
Christopher V DeSimone MD PhD
Cardiac Electrophysiology
Associate Professor of Medicine; Mayo Clinic Medical School
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200 1st St SwRochester, MN 55905
Phone+1 507-284-2511
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Summary
- Dr. Christopher DeSimone is a Cardiologist with a subspecialty in Cardiac Electrophysiology based in Rochester, MN. His education background includes a medical degree from Jacobs School of Medicine and Biomedical Sciences at the University at Buffalo, residencies and fellowships at Mayo Clinic College of Medicine and Science, and undergraduate degrees in Biology and Biochemistry from Niagara University. Dr. DeSimone's expertise lies in procedures such as invasivecardiac electrophysiology, including complex atrial fibrillation and flutter ablations, PVC and VT ablations, and has expertise with Pulse Field ablation. He has contributed to a number of publications within his field. Notably, he has received several honors and awards, including the Mayo Brothers Distinguished Fellow Award and Mayo Clinic Cardiovascular Medicine Outstanding Research Fellow Award.
Education & Training
Mayo Clinic College of Medicine and Science (Rochester)Fellowship, Clinical Cardiac Electrophysiology, 2017 - 2019
Mayo Clinic College of Medicine and Science (Rochester)Fellowship, Cardiovascular Disease, 2014 - 2017
Mayo Clinic College of Medicine and Science (Rochester)Residency, Internal Medicine, 2010 - 2013
Jacobs School of Medicine and Biomedical Sciences at the University at BuffaloClass of 2010
Niagara UniversityB.S., Biology, Summa Cum Laude, 1999 - 2003
Certifications & Licensure
MN State Medical License 2011 - 2026
WI State Medical License 2020 - 2025
American Board of Internal Medicine Cardiovascular Disease
American Board of Internal Medicine Clinical Cardiac Electrophysiology
Awards, Honors, & Recognition
- Mayo Clinic Cardiovascular Medicine Outstanding Research Fellow Award Mayo Clinic, 2017
- Mayo Brothers Distinguished Fellow Award Mayo Clinic, 2017
- Cardiovascular Division Nominee; Donald C. Balfour Award for Meritorious Research Mayo Clinic, 2015
Publications & Presentations
PubMed
- Outcomes of cardiac pacing in adults with congenitally corrected transposition of great arteries.Alexander C Egbe, Christopher V DeSimone, Malini Madhavan, Samuel J Asirvatham, Abhishek J Deshmukh
International Journal of Cardiology. 2026-02-01 - Exploring the cardiopulmonary effects of tirzepatide in atrial fibrillation and comorbid chronic obstructive pulmonary disease.Min Choon Tan, Ming Fong Yee, Aravinthan Vignarajah, Girish Pathangey, Mahmoud Abdelnabi
The American Journal of Medicine. 2026-01-01 - Preimplantation AI-ECG Age as a Predictor of Survival Following Cardiac Resynchronization Therapy.Anshul R Gupta, Ashish Kumar, Jenny Jia Ling Cao, David M Harmon, Paul A Friedman
JACC. Clinical Electrophysiology. 2025-12-24
Journal Articles
- Blood Pressure Responses to Endovascular Stimulation: A Potential Therapy for Autonomic Disorders with VasodilatationNaksuk N, Killu AM, Yogeshwaran V, DeSimone CV, Suddendorf S, Ladewig D, Madhavan M, Cha YM, Kapa S, Asirvatham SJ, J Cardiovasc Electrophysiol, 1/28/2016
- Cardiac Implantable Electronic Device Lead Vegetation and Atrial Fibrillation Ablation: A Case-based Illustration of Peri-Procedural Anticoagulation Management StrategiesLenz CJ, DeSimone CV, Ponamgi SP, Sugrue A, Sinak L, Chandrasekaran K, Packer DL, Asirvatham SJ, J Interv Card Electrophysiol, 1/22/2016
- Ischemic Stroke or Systemic Embolism following Transseptal Ablation of Arrhythmias in Patients with Cardiac Implantable Electronic DevicesMadhavan M, Yao X, Sangaralingham LR, Asirvatham SJ, Friedman PA, McLeod CJ, DeSimone CV, Noseworthy PA, J Am Heart Assoc, 1/13/2016
Books/Book Chapters
Abstracts/Posters
- A Novel Means to Successfully Differentiate Wide-Complex Tachycardias Using Mathematically-Synthesized Vectorcardiogram SignalsKashou AH, May AM, DeSimone CV, Deshmukh AJ, Noseworthy PA, Minneapolis, MN, 1/1/2018
- Stroke in Patients with Cardiovascular Implantable Electronic Device Infection Undergoing Transvenous Lead RemovalLee JZ, Pradyumma A, Pasha AK, C, Tseng AS, Diehl NN, Hodge DO, DeSimone CV, Killu AM, Brady PA, Kancharla K, Kusumoto FM, Srivathsan K, Osborn MJ, Espinosa RE, Rea RF..., HRS, 1/1/2018
- Direct Pulmonary Vein Ablation Without Stenosis: Chronic Efficacy of a Novel Electroporation TechniqueWitt C, Sugrue A, Padmanabhan D, Vaidya V, Gruba S, Rohl J, Killu A, Naksuk N, DeSimone C, Kapa S, Asirvatham SJ, ACC, 1/1/2018
Lectures
- Essential Anatomy for Ventricular Tachycardia1/1/2018
- Great Cases- Atriofascular Pathways: ECG clues and Mapping and Ablation Str1/1/2018
- Case Studies in Disease Management: Anatomy and Arrhythmias1/1/2017
Other
- New Approach to Chronic Resynchronization Therapy: CRT without LV lead. Invited CommentaryDeSimone CV and Asirvatham SJ, Cardiac Rhythm News
http://www.cxvascular.com/crn-features/cardiac-rhythm-news---features/new-approach-to-cardiac-resynchronisation-therapy-crt-without-left-ventricular-lead
1/25/2014 - Doctoral Dissertation: Binding Studies of the Gating Modifier toxin HpTx2 with Kv4.3DeSimone CV, The State University at Buffalo School of Medicine and Biomedical Sciences
1/17/2008 - Porphyrin localization and Apoptosis induction in RIF cells in culture. The Miami Nature Biotechnology Winter Symposium: 50 Years on: From the double helix to molecula...DeSimone CV and Greene RS, Proceedings of the Miami Nature Biotechnology Winter Symposium Short Reports
http://www.med.miami.edu/mnbws/x26.xml
1/1/2003
Press Mentions
Patients Struggling with SVT/AVNRT and Catheter AblationOctober 7th, 2025
Recent Updates in AF GuidelinesSeptember 9th, 2025
How a Years Worth of Experience of PFA for AF Has Revolutionized My PracticeJuly 15th, 2025
Professional Memberships
- Associate
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