CassianKYeeMD

Oncology • Houston, TX

Professor, Medicine, University of Washington School of Medicine

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Office
1515 Holcombe Blvd
Houston, TX 77030
Phone+1 713-792-6161
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Education & Training

University of WashingtonFellowship, Hematology and Medical Oncology, 1991 - 1994
Stanford Health Care-Sponsored Stanford UniversityResidency, Internal Medicine, 1989 - 1991
University of ManitobaClass of 1986

Certifications & Licensure

CA State Medical License 1990 - Present
TX State Medical License 2014 - 2024
WA State Medical License 1991 - 2015

Awards, Honors, & Recognition

Elected Member The American Society for Clinical Investigation, 2009
Whos Who in Medicine and Healthcare Marquis Whos Who
Super Doctor SuperDoctors.com

Clinical Trials

Biological Therapy in Treating Patients With Metastatic Melanoma Start of enrollment: 1995 Oct 01
Completed
Phase 1, Phase 2
Biological Therapy in Treating Patients With Metastatic Melanoma Start of enrollment: 2002 Oct 01
Completed
Phase 1
Biological Therapy in Treating Patients With Metastatic Melanoma Start of enrollment: 2001 Nov 01
Completed
Phase 1
Cellular Adoptive Immunotherapy in Treating Patients With Stage III or Stage IV Ovarian Cancer or Primary Peritoneal Cancer Start of enrollment: 2004 Oct 01
Completed
Phase 1
Fludarabine Followed By Adoptive Immunotherapy in Treating Patients With Stage IV Melanoma Start of enrollment: 2003 May 01
Completed
Phase 1
Therapeutic Autologous Lymphocytes, Cyclophosphamide, and Aldesleukin in Treating Patients With Stage IV Melanoma Start of enrollment: 2006 Dec 01
Completed
Phase 1
Laboratory-Treated T Cells and Aldesleukin After Cyclophosphamide in Treating Patients With Stage IV Melanoma Start of enrollment: 2007 Sep 01
Completed
Phase 1, Phase 2
Cyclophosphamide, Autologous Lymphocytes, and Aldesleukin in Treating Patients With Metastatic Melanoma Start of enrollment: 2009 Jun 01
No longer available
Therapeutic Autologous Lymphocytes, Cyclophosphamide, and Aldesleukin in Treating Patients With Metastatic Melanoma Start of enrollment: 2010 Apr 01
Terminated
Phase 1
CD8+ Antigen-Specific T Cells, Cyclophosphamide, Aldesleukin, and Ipilimumab in Treating Patients With Metastatic Melanoma Start of enrollment: 2015 Jan 22
Active, not recruiting
Phase 2
Adoptive Therapy Using Antigen-Specific CD4 T-Cells Start of enrollment: 2016 Dec 01
Withdrawn
Phase 1
CD8+ T Cell Therapy and Pembrolizumab in Treating Patients With Metastatic Gastrointestinal Tumors Start of enrollment: 2019 Aug 09
Terminated
Phase 1
T-Cell Infusion, Aldesleukin, and Utomilumab in Treating Patients With Recurrent Ovarian Cancer Start of enrollment: 2018 Jul 16
Completed
Phase 1, Phase 2
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Publications & Presentations

PubMed

Nanofibrous MultiDomain Peptide Hydrogels Provide T Cells a 3D, Cytocompatible Environment for Cell Expansion and Antigen-Specific Killing.
Viridiana Leyva-Aranda, Shailbala Singh, Maria J Telesforo, Simon Young, Cassian Yee, Jeffrey D Hartgerink> ;ACS Biomaterials Science & Engineering. 2024 Mar 11
3 citations
Model-informed drug development of autologous CAR-T cell therapy: Strategies to optimize CAR-T cell exposure leveraging cell kinetic/dynamic modeling.
Anna M Mc Laughlin, Peter A Milligan, Cassian Yee, Martin Bergstrand> ;CPT. 2023 Nov 1
13 citations
Concurrent intrathecal and intravenous nivolumab in leptomeningeal disease: phase 1 trial interim results.
Isabella C Glitza Oliva, Sherise D Ferguson, Roland Bassett Jr, Alexandra P Foster, Ida John, Tarin D Hennegan, Michelle Rohlfs, Jessie Richard, Masood Iqbal, Tina Det...> ;Nature Medicine. 2023 Apr 1
2 citations
Single-cell CRISPR immune screens reveal immunological roles of tumor intrinsic factors.
Jiakai Hou, Shaoheng Liang, Chunyu Xu, Yanjun Wei, Yunfei Wang, Yukun Tan, Nidhi Sahni, Daniel J McGrail, Chantale Bernatchez, Michael Davies, Yumei Li, Rui Chen, S St...> ;NAR Cancer. 2022 Dec 1
12 citations
Tertiary lymphoid structure signatures are associated with immune checkpoint inhibitor related acute interstitial nephritis.
Shailbala Singh, James P Long, Amanda Tchakarov, Yanlan Dong, Cassian Yee, Jamie S Lin> ;JCI Insight. 2022 Dec 1
8 citations
Evolution and modulation of antigen-specific T cell responses in melanoma patients.
Jani Huuhtanen, Liang Chen, Emmi Jokinen, Henna Kasanen, Tapio Lönnberg, Anna Kreutzman, Katriina Peltola, Micaela Hernberg, Chunlin Wang, Cassian Yee, Harri Lähdesmäk...> ;Nature Communications. 2022 Oct 11
5 citations
Immune landscape of a genetically engineered murine model of glioma compared with human glioma.
Daniel B Zamler, Takashi Shingu, Laura M Kahn, Kristin Huntoon, Cynthia Kassab, Martina Ott, Katarzyna Tomczak, Jintan Liu, Yating Li, Ivy Lai, Rocio Zorilla-Veloz, Ca...> ;JCI Insight. 2022 Jun 22
77 citations
Interleukin-6 blockade abrogates immunotherapy toxicity and promotes tumor immunity.
Yared Hailemichael, Daniel H Johnson, Noha Abdel-Wahab, Wai Chin Foo, Salah-Eddine Bentebibel, May Daher, Cara Haymaker, Khalida Wani, Chantal Saberian, Dai Ogata, San...> ;Cancer Cell. 2022 May 9
3 citations
Genomic Correlates of Outcome in Tumor-Infiltrating Lymphocyte Therapy for Metastatic Melanoma.
Caitlin A Creasy, Yuzhong Jeff Meng, Marie-Andrée Forget, Tatiana Karpinets, Katarzyna Tomczak, Chip Stewart, Carlos A Torres-Cabala, Shari Pilon-Thomas, Amod A Sarnai...> ;Clinical Cancer Research. 2022 May 2
5 citations
Targeting TCTP sensitizes tumor to T cell-mediated therapy by reversing immune-refractory phenotypes.
Hyo-Jung Lee, Kwon-Ho Song, Se Jin Oh, Suyeon Kim, Eunho Cho, Jungwon Kim, Yun Gyu Park, Kyung-Mi Lee, Cassian Yee, Seung-Hwa Song, Suhwan Chang, Jungmin Choi, Sang Ta...> ;Nature Communications. 2022 Apr 19
3 citations
Urinary T cells are detected in patients with immune checkpoint inhibitor-associated immune nephritis that are clonotypically identical to kidney T cell infiltrates.
Shailbala Singh, Leticia C Clemente, Edwin R Parra, Amanda Tchakarov, Chao Yang, Yisheng Li, James P Long, Cassian Yee, Jamie S Lin> ;Oncoimmunology. 2022 Jan 1
83 citations
The allergy mediator histamine confers resistance to immunotherapy in cancer patients via activation of the macrophage histamine receptor H1
Hongzhong Li, Yi Xiao, Li Qin, Jun Yao, Xiangliang Yuan, Yuan Zhang, Xuedong Yin, Yohei Saito, Huihui Fan, Ping Li, Wenling Kuo, Angela Halpin, Don L. Gibbons, Hideo Y...> ;Cancer Cell. 2021 Nov 24
15 citations
Mass spectrometric identification of immunogenic SARS-CoV-2 epitopes and cognate TCRs.
Ke Pan, Yulun Chiu, Eric C. Huang, Michelle Chen, Junmei Wang, Ivy Lai, Shailbala Singh, Rebecca M. Shaw, Michael J. MacCoss, Cassian Yee> ;Proceedings of the National Academy of Sciences of the United States of America. 2021 Nov 16
28 citations
Hematologic complications of immune checkpoint inhibitors.
Michael H. Kroll, Cassian Yee, Cristhiam Rojas Hernandez> ;Blood. 2021 Oct 5
45 citations
Single-dose intranasal vaccination elicits systemic and mucosal immunity against SARS-CoV-2.
Xingyue An, Melisa Martinez-Paniagua, Ali Rezvan, Samiur Rahman Sefat, Mohsen Fathi, Shailbala Singh, Sujit Biswas, Melissa Pourpak, Cassian Yee, Xinli Liu, Navin Vara...> ;Iscience. 2021 Sep 24
2 citations
Immunogenic SARS-CoV2 Epitopes Defined by Mass Spectrometry
Ke Pan, Yulun Chiu, Eric C. Huang, Michelle Chen, Junmei Wang, Ivy Lai, Shailbala Singh, Rebecca M. Shaw, Michael J. MacCoss, Cassian Yee> ;Biorxiv. 2021 Jul 21
In Silico Defined SARS-CoV2 Epitopes May Not Predict Immunogenicity to COVID19
Ke Pan, Yulun Chiu, Mei-Ju May Chen, Junmei Wang, Ivy Lai, Shubhra Singh, Richard Shaw, Cassian Yee> ;Biorxiv. 2021 Jul 8
19 citations
Neoantigen vaccination induces clinical and immunologic responses in non-small cell lung cancer patients harboring EGFR mutations.
Fenge Li, Deng Ligang, Kyle R. Jackson, Amjad H. Talukder, Arjun S. Katailiha, Sherille D. Bradley, Zou Qingwei, Caixia Chen, Chong Huo, Yulun Chiu, Matthew Stair, Wei...> ;Journal for Immunotherapy of Cancer. 2021 Jul 1
16 citations
Early Survival Prediction Framework in CD19-Specific CAR-T Cell Immunotherapy Using a Quantitative Systems Pharmacology Model.
Anna Mueller-Schoell, Nahum Puebla-Osorio, Robin Michelet, Michael R. Green, Annette Künkele, Wilhelm Huisinga, Paolo Strati, Beth Chasen, Sattva S. Neelapu, Cassian Y...> ;Cancers. 2021 Jun 3
23 citations
Hypoxia acts as an environmental cue for the human tissue-resident memory T cell differentiation program
Farah Hasan, Yulun Chiu, Rebecca M. Shaw, Junmei Wang, Cassian Yee> ;JCI Insight. 2021 May 24
22 citations
Incidence, predictors, and survival impact of acute kidney injury in patients with melanoma treated with immune checkpoint inhibitors: a 10-year single-institution ana...
Maen Abdelrahim, Omar Mamlouk, Heather Lin, Jamie S. Lin, Valda D. Page, Noha Abdel-Wahab, Joshua T. Swan, Umut Selamet, Cassian Yee, Adi Diab, Wadi N. Suki, Ala Abuda...> ;Oncoimmunology. 2021 May 23
8 citations
IL-15 mediated expansion of rare durable memory T cells following adoptive cellular therapy.
Karan Kohli, Lu Yao, Theodore S. Nowicki, Shihong Zhang, Ralph Graeme Black, Brett Schroeder, Erik A. Farrar, Jianhong Cao, Heather L. Sloan, Dawn Stief, Lee D. Cranme...> ;Journal for Immunotherapy of Cancer. 2021 May 1
15 citations
Randomized phase II trial of lymphodepletion plus adoptive cell transfer of tumor-infiltrating lymphocytes, with or without dendritic cell vaccination, in patients wit...
Chantal Saberian, Rodabe N. Amaria, Amer Najjar, Laszlo Radvanyi, Cara Haymaker, Marie Andrée Forget, Roland L. Bassett, Silvana de Castro Faria, Isabella C. Glitza, E...> ;Journal for Immunotherapy of Cancer. 2021 May 1
17 citations
Hypoxia-Driven HIF-1α Activation Reprograms Pre-Activated NK Cells towards Highly Potent Effector Phenotypes via ERK/STAT3 Pathways
Seon Ah Lim, Yunwon Moon, Min Hwa Shin, Tae Jin Kim, Sehyun Chae, Cassian Yee, Daehee Hwang, Hyunsung Park, Kyung Mi Lee> ;Cancers. 2021 Apr 15
20 citations
Infliximab for the treatment of patients with checkpoint inhibitor-associated acute tubular interstitial nephritis.
Jamie S. Lin, Omar Mamlouk, Umut Selamet, Amanda Tchakarov, William F. Glass, Rahul A. Sheth, Rachel M. Layman, Ramona Dadu, Noha Abdel-Wahab, Maen Abdelrahim, Adi Dia...> ;Oncoimmunology. 2021 Feb 2
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Lectures

Update on T-Cell Receptor Therapy
ASCO Annual Meeting 2019 - Chicago, IL - 6/3/2019

Press Mentions

MD Anderson Research Highlights for December 19, 2022December 19th, 2022
Gadeta Appoints Scientific Advisory Board and Provides Business UpdateOctober 20th, 2022
Immunotherapy for Rare Cancers: New Horizons and New HopeJuly 22nd, 2022
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Hospital Affiliations

University of Texas M.D. Anderson Cancer CenterHouston, Texas

CassianKYeeMD

Dr. Yee is on Doximity

Education & Training

Certifications & Licensure

Awards, Honors, & Recognition

Clinical Trials

Publications & Presentations

Press Mentions

Hospital Affiliations

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