CharlesLSawyersMD

PubMed

• Dickkopf-1 Can Lead to Immune Evasion in Metastatic Castration-Resistant Prostate Cancer
  David R. Wise, Jeffrey A. Schneider, Joshua Armenia, Victor Ricardo Adorno Febles, Bridget McLaughlin, Ryan Brennan, Katie L. Thoren, Wassim Abida, Karen S. Sfanos, An...> ;JCO precision oncology. 2020 Sep 29
• FOXA1 Mutations Reveal Distinct Chromatin Profiles and Influence Therapeutic Response in Breast Cancer.
  Arruabarrena-Aristorena, A., Maag, J. L., Kittane, S., Cai, Y., Karthaus, W. R., Ladewig, E., Park, J., Kannan, S., Ferrando, L., Cocco, E., Ho, S. Y., Tan, D. S., Sal...> ;Cancer cell. 2020 Sep 6
• Tumor Microenvironment-Derived NRG1 Promotes Antiandrogen Resistance in Prostate Cancer.
  Zeda Zhang, Wouter R. Karthaus, Young Sun Lee, Vianne R. Gao, Chao Wu, Joshua W. Russo, Menghan Liu, Jose Mauricio Mota, Wassim Abida, Eliot Linton, Eugine Lee, Spence...> ;Cancer Cell. 2020 Aug 10
• Somatic Tissue Engineering in Mouse Models Reveals an Actionable Role for WNT Pathway Alterations in Prostate Cancer Metastasis.
  Leibold, J., Ruscetti, M., Cao, Z., Ho, Y., Baslan, T., Zou, M., Abida, W., Feucht, J., Han, T., Barriga, F. M., Tsanov, K. M., Zamechek, L., Kulick, A., Amor, C., Tia...> ;Cancer discovery. 2020 May 8
• Regenerative potential of prostate luminal cells revealed by single-cell analysis.
  Karthaus, W. R., Hofree, M., Choi, D., Linton, E. L., Turkekul, M., Bejnood, A., Carver, B., Gopalan, A., Abida, W., Laudone, V., Biton, M., Chaudhary, O., Xu, T., Mas...> ;Science (New York, N.Y.). 2020 May 2
• Oncogenic ERG Represses PI3K Signaling through Downregulation of IRS2
  Ninghui Mao, Dong Gao, Wenhuo Hu, Sunyana Gadal, Haley Hieronymus, Shangqian Wang, Young Sun Lee, Patrick F. Sullivan, Zeda Zhang, Danielle Choi, Neal Rosen, Charles L...> ;Cancer Research. 2020 Apr 1
• Modulation of androgen receptor DNA binding activity through direct interaction with the ETS transcription factor ERG.
  Wasmuth, E. V., Hoover, E. A., Antar, A., Klinge, S., Chen, Y., Sawyers, C. L.> ;Proceedings of the National Academy of Sciences of the United States of America. 2020 Mar 30
• Loss of CHD1 Promotes Heterogeneous Mechanisms of Resistance to AR-Targeted Therapy via Chromatin Dysregulation.
  Zhang, Z., Zhou, C., Li, X., Barnes, S. D., Deng, S., Hoover, E., Chen, C., Lee, Y. S., Zhang, Y., Wang, C., Metang, L. A., Wu, C., Tirado, C. R., Johnson, N. A., Wong...> ;Cancer cell. 2020 Mar 30
• Publisher Correction: Lineage plasticity in cancer: a shared pathway of therapeutic resistance.
  Quintanal-Villalonga, Á., Chan, J. M., Yu, H. A., Pe'er, D., Sawyers, C. L., Sen, T., Rudin, C. M.> ;Nature reviews. Clinical oncology. 2020 Mar 24
• Lineage plasticity in cancer: a shared pathway of therapeutic resistance.
  Quintanal-Villalonga, Á., Chan, J. M., Yu, H. A., Pe'er, D., Sawyers, C. L., Sen, T., Rudin, C. M.> ;Nature reviews. Clinical oncology. 2020 Mar 11
• Characteristics and Outcome of <i>AKT1</i> ^E17K-Mutant Breast Cancer Defined through AACR Project GENIE, a Clinicogenomic Registry.
  Smyth, L. M., Zhou, Q., Nguyen, B., Yu, C., Lepisto, E. M., Arnedos, M., Hasset, M. J., Lenoue-Newton, M. L., Blauvelt, N., Dogan, S., Micheel, C. M., Wathoo, C., Horl...> ;Cancer discovery. 2020 Jan 12
• Prostate Organoid Cultures as Tools to Translate Genotypes and Mutational Profiles to Pharmacological Responses
  Kyrie J Pappas, Danielle Choi, Charles L. Sawyers, Wouter R. Karthaus> ;Journal of Visualized Experiments. 2019 Oct 24
• A rectal cancer organoid platform to study individual responses to chemoradiation.
  Karuna Ganesh, Chao Wu, Kevin P. O’Rourke, Bryan Szeglin, Youyun Zheng, Charles-Etienne Gabriel Sauvé, Mohammad Adileh, Isaac Wasserman, Michael R. Marco, Amanda S. Ki...> ;Nature Medicine. 2019 Oct 1
• Herceptin: A First Assault on Oncogenes that Launched a Revolution.
  Sawyers, C. L.> ;Cell. 2019 Sep 15
• Disruption of MAGI2-RapGEF2-Rap1 signaling contributes to podocyte dysfunction in congenital nephrotic syndrome caused by mutations in MAGI2
  Bingbing Zhu, Aili Cao, Jianhua Li, James J. Young, Jenny Wong, Shazia Ashraf, Agnieszka Bierzynska, Madhav C. Menon, Steven Hou, Charles L. Sawyers, Kirk N. Campbell,...> ;Kidney International. 2019 Sep 1
• The Role of Lineage Plasticity in Prostate Cancer Therapy Resistance.
  Beltran, H., Hruszkewycz, A., Scher, H. I., Hildesheim, J., Isaacs, J., Yu, E. Y., Kelly, K., Lin, D., Dicker, A., Arnold, J., Hecht, T., Wicha, M., Sears, R., Rowley,...> ;Clinical cancer research : an official journal of the American Association for Cancer Research. 2019 Aug 1
• FOXA1 mutations alter pioneering activity, differentiation and prostate cancer phenotypes
  Elizabeth J. Adams, Wouter R. Karthaus, Elizabeth Hoover, Deli Liu, Antoine Gruet, Zeda Zhang, Hyunwoo Cho, Rose DiLoreto, Sagar Chhangawala, Yang Liu, Philip A. Watso...> ;Nature. 2019 Jun 26
• Publisher Correction: The long tail of oncogenic drivers in prostate cancer.
  Armenia, J., Wankowicz, S. A., Liu, D., Gao, J., Kundra, R., Reznik, E., Chatila, W. K., Chakravarty, D., Han, G. C., Coleman, I., Montgomery, B., Pritchard, C., Morri...> ;Nature genetics. 2019 Jun 4
• Genomic correlates of clinical outcome in advanced prostate cancer.
  Wassim Abida, Joanna Cyrta, Glenn Heller, Davide Prandi, Joshua Armenia, Ilsa Coleman, Marcin Cieslik, Matteo Benelli, Dan R. Robinson, Eliezer M. Van Allen, Andrea Sb...> ;Proceedings of the National Academy of Sciences of the United States of America. 2019 Jun 4
• American Association for Cancer Research Project Genomics Evidence Neoplasia Information Exchange: From Inception to First Data Release and Beyond-Lessons Learned and ...
  Micheel, C. M., Sweeney, S. M., LeNoue-Newton, M. L., André, F., Bedard, P. L., Guinney, J., Meijer, G. A., Rollins, B. J., Sawyers, C. L., Schultz, N., Shaw, K. R., V...> ;JCO clinical cancer informatics. 2019 Jan 18
• GREB1 amplifies androgen receptor output in human prostate cancer and contributes to antiandrogen resistance.
  Eugine Lee, John Wongvipat, Danielle Choi, Ping Wang, Young Sun Lee, Deyou Zheng, Philip A. Watson, Anuradha Gopalan, Charles L. Sawyers> ;eLife. 2019 Jan 15
• Analysis of the Prevalence of Microsatellite Instability in Prostate Cancer and Response to Immune Checkpoint Blockade.
  Abida, W., Cheng, M. L., Armenia, J., Middha, S., Autio, K. A., Vargas, H. A., Rathkopf, D., Morris, M. J., Danila, D. C., Slovin, S. F., Carbone, E., Barnett, E. S., ...> ;JAMA oncology. 2018 Dec 28
• SMAD4 Loss in Colorectal Cancer Patients Correlates with Recurrence, Loss of Immune Infiltrate, and Chemoresistance.
  Wasserman, I., Lee, L. H., Ogino, S., Marco, M. R., Wu, C., Chen, X., Datta, J., Sadot, E., Szeglin, B., Guillem, J. G., Paty, P. B., Weiser, M. R., Nash, G. M., Saltz...> ;Clinical cancer research : an official journal of the American Association for Cancer Research. 2018 Dec 28
• Immunogenomic analyses associate immunological alterations with mismatch repair defects in prostate cancer.
  Rodrigues, D. N., Rescigno, P., Liu, D., Yuan, W., Carreira, S., Lambros, M. B., Seed, G., Mateo, J., Riisnaes, R., Mullane, S., Margolis, C., Miao, D., Miranda, S., D...> ;The Journal of clinical investigation. 2018 Nov 2
• Strategies to Identify and Target Cells of Origin in Prostate Cancer.
  Karthaus, W. R., Sawyers, C. L.> ;Journal of the National Cancer Institute. 2018 Oct 13
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Journal Articles

• Strategies to Identify and Target Cells of Origin in Prostate Cancer  
  Charles Sawyers, MD, Journal of the National Cancer Institute

Lectures

• GENIE: Lessons Learned and Challenges With Data Curation 
  2018 ASCO Annual Meeting - Chicago, Illinois - 06/4/2018