ClarenceWilliamBalkeMD

Cardiology • San Francisco, CA

Cardiac Electrophysiology

Professor, Medicine, University of California, San Francisco, School of Medicine

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Office
185 Berry St
Campus Box 0558, Lobby 3, Suite 5300
San Francisco, CA 94107
Phone+1 415-244-1570

Fax+1 415-514-8520
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Education & Training

Brigham and Women's HospitalFellowship, Cardiovascular Disease, 1986 - 1988
Johns Hopkins UniversityResidency, Internal Medicine, 1981 - 1984
Lewis Katz School of Medicine at Temple UniversityClass of 1981

Certifications & Licensure

KY State Medical License 2005 - 2025
CA State Medical License 2010 - 2024
MD State Medical License 1984 - 2014

Publications & Presentations

PubMed

40 citations
Cardiac troponin T, a sarcomeric AKAP, tethers protein kinase A at the myofilaments.
C. Amelia Sumandea, Mary L. Garcia-Cazarin, Catherine H. Bozio, Gail Sievert, C. William Balke, Marius P. Sumandea> ;The Journal of Biological Chemistry. 2011 Jan 7
21 citations
CARDIOMYOPATHY-CAUSING DELETION K210 IN CARDIAC TROPONIN T ALTERS PHOSPHORYLATION PROPENSITY OF SARCOMERIC PROTEINS
Liliana Sfichi-Duke, Mary L. Garcia-Cazarin, C. Amelia Sumandea, Gail Sievert, C. William Balke, Dong Yun Zhan, Sachio Morimoto, Marius P. Sumandea> ;Journal of Molecular and Cellular Cardiology. 2010 May 1
15 citations
Funding Opportunities for Investigators in the Early Stages of Career Development
C. Amelia Sumandea, C. William Balke> ;Circulation. 2009 Mar 10
51 citations
Tyrosine Phosphorylation Modifies Protein Kinase C δ-dependent Phosphorylation of Cardiac Troponin I
Marius P. Sumandea, Vitalyi O. Rybin, Aaron C. Hinken, Chaojian Wang, Tomoyoshi Kobayashi, Erin Harleton, Gail Sievert, C. William Balke, Steven J. Feinmark, R. John S...> ;The Journal of Biological Chemistry. 2008 Aug 15
137 citations
Calcium handling in human embryonic stem cell-derived cardiomyocytes.
Jonathan Satin, Ilanit Itzhaki, Sophia Rapoport, Elizabeth A. Schroder, Leighton T. Izu, Gil Arbel, Rafael Beyar, C. William Balke, Jackie Schiller, Lior Gepstein> ;Stem Cells. 2008 Aug 1
76 citations
Transformation of adult rat cardiac myocytes in primary culture
Tamás Bányász, Ilya Lozinskiy, Charles E. Payne, Stephanie E. Edelmann, Byron Norton, Biyi Chen, Ye Chen-Izu, Leighton T. Izu, C. William Balke> ;Experimental Physiology. 2008 Mar 1
75 citations
Left ventricular dysfunction and associated cellular injury in rats exposed to chronic intermittent hypoxia.
Ling Chen, Jin Zhang, Tracey X. Gan, Ye Chen-Izu, Jeffrey D. Hasday, Morris Karmazyn, C. William Balke, Steven M. Scharf> ;Journal of Applied Physiology. 2008 Jan 1
42 citations
Hypertension-induced remodeling of cardiac excitation-contraction coupling in ventricular myocytes occurs prior to hypertrophy development
Ye Chen-Izu, Ling Chen, Tamás Bányász, Stacey L. McCulle, Byron Norton, Steven M. Scharf, Anuj Agarwal, Abhijit Patwardhan, Leighton T. Izu, C. William Balke> ;American Journal of Physiology. Heart and Circulatory Physiology. 2007 Dec 1
8 citations
Eavesdropping on the Social Lives of Ca2+ Sparks
Leighton T. Izu, Tamás Bányász, C. William Balke, Ye Chen-Izu> ;Biophysical Journal. 2007 Nov 15
42 citations
Phosphorylation of RyR2 and shortening of RyR2 cluster spacing in spontaneously hypertensive rat with heart failure.
Ye Chen-Izu, Christopher W. Ward, Wayne N. Stark, Tamás Bányász, Marius P. Sumandea, C. William Balke, Leighton T. Izu, Xander H.T. Wehrens> ;American Journal of Physiology. Heart and Circulatory Physiology. 2007 Oct 1
284 citations
Application of blebbistatin as an excitation-contraction uncoupler for electrophysiologic study of rat and rabbit hearts.
Vadim V. Fedorov, Ilya T. Lozinsky, Eugene A. Sosunov, Evgeniy P. Anyukhovsky, M R Rosen, C. William Balke, Igor R. Efimov> ;Heart Rhythm. 2007 May 1
50 citations
Cellular and molecular determinants of altered Ca2+ handling in the failing rabbit heart: primary defects in SR Ca2+ uptake and release mechanisms
Antonis A. Armoundas, Jochen Rose, Rajesh Aggarwal, Bruno D. Stuyvers, Brian O'Rourke, David A. Kass, Eduardo Marbán, Stephen R. Shorofsky, Gordon F. Tomaselli, C. Wil...> ;American Journal of Physiology. Heart and Circulatory Physiology. 2007 Mar 1
7 citations
Robust gene expression with amplified RNA from biopsy-sized human heart tissue.
Brian R. Barrows, Agnes M. Azimzadeh, Stacey L. McCulle, Gloria Vives-Rodriguez, Wayne N. Stark, Nicholas P. Ambulos, Jing Yin, Hegang Chen, C. William Balke, Christin...> ;Journal of Molecular and Cellular Cardiology. 2007 Jan 1
1 citations
Progress in the development of a unifying hypothesis on the mechanisms underlying the electrical and mechanical abnormalities of the failing heart: one step backward b...
Ye Chen-Izu, C. William Balke> ;Journal of Molecular and Cellular Cardiology. 2006 Sep 1
5 citations
Mitochondrial buffering of calcium in the heart: potential mechanism for linking cyclic energetic cost with energy supply?
Patrick G. Sullivan, C. William Balke, Karyn A. Esser> ;Circulation Research. 2006 Jul 21
73 citations
Interplay of ryanodine receptor distribution and calcium dynamics
Leighton T. Izu, Shawn Means, John N. Shadid, Ye Chen-Izu, C. William Balke> ;Biophysical Journal. 2006 Jul 1
147 citations
Three-Dimensional Distribution of Ryanodine Receptor Clusters in Cardiac Myocytes
Ye Chen-Izu, Stacey L. McCulle, Christopher W. Ward, Christian Soeller, Bryan M. Allen, Cal Rabang, Mark B. Cannell, C. William Balke, Leighton T. Izu> ;Biophysical Journal. 2006 Jul 1
355 citations
Orphaned ryanodine receptors in the failing heart
Long-Sheng Song, Eric A. Sobie, Stacey L. McCulle, W. J. Lederer, C. William Balke, Heping Cheng> ;Proceedings of the National Academy of Sciences of the United States of America. 2006 Mar 14
18 citations
Redox mechanisms of muscle dysfunction in inflammatory disease.
Michael B. Reid, Francisco H. Andrade, C. William Balke, Karyn A. Esser> ;Physical Medicine and Rehabilitation Clinics of North America. 2005 Nov 1
139 citations
Sodium pump α2 subunits control myogenic tone and blood pressure in mice
Jin Zhang, Moo Yeol Lee, Maurizio Cavalli, Ling Chen, Roberto Berra-Romani, C. William Balke, Bianchi Giuseppe, Patrizia Ferrari, John M. Hamlyn, Takahiro Iwamoto, Jer...> ;The Journal of Physiology. 2005 Nov 1
187 citations
Oxidative Stress and Left Ventricular Function with Chronic Intermittent Hypoxia in Rats
Ling Chen, Elliot Einbinder, Qi Zhang, Jeffrey D. Hasday, C. William Balke, Steven M. Scharf> ;American Journal of Respiratory and Critical Care Medicine. 2005 Oct 1
7 citations
Excitation contraction coupling in cardiac muscle: is there a purely voltage-dependent component?
C. William Balke, L. Goldman> ;The Journal of General Physiology. 2003 May 1
8 citations
An antisense oligonucleotide against H1 inhibits the classical sodium current but not ICa(TTX) in rat ventricular cells.
Qun Sha, Shawn W. Robinson, Stacey L. McCulle, Stephen R. Shorofsky, Paul A. Welling, L. Goldman, C. William Balke> ;The Journal of Physiology. 2003 Mar 1
90 citations
Role of the transverse-axial tubule system in generating calcium sparks and calcium transients in rat atrial myocytes
Malcolm M. Kirk, Leighton T. Izu, Ye Chen-Izu, Stacey L. McCulle, W. Gil Wier, C. William Balke, Stephen R. Shorofsky> ;The Journal of Physiology. 2003 Mar 1
3 citations
The Ca2+ Synapse Redo: A Matter of Location, Location, Location
Leighton T. Izu, C. William Balke> ;Circulation Research. 2002 Aug 23
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Hospital Affiliations

John J. Cochran Veterans HospitalSaint Louis, Missouri