Carl June MD

PubMed

• CD22-targeted chimeric antigen receptor-modified T cells for children and adults with relapse of B-cell acute lymphoblastic leukemia after CD19-directed immunotherapy.
  Regina M Myers, Amanda M DiNofia, Yimei Li, Caroline Diorio, Hongyan Liu
  Journal for Immunotherapy of Cancer. 2025-04-17
• Overcoming extracellular vesicle-mediated fratricide improves CAR T cell treatment against solid tumors.
  Wenqun Zhong, Zhiyuan Qin, Ziyan Yu, Jingbo Yang, Dongdong Yan
  Nature Cancer. 2025-04-15
• LOXHD1 is an oncofusion-regulated antigen of ewing sarcoma.
  Tatiana Blanchard, Pouya Faridi, Chong Xu, Adham S Bear, Reyaz Ur Rasool
  Scientific Reports. 2025-04-15

Journal Articles

• Expanding the Therapeutic Window for CAR T Cell Therapy in Solid Tumors: The Knowns and Unknowns of CAR T Cell Biology  
  Carl June, MD, Frontiers in Neurology
• Induction of Resistance to Chimeric Antigen Receptor T Cell Therapy by Transduction of a Single Leukemic B Cell  
  Vijay G Bhoj, David M Barrett, Carl H June, Stephan A Grupp, David E Ambrose, Saar I Gill, Marco Ruella, Bruce L Levine, Shannon L Maude, Nature
• Immunotherapy for Glioblastoma: Adoptive T-cell Strategies  
  Marcela V Maus, Carl H June, Clinical Cancer Research
• Disruption of TET2 Promotes the Therapeutic Efficacy of CD19-Targeted T Cells  
  Shannon A Carty, Carl H June, David L Porter, Bruce L Levine, Rahul M Kohli, Nature
• CAR T Cell Immunotherapy for Human Cancer  
  Carl H June, Michael C Milone, Science Magazine
• Clinical Pharmacology of Tisagenlecleucel in B-cell Acute Lymphoblastic Leukemia  
  Michael W Boyer, Bruce L Levine, Carl H June, Theodore W Laetsch, Clinical Cancer Research
• Non-Viral RNA Chimeric Antigen Receptor Modified T Cells in Patients with Hodgkin Lymphoma  
  Stephan A Grupp, Sunita Dwivedy Nasta, Susan R Rheingold, Daniel J Landsburg, Carl H June, Jakub Svoboda, Stephen J Schuster, Saar I Gill, David L Porter, Bruce L Levine, Blood
• Safety and Efficacy of Intratumoral Injections of Chimeric Antigen Receptor (CAR) T Cells in Metastatic Breast Cancer  
  Austin D Williams, Amy S Clark, Paul J Zhang, Julia Tchou, Bruce L Levine, Jennifer M Matro, Laurence J Cooper, Alycia So, Lynn M Schuchter, Carl H June, Angela M DeMi..., Clinical Cancer Research
• Genome-Editing Technologies in Adoptive T Cell Immunotherapy for Cancer  
  Nathan Singh, Marco Ruella, Carl H June, Current Hematologic Malignancy Reports
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Abstracts/Posters

• A Failure to Start: Aborted Activation of CAR T Cells in Chronic Lymphocytic Leukemia
  Carl H June, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/9/2019
• Identification and Validation of Predictive Biomarkers to CD19- and BCMA-Specific CAR T-Cell Responses in CAR T-Cell Precursors
  Carl H June, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/9/2019
• Outcomes in Aggressive B-Cell Non-Hodgkin Lymphomas with Anti-CD19 CAR T-Cell (CTL019) Products Not Meeting Commercial Release Specifications
  Carl H June, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/9/2019
• Single Chain Variable Fragment Linker Length Regulates CAR Biology and T Cell Efficacy
  Carl H June, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/7/2019
• Original Article Checkpoint Blockade Reverses Anergy in IL-13Rα2 Humanized scFv-Based CAR T Cells to Treat Murine and Canine Gliomas
  Carl June, MD, ScienceDirect, Orlando, FL, 12/7/2019
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Lectures

• Clinical Predictors of T Cell Fitness for CAR T Cell Manufacturing and Efficacy in Multiple Myeloma 
  2018 ASH Annual Meeting - San Diego, CA - 12/1/2018
• PD-1 Inhibitor Combinations As Salvage Therapy for Relapsed/Refractory Multiple Myeloma (MM) Patients Progressing after Bcma-Directed CAR T Cells 
  2018 ASH Annual Meeting - San Diego, CA - 12/1/2018
• Chronic Lymphocytic Leukemia Cells Impair Mitochondrial Fitness in CD8+ T Cells and Impede CAR T Cell Efficacy 
  2018 ASH Annual Meeting - San Diego, CA - 12/1/2018
• CD19-Directed CAR T-Cell (CTL019) Product Viability and Clinical Outcomes in Non-Hodgkin Lymphomas and B-Cell Acute Lymphoblastic Leukemia 
  2018 ASH Annual Meeting - San Diego, CA - 12/1/2018
• Predictors of T Cell Expansion and Clinical Responses Following B-Cell Maturation Antigen-Specific Chimeric Antigen Receptor T Cell Therapy (CART-BCMA) for Relapsed/Re... 
  2018 ASH Annual Meeting - San Diego, CA - 12/1/2018
• Integration of Immunotherapy Into Treatment for Hematologic Malignancies 
  60th American Society of Hematology Annual Meeting - 11/30/2018
• Integration of Immunotherapy Into Treatment for Hematologic Malignancies 
  60th American Society of Hematology Annual Meeting - 11/30/2018
• Genetically Modified Cell Therapy 
  2018 ASCO Annual Meeting - Chicago, Illinois - 06/4/2018
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