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Christopher DeSimone, MD, Cardiology, Rochester, MN

Christopher V DeSimone MD PhD

Cardiac Electrophysiology


Associate Professor of Medicine; Mayo Clinic Medical School

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  • 200 1st St SwRochester, MN 55905

  • Phone+1 507-284-2511

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Summary

  • Dr. Christopher DeSimone is a Cardiologist with a subspecialty in Cardiac Electrophysiology based in Rochester, MN. His education background includes a medical degree from Jacobs School of Medicine and Biomedical Sciences at the University at Buffalo, residencies and fellowships at Mayo Clinic College of Medicine and Science, and undergraduate degrees in Biology and Biochemistry from Niagara University. Dr. DeSimone's expertise lies in procedures such as invasivecardiac electrophysiology, including complex atrial fibrillation and flutter ablations, PVC and VT ablations, and has expertise with Pulse Field ablation. He has contributed to a number of publications within his field. Notably, he has received several honors and awards, including the Mayo Brothers Distinguished Fellow Award and Mayo Clinic Cardiovascular Medicine Outstanding Research Fellow Award.

Education & Training

  • Mayo Clinic College of Medicine and Science (Rochester)
    Mayo Clinic College of Medicine and Science (Rochester)Fellowship, Clinical Cardiac Electrophysiology, 2017 - 2019
  • Mayo Clinic College of Medicine and Science (Rochester)
    Mayo Clinic College of Medicine and Science (Rochester)Fellowship, Cardiovascular Disease, 2014 - 2017
  • Mayo Clinic College of Medicine and Science (Rochester)
    Mayo Clinic College of Medicine and Science (Rochester)Residency, Internal Medicine, 2010 - 2013
  • Jacobs School of Medicine and Biomedical Sciences at the University at Buffalo
    Jacobs School of Medicine and Biomedical Sciences at the University at BuffaloClass of 2010
  • Niagara University
    Niagara UniversityB.S., Biology, Summa Cum Laude, 1999 - 2003

Certifications & Licensure

  • MN State Medical License
    MN State Medical License 2011 - 2026
  • WI State Medical License
    WI State Medical License 2020 - 2025
  • Cardiovascular Disease
    American Board of Internal Medicine Cardiovascular Disease
  • Clinical Cardiac Electrophysiology
    American Board of Internal Medicine Clinical Cardiac Electrophysiology

Awards, Honors, & Recognition

  • Mayo Clinic Cardiovascular Medicine Outstanding Research Fellow Award Mayo Clinic, 2017
  • Mayo Brothers Distinguished Fellow Award Mayo Clinic, 2017
  • Cardiovascular Division Nominee; Donald C. Balfour Award for Meritorious Research Mayo Clinic, 2015

Publications & Presentations

PubMed

Journal Articles

  • Blood Pressure Responses to Endovascular Stimulation: A Potential Therapy for Autonomic Disorders with Vasodilatation  
    Naksuk N, Killu AM, Yogeshwaran V, DeSimone CV, Suddendorf S, Ladewig D, Madhavan M, Cha YM, Kapa S, Asirvatham SJ, J Cardiovasc Electrophysiol, 1/28/2016
  • Cardiac Implantable Electronic Device Lead Vegetation and Atrial Fibrillation Ablation: A Case-based Illustration of Peri-Procedural Anticoagulation Management Strategies  
    Lenz CJ, DeSimone CV, Ponamgi SP, Sugrue A, Sinak L, Chandrasekaran K, Packer DL, Asirvatham SJ, J Interv Card Electrophysiol, 1/22/2016
  • Ischemic Stroke or Systemic Embolism following Transseptal Ablation of Arrhythmias in Patients with Cardiac Implantable Electronic Devices  
    Madhavan M, Yao X, Sangaralingham LR, Asirvatham SJ, Friedman PA, McLeod CJ, DeSimone CV, Noseworthy PA, J Am Heart Assoc, 1/13/2016

Books/Book Chapters

Abstracts/Posters

  • A Novel Means to Successfully Differentiate Wide-Complex Tachycardias Using Mathematically-Synthesized Vectorcardiogram Signals
    Kashou AH, May AM, DeSimone CV, Deshmukh AJ, Noseworthy PA, Minneapolis, MN, 1/1/2018
  • Stroke in Patients with Cardiovascular Implantable Electronic Device Infection Undergoing Transvenous Lead Removal
    Lee JZ, Pradyumma A, Pasha AK, C, Tseng AS, Diehl NN, Hodge DO, DeSimone CV, Killu AM, Brady PA, Kancharla K, Kusumoto FM, Srivathsan K, Osborn MJ, Espinosa RE, Rea RF..., HRS, 1/1/2018
  • Direct Pulmonary Vein Ablation Without Stenosis: Chronic Efficacy of a Novel Electroporation Technique
    Witt C, Sugrue A, Padmanabhan D, Vaidya V, Gruba S, Rohl J, Killu A, Naksuk N, DeSimone C, Kapa S, Asirvatham SJ, ACC, 1/1/2018

Lectures

  • Essential Anatomy for Ventricular Tachycardia 
    1/1/2018
  • Great Cases- Atriofascular Pathways: ECG clues and Mapping and Ablation Str 
    1/1/2018
  • Case Studies in Disease Management: Anatomy and Arrhythmias 
    1/1/2017

Other

Press Mentions

  • Patients Struggling with SVT/AVNRT and Catheter Ablation
    Patients Struggling with SVT/AVNRT and Catheter AblationOctober 7th, 2025
  • Recent Updates in AF Guidelines
    Recent Updates in AF GuidelinesSeptember 9th, 2025
  • How a Years Worth of Experience of PFA for AF Has Revolutionized My Practice
    How a Years Worth of Experience of PFA for AF Has Revolutionized My PracticeJuly 15th, 2025

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