
Christopher Michael Horvat MD
Pediatric Critical Care Medicine, Clinical Informatics
Physician
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4401 Penn AvenuePittsburgh, PA 15224
Phone+1 412-692-5325
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Summary
- Dr. Horvat is a board-certified pediatric intensivist and clinical informatician with expertise in quality improvement, clinical research, and learning health systems. As Senior Director of Clinical Informatics, he leads operational and research initiatives at UPMC and the University of Pittsburgh, focusing on data-driven approaches to improve patient outcomes. Dr. Horvat serves as Associate Program Director for the Clinical Informatics Fellowship at UPMC. Nationally recognized for his work integrating clinical informatics with performance improvement initiatives, he has authored over 150 peer-reviewed publications and is a frequent contributor to national research collaborations, large scale quality improvement programs, and digital health innovation efforts. He is also the founder of Care Performance Insights, LLC, a healthcare analytics company.
Education & Training
- UPMC Medical EducationFellowship, Pediatric Critical Care Medicine, 2013 - 2016
- University of WashingtonResidency, Pediatrics, 2010 - 2013
- University of North Carolina at Chapel Hill School of MedicineClass of 2010
- University of North Carolina School of Public HealthB.S., Major in Chemistry, Minor in Biochemistry Track, 2002 - 2006
Certifications & Licensure
- FL State Medical License 2017 - 2027
- PA State Medical License 2013 - 2026
- WA State Medical License 2010 - 2013
- American Board of Pediatrics Pediatrics
- American Board of Pediatrics Pediatric Critical Care Medicine
- American Board of Preventive Medicine Clinical Informatics
Awards, Honors, & Recognition
- Ann E. Thompson Scholarship 2014
- Resident Peer-Teacher Award Seattle Children’s Hospital, 2013
- Course Scholarship National Outdoor Leadership School (NOLS), 2008
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Clinical Trials
- Randomized, Embedded, Multifactorial Adaptive Platform Trial for Community- Acquired Pneumonia Start of enrollment: 2016 Apr 11
- ACTIV-3: Therapeutics for Inpatients With COVID-19 Start of enrollment: 2020 Aug 04
Publications & Presentations
PubMed
- Application of New Pediatric Sepsis Definition to a Multicenter Observational Cohort of Previously Enrolled Severe Sepsis Patients Defined by SIRS Plus Organ Dysfunction.Kate F Kernan, Mohammed Shaik, Christopher M Horvat, Dana Y Fuhrman, Zachary Aldewereld
Journal of Intensive Care Medicine. 2025-06-16 - Early Use of a Risk-Adjusted Mechanical Ventilation Digital Quality Measure Bundle in a Large Health System.Christopher M Horvat, Jesse Klug, Ruoting Li, Jesse Raffa, Thomas Pollard
Critical Care Medicine. 2025-06-12 - Association of Early Epinephrine with Hemodynamics and Outcome in Pediatric In-Hospital Cardiac Arrest: A Secondary Analysis of a Multi-center, Cluster-randomized Clin...Ashley Siems, Maryam Y Naim, Robert A Berg, Ron W Reeder, Tageldin Ahmed
Annals of the American Thoracic Society. 2025-06-04
Journal Articles
- Trends in US Pediatric Hospital Admissions in 2020 Compared with the Decade Before the COVID-19 PandemicJonathan H Pelletier, Jaskaran Rakkar, Alicia K Au, Christopher M Horvat, JAMA Network Open
- Prescribing Prevalence of Medications with Potential Genotype-Guided Dosing in Pediatric PatientsAmber L Beitelshees, Philip E Empey, Christopher M Horvat, Jeffrey R Bishop, JAMA Network Open
- Taking Predictive Analytics to Point-of-CareHorvat CM, Clark RS, Critical Care Connections, 1/1/2016
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Abstracts/Posters
- Post-resuscitation GCS is Associated with Outcome in Pediatric Traumatic Brain InjuryHorvat CM, Bell M, Wisniewski S, Balasubramani G, Kochanek P, Beers S, Danielle Brown S, Adelson P, Soc. Crit. Care Med. Annual Congress, Honolulu, HI, 1/25/2017
- Pharmacogenomic-based Evaluation of Fentanyl Requirements in Diagnostically Diverse PICU PatientsHorvat CM, Au A, Empey P, Conley Y, Clark RS, Soc. Crit. Care Med. Annual Congress, Honolulu, HI, 1/25/2017
- Prospective Evaluation of the Pediatric Rothman Index as a Measure of Pediatric Inpatient AcuityHorvat CM, Hamilton MF, Almasi GS, Palmer F, Valenta C, Kyper C, Rothman MJ, and Clark RS, Health Services Research Session, Fink Scholar Day, Pittsburgh, PA, 1/26/2016
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Lectures
- Thoracic ultrasoundPittsburgh, PA - 1/11/2016
- Point-of-Care Ultrasound in Pediatric Critical CarePittsburgh, PA - 1/29/2015
- Condition E: Early, EMR-Based Recognition of Clinical DeteriorationPittsburgh, PA - 1/22/2015
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Press Mentions
- Association of Severe Hyperoxemia Events and Mortality Among Patients Admitted to a Pediatric Intensive Care UnitAugust 23rd, 2019
- Opioid E-prescribing Trends at Discharge in a Large Pediatric Health SystemApril 18th, 2019
- Healthy Babies Can Still Get Very Sick from RSVAugust 23rd, 2023
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Grant Support
- Bio-digital Rapid Alert to Identify NeuromorbidityUNIVERSITY OF PITTSBURGH AT PITTSBURGH2021–2026
- A Learning Health System Approach to Precision Sedation and Analgesia in Critically-Ill ChildrenUNIVERSITY OF PITTSBURGH AT PITTSBURGH2020–2025
- A Learning Health System Approach to Precision Sedation and Analgesia in Critically Ill ChildrenEunice Kennedy Shriver National Institute of Child Health and Human Development2020–2025
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