  Page 8 - 16Troen, B.R. and Jurivich, D.AEditors: Pompei, P. & Murphy, J.B.American Geriatrics Society, New YorkEdition 6th,
• Skeletal Aging. 
  Chapter: Geriatric Nutrition: The Health Professional’s Handbook 
  Page 325 - 344Duque, G. and Troen, B.REditors: Chernoff.Jones and Bartlett, Boston, MAEdition 3rd,
• The Demographics of Aging in Women. 
  Chapter: The Menopause: Endocrinologic Basis & Management Options 
  Page 23 - 34Paniagua, M. and Troen, B.REditors: Eskin, B.A.Taylor and Francis, Boca Raton, FLEdition 6th,
• Calciotropic Hormones. 
  Chapter: Senile Osteoporosis: Advances in Pathophysiology and Therapeutic Approach 
  Page 34 - 46Cherniack, E.P. and Troen, B.REditors: Duque, G. and Kiel, D.Springer-Verlag London Limited
• Osteoporosis. 
  Chapter: Hazzard's Principles of Geriatric Medicine and Gerontology 
  Page 1421 - 1434Duque, G. and Troen, B.REditors: Halter, Ouslander, Tinetti, Asthana, High, Studenski.McGraw-Hill, New YorkEdition 6th,
• Cell and Molecular Aging. 
  Chapter: Principles and Practice of Geriatric Surgery 
  Page 5 - 38Rai, P. and Troen, B.REditors: Rosenthal, Zenilman, Katlic.Springer Verlag, New YorkEdition 2nd,
• Join now to see all

Abstracts/Posters

• Vitamin D supplementation reduces blood pressure in the elderly and this is modified by frailty.
  Florez, H.J., Apaza, A., Sosa-Melo, A., Cherniack, E. P., Levis, S., Troen, B.R., Roos, B. A, Gerontological Society of American Annual Meeting
• Sirtuin Activating Compounds Inhibit Reactive Oxygen Species and Osteoclastogenesis.
  Pang, M., Rodriguez-Gonzalez, M., Hernandez, M., Fernandez, I., Duque, G., Troen, B.R, Gerontological Society of American Annual Meeting
• Sirtuin Activating Compounds Inhibit Rac1 Activation, Actin Ring Formation, and Osteoclastogenesis.
  Pang, M., Hernandez, M., Fernandez, I., Rodriguez-Gonzalez, M., Troen, B.R, American Society for Bone and Mineral Research Annual Meeting
• Higher Vitamin D Requirements In Older Persons.
  Florez, H.J., Troen, B.R., Roos, B. A., Cherniack, E. P., Levis, S, American Society for Bone and Mineral Research Annual Meeting
• Relationship of Insulin Resistance and Metabolic Syndrome with Endothelial Progenitor Cells and Flow-Mediated Vasodilation.
  Montenegro, A., Salgueiro, L., Troen, B.R., Florez, H., Hurwitz, B, American Heart Association Annual Meeting
• Sirtuin activating compounds and aging bone, Keystone Symposium: New Insights into Healthspan and Diseases of Aging.
  Pang, M., Hernandez, M., Rodriguez-Gonzalez, M., Fernandez, I., Duque, G., Troen, B.R, Molecular to Functional Senescence
• Osteoprotegerin Ligand Stimulates Cathepsin K Gene Expression in Osteoclasts.
  Corisdeo, S., Gyda, M., Troen, B.R, P426 at the American Geriatrics Society Meeting
• IFN-γ Suppresses Cathepsin K Gene Transcription.
  Gyda, M., Jasti, S., Corisdeo, S., Troen, B.R, P36 at the American Geriatrics Society Meeting
• Regulation of cathepsin gene expression in promonocytes.
  Jain, V., Troen, B.R, the American Geriatrics Society Meeting
• Analysis of gene expression and senescence by differential display of the polymerase chain reaction.
  Lee, T., Troen, B.R, the American Geriatrics Society Meeting
• Expression of cathepsin L in human monocytes stimulated by phorbol esters.
  Chu, B., Troen, B.R, the American Geriatrics Society Meeting
• Molecular analysis of the MEP gene.
  Garber, J.E., Troen, B.R, the American Geriatrics Society Meeting
• Join now to see all

Lectures

• Some Perspectives on the Biology of Aging. 
  Division of Gerontology and Geriatric Medicine, Miller School of Medicine, University of Miami
• Basics of Basic Science. 
  Division of Gerontology and Geriatric Medicine, University of Miami School of Medicine, Miami, FL
• PowerPoint Presentation Tips. 
  Division of Gerontology and Geriatric Medicine, University of Miami School of Medicine, Miami, FL
• Endocrine Aging. 
  University of Miami School of Medicine, Miami, FL
• Osteoporosis: Age-Related Bone Loss - Pathogenesis and Treatment. 
  Miami VA Primary Care Clinic - Miller School of Medicine, University of Miami, Miami, FL
• Clinical and Molecular Bases of Frailty. 
  Center on Aging - University of Miami, Miami, FL
• American Society for Bone and Mineral Research 2007 Annual Meeting Overview. 
  Miami VAHS GRECC, Miami FL
• Research ongoing in the Troen Laboratory. 
  Miami VAHS GRECC, Miami FL
• The role of sirtuins in longevity: impact upon stem cells, osteoblasts, and osteoclasts. 
  Miami VAHS GRECC, Miami FL
• Approach to the osteoporosis patient; 2007 
  Division of Gerontology and Geriatric Medicine, Miller School of Medicine, University of Miami
• Cathepsin K promoter driven transgene and microarray analysis of RAW cell differentiation. 
  Data Club, VAMC GRECC, University of Miami, Miami, FL
• Metabolic Insights into Longevity, 2008 
  Reactive Oxygen Species Seminar, Miami VAHS Research Service, Miami, FL
• Regulation of osteoclastogenesis and osteoclast gene expression by sirtuin activating compounds. 
  Miami VA Geriatric Research Education and Clinical Center, Miami, FL
• Prolongevity Compounds and Aging Bone. 
  Center on Aging, Miller School of Medicine, University of Miami, Miami, FL
• Prolongevity Compounds, Sirtuins, and Aging: Bone and Beyond. 
  Division of Nephrology Research Seminar, Miller School of Medicine, University of Miami, Miami, FL
• Optimizing Healthspan: Geriatric Syndromes, Frailty, and Sarcopenic-Obesity. 
  Division of Endocrinology Grand Rounds, Miller School of Medicine, University of Miami, Miami, FL
• Falls and Their Prevention: A Geriatrics Imperative. 
  Division of Endocrinology – Bone Course, Miller School of Medicine, University of Miami, Miami, FL
• Osteoporosis: Falls and Fracture Prevention. 
  Division of Gerontology and Geriatric Medicine, Miller School of Medicine, University of Miami
• Genes and Geriatrics; 1990 
  University of Michigan Alumni Society, East Lansing, MI
• Cathepsin Genes: Structure, Expression, and Regulation. 
  INRA Workshop, Clermont-Ferrand, France
• Regulation of cathepsin and interleukin-8 gene expression in HL-60 cells. 
  Geriatric Division Journal Club, Allegheny University of the Health Sciences, Philadelphia, PA
• Of Mice and Men: Cancer, Immunity and Bones. 
  Institute of Gerontology Faculty Business Seminars, University of Michigan, Ann Arbor, MI
• Systolic Hypertension in the Elderly. 
  Geriatric Division Conference, University of Michigan Geriatric Division, Ann Arbor, MI
• Update on Osteoporosis Treatment. 
  CME Course, University of Michigan Geriatric Division, Ann Arbor, MI
• Use of MRI in the Elderly. 
  Clinical Conference, University of Michigan Geriatric Division, Ann Arbor, MI
• Join now to see all

Other

• Transcription of Human Cathepsin B Is Mediated by Sp1 and Ets Family Factors in Glioma. 
  Yan, S., Berquin, I.M., Troen, B.R., Sloane, B.F
• Role of circulating epinephrine in the control of plasma renin activity in conscious dogs. 
  Johnson, M.D., Troen, B.R., Farhi, E.R., Barger A.C
• Age-Related decrease in basal and triiodothyronine-stimulated uptake of sugar by rat thymocytes. 
  Troen, B.R., Ingbar, S.H., Segal J
• Transfer and expression of the gene for a growth-regulated lysosomal protease. 
  Troen, B.R., Gottesman, M.M
• Isolation and characterization of the promoter for a transformation-regulated cathepsin. 
  Troen, B.R., Gottesman, M.M
• Analysis of the induction of mouse cathepsin L promoter by cAMP. 
  Chang, M.Y., Troen, B.R
• Are tumor promoter and transformation responsive elements distinct within the cathepsin L gene? 
  Troen, B.R., Chang, M.Y
• Tyrosine kinase dependence of the TPA regulated IL-8 gene expression in U937 cells. 
  Atkins, K.B., Troen, B.R
• Retinoic acid induces cathepsin D gene expression in HL-60 cells. 
  Atkins, K.B., Troen, B.R
• Dysfunctional Osteoblasts, Impaired Osteoblastogenesis, Reduced Bone Formation and Severe Osteoporosis in a Calcineurin Aα Null Mouse. 
  Sun, L., Adebanjo, O. A., Liu, X. H., Moonga, B. S., Inzerillo, A., Koval, A., Wu, X. B., Bevis, P. J. R., Blair, H. C., Conner, D., Seidman, J., Troen, B.R., Epstein...
• Osteoclast Differentiation and the Regulation of Cathepsin K Expression. 
  Troen, B.R
• Sympathetic nervous system and aging in man. 
  Rowe, J.W. and Troen, B.R, Endocrine Reviews
• Effects of age and sex on certain metabolic functions and mitogenic activity in rat thymocytes. 
  Segal, J., Troen, B.R., Ingbar, S.H
• Use of a cloned multidrug resistance gene for co-amplification and overproduction of major excreted protein, a transformation-regulated secreted acid protease. 
  Kane, S.E., Troen, B.R., Gal, S., Ueda, K., Pastan, I.,Gottesman, M.M
• Downstream sequences mediate induction of the mouse cathepsin L promoter by phorbol esters. 
  Troen, B.R., Chauhan, S.S., Ray, D., Gottesman, M.M, Cell Growth and Differ
• Comparative responsiveness of HL60, HL60R and HL60R+ (LRARSN) cells to various differentiating agents. 
  Atkins, K.B., Troen, B.R
• Effects on Lipids and Cardiovascular Risk. 
  Cherniack, E.P. and Troen, B.R, Curr Cardiovasc Risk Rep
• New Insights into the Regulation of Cathepsin K Gene Expression by Osteoprotegerin Ligand. 
  Corisdeo, S., Gyda, M., Zaidi, M., Moonga, B.S., and Troen, B.R
• Macrophage Colony-Stimulating Factor Suppresses Osteoblast Formation. 
  Gyda, M., Corisdeo, S., Zaidi, M., and Troen, B.R
• Geripause: A Newly Defined Postmenopausal Phase. 
  Eskin, B.A. and Troen, B.R
• RANK-L induces the expression of NFATc1, but not of NFκB subunits during osteoclast formation. 
  Zhu, L., Zaidi, S., Moonga, B.S., Troen, B.R., Sun, Li
• RANK ligand and interferon gamma differentially regulate cathepsin gene expression in pre-osteoclastic cells. 
  Pang, M., Martinez, A.F., Jacobs, J., Balkan, W., Troen, B.R
• Unlocking the Mysteries of Adult Stem Cells and Regenerative Medicine. 
  Howard, G.A., Schiller, P.C., D'Ippolito, G., Cheung, H.S., Troen, B.R., Roos, B.A
• AP-1 Stimulates the Cathepsin K Promoter in RAW 264.7 Cells. 
  Pang, M., Martinez, A.F., Fernandez, I., Balkan, W., Troen, B.R
• Functional grouping of osteoclast genes revealed through microarray analysis. 
  Yang, G., Zaidi, M., Zhang, W., Zhu, L.L., Li, J., Iqbal, J., Varbanov, A., Gross, G., Phipps, R., Troen, B.R., Sun, L, Biochem Biophys Res Commun
• Join now to see all