CharlesGordonCaldwellMD

PubMed

• 25 citations
  Novel tetrahydropyran analogs as dipeptidyl peptidase IV inhibitors: Profile of clinical candidate (2R,3S,5R)-2-(2,5-difluorophenyl)-5-[2-(methylsulfonyl)-2,6-dihydrop...
  Tesfaye Biftu, Xiaoxia Qian, Ping Chen, Dennis Feng, Giovanna Scapin, Ying-Duo Gao, Jason M. Cox, Ranabir Sinha Roy, George J. Eiermann, Huabing He, Kathy Lyons, Gino ...> ;Bioorganic & Medicinal Chemistry Letters. 2013 Oct 1
• Genome-wide DNA methylation analysis reveals novel epigenetic changes in chronic lymphocytic leukemia.
  Pei, L., Choi, J. H., Liu, J., Lee, E. J., McCarthy, B., Wilson, J. M., Speir, E., Awan, F., Tae, H., Arthur, G., Schnabel, J. L., Taylor, K. H., Wang, X., Xu, D., Din...> ;Epigenetics. 2012 Jun 1
• 5 citations
  Synthesis and evaluation of [(1R)-1-amino-2-(2,5-difluorophenyl)ethyl]cyclohexanes and 4-[(1R)-1-amino-2-(2,5-difluorophenyl)ethyl]piperidines as DPP-4 inhibitors.
  Ping Chen, Charles G. Caldwell, Wallace T. Ashton, Joseph K. Wu, Huaibing He, Kathryn A. Lyons, Nancy A. Thornberry, Ann E. Weber> ;Bioorganic & Medicinal Chemistry Letters. 2011 Mar 15
• 13 citations
  Imidazopiperidine amides as dipeptidyl peptidase IV inhibitors for the treatment of diabetes
  Ping Chen, Charles G. Caldwell, Robert J. Mathvink, Barbara Leiting, Frank Marsilio, Reshma A. Patel, Joseph K. Wu, Huaibing He, Kathryn A. Lyons, Nancy A. Thornberry,...> ;Bioorganic & Medicinal Chemistry Letters. 2007 Nov 1
• 21 citations
  Metabolic activation of fluoropyrrolidine dipeptidyl peptidase-IV inhibitors by rat liver microsomes.
  Shiyao Xu, Bing Zhu, Yohannes Teffera, Deborah E. Pan, Charles G. Caldwell, George A. Doss, Ralph A. Stearns, David C. Evans, Maria G. Beconi> ;Drug Metabolism and Disposition. 2005 Jan 1
• 9 citations
  Synthesis of analogs of (1,4)-3- and 5-imino oxazepane, thiazepane, and diazepane as inhibitors of nitric oxide synthases.
  Kothandaraman Shankaran, Karla L. Donnelly, Shrenik K. Shah, Charles G. Caldwell, Ping Chen, William K. Hagmann, Malcolm MacCoss, John L. Humes, Stephen G. Pacholok, T...> ;Bioorganic & Medicinal Chemistry Letters. 2004 Dec 6
• 8 citations
  Syntheses and biological evaluation of 5-(piperidin-1-yl)-3-phenyl-pentylsulfones as CCR5 antagonists.
  Kothandaraman Shankaran, Karla L. Donnelly, Shrenik K. Shah, Charles G. Caldwell, Ping Chen, Paul E. Finke, Bryan Oates, Malcolm MacCoss, Sander G. Mills, Julie A. DeM...> ;Bioorganic & Medicinal Chemistry Letters. 2004 Jul 5
• 39 citations
  Fluoropyrrolidine amides as dipeptidyl peptidase IV inhibitors.
  Charles G. Caldwell, Ping Chen, Jiafang He, Emma R. Parmee, Barbara Leiting, Frank Marsilio, Reshma A. Patel, Joseph K. Wu, George J. Eiermann, Aleksandr Petrov, Huaib...> ;Bioorganic & Medicinal Chemistry Letters. 2004 Mar 8
• 3 citations
  CCR5 antagonists: 3-(pyrrolidin-1-yl)propionic acid analogues with potent anti-HIV activity.
  Christopher L. Lynch, Jeffrey J. Hale, Richard J. Budhu, Amy L. Gentry, Paul E. Finke, Charles G. Caldwell, Sander G. Mills, Malcolm MacCoss, Dong-Ming Shen, Kevin T. ...> ;Organic Letters. 2003 Jun 11
• 60 citations
  Binding of 2-aryl-4-(piperidin-1-yl)butanamines and 1,3,4-trisubstituted pyrrolidines to human CCR5: a molecular modeling-guided mutagenesis study of the binding pocket.
  Laurie A. Castonguay, Youmin Weng, Adolfsen W, Di Salvo J, Ruth Kilburn, Charles G. Caldwell, Bruce L. Daugherty, Paul E. Finke, J. J. Hale, Christopher L. Lynch, Sand...> ;Biochemistry. 2003 Jan 22
• 29 citations
  1,3,4-Trisubstituted pyrrolidine CCR5 receptor antagonists: modifications of the arylpropylpiperidine side chains.
  Christopher L. Lynch, Christopher A. Willoughby, Jeffrey J. Hale, Edward J. Holson, Richard J. Budhu, Amy Gentry, Keith G. Rosauer, Charles G. Caldwell, Ping Chen, San...> ;Bioorganic & Medicinal Chemistry Letters. 2003 Jan 1
• 25 citations
  Discovery of human CCR5 antagonists containing hydantoins for the treatment of HIV-1 infection.
  Dooseop Kim, Liping Wang, Charles G. Caldwell, Ping Chen, Paul E. Finke, Bryan Oates, Malcolm MacCoss, Sander G. Mills, Lorraine Malkowitz, Sandra L. Gould, Julie A. D...> ;Bioorganic & Medicinal Chemistry Letters. 2001 Dec 17
• 24 citations
  Design, synthesis, and SAR of heterocycle-containing antagonists of the human CCR5 receptor for the treatment of HIV-1 infection.
  Dooseop Kim, Liping Wang, Charles G. Caldwell, Ping Chen, Paul E. Finke, Bryan Oates, Malcolm MacCoss, Sander G. Mills, Lorraine Malkowitz, Sandra L. Gould, Julie A. D...> ;Bioorganic & Medicinal Chemistry Letters. 2001 Dec 17
• 47 citations
  Inhibition of stromelysin-1 (MMP-3) by P1'-biphenylylethyl carboxyalkyl dipeptides.
  Craig K. Esser, Robert L. Bugianesi, Charles G. Caldwell, Kevin T. Chapman, Philippe L. Durette, Narindar N. Girotra, Ihor E. Kopka, Thomas J. Lanza, Dorothy Levorse, ...> ;Journal of Medicinal Chemistry. 1997 Mar 14
• 19 citations
  Comparison of the structure of human recombinant short form stromelysin by multidimensional heteronuclear NMR and X-ray crystallography.
  Paul R. Gooley, John F. O'Connell, Alice I. Marcy, Gregory C. Cuca, Melinda G. Axel, Charles G. Caldwell, William K. Hagmann, Joseph W. Becker> ;Journal of Biomolecular NMR. 1996 Jan 1
• 36 citations
  Substituted 2-aminopyridines as inhibitors of nitric oxide synthase
  Craig K. Esser, William K. Hagmann, William F. Hoffman, Shrenik K. Shah, Kenny K. Wong, Renee M. Chabin, Ravindra K. Guthikonda, Malcolm MacCoss, Charles G. Caldwell, ...> ;Bioorganic & Medicinal Chemistry Letters. 1995 Dec 8
• 2 citations
  Effects of matrix metalloproteinases on cartilage biophysical properties in vitro and in vivo.
  Lawrence J. Bonassar, Claribel G. Paguio, Eliot H. Frank, Kimberly A. Jeffries, Vernon L. Moore, Michael W. Lark, Charles G. Caldwell, William K. Hagmann, Alan J. Grod...> ;Annals of the New York Academy of Sciences. 1994 Sep 1
• 53 citations
  Substituted 4,6-diaminoquinolines as inhibitors of C5a receptor binding
  Thomas J. Lanza, Philippe L. Durette, Thomas E. Rollins, Salvatore J. Siciliano, Dana N. Cianciarulo, Sumire V. Kobayashi, Charles G. Caldwell, Martin Springer, Willia...> ;Journal of Medicinal Chemistry. 1992 Jan 24
• 24 citations
  L-156,602, a C5a antagonist with a novel cyclic hexadepsipeptide structure from Streptomyces sp. MA6348. Fermentation, isolation and structure determination.
  Otto D. Hensens, Robert P. Borris, Lawrence R. Koupal, Charles G. Caldwell, Sara A. Currie, Akber A. Haidri, Carl F. Homnick, Susan S. Honeycutt, Susan M. Lindenmayer,...> ;The Journal of Antibiotics. 1991 Feb 25
• 16 citations
  2,3-Dihydro-5-benzofuranols as antioxidant-based inhibitors of leukotriene biosynthesis.
  Milton L. Hammond, Ihor E. Kopka, Robert A. Zambias, Charles G. Caldwell, Joshua S. Boger, Baker F, Bach Tj, Silvi Luell, MacIntyre De> ;Journal of Medicinal Chemistry. 1989 May 1
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