AlanN.HoughtonMD

Professor, Medicine, Weill Cornell Medical College

Overview of Dr. Houghton

Dr. Alan Houghton is an oncologist in New York, NY and is affiliated with Memorial Sloan Kettering Cancer Center. He received his medical degree from University of Connecticut and has been in practice 43 years. He is one of 464 doctors at Memorial Sloan Kettering Cancer Center who specialize in Oncology. He has more than 100 publications and over 500 citings.

Office
Memorial Sloan Kettering Cancer Center New York
1275 York Avenue
New York, NY 10021
Book by Phone+1(325) 603-3485
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Education & Training

Memorial Sloan Kettering Cancer CenterFellowship, Hematology and Medical Oncology, 1977 - 1979
University of ConnecticutResidency, Internal Medicine, 1976 - 1977
Sidney Kimmel Medical College at Thomas Jefferson UniversityInternship, Transitional Year, 1974 - 1975
Uconn School Of MedicineClass of 1974

Certifications & Licensure

CT State Medical License 1976 - 2021
NY State Medical License 1979 - 2014

Awards, Honors, & Recognition

Elected Member The American Society for Clinical Investigation, 1989

Clinical Trials

Injection Of AJCC Stage IIB, IIC, III And IV Melanoma Patients With A Multi-Epitope Peptide Vaccine Using GM-CSF DNA As An Adjuvant: A Pilot Trial To Assess Safety And Immunity Start of enrollment: 2003 Dec 01
Xenogeneic HER2/Neu DNA Immunization for Patients With Metastatic and High Risk Breast Cancer: A Phase I Study to Assess Safety and Immunogenicity Start of enrollment: 2006 May 01
Active, not recruiting
Phase 1
Vaccine Therapy in Treating Patients With Recurrent B-Cell Lymphoma Start of enrollment: 2007 Oct 01
Completed
Phase 1

Publications & Presentations

PubMed

2 citations
Cyclophosphamide enhances the antitumor potency of GITR engagement by increasing oligoclonal cytotoxic T cell fitness
Daniel Hirschhorn, Allison Betof Warner, Rachana Maniyar, Andrew Chow, Levi Mangarin, Adam D. Cohen, Linda Hamadene, Sadna Budhu, Nathan Suek, Cailian Liu, Alan N. Hou...> ;JCI Insight. 2021 Oct 22
90 citations
Blockade of surface-bound TGF-β on regulatory T cells abrogates suppression of effector T cell function in the tumor microenvironment
Sadna Budhu, David Schaer, Yongbiao Li, Ricardo Toledo-Crow, Katherine S. Panageas, Xia Yang, Hong Zhong, Alan N. Houghton, Samuel C. Silverstein, Taha Merghoub> ;Science Signaling. 2017 Aug 29
12 citations
Enhanced responses to tumor immunization following total body irradiation are time-dependent.
, , , , , , , , , , , , , , , > ;Plos One. 2013 Dec 12
28 citations
Immunologic responses to xenogeneic tyrosinase DNA vaccine administered by electroporation in patients with malignant melanoma
Jianda Yuan, Geoffrey Y. Ku, Matthew Adamow, Zhenyu Mu, Sapna Tandon, Drew Hannaman, Paul B. Chapman, Gary K. Schwartz, Richard D. Carvajal, Katherine S. Panageas, Ala...> ;Journal for Immunotherapy of Cancer. 2013 Nov 18
117 citations
GITR Pathway Activation Abrogates Tumor Immune Suppression through Loss of Regulatory T-cell Lineage Stability
David Schaer, Sadna Budhu, Cailian Liu, Campbell Bryson, Nicole Malandro, Adam D. Cohen, Hong Zhong, Xia Yang, Alan N. Houghton, Taha Merghoub> ;Cancer Immunology Research. 2013 Nov 1
118 citations
Induction of tumoricidal function in CD4+ T cells is associated with concomitant memory and terminally differentiated phenotype
Daniel Hirschhorn-Cymerman, Sadna Budhu, Shigehisa Kitano, Cailian Liu, Feng Zhao, Hong Zhong, Alexander M. Lesokhin, Francesca Avogadri-Connors, Jianda Yuan, Yanyun L...> ;The Journal of Experimental Medicine. 2012 Oct 22
26 citations
Innate immune response of human plasmacytoid dendritic cells to poxvirus infection is subverted by vaccinia E3 via its Z-DNA/RNA binding domain.
Hua Cao, Peihong Dai, Weiyi Wang, Hao Li, Jianda Yuan, Fangjin Wang, Chee-Mun Fang, Paula M. Pitha, Jia Liu, Richard C. Condit, Grant McFadden, Taha Merghoub, Alan N. ...> ;Plos One. 2012 May 14
265 citations
Monocytic CCR2+ Myeloid Derived Suppressor Cells Promote Immune Escape By Limiting Activated CD8 T Cell Infiltration Into The Tumor Microenvironment
Alexander M. Lesokhin, Tobias M. Hohl, Shigehisa Kitano, Czrina Cortez, Daniel Hirschhorn-Cymerman, Francesca Avogadri, Gabrielle Rizzuto, John J. Lazarus, Eric G. Pam...> ;Cancer Research. 2012 Feb 15
39 citations
Myxoma virus induces type I interferon production in murine plasmacytoid dendritic cells via a TLR9/MyD88-, IRF5/IRF7-, and IFNAR-dependent pathway
Peihong Dai, Hua Cao, Taha Merghoub, Francesca Avogadri, Weiyi Wang, Tanvi Parikh, Chee-Mun Fang, Paula M. Pitha, Katherine A. Fitzgerald, Masmudur M. Rahman, Grant Mc...> ;Journal of Virology. 2011 Oct 15
12 citations
Detection of Intra-Tumor Self Antigen Recognition during Melanoma Tumor Progression in Mice Using Advanced Multimode Confocal/Two Photon Microscope
David Schaer, Yongbiao Li, Taha Merghoub, Gabrielle Rizzuto, Amos Shemesh, Adam D. Cohen, Yanyun Li, Francesca Avogadri, Ricardo Toledo-Crow, Alan N. Houghton> ;Plos One. 2011 Jun 22
55 citations
Peptide-Loaded Langerhans Cells, Despite Increased IL15 Secretion and T-Cell Activation In Vitro, Elicit Antitumor T-Cell Responses Comparable to Peptide-Loaded Monocy...
Emanuela Romano, Marco Rossi, Gudrun Ratzinger, Maria-Angeles de Cos, David J. Chung, Katherine S. Panageas, Jedd D. Wolchock, Alan N. Houghton, Paul B. Chapman, Glenn...> ;Clinical Cancer Research. 2011 Apr 1
10 citations
Combination of epitope-optimized DNA vaccination and passive infusion of monoclonal antibody against HER2/neu leads to breast tumor regression in mice.
Francesca Orlandi, José A. Guevara-Patiño, Taha Merghoub, Alan N. Houghton, Polly D. Gregor> ;Vaccine. 2011 May 9
47 citations
Alphavirus Replicon Particles Expressing TRP-2 Provide Potent Therapeutic Effect on Melanoma through Activation of Humoral and Cellular Immunity
Francesca Avogadri, Taha Merghoub, Maureen F. Maughan, Daniel Hirschhorn-Cymerman, John N. Morris, Erika Ritter, Robert A. Olmsted, Alan N. Houghton> ;Plos One. 2010 Sep 10
34 citations
Immunologic response to xenogeneic gp100 DNA in melanoma patients: comparison of particle-mediated epidermal delivery with intramuscular injection.
Brian A. Ginsberg, Humilidad F. Gallardo, Teresa S. Rasalan, Matthew Adamow, Zhenyu Mu, Sapna Tandon, Barrett B. Bewkes, Ruth-Ann Roman, Paul B. Chapman, Gary K. Schwa...> ;Clinical Cancer Research. 2010 Aug 1
90 citations
Cyclophosphamide enhances immunity by modulating the balance of dendritic cell subsets in lymphoid organs.
Takeshi Nakahara, Hiroshi Uchi, Alexander M. Lesokhin, Francesca Avogadri, Gabrielle Rizzuto, Daniel Hirschhorn-Cymerman, Katherine S. Panageas, Taha Merghoub, Alan N....> ;Blood. 2010 Jun 3
189 citations
Agonist anti-GITR monoclonal antibody induces melanoma tumor immunity in mice by altering regulatory T cell stability and intra-tumor accumulation.
Adam D. Cohen, David Schaer, Cailian Liu, Yanyun Li, Daniel Hirschhorn-Cymmerman, Soo Chong Kim, Adi Diab, Gabrielle Rizzuto, Fei Duan, Miguel Perales, Taha Merghoub, ...> ;Plos One. 2010 May 3
124 citations
Cutting Edge: OX40 agonists can drive regulatory T cell expansion if the cytokine milieu is right.
Carl E. Ruby, Melissa A. Yates, Daniel Hirschhorn-Cymerman, Peter Chlebeck, Alan N. Houghton, Halina Offner, Andrew D. Weinberg> ;Journal of Immunology. 2009 Oct 15
166 citations
OX40 engagement and chemotherapy combination provides potent antitumor immunity with concomitant regulatory T cell apoptosis
Daniel Hirschhorn-Cymerman, Gabrielle Rizzuto, Taha Merghoub, Adam D. Cohen, Francesca Avogadri, Alexander M. Lesokhin, Andrew D. Weinberg, Alan N. Houghton> ;The Journal of Experimental Medicine. 2009 May 11
13 citations
Immune rejection of mouse tumors expressing mutated self.
Fei Duan, Yun Lin, Cailian Liu, Manuel E. Engelhorn, Adam D. Cohen, Michael A. Curran, Shimon Sakaguchi, Taha Merghoub, Stephanie L. Terzulli, Alan N. Houghton> ;Cancer Research. 2009 Apr 15
89 citations
Self-antigen–specific CD8+ T cell precursor frequency determines the quality of the antitumor immune response
Gabrielle Rizzuto, Taha Merghoub, Daniel Hirschhorn-Cymerman, Cailian Liu, Alexander M. Lesokhin, Diana Sahawneh, Hong Zhong, Katherine S. Panageas, Miguel-Angel Peral...> ;The Journal of Experimental Medicine. 2009 Apr 13
21 citations
Keratinocyte growth factor enhances DNA plasmid tumor vaccine responses after murine allogeneic bone marrow transplantation.
, , , , , , , , , , , , , , , , , , > ;Blood. 2009 Feb 12
62 citations
Safety and immunogenicity of a human and mouse gp100 DNA vaccine in a phase I trial of patients with melanoma.
, , , , , , , , , , , , , , , > ;Cancer Immunity. 2009 Jan 1
28 citations
Optimization and validation of a robust human T-cell culture method for monitoring phenotypic and polyfunctional antigen-specific CD4 and CD8 T-cell responses
Yun Lin, Humilidad F. Gallardo, Geoffrey Y. Ku, Hao Li, Gregor Manukian, Teresa S. Rasalan, Yinyan Xu, Stephanie L. Terzulli, Lloyd J. Old, James P. Allison, Alan N. H...> ;Cytotherapy. 2009 Jan 1
5 citations
Development of effective vaccines for old mice in a tumor model.
David N. Posnett, Manuel E. Engelhorn, Yun Lin, Taha Merghoub, Fei Duan, Alan N. Houghton> ;Vaccine. 2009 Feb 11
23 citations
Selective expression of inhibitory Fcγ receptor by metastatic melanoma impairs tumor susceptibility to IgG‐dependent cellular response
Lydie Cassard, Joël F. G. Cohen-Solal, Emilie M. Fournier, Sophie Camilleri-Broët, Alain Spatz, Salem Chouaib, Cécile Badoual, Audrey Varin, Sylvain Fisson, Pierre Duv...> ;International Journal of Cancer. 2008 Dec 15
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Press Mentions

Immunotherapy Innovator Jedd Wolchok HonoredApril 11th, 2015

Grant Support

Immunization Against Melanoma Differentiation AntigensNational Cancer Institute2000–2012
Genetic Approaches To Immune AdjuvantsNational Cancer Institute2006–2010
DNA Vaccination Against MelanomaNational Cancer Institute2008–2009
Administrative CoreNational Cancer Institute2008–2009
Targeted Antigen Receptor Treatment Of CancerNational Cancer Institute2005–2007
Immunology Research TrainingNational Cancer Institute1997–2005
Biological Approaches To The Treatment Of CancerNational Cancer Institute2000–2004
DNA Vaccination With Altered AntigensNational Cancer Institute2000–2002
Dendritic Cells For Induction Of Cancer ImmunityNational Cancer Institute2000–2002
Clinical Studies/TrialsNational Cancer Institute2000–2002
ImmunologyNational Cancer Institute1998–2002
Genetically Modified Dendritic Cells For Induction Of Cancer ImmunityNational Cancer Institute1997–1999
Monoclonal Antibody Therapy Against Ganglioside AntigensNational Cancer Institute1996–1999
Biological Approaches To Treatment Of CancerNational Cancer Institute1995–1999
Immunization Against Cancer Differentiation AntigensNational Cancer Institute1996–1998
Monoclonal Antibodies And Vaccines In Cancer TherapyNational Cancer Institute1994
Active Immunotherapy Of MelanomaNational Cancer Institute1992–1994
Specificity Of Monoclonal Antibodies To Human CancerNational Cancer Institute1985
Diagnostic And Therapeutic Trials With Monoclonal AntibodiesNational Cancer Institute1985

Hospital Affiliations

Memorial Sloan Kettering Cancer CenterNew York, New York