ShakeelModakMD

Pediatric Hematology & Oncology • New York, NY

Physician

Overview of Dr. Modak

Dr. Shakeel Modak is a pediatric hematologist/oncologist in New York, NY and is affiliated with Memorial Sloan Kettering Cancer Center. He received his medical degree from Topiwala National Medical College and has been in practice 29 years. He is one of 92 doctors at Memorial Sloan Kettering Cancer Center who specialize in Pediatric Hematology & Oncology. He has more than 100 publications and over 500 citings.

Office
Memorial Sloan Kettering Cancer Center New York
1275 York Avenue
New York, NY 10021
Book by Phone+1(805) 419-2431
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Education & Training

New York Presbyterian Hospital (Cornell Campus)Fellowship, Pediatric Hematology/Oncology, 1996 - 1999
Central Iowa Health System (Iowa Methodist Medical Center)Residency, Pediatrics, 1995 - 1996
Topiwala National Medical CollegeClass of 1988

Certifications & Licensure

NY State Medical License 2001 - 2025
IA State Medical License 1995 - 1996
American Board of Pediatrics Pediatric Hematology-Oncology

Awards, Honors, & Recognition

New York Magazine: Top Doctors Castle Connolly, 2014-2020

Clinical Trials

Beta-Glucan and Rituximab in Treating Young Patients With Relapsed or Progressive Lymphoma or Leukemia, or Lymphoproliferative Disorder Related to Donor Stem Cell Transplantation Start of enrollment: 2004 May 01
Terminated
Phase 1
Iodine I 131 Metaiodobenzylguanidine in Treating Patients With Recurrent, Progressive, or Refractory Neuroblastoma or Malignant Pheochromocytoma or Paraganglioma Start of enrollment: 2006 May 01
Recruiting
Phase 2
Iodine I 131 Monoclonal Antibody 3F8 and Bevacizumab in Treating Patients With Relapsed or Refractory Neuroblastoma Start of enrollment: 2006 Aug 01
Completed
Phase 1
Beta-Glucan and Monoclonal Antibody 3F8 in Treating Patients With Metastatic Neuroblastoma Start of enrollment: 2005 Sep 09
Completed
Phase 1
Tumor Detection Using Iodine-131-Labeled Monoclonal Antibody 8H9 Start of enrollment: 2001 Oct 01
Terminated
Not Applicable
Anti-GD2 3F8 Antibody and Allogeneic Natural Killer Cells for High-Risk Neuroblastoma Start of enrollment: 2009 Apr 02
Completed
Phase 1
Intraperitoneal RIT With 131I-8H9 for Pts With DSRCT and Other Solid Tumors Involving the Peritoneum Start of enrollment: 2010 Apr 01
Terminated
Phase 1
Bevacizumab, Irinotecan and Temozolomide for Relapsed or Refractory Neuroblastoma Start of enrollment: 2010 Apr 29
Completed
Phase 2
Phase I Study of LDK378 in Pediatric, Malignancies With a Genetic Alteration in Anaplastic Lymphoma Kinase (ALK) Start of enrollment: 2013 Aug 28
Completed
Phase 1
Humanized Anti-GD2 Antibody Hu3F8 and Allogeneic Natural Killer Cells for High-Risk Neuroblastoma Start of enrollment: 2016 Jan 01
Active, not recruiting
Phase 1
Study of the Safety and Efficacy of Humanized 3F8 Bispecific Antibody (Hu3F8-BsAb) in Patients With Relapsed/Refractory Neuroblastoma, Osteosarcoma and Other Solid Tumor Cancers Start of enrollment: 2019 Feb 22
Terminated
Phase 1, Phase 2
A Study of the Drug I131-Omburtamab in People With Desmoplastic Small Round Cell Tumors and Other Solid Tumors in the Peritoneum Start of enrollment: 2019 Jul 15
Recruiting
Phase 2
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Publications & Presentations

PubMed

Targeting refractory/recurrent neuroblastoma and osteosarcoma with anti-CD3×anti-GD2 bispecific antibody armed T cells.
Archana Thakur, Roland Chu, Jeffrey Taub, Alissa Martin, Dana Schalk, Amy Schienshang, Sarah Whitaker, Katie Rea, Qin Liu, Maxim Yankelevich, Shakeel Modak, Daniel W L...> ;Journal for Immunotherapy of Cancer. 2024 Mar 21
Intraoperative Radiation Therapy for Relapsed or Refractory High-Risk Neuroblastoma: A 27-Year Experience.
Conte, B., Narayan, N., Gerstle, J., Kushner, B., Kramer, K., Casey, D., Tringale, K., Honeyman, J., LaQuaglia, M., Modak, S., Wolden, S.> ;Practical Radiation Oncology. 2024 Feb 1
GM-CSF, G-CSF or no cytokine therapy with anti-GD2 immunotherapy for high-risk neuroblastoma.
Mora, J., Kinsey, J., Ragsdale, C., Modak, S., Lazarus, H.> ;International Journal of Cancer. 2024 Apr 15
Targeting GD2-positive Refractory/Resistant Neuroblastoma and Osteosarcoma with Anti- CD3 x Anti-GD2 Bispecific Antibody Armed T cells.
Archana Thakur, Roland Chu, Jeffrey Taub, Alissa Martin, Dana L Schalk, Amy Schienshang, Sara Whitaker, Katie Rea, Daniel W Lee, Qin Liu, Anthony Shields, Lawrence G L...> ;Research Square. 2023 Nov 9
Stage 4N neuroblastoma before and during the era of anti-Gimmunotherapy.
Brian H Kushner, Michael P LaQuaglia, Fiorella Iglesias Cardenas, Ellen M Basu, Justin T Gerstle, Kim Kramer, Stephen S Roberts, Suzanne L Wolden, Nai-Kong V Cheung, S...> ;International Journal of Cancer. 2023 Dec 15
Anaplastic Lymphoma Kinase Inhibitors for Therapy of Neuroblastoma in Adults.
Brian H Kushner, Stephen S Roberts, Fiorella Iglesias-Cardenas, Kim Kramer, Shakeel Modak, Stiefel, J., Jessica Stiefel> ;JCO Precision Oncology. 2023 Aug 1
3 citations
Clonal evolution during metastatic spread in high-risk neuroblastoma.
Gundem, G., Levine, M., Roberts, S., Cheung, I., Medina-Martínez, J., Feng, Y., Arango-Ossa, J., Chadoutaud, L., Rita, M., Asimomitis, G., Zhou, J., You, D., Bouvier, ...> ;Nature Genetics. 2023 Jun 1
3 citations
Ganglioneuroblastoma intermixed: Clinicopathological implications of diagnosis at presentation and genomic correlations.
Behtash G Nezami, Shakeel Modak, Fiorella Iglesias Cardenas, Judy Sarungbam, Sahussapont J Sirintrapun, Anuradha Gopalan, Yingbei Chen, Hikmat Al-Ahmadie, Samson W Fin...> ;Pediatric Blood & Cancer. 2023 Aug 1
2 citations
Radioimmunoscintigraphy and Pretreatment Dosimetry ofI-Omburtamab for Planning Treatment of Leptomeningeal Disease.
Neeta Pandit-Taskar, Milan Grkovski, Pat B Zanzonico, Keith S Pentlow, Shakeel Modak, Kim Kramer, John L Humm> ;Journal of Nuclear Medicine. 2023 Jun 1
2 citations
Effect of Oral β-Glucan on Antibody Response to Ganglioside Vaccine in Patients With High-Risk Neuroblastoma: A Phase 2 Randomized Clinical Trial.
Irene Y Cheung, Audrey Mauguen, Shakeel Modak, Govind Ragupathi, Ellen M Basu, Stephen S Roberts, Brian H Kushner, Nai-Kong Cheung> ;JAMA Oncology. 2023 Feb 1
16 citations
Phase 1 study of intraventricularI-omburtamab targeting B7H3 (CD276)-expressing CNS malignancies.
Kim Kramer, Neeta Pandit-Taskar, Brian H Kushner, Pat Zanzonico, John L Humm, Ursula Tomlinson, Maria Donzelli, Suzanne L Wolden, Sophia Haque, Ira Dunkel, Mark M Souw...> ;Journal of Hematology & Oncology. 2022 Nov 12
Clinical outcomes of pediatric patients receiving multimodality treatment of second central nervous system relapse of neuroblastoma.
Kathryn R Tringale, Suzanne L Wolden, Dana L Casey, Brian H Kushner, Leo Luo, Neeta Pandit-Taskar, Mark Souweidane, Nai-Kong V Cheung, Shakeel Modak, Ellen M Basu, Kim...> ;Pediatric Blood & Cancer. 2023 Feb 1
3 citations
Immunotherapy with anti-Gmonoclonal antibody in infants with high-risk neuroblastoma.
Brian H Kushner, Shakeel Modak, Kim Kramer, Ellen M Basu, Fiorella Iglesias-Cardenas, Stephen S Roberts, Nai-Kong V Cheung> ;International Journal of Cancer. 2023 Jan 15
3 citations
Bone Marrow Surveillance of Pediatric Cancer Survivors Identifies Clones that Predict Therapy-Related Leukemia.
Barbara Spitzer, Kayleigh D Rutherford, Gunes Gundem, Erin M McGovern, Nathan E Millard, Juan E Arango Ossa, Irene Y Cheung, Teng Gao, Max F Levine, Yanming Zhang, Jua...> ;Clinical Cancer Research. 2022 Apr 14
7 citations
F-18 meta-fluorobenzylguanidine PET imaging of myocardial sympathetic innervation.
Milan Grkovski, Pat B Zanzonico, Shakeel Modak, John L Humm, Jagat Narula, Neeta Pandit-Taskar> ;Journal of Nuclear Cardiology. 2022 Dec 1
Skeletal muscle metastases in neuroblastoma share common progenitors with primary tumor and biologically resemble stage MS disease.
Christina Fong, Brian H Kushner, Angela Di Giannatale, Gunes Gundem, Shanita Li, Stephen S Roberts, Ellen M Basu, Anita Price, Nai-Kong V Cheung, Shakeel Modak> ;Frontiers in Oncology. 2022 Jan 1
5 citations
Phase I Trial of Oral Yeast-Derived β-Glucan to Enhance Anti-GD2 Immunotherapy of Resistant High-Risk Neuroblastoma.
Fiorella Iglesias Cardenas, Audrey Mauguen, Irene Y Cheung, Kim Kramer, Brian H Kushner, Govind Ragupathi, Nai-Kong V Cheung, Shakeel Modak> ;Cancers. 2021 Dec 14
1 citations
Biodistribution and radiation dosimetry of intraperitoneally administered 124I-omburtamab in patients with desmoplastic small round cell tumors.
Milan Grkovski, Shakeel Modak, Pat Zanzonico, Jorge A. Carrasquillo, Steven M. Larson, John L. Humm, Neeta Pandit-Taskar> ;Journal of Nuclear Medicine. 2021 Dec 1
4 citations
Association of BRAF V600E mutations with vasoactive intestinal peptide syndrome in MYCN-amplified neuroblastoma
Sanam Shahid, Brian H. Kushner, Shakeel Modak, Ellen M. Basu, Elyssa M Rubin, Gunes Gundem, Elli Papaemmanuil, Stephen S. Roberts> ;Pediatric Blood & Cancer. 2021 Jul 31
11 citations
Comprehensive Molecular Profiling of Desmoplastic Small Round Cell Tumor
, , , , , , , , , , , , , , , , , , , , , , > ;Molecular Cancer Research. 2021 Mar 22
5 citations
Differential Impact of ALK Mutations in Neuroblastoma
Tara O'Donohue, Nitya Gulati, Audrey Mauguen, Brian H. Kushner, M I Rodriguez-Sanchez, Nancy Bouvier, Stephen S. Roberts, Ellen M. Basu, Nai-Kong V. Cheung, Shakeel Modak> ;JCO Precision Oncology. 2021 Mar 19
66 citations
Prospective pan-cancer germline testing using MSK-IMPACT informs clinical translation in 751 patients with pediatric solid tumors.
, , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , > ;Nature Cancer. 2021 Feb 15
4 citations
Mandibular metastases in neuroblastoma: Outcomes and dental sequelae.
Annu Singh, Shakeel Modak, Armand Karl Solano, Brian H. Kushner, Suzanne L. Wolden, Joseph M. Huryn, Cherry L. Estilo> ;Pediatric Blood & Cancer. 2021 Jan 28
45 citations
Survival Impact of Anti-GD2 Antibody Response in a Phase II Ganglioside Vaccine Trial Among Patients With High-Risk Neuroblastoma With Prior Disease Progression
Irene Y. Cheung, Nai-Kong V. Cheung, Shakeel Modak, Audrey Mauguen, Yi Feng, Ellen M. Basu, Stephen S. Roberts, Govind Ragupathi, Brian H. Kushner> ;Journal of Clinical Oncology. 2021 Jan 20
34 citations
B7H3-Directed Intraperitoneal Radioimmunotherapy With Radioiodinated Omburtamab for Desmoplastic Small Round Cell Tumor and Other Peritoneal Tumors: Results of a Phase...
Shakeel Modak, Pat Zanzonico, Milan Grkovski, Emily K. Slotkin, Jorge A. Carrasquillo, Serge K. Lyashchenko, Jason S. Lewis, Irene Y. Cheung, Todd E. Heaton, Michael P...> ;Journal of Clinical Oncology. 2020 Oct 29
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Press Mentions

Y-mAbs Announces Naxitamab Chemoimmunotherapy Investigational Trial for High-Risk Neuroblastoma Meets Primary EndpointMay 26th, 2022
Y-mAbs to Host Key Opinion Leader Webinar on DANYELZA® (Naxitamab-Gqgk) Frontline and HITS Data in High-Risk NeuroblastomaSeptember 10th, 2021
Y-mAbs to Host Virtual Research & Development Day on Wednesday, December 16December 7th, 2020
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Hospital Affiliations

Memorial Sloan Kettering Cancer CenterNew York, New York