ClareJTwistMD

Pediatric Hematology & Oncology • Buffalo, NY

Pediatric Solid Tumor Oncology

Clinical Professor and Fellowship Program Director, Jacobs School of Medicine and Biomedical Sciences at University at Buffalo; Professor, Roswell Park Comprehensive Cancer Center; Director of Pediatric Experimental Therapeutics, Roswell Park Comprehensive Cancer Center

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Office
Elm and Carlton St
Buffalo, NY 14263
Phone+1 716-845-2333

Fax+1 716-845-8003
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Education & Training

Children's Hospital/Boston Medical CenterFellowship, Pediatric Hematology/Oncology, 1990 - 1993
McGaw Medical Center of Northwestern UniversityResidency, Pediatrics, 1988 - 1990
McGaw Medical Center of Northwestern UniversityInternship, Pediatrics, 1987 - 1988
Albany Medical CollegeClass of 1987

Certifications & Licensure

CA State Medical License 1999 - Present
NY State Medical License 2016 - 2026
IL State Medical License 1987 - 1990
American Board of Pediatrics Pediatric Hematology-Oncology

Awards, Honors, & Recognition

Outstanding Resident Teacher Award Children's Memorial Hospital, 1990

Clinical Trials

N2004-04: Fenretinide LXS in Treating Patients With Recurrent, Refractory, or Persistent Neuroblastoma Start of enrollment: 2005 Dec 01
Completed
Phase 1
Combination Chemotherapy and Surgery With or Without Isotretinoin in Treating Young Patients With Neuroblastoma Start of enrollment: 2007 Oct 08
Completed
Phase 3
N2004-03: Intravenous Fenretinide in Treating Young Patients With Recurrent or Resistant Neuroblastoma Start of enrollment: 2006 Dec 01
Completed
Phase 1
N2007-02:Bevacizumab,Cyclophosphamide,& Zoledronic Acid in Patients W/ Recurrent or Refractory High-Risk Neuroblastoma Start of enrollment: 2009 Dec 01
Completed
Phase 1
N2007-03: Vorinostat and 131-I MIBG in Treating Patients With Resistant or Relapsed Neuroblastoma Start of enrollment: 2010 Mar 01
Completed
Phase 1
Vorinostat and Isotretinoin in Treating Patients With High-Risk Refractory or Recurrent Neuroblastoma Start of enrollment: 2010 Dec 01
Completed
Phase 1
Lenalidomide and Dinutuximab With or Without Isotretinoin in Treating Younger Patients With Refractory or Recurrent Neuroblastoma Start of enrollment: 2013 Feb 04
Active, not recruiting
Phase 1
N2012-01: Phase 1 Study of Difluoromethylornithine (DFMO) and Celecoxib With Cyclophosphamide/Topotecan Start of enrollment: 2014 Jan 16
Active, not recruiting
Phase 1
Irinotecan Hydrochloride, Temozolomide, and Dinutuximab With or Without Eflornithine in Treating Patients With Relapsed or Refractory Neuroblastoma Start of enrollment: 2019 Jul 08
Active, not recruiting
Phase 2
A Pilot Study of SurVaxM in Children Progressive or Relapsed Medulloblastoma, High Grade Glioma, Ependymoma and Newly Diagnosed Diffuse Intrinsic Pontine Glioma Start of enrollment: 2022 Jul 01
Recruiting
Phase 1
Roles: Study Chair, Contact
Bosutinib in Pediatric Patients With Newly Diagnosed Chronic Phase or Resistant/Intolerant Ph + Chronic Myeloid Leukemia Start of enrollment: 2020 Apr 06
Active, not recruiting
Phase 1, Phase 2
Roles: Contact
A Study of TAK-755 in Participants With Congenital Thrombotic Thrombocytopenic Purpura Start of enrollment: 2021 Apr 14
Recruiting
Phase 3
Roles: Principal Investigator
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Publications & Presentations

PubMed

Factors influencing parents' choice of palliative treatment goals for children with relapsed or refractory neuroblastoma: A multi-site longitudinal survey study.
Cohn, S. L., Erica C Kaye, Jesse Smith, Yiwang Zhou, Rochelle Bagatell, Justin N Baker, Susan L Cohn, Lisa R Diller, Julia L Glade Bender, M Meaghan Granger, Araz Mara...> ;Cancer. 2024 Apr 1
1 citations
Aryl hydrocarbon receptor is a tumor promoter in-amplified neuroblastoma cells through suppression of differentiation.
Kanita A Chaudhry, Justine J Jacobi, Bryan M Gillard, Ellen Karasik, Jeffrey C Martin, Tatiane da Silva Fernandes, Edward Hurley, Maria Laura Feltri, Kristopher M Attw...> ;Iscience. 2023 Nov 17
311.2: Risk factors for Epstein-Barr virus DNAemia in pediatric transplantation: A multicenter study in the United States.
Tetsuya Tajima, Daniel Bernstein, Scott D Boyd, Dita Gratzinger, Grant Lum, Kazunari Sasaki, Brent Tan, Kenneth Weinberg, Brian Armstrong, Meredith Brown, Clifford Chi...> ;Transplantation. 2023 Oct 1
A Review of the Use of Hyperthermic Intraperitoneal Chemotherapy for Peritoneal Malignancy in Pediatric Patients.
David J Byrwa, Clare J Twist, Joseph Skitzki, Elizabeth Repasky, P Ben Ham 3rd, Ajay Gupta> ;Cancers. 2023 May 18
Mutations in latent membrane protein 1 of Epstein-Barr virus are associated with increased risk of posttransplant lymphoproliferative disorder in children.
Martinez, O., Krams, S., Robien, M., Lapasaran, M., Arvedson, M., Reitsma, A., Balachandran, Y., Harris-Arnold, A., Weinberg, K., Boyd, S., Armstrong, B., Trickey, A.,...> ;American Journal of Transplantation. 2023 May 1
3 citations
Host microRNAs are decreased in pediatric solid-organ transplant recipients during EBV+ Post-transplant Lymphoproliferative Disorder.
Sen, A., Enriquez, J., Rao, M., Glass, M., Balachandran, Y., Syed, S., Twist, C., Weinberg, K., Boyd, S., Bernstein, D., Trickey, A., Gratzinger, D., Tan, B., Lapasara...> ;Frontiers in Immunology. 2022 Jan 1
2 citations
CLINICOPATHOLOGIC AND MOLECULAR ANALYSIS OF A SINGLE BCOR-CCNB3+ UNDIFFERENTIATED SARCOMA OF THE KIDNEY CONFERS SIGNIFICANT EPIGENETIC ALTERATIONS.
Tamara J. Hagoel, Eduardo Cortez Gomez, Ajay Gupta, Clare J. Twist, Rafal Kozielski, Jeffrey C Martin, Lingui Gao, Joseph Kuechle, Prashant Singh, Miranda L. Lynch, Le...> ;Cold Spring Harbor Molecular Case Studies. 2021 Nov 24
25 citations
Randomized Phase II Trial of MIBG Versus MIBG, Vincristine, and Irinotecan Versus MIBG and Vorinostat for Patients With Relapsed or Refractory Neuroblastoma: A Report ...
Steven G. DuBois, M. Meaghan Granger, Susan Groshen, Denice D. Tsao-Wei, Lingyun Ji, Anasheh Shamirian, Scarlett Czarnecki, Fariba Goodarzian, Rachel Berkovich, Hiroyu...> ;Journal of Clinical Oncology. 2021 Jul 16
Retroperitoneal Sclerosing Lipogranuloma in an Adolescent With Congenital Atresia of the Inferior Vena Cava: Case Report and Literature Review.
Abdulraouf Lamoshi, David H. Rothstein, Phillip Benson Ham, Abdur Rauf Khan, Richard Cheney, Pierre Williot, Clare Twist, Beverly Schaefer> ;Journal of Pediatric Hematology/oncology. 2021 May 1
5 citations
Anaplastic lymphoma kinase inhibitor therapy in the treatment of inflammatory myofibroblastic tumors in pediatric patients: Case reports and literature review.
Ethan Craig, Laura M. Wiltsie, Lynda K. Beaupin, Ayesha Baig, Rafal Kozielski, David H. Rothstein, Veetai Li, Clare J. Twist, Matthew J. Barth> ;Journal of Pediatric Surgery. 2021 Feb 11
27 citations
Racial and Ethnic Differences in Communication and Care for Children With Advanced Cancer.
Jennifer W. Mack, Hajime Uno, Clare J. Twist, Rochelle Bagatell, Abby R. Rosenberg, Araz Marachelian, M. Meaghan Granger, Julia Glade Bender, Justin N. Baker, Julie R....> ;Journal of Pain and Symptom Management. 2020 Oct 1
32 citations
Unrealistic parental expectations for cure in poor‐prognosis childhood cancer
Jennifer W. Mack, Angel M. Cronin, Hajime Uno, Suzanne Shusterman, Clare J. Twist, Rochelle Bagatell, Abby R. Rosenberg, Araz Marachelian, M. Meaghan Granger, Julia Gl...> ;Cancer. 2020 Jan 15
2 citations
Treatment and outcomes in classic Hodgkin lymphoma post-transplant lymphoproliferative disorder in children.
Clare J. Twist, Susan M. Hiniker, Dita Gratzinger, D.J. Merriott, Andrei Iagaru, Michael P. Link, Sarah S. Donaldson, Paulina M. Gutkin> ;Pediatric Blood & Cancer. 2019 Aug 1
3 citations
Retroperitoneoscopic resection of a T11-L2 right-sided ganglioneuroma.
P. Benson Ham, Clare J. Twist, David H. Rothstein> ;Journal of Pediatric Surgery. 2019 Mar 6
35 citations
Defining Risk Factors for Chemotherapeutic Intervention in Infants With Stage 4S Neuroblastoma: A Report From Children's Oncology Group Study ANBL0531.
Clare J. Twist, Arlene Naranjo, Mary Lou Schmidt, Sheena C. Tenney, Susan L. Cohn, Holly J. Meany, Peter Mattei, E. Stanton Adkins, Hiroyuki Shimada, Wendy B. London, ...> ;Journal of Clinical Oncology. 2019 Jan 10
48 citations
Phase II Trial of Alisertib in Combination with Irinotecan and Temozolomide for Patients with Relapsed or Refractory Neuroblastoma
Steven G. DuBois, Yael P. Mosse, Elizabeth Fox, Rachel A. Kudgus, Joel M. Reid, Renee M. McGovern, S. Groshen, Rochelle Bagatell, John M. Maris, Clare J. Twist, Kelly ...> ;Clinical Cancer Research. 2018 Dec 15
8 citations
Measuring pediatric hematology–oncology fellows’ skills in humanism and professionalism: A novel assessment instrument
Jennifer C. Kesselheim, Anurag K. Agrawal, Nita Bhatia, Angel M. Cronin, Rima Jubran, Paul Kent, Leslie S. Kersun, Amulya A. Nageswara Rao, Melissa J. Rose, Stephanie ...> ;Pediatric Blood & Cancer. 2017 May 1
19 citations
Cancer recurrence and mortality after pediatric heart transplantation for anthracycline cardiomyopathy: A report from the Pediatric Heart Transplant Study (PHTS) group.
M.J. Bock, Elfriede Pahl, Paolo G. Rusconi, Gerard J. Boyle, John J. Parent, Clare J. Twist, James K. Kirklin, Elizabeth Pruitt, Daniel Bernstein> ;Pediatric Transplantation. 2017 Aug 1
12 citations
Tumor-induced Osteomalacia in a 3-Year-Old With Unresectable Central Giant Cell Lesions
Stephanie S. Crossen, Eduardo Zambrano, Beverley Newman, Jonathan A. Bernstein, Anna H. Messner, Laura K. Bachrach, Clare J. Twist> ;Journal of Pediatric Hematology/oncology. 2017 Jan 1
4 citations
Plasmacytic posttransplant lymphoproliferative disorder with hyperviscosity syndrome in a child after liver transplant.
Christine H. Yang, Saurabh Gombar, Clare J. Twist, Dita Gratzinger, Carlos O. Esquivel, Audrey H. Lau> ;Hepatology. 2016 Dec 1
12 citations
Premature physeal closure following 13-cis-retinoic acid and prolonged fenretinide administration in neuroblastoma.
Angela Steineck, John D. MacKenzie, Clare J. Twist> ;Pediatric Blood & Cancer. 2016 Nov 1
54 citations
Trends in End-of-Life Care in Pediatric Hematology, Oncology, and Stem Cell Transplant Patients.
Katharine E. Brock, Angela Steineck, Clare J. Twist> ;Pediatric Blood & Cancer. 2016 Mar 1
12 citations
Impact of Whole-Body Radiation Dose on Response and Toxicity in Patients With Neuroblastoma After Therapy With 131 I-Metaiodobenzylguanidine (MIBG).
Megan Trieu, Steven G. DuBois, Elizabeth Pon, Lorenzo Nardo, Randall A. Hawkins, Araz Marachelian, Clare J. Twist, Julie R. Park, Katherine K. Matthay> ;Pediatric Blood & Cancer. 2016 Mar 1
5 citations
Successful treatment of systemic and central nervous system post‐transplant lymphoproliferative disorder without the use of high‐dose methotrexate or radiation
Sidharth Mahapatra, Clifford Chin, Andrei Iagaru, Amy Heerema-McKenney, Clare J. Twist> ;Pediatric Blood & Cancer. 2014 Nov 1
54 citations
Maintaining Outstanding Outcomes Using Response- and Biology-Based Therapy for Intermediate-Risk Neuroblastoma: A Report From the Children's Oncology Group Study ANBL0...
Clare J. Twist, Mary Lou Schmidt, Arlene Naranjo, Wendy B. London, Sheena C. Tenney, Araz Marachelian, Hiroyuki Shimada, Margaret H. Collins, Natia Esiashvili, E. Stan...> ;Journal of Clinical Oncology. 2014 May 20
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Press Mentions

Roswell Park-Developed Immunotherapy Now Part of Nationwide Study in Kids with Brain CancerJune 7th, 2022

Professional Memberships

Children's Oncology Group
Member
American Society of Hematology - ASH
Member
American Society of Clinical Oncology - ASCO
Member
American Society of Pediatric Hematology/Oncology
Member

Hospital Affiliations

John R Oishei Children's HospitalBuffalo, New York
KALEIDA HealthBuffalo, New York
Roswell Park Comprehensive Cancer CenterBuffalo, New York
Roswell Park Comprehensive Cancer CenterBuffalo, New York
Roswell Park Comprehensive Cancer CenterBuffalo, New York
Roswell Park Comprehensive Cancer CenterBuffalo, New York

External Links

Roswell Park Comprehensive Cancer Centerhttps://www.roswellpark.org/
Oishei Children's Hospitalhttp://ochbuffalo.org
University at Buffalo Department of Pediatricshttp://medicine.buffalo.edu/pediatrics