Gregory J Riely MD PhD

Thoracic Cancer

Attending Physician Thoracic Oncology Service, Department of Medicine, Memorial Hospital Member Memorial Sloan Kettering Cancer Center

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1275 York AveNew York, NY 10065
Book by Phone+1(779) 209-1312

Education & Training

Memorial Sloan Kettering Cancer CenterFellowship, Hematology and Medical Oncology, 2003 - 2006
New York Presbyterian Hospital (Cornell Campus)Residency, Internal Medicine, 2001 - 2003
Case Western Reserve University School of MedicineClass of 2001

Certifications & Licensure

FL State Medical License 2021 - Present
NJ State Medical License 2022 - 2027
NY State Medical License 2003 - 2026
NC State Medical License 2020 - 2022
American Board of Internal Medicine Internal Medicine
American Board of Internal Medicine Medical Oncology

Clinical Trials

Study of Salirasib to Treat Non-Small Cell Lung Cancer Start of enrollment: 2007 Sep 01
Completed
Phase 2
Dasatinib in Treating Patients With Advanced Lung Cancer That Is No Longer Responding to Erlotinib or Gefitinib Start of enrollment: 2006 Jun 01
Completed
Phase 2
Phase I Study of IPI-504 and Docetaxel in Patients With Advanced Solid Tumors Start of enrollment: 2007 Dec 01
Completed
Phase 1
Cetuximab in Patients With Lung Adenocarcinoma Receiving Erlotinib That Have Developed "Acquired Resistance" to Erlotinib Start of enrollment: 2008 Jul 01
Completed
Phase 1, Phase 2
Chemotherapy Plus Cetuximab Followed by Surgical Resection in Patients With Locally Advanced or Recurrent Thymoma or Thymic Carcinoma
ACTIVE_NOT_RECRUITING
PHASE2
Molecular Determinants of Acquired Clinical Resistance to Crizotinib in Non-small Cell Lung Cancer Harboring a Translocation or Inversion Event Involving the ALK Gene Locus Start of enrollment: 2011 Feb 08
Completed
Crizotinib and Ganetespib (STA-9090) in ALK Positive Lung Cancers Start of enrollment: 2012 Apr 16
Completed
Phase 1
Bortezomib in KRAS-Mutant Non-Small Cell Lung Cancer in Never Smokers or Those With KRAS G12D Start of enrollment: 2013 Apr 11
Completed
Phase 2
Pemetrexed Disodium and Carboplatin or Cisplatin With or Without Erlotinib Hydrochloride in Treating Patient With Stage IV Non-Small Cell Lung Cancer Resistant to First-Line Therapy With Erlotinib Hydrochloride or Gefitinib Start of enrollment: 2014 Jun 01
Withdrawn
Phase 2
A Phase I/II, Multicenter, Open-label Study of EGFRmut-TKI EGF816, Administered Orally in Adult Patients With EGFRmut Solid Malignancies Start of enrollment: 2014 Jun 06
COMPLETED
PHASE1, PHASE2
RO5126766 for Patients With Advanced KRAS-Mutant Lung Cancer Start of enrollment: 2018 Oct 31
COMPLETED
PHASE1
Trial of Trametinib and Ponatinib in Patients With KRAS Mutant Advanced Non-Small Cell Lung Cancer Start of enrollment: 2018 Oct 09
COMPLETED
PHASE1, PHASE2
Osimertinib Alone or With Chemotherapy for EGFR-Mutant Lung Cancers Start of enrollment: 2020 May 28
RECRUITING
PHASE2
A Phase 1/2 Trial of CLN-081 in Patients with Non-Small Cell Lung Cancer Start of enrollment: 2019 Oct 31
ACTIVE_NOT_RECRUITING
PHASE1, PHASE2
Roles: Sub-Investigator
A Study of Lorlatinib in Combination With Ramucirumab in People With Lung Cancer Start of enrollment: 2023 Aug 17
RECRUITING
PHASE1, PHASE2
Roles: Principal Investigator, Contact
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Publications & Presentations

PubMed

Clinical Significance of MTAP Deletions and their Overlap with Concurrent Oncogenic Driver Alterations Including EGFR in Non-Small Cell Lung Cancer.
Jessica S Ross, Rohit Thummalapalli, Christopher A Febres-Aldana, Daniel Muldoon, Christina Falcon
Journal of Thoracic Oncology. 2025-11-17
Phase 2 Study of Amivantamab Plus Lazertinib in Previously Treated Patients With EGFR-Mutant Lung Cancers With Brain and Leptomeningeal Metastases.
Monica F Chen, Jake June-Koo Lee, Noura J Choudhury, Angela B Hui, Mark Y Jeng
Journal of Thoracic Oncology. 2025-10-23
Updated Overall Survival Analysis From the Phase II PHAROS Study of Encorafenib Plus Binimetinib in Patients With BRAF V600E-Mutant Metastatic Non-Small Cell Lung Cancer.
Melissa L Johnson, Egbert F Smit, Enriqueta Felip, Suresh S Ramalingam, Myung-Ju Ahn
Journal of Clinical Oncology. 2025-10-19

Journal Articles

Effect of Osimertinib and Bevacizumab on Progression-Free Survival for Patients with Metastatic EGFR-Mutant Lung Cancers
Helena A Yu, Adam J Schoenfeld, Jamie E Chaft, Gregory J Riely, JAMA Oncology
PD-L1 Expression, Tumor Mutational Burden, and Response to Immunotherapy in Patients with MET Exon 14 Altered Lung Cancers
G J Riely, J Dienstag, C Mrad, J K Sabari, M G Kris, K C Arbour, N Rekhtman, A J Plodkowski, P K Paik, B T Li, I Bergagnini, M D Offin, C M Rudin, L M Sholl, Annals of Oncology
YES1 Amplification Is a Mechanism of Acquired Resistance to EGFR Inhibitors Identified by Transposon Mutagenesis and Clinical Genomics
Emmet J Jordan, Helena A Yu, Yelena Y Janjigian, Mark G Kris, Paul K Paik, Jamie E Chaft, Lu Wang, Gregory J Riely, Proceedings of the National Academy of Sciences

Lectures

Real-world utilization of EGFR TKI therapies and treatment outcomes in patients with advanced EGFR-sensitizing mutation-positive NSCLC.
2019 ASCO Annual Meeting - 6/1/2019
American Society for Radiation Oncology(ASTRO): 20th Chicago Multidisciplinary Symposium inThoracic Oncology
American Society for Radiation Oncology, Chicago, Illinois - 9/6/2012
Treating Stage I to III Non-Small-Cell Lung Cancer With Limited Evidence
2013 International Conference, Philadelphia, Pennsylvania, USA
Treating Stage I to III Non-Small-Cell Lung Cancer With Limited Evidence
American Thoracic Society, 2013 International Conference, Philadelphia, Pennsylvania, USA
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Press Mentions

Patients Benefit from a Comprehensive Program That Focuses on Cancer Treatment and Addresses Their Tobacco AddictionMay 30th, 2025
Lung Cancer Patients Who Never Smoked Often Carry Mutations like EGFRMay 26th, 2025
Pfizer’s BRAFTOVI® + MEKTOVI® Shows Long-Term Clinically Meaningful Response in Patients with BRAF V600E-Mutant Metastatic Non-Small Cell Lung CancerSeptember 14th, 2024
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Gregory J Riely MD PhD

Overview of Dr. Riely

Education & Training

Certifications & Licensure

Clinical Trials

Publications & Presentations

Press Mentions

Insurance Accepted

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