CarlJPepineMD

Cardiology • Gainesville, FL

Adult Congenital Heart Disease

Professor of Medicine, University Fla College of Medicine

Join to view full profile

Dr. Pepine is on Doximity

As a Doximity member you'll join over a million verified healthcare professionals in a private, secure network.

Connect with other colleagues in the same hospital or clinic
Search all U.S. specialist profiles and refer a patient
Read the latest clinical news and earn CME/CEU credits

See Dr. Pepine's full profile

Already have an account?

Office
1600 SW Archer Road
Box 100277
Gainesville, FL 32610
Phone(352) 273-9082
Fax(352) 392-3606
Is this information wrong?

Education & Training

Naval Regional Medical CenterResidency, Internal Medicine, 1968 - 1971
Thomas Jefferson UniversityResidency, Internal Medicine, 1967 - 1968
Allegheny General Hospital - Western Pennsylvania HospitalInternship, Internal Medicine, 1966 - 1967
Rutgers New Jersey Medical SchoolClass of 1966

Certifications & Licensure

FL State Medical License 1974 - 2022
PA State Medical License 1967 - 1984
American Board of Internal Medicine Internal Medicine
American Board of Internal Medicine Cardiovascular Disease

Awards, Honors, & Recognition

America's Top Doctors Castle Connolly, 2002-2014
CMS Meaningful Use Stage 1 Certification EpicCare Ambulatory EMR, Epic Systems Corporation, 2012-2013
Women's Health Castle Connolly, 2008
Men's Health Castle Connolly, 2007
Top Doctors: Florida Castle Connolly, 2000
Elected Member The American Society for Clinical Investigation, 1982
Whos Who in Medicine and Healthcare Marquis Whos Who
Join now to see all

Clinical Trials

The Role of Gut Microbiota in Heart Failure and Pre-Heart Failure With Preserved Ejection Fraction Start of enrollment: 2016 May 01Carl J Pepine, MD
Stem Cell Injection in Cancer Survivors Start of enrollment: 2016 Mar 01Bolli R.,Finet J.E.,Hare J.,Pepine C.,Sayre S.L.,Simari R.,Traverse J.,Willerson J.,Yang P.
Combination of Mesenchymal and C-kit+ Cardiac Stem Cells as Regenerative Therapy for Heart Failure Start of enrollment: 2015 Oct 01Bolli R.,Caccamo M.,Mitrani R.,Pepine C.J.,Simari R.,Traverse J.,Vojvodic R.,Willerson J.T.,Yang P.
The Role of Gut Microbiota in Hypertension Start of enrollment: 2014 Jul 01Handberg, E.M.,Raizada, M.
Angiotensin and Neuroimmune Activation in Hypertension Start of enrollment: 2014 May 01Leach, D.,Raizada, M.
Patients With Intermittent Claudication Injected With ALDH Bright Cells Start of enrollment: 2013 Jun 01Hirsch, A.,Bruhn-Ding, B.,Pepine, C.,Leach, D.,DiFede, D.,Perin, E.,Khan, F.,Alexander, J.,Chambers, J.,Goldman, J.,Hare, J.,Moye, L.A.,Murphy, M.,G'Sell, P.,Yang, P.,Simari, R.,Bolli, R.,Williams, S.
Randomized, Double-Blind, Placebo-Controlled Phase I/II Study of the Safety and Efficacy of Intracoronary Delivery of Allogeneic Cardiosphere-Derived Cells in Patients With an Anterior Myocardial Infarction and Ischemic Left Ventricular Dysfunction Start of enrollment: 2012 Oct 01Pepine, C.J.,Makkar, R.R.,Kereiakes, D.,Henry, T.J.,Traverse, J.H.,Schatz, R.A.,Rade, J.J.,Hermiller, J.B.,Gammon, R.S.,Aguirre, F.V.
Safety and Feasibility Trial of Adipose-Derived Regenerative Cells in the Treatment of Chronic Myocardial Ischemia Start of enrollment: 2012 Jun 01Patel, A.,Nordgren, B.K.,Pepine, C.J.,Lambert, C.R.,Leach, D.,Smith, D.,Perin, E.,Mendelsohn, F.O.,Catchpole, H.,Gibbs, J.,Brobeck, M.J.,Olson, R.,Schatz, R.A.,DeRamus, S.,Povsic, T.,Henry, T.,James, W.T.
IK-5001 for the Prevention of Remodeling of the Ventricle and Congestive Heart Failure After Acute Myocardial Infarction Start of enrollment: 2012 Apr 01Greenbaum, A.,Elsasser, A.,Merdler, A.,Katz, A.,Kokis, A.,Wysokinski, A.,Pollak, A.,Quraishi, A.,Linke, A.,Pepine, C.J.,Kupatt, C.,Naber, C.K.,Tron, C.,Buller, C.,Logeart, D.,Schoors, D.,Czarnecka, D.,Las...
Treatment With Ranolazine in Microvascular Coronary Dysfunction (MCD): Impact on Angina Myocardial Ischemia Start of enrollment: 2011 May 01Mehta, P.,Mou, Y.,Pepine, C.
Women's Ischemia Syndrome Evaluation (WISE) Coronary Vascular Dysfunction Start of enrollment: 2008 Sep 01Ando, R.,Mou, Y.,Pepine, C.J.
A Double-Blind, Multicenter, Placebo Controlled Study of Aldosterone Blockade (Eplerenone) in Women With Chest Pain, Coronary Vascular Dysfunction and Evidence of Myocardial Ischemia in the Absence of Significant Epicardial Coronary Artery Disease Start of enrollment: 2004 Aug 01Pepine, C.J.
Retinal Photography in Women With Chest Pain: A WISE/ARIC Collaboration Start of enrollment: 2003 Jun 01Handberg, E.
Women's Ischemia Syndrome Evaluation (WISE) Start of enrollment: 2001 May 01Kelsey, S.,Pepine, C.,Reis, S.
QWISE - Study of Quinapril in Women With Chest Pain, Coronary Flow Reserve Limitations and Evidence of Myocardial Ischemia Start of enrollment: 2000 May 01Pepine, C.J.
INternational VErapamil SR Trandolapril STudy Start of enrollment: 1997 Sep 01Pepine, C.J.
Asymptomatic Cardiac Ischemia Pilot (ACIP) Study Start of enrollment: 1990 Nov 01Cohen, J.,Davies, R.,Deanfield, J.,Ketterer, M.,Knatterud, G.,Mueller, H.,Ouyang, P.,Pepine, C.,Pratt, C.,Rogers, W.,Selwyn, A.
Gut Organoid Study Carl Pepine
Join now to see all

Publications & Presentations

PubMed

Preparticipation Cardiac Evaluation Findings in a Cohort of Collegiate Female Athletes.
Cecil A. Rambarat, Fred Reifsteck, James R. Clugston, Eileen M. Handberg, Matthew W. Martinez, Robert Hamburger, Joan Street, Breton M. Asken, Yasmeen Taha, Matthew Ke...> ;American Journal of Cardiology. 2021 Feb 1
Sex Differences, Aspirin, and Primary Prevention.
Osama Dasa, Carl J. Pepine> ;The American Journal of Medicine. 2021 Jan 1
Would Repurposing Minocycline Alleviate Neurologic Manifestations of COVID-19?
Oliveira, A. C., Richards, E. M., Karas, M. M., Pepine, C. J., Raizada, M. K.> ;Frontiers in neuroscience. 2020 Oct 30
Point of care, bone marrow mononuclear cell therapy in ischemic heart failure patients personalized for cell potency: 12-month feasibility results from CardiAMP heart ...
Amish N. Raval, Peter V. Johnston, Henricus J. Duckers, Thomas D. Cook, Jay H. Traverse, Peter A. Altman, Ravi Dhingra, Peiman Hematti, Ivan Borrello, R. David Anderso...> ;International Journal of Cardiology. 2020 Oct 20
Cell Therapy Strategies With No Safety Concerns and Demonstrated Benefits Warrant Study.
Pepine, C. J., Raval, A. N.> ;Circulation journal : official journal of the Japanese Circulation Society. 2020 Oct 13
The Clinical Spectrum of Myocardial Infarction and Ischemia With Nonobstructive Coronary Arteries in Women.
van den Hoogen, I. J., Gianni, U., Wood, M. J., Taqueti, V. R., Lin, F. Y., Hayes, S. N., Feuchtner, G. M., van Rosendael, A. R., Wenger, N. K., Wei, J., Merz, C. N., ...> ;JACC. Cardiovascular imaging. 2020 Oct 5
Attended vs unattended systolic blood pressure measurement: A randomized comparison in patients with cardiovascular disease.
Ellen C. Keeley, Matthew Villanueva, Yiqing E. Chen, Yan Gong, Eileen M. Handberg, Steven M. Smith, Carl J. Pepine, Rhonda M. Cooper-DeHoff> ;Journal of Clinical Hypertension. 2020 Sep 20
What is the Real Message of the ISCHEMIA Trial from a Clinician's Perspective?
Islam Y. Elgendy, Carl J. Pepine> ;European Cardiology Review. 2020 Aug 31
Assessment of Vascular Dysfunction in Patients Without Obstructive Coronary Artery Disease: Why, How, and When
Thomas J. Ford, Peter Ong, Udo Sechtem, John F. Beltrame, Paolo G. Camici, Filippo Crea, Juan-Carlos Kaski, C. Noel Bairey Merz, Carl J. Pepine, Hiroaki Shimokawa, Col...> ;Jacc-cardiovascular Interventions. 2020 Aug 24
Association of Factor V Leiden with Subsequent Atherothrombotic Events: A GENIUS-CHD Study of Individual Participant Data
Bakhtawar K. Mahmoodi, Vinicius Tragante, Marcus E. Kleber, Michael V. Holmes, Amand F. Schmidt, Raymond O. McCubrey, Laurence J. Howe, Kenan Direk, Hooman Allayee, Ek...> ;Circulation. 2020 Aug 11
Left ventricular mass and myocardial scarring in women with hypertensive disorders of pregnancy
Odayme Quesada, Ki Park, Janet Wei, Eileen M. Handberg, Chrisandra Shufelt, Margo Minissian, Galen Cook-Wiens, Parham Zarrini, Christine Pacheco, Balaji Tamarappoo, Lo...> ;Open heart. 2020 Aug 1
Cardiac stem cell therapy among Clinics of Uncertain Regulatory Status (COURS): under-regulated, under-observed, incompletely understood.
Lindeman, A., Pepine, C. J., March, K. L.> ;Journal of translational medicine. 2020 Jul 18
Cardiovascular Considerations for the Internist and Hospitalist in the COVID-19 Era.
Michael Massoomi, R. David Anderson, Mustafa M. Ahmed, Osama Dasa, Philip George, William M. Miles, Juan M. Aranda, Carl J. Pepine> ;The American Journal of Medicine. 2020 Jul 10
Temporal Trends in Angina, Myocardial Perfusion, and Left Ventricular Remodeling in Women With No Obstructive Coronary Artery Disease Over 1‐Year Follow‐Up: Results Fr...
Odayme Quesada, Melody Hermel, Nissi Suppogu, Haider Aldiwani, Chrisandra Shufelt, Puja K. Mehta, Galen Cook-Wiens, Jenna Maughan, Daniel S. Berman, Louise Thomson, Ei...> ;Journal of the American Heart Association. 2020 Jul 7
Clinical safety profile of transendocardial catheter injection systems: A plea for uniform reporting
Amish N. Raval, Carl J. Pepine> ;Cardiovascular Revascularization Medicine. 2020 Jun 30
Resting coronary velocity and myocardial performance in women with impaired coronary flow reserve: Results from the Women's Ischemia Syndrome Evaluation-Coronary Vascu...
Nissi Suppogu, Janet Wei, Michael D. Nelson, Galen Cook-Wiens, Susan Cheng, Chrisandra Shufelt, Louise Thomson, Balaji Tamarappoo, Daniel S. Berman, Bruce Samuels, Bab...> ;International Journal of Cardiology. 2020 Jun 15
Why are women better protected from COVID-19: Clues for men? Sex and COVID-19.
Elgendy, I. Y., Pepine, C. J.> ;International journal of cardiology. 2020 May 19
Oxidative Stress Is Associated With Diastolic Dysfunction in Women With Ischemia With No Obstructive Coronary Artery Disease.
Mohamad Raad, Ahmed AlBadri, Janet Wei, Puja K. Mehta, Jenna Maughan, Adit Gadh, Louise Thomson, Dean P. Jones, Arshed A. Quyyumi, Carl J. Pepine, C. Noel Bairey Merz> ;Journal of the American Heart Association. 2020 May 18
Adverse Pregnancy Outcomes Are Associated with Reduced Coronary Flow Reserve in Women With Signs and Symptoms of Ischemia Without Obstructive Coronary Artery Disease: ...
Ki Park, Odayme Quesada, Galen Cook-Wiens, Janet Wei, Margo Minissian, Eileen M. Handberg, Noel Bairey Merz, Carl J. Pepine> ;Journal of Womens Health. 2020 Apr 17
Heart failure with preserved ejection fraction: Similarities and differences between women and men.
Carl J. Pepine, C. Noel Bairey Merz, Stephanie El Hajj, Keith C. Ferdinand, Michele A. Hamilton, Kathryn J. Lindley, Michael D. Nelson, Odayme Quesada, Nanette K. Weng...> ;International Journal of Cardiology. 2020 Apr 1
Not typical angina and mortality in women with obstructive coronary artery disease: Results from the Women's Ischemic Syndrome Evaluation study (WISE).
Erika Jones, B. Delia Johnson, Leslee J. Shaw, May Bakir, Janet Wei, Puja K. Mehta, Margo Minissian, Carl J. Pepine, Steven E. Reis, Sheryl F. Kelsey, Eileen M. Handbe...> ;IJC Heart & Vasculature. 2020 Mar 24
Maternal Treatment With Captopril Persistently Alters Gut-Brain Communication and Attenuates Hypertension of Male Offspring.
Hong-Bao Li, Tao Yang, Elaine M. Richards, Carl J. Pepine, Mohan K. Raizada> ;Hypertension. 2020 Mar 23
Coronary Vascular Function and Cardiomyocyte Injury: A Report From the WISE-CVD.
Ahmed AlBadri, Janet Wei, Odayme Quesada, Puja K. Mehta, Yi Xiao, Yi-An Ko, R. David Anderson, John Petersen, Babak Azarbal, Bruce Samuels, Timothy D. Henry, Galen Coo...> ;Arteriosclerosis, Thrombosis, and Vascular Biology. 2020 Mar 6
Treatment of coronary microvascular dysfunction.
C. Noel Bairey Merz, Carl J. Pepine, Hiroki Shimokawa, Colin Berry> ;Cardiovascular Research. 2020 Mar 1
Transcriptomic signature of gut microbiome-contacting cells in colon of spontaneously hypertensive rats.
Tao Yang, Hong-Bao Li, Aline C. Oliveira, Ruby Goel, Elaine M. Richards, Carl J. Pepine, Mohan K. Raizada> ;Physiological Genomics. 2020 Mar 1
Join now to see all

Journal Articles

Gut Microbiota and Serum Metabolite Differences in African Americans and White Americans with High Blood Pressure☆
Carl Pepine, MD, International Journal of Cardiology

Lectures

Refractory Angina: Options for Patients With 'No Options
2019 ACC Scientific Session & Expo, New Orleans - 3/18/2019

Authored Content

Invasive Functional Assessment in Patients with Angina and Coronary Microvascular Dysfunction A Plea for MoreMay 2020
Invasive Functional Assessment in Patients with Angina and Coronary Microvascular Dysfunction A Plea for MoreMay 2020

Press Mentions

Biocardia Reports 2019 Financial Results and Recent Business HighlightsApril 9th, 2020
Biocardia Announces Positive Dsmb Recommendation to Continue Phase Iii Pivotal Cardiamp Heart Failure Study, as PlannedMarch 31st, 2020
Biocardia Announces Timing for Prespecified Data Safety Monitoring Board Report on Pivotal Cardiamp Heart Failure TrialMarch 12th, 2020
Join now to see all

Grant Support

Ufrcc For Cardiovascular Cell Therapy Research NetworkNational Heart, Lung, And Blood Institute2012
Women'S Ischemia Syndrome Evaluation (WISE) Coronary Vascular DysfunctionNational Heart, Lung, And Blood Institute2008–2011
Ancillary Functional Studies For The CctrnNational Heart, Lung, And Blood Institute2008–2011
Ufcc For Cardiovascular Cell Therapy Research NetworkNational Heart, Lung, And Blood Institute2007–2011
Renin Angiotensin For Coronary Microvascular DysfunctionNational Heart, Lung, And Blood Institute2001–2005
Scientific Review And Evaluation GrantNational Heart, Lung, And Blood Institute2001–2002
Ischemic Heart Disease In Women--Clinical CenterDivision Of Heart And Vascular Diseases1996–2001
Exercise Induced Ischemia In Patients With Stable Exertional AnginaNational Center For Research Resources1997–1999
DMP 754 In Patients With Chronic Stable Coronary Artery DiseaseNational Center For Research Resources1997