CoreyJLangerMD

Oncology • Philadelphia, PA

Head & Neck Cancer, Hematologic Oncology, Thoracic Cancer

Director of Thoracic Oncology

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Office
3400 Civic Center Blvd
2 PCAM
Philadelphia, PA 19104
Phone+1 215-615-5121

Fax+1 215-615-5122
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Education & Training

Temple University HospitalFellowship, Hematology and Medical Oncology, 1986 - 1987
University of Pennsylvania Health SystemFellowship, Hematology and Medical Oncology, 1984 - 1986
Graduate HospitalResidency, Internal Medicine, 1981 - 1984
Boston University School of MedicineClass of 1981

Certifications & Licensure

PA State Medical License 1982 - 2024
American Board of Internal Medicine Internal Medicine
American Board of Internal Medicine Hematology
American Board of Internal Medicine Medical Oncology

Awards, Honors, & Recognition

Philadelphia Magazine Castle Connolly, 2004-2014
America's Top Doctors Castle Connolly, 2002-2014
America's Top Doctors for Cancer Castle Connolly, 2005-2013
CMS Meaningful Use Stage 1 Certification EpicCare Ambulatory EMR, Epic Systems Corporation, 2012-2013
Fellow (FACP) American College of Physicians, 1996
Super Doctor SuperDoctors.com
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Clinical Trials

Paclitaxel in Treating Patients With Advanced Head and Neck Cancer Start of enrollment: 1997 Feb 21
Completed
Phase 2
Cisplatin, Interferon Alfa, Surgery, and Radiation Therapy in Treating Patients With Malignant Pleural Mesothelioma Start of enrollment: 1996 Aug 01
Completed
Phase 1
Cisplatin Plus Gemcitabine in Treating Patients With Advanced Squamous Cell Head and Neck Cancer Start of enrollment: 1997 Oct 01
Completed
Phase 2
Methotrexate Compared With Paclitaxel in Treating Patients With Advanced Head and Neck Cancer Start of enrollment: 1999 Apr 22
Completed
Phase 3
Trastuzumab Plus Chemotherapy in Treating Patients With Advanced Non-small Cell Lung Cancer Start of enrollment: 1999 May 01
Completed
Phase 2
S9900: Surgery With or Without Combination Chemotherapy in Treating Patients With Non-small Cell Lung Cancer Start of enrollment: 1999 Oct 01
Completed
Phase 3
Combination Chemotherapy With or Without Biological Therapy in Treating Patients With Refractory Solid Tumor or Lymphoma Start of enrollment: 1996 Jul 01
Completed
Phase 1
Temozolomide in Treating Patients With Stage IIIB, Stage IV, or Recurrent Non-small Cell Lung Cancer Start of enrollment: 2000 Jan 01
Completed
Phase 2
Paclitaxel, Cisplatin, and Filgrastim Combined With Radiation Therapy in Treating Patients With Locally Recurrent Head and Neck Cancer Start of enrollment: 2000 Mar 01
Completed
Phase 2
Comparison of Two Combination Chemotherapy Regimens in Treating Non-small Cell Lung Cancer Start of enrollment: 2000 Aug 22
Completed
Phase 2
Paclitaxel and Cisplatin Plus Radiation Therapy Followed by Filgrastim in Treating Patients With Recurrent Head and Neck Cancer or Lung Cancer Start of enrollment: 1999 Sep 01
Completed
Phase 2
Carboplatin and Gemcitabine in Treating Patients With Advanced Solid Tumors Start of enrollment: 1997 Nov 01
Completed
Phase 1
Chemotherapy and Radiation Therapy in Treating Patients With Non-Small Cell Lung Cancer Start of enrollment: 1999 Jan 01
Completed
Phase 1
Temozolomide in Treating Patients With Relapsed or Progressive Small Cell Lung Cancer Start of enrollment: 2002 Jan 01
Completed
Phase 2
Chemotherapy Combined With Radiation Therapy in Treating Patients With Limited-Stage Small Cell Lung Cancer Start of enrollment: 2003 Mar 01
Completed
Phase 1
Phase II Study of Concurrent C225, Cisplatin and Radiation in Stage IV Squamous Cell Carcinoma of the Head and Neck Start of enrollment: 2005 Apr 08
Completed
Phase 2
Study of Paclitaxel, Carboplatin, and Cetuximab for Advanced Lung Cancer Start of enrollment: 2004 Dec 01
Completed
Phase 2
A Study Comparing Sequential Satraplatin & Erlotinib to Erlotinib in Unresectable Stage 3/4 Non-small-cell Lung Cancer (NSCLC) Start of enrollment: 2006 Jul 01
Completed
Phase 2
Trial of Poor Performance Status Patients (ToPPS) Start of enrollment: 2009 Jun 01
Completed
Phase 2
Capecitabine and Lapatinib Ditosylate in Treating Patients With Squamous Cell Cancer of the Head and Neck Start of enrollment: 2009 Oct 01
Completed
Phase 2
Circulating Tumor Cells (CTCs) as a Blood-based Tumor Marker in Patients With Small Cell Lung Cancer (SCLC) Start of enrollment: 2010 Jul 01
Completed
Tivantinib Plus Erlotinib Versus Placebo Plus Erlotinib for the Treatment of Non-squamous, Non-small-cell Lung Cancer Start of enrollment: 2011 Jan 11
Terminated
Phase 3
Pembrolizumab in Combination With Chemotherapy and Image-Guided Surgery for Malignant Pleural Mesothelioma (MPM) Start of enrollment: 2023 Jan 10
Recruiting
Phase 1
Roles: Principal Investigator, Contact
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Publications & Presentations

PubMed

Brief Report: Impact of Reflex Testing on Tissue-Based Molecular Genotyping in Patients With Advanced Non-Squamous Non-Small Cell Lung Cancer.
Melina E Marmarelis, Dylan G Scholes, Cindy M McGrath, Salvatore F Priore, Jacquelyn J Roth, Michael Feldman, Jennifer J D Morrissette, Leslie Litzky, Charu Deshpande,...> ;Clinical Lung Cancer. 2024 Mar 12
Acute hospitalizations after proton therapy versus intensity-modulated radiotherapy for locally advanced non-small cell lung cancer in the durvalumab era.
Iocolano, M., Yegya-Raman, N., Friedes, C., Wang, X., Kegelman, T., Lee, S., Duan, L., Li, B., Levin, W., Cengel, K., Konski, A., Langer, C., Cohen, R., Sun, L., Aggar...> ;Cancer. 2024 Jan 31
Plunging Into the PACIFIC: Outcomes of Patients With Unresectable KRAS-Mutated Non-Small Cell Lung Cancer Following Definitive Chemoradiation and Durvalumab Consolidat...
Barsouk, A., Friedes, C., Iocolano, M., Doucette, A., Cohen, R., Robinson, K., D'Avella, C., Marmarelis, M., Kosteva, J., Singh, A., Ciunci, C., Levin, W., Cengel, K.,...> ;Clinical Lung Cancer. 2023 Dec 22
1 citations
Tumor Treating Fields therapy in metastatic non-small-cell lung cancer - Authors' reply.
Ticiana Leal, Corey Langer> ;The Lancet. Oncology. 2023 Dec 1
2 citations
The effective radiation dose to immune cells predicts lymphopenia and inferior cancer control in locally advanced NSCLC.
Friedes, C., Iocolano, M., Lee, S., Duan, L., Li, B., Doucette, A., Cohen, R., Aggarwal, C., Sun, L., Levin, W., Cengel, K., Kao, G., Teo, B., Langer, C., Xiao, Y., Br...> ;Radiotherapy and Oncology. 2024 Jan 1
3 citations
Cardiac radiation dose is associated with inferior survival but not cardiac events in patients with locally advanced non-small cell lung cancer in the era of immune ch...
Nikhil Yegya-Raman, Sang Ho Lee, Cole Friedes, Xingmei Wang, Michelle Iocolano, Timothy P Kegelman, Lian Duan, Bolin Li, Eva Berlin, Kristine N Kim, Abigail Doucette, ...> ;Radiotherapy and Oncology. 2024 Jan 1
Patterns of Failure, Low-Volume Relapse, and Subsequent Ablative Management in Locally Advanced Non-Small Cell Lung Cancer Treated With Definitive Chemoradiation and C...
Cole Friedes, Michelle Iocolano, Sang Ho Lee, Bolin Li, Lian Duan, William P Levin, Keith A Cengel, Lova L Sun, Charu Aggarwal, Melina E Marmarelis, Abigail Doucette, ...> ;International Journal of Radiation Oncology, Biology, Physics. 2024 Apr 1
Patterns of Failure in Metastatic NSCLC Treated With First Line Pembrolizumab and Use of Local Therapy in Patients With Oligoprogression.
Cole Friedes, Nikhil Yegya-Raman, Siqi Zhang, Michelle Iocolano, Roger B Cohen, Charu Aggarwal, Jeffrey C Thompson, Melina E Marmarelis, William P Levin, Keith A Cenge...> ;Clinical Lung Cancer. 2024 Jan 1
9 citations
Tumor Treating Fields therapy with standard systemic therapy versus standard systemic therapy alone in metastatic non-small-cell lung cancer following progression on o...
Ticiana Leal, Rupesh Kotecha, Rodryg Ramlau, Li Zhang, Janusz Milanowski, Manuel Cobo, Jaromir Roubec, Lubos Petruzelka, Libor Havel, Sujith Kalmadi, Jeffrey Ward, Zor...> ;The Lancet. Oncology. 2023 Sep 1
Phase 2 Trial of Consolidation Pembrolizumab After Proton Reirradiation for Thoracic Recurrences of Non-Small Cell Lung Cancer.
Nikhil Yegya-Raman, Abigail T Berman, Christine A Ciunci, Cole Friedes, Eva Berlin, Michelle Iocolano, Xingmei Wang, Ching Lai, William P Levin, Keith A Cengel, Shanno...> ;International Journal of Radiation Oncology, Biology, Physics. 2023 Aug 29
2 citations
Pneumonitis Rates Before and After Adoption of Immunotherapy Consolidation in Patients With Locally Advanced Non-Small Cell Lung Cancer Treated With Concurrent Chemora...
Nikhil Yegya-Raman, Cole Friedes, Sang Ho Lee, Michelle Iocolano, Lian Duan, Xingmei Wang, Bolin Li, Charu Aggarwal, Roger B Cohen, William Su, Abigail Doucette, Willi...> ;International Journal of Radiation Oncology, Biology, Physics. 2024 Apr 1
5 citations
Association Between Availability of Molecular Genotyping Results and Overall Survival in Patients With Advanced Nonsquamous Non-Small-Cell Lung Cancer.
Charu Aggarwal, Melina E Marmarelis, Wei-Ting Hwang, Dylan G Scholes, Tara L McWilliams, Aditi P Singh, Lova Sun, John Kosteva, Michael R Costello, Roger B Cohen, Core...> ;JCO Precision Oncology. 2023 Jul 1
15 citations
Association Between Duration of Immunotherapy and Overall Survival in Advanced Non-Small Cell Lung Cancer.
Lova Sun, Benjamin Bleiberg, Wei-Ting Hwang, Melina E Marmarelis, Corey J Langer, Aditi Singh, Roger B Cohen, Ronac Mamtani, Charu Aggarwal> ;JAMA Oncology. 2023 Aug 1
Prospective Feasibility and Phase 1/2 Trial of Preoperative Proton Beam Therapy With Concurrent Chemotherapy for Resectable Stage IIIA or Superior Sulcus Non-Small Cel...
Charles B Simone 2nd, Nikhil Yegya-Raman, Shwetha Manjunath, Vivek Verma, Jacob E Shabason, Lee Xu, Keith A Cengel, William P Levin, Abigail T Berman, John P Christodo...> ;International Journal of Radiation Oncology, Biology, Physics. 2023 Nov 1
71 citations
Randomized Phase II Trial Comparing Bevacizumab Plus Carboplatin and Paclitaxel With Carboplatin and Paclitaxel Alone in Previously Untreated Locally Advanced or Metas...
David H Johnson, Louis Fehrenbacher, William F Novotny, Roy S Herbst, John J Nemunaitis, David M Jablons, Corey J Langer, Russell F DeVore 3rd, Jacques Gaudreault, Lis...> ;Journal of Clinical Oncology. 2023 May 1
2 citations
A Phase II Open-Label Trial of Binimetinib and Hydroxychloroquine in Patients With Advanced KRAS-Mutant Non-Small Cell Lung Cancer.
Charu Aggarwal, Alisha P Maity, Joshua M Bauml, Qi Long, Tomas Aleman, Christine Ciunci, Christopher D'Avella, Melissa Volpe, Evan Anderson, Lisa McCormick Jones, Lova...> ;The Oncologist. 2023 Jul 5
Cardiovascular Substructure Dose and Cardiac Events following Proton- and Photon-Based Chemoradiotherapy for Non-Small Cell Lung Cancer.
Jyotsna Natarajan, Nikhil Yegya-Raman, Timothy P Kegelman, Michael J Kallan, Leonid Roshkovan, Sharyn Katz, Bonnie Ky, Michael Fradley, Ying Xiao, Sang Ho Lee, Zheng Z...> ;Advances in Radiation Oncology. 2023 Apr 5
1 citations
Utilization and Factors Precluding Receipt of Checkpoint Inhibitor Consolidation for Stage III NSCLC in a Large US Academic Health System.
Nikhil Yegya-Raman, Cole Friedes, Lova Sun, Michelle Iocolano, Kristine N Kim, Abigail Doucette, Roger B Cohen, Kyle W Robinson, William P Levin, Keith A Cengel, Brian...> ;Clinical Lung Cancer. 2023 Jul 1
1 citations
Clinical Outcomes Associated With Pembrolizumab Monotherapy Among Adults With Diffuse Malignant Peritoneal Mesothelioma.
Melina E Marmarelis, Xiao Wang, Leonid Roshkovan, Connor B Grady, John T Miura, Michelle S Ginsberg, Christine A Ciunci, Jacklynn Egger, Suzanne Walker, Andrea Cercek,...> ;JAMA Network Open. 2023 Mar 1
1 citations
Death without progression as an endpoint to describe cardiac radiation effects in locally advanced non-small cell lung cancer.
Nikhil Yegya-Raman, Timothy P Kegelman, Sang Ho Lee, Michael J Kallan, Kristine N Kim, Jyotsna Natarajan, Matthew P Deek, Wei Zou, Shannon E O'Reilly, Zheng Zhang, Wil...> ;Clinical and Translational Radiation Oncology. 2023 Mar 1
1 citations
Toxicities and Deaths From Intercurrent Disease Following Contemporary Postoperative Radiotherapy in Resected Non-Small-Cell Lung Cancer.
Kristine N Kim, Jonathan Heintz, Nikhil Yegya-Raman, Roger Cohen, Timothy Kegelman, Keith Cengel, Melina Marmarelis, Lova Sun, Corey Langer, Charu Aggarwal, Aditi Sing...> ;Clinical Lung Cancer. 2023 Mar 1
6 citations
Long-Term Efficacy and Safety of Brigatinib in Crizotinib-Refractory+ NSCLC: Final Results of the Phase 1/2 and Randomized Phase 2 (ALTA) Trials.
Scott N Gettinger, Rudolf M Huber, Dong-Wan Kim, Lyudmila Bazhenova, Karin Holmskov Hansen, Marcello Tiseo, Corey J Langer, Luis G Paz-Ares Rodríguez, Howard L West, K...> ;JTO Clinical and Research Reports. 2022 Sep 1
1 citations
Phase II Trial of Combination Nab-paclitaxel and Gemcitabine in Non-squamous Non-small Cell Lung Cancer After Progression on Platinum and Pemetrexed.
Christine A Ciunci, Jacob B Reibel, Tracey L Evans, Rosemarie Mick, Joshua M Bauml, Charu Aggarwal, Melina E Marmarelis, Aditi P Singh, Christopher D'Avella, Roger B C...> ;Clinical Lung Cancer. 2022 Jun 1
2 citations
Platinum Re-Exposure as a Non-Small Cell Lung Cancer (NSCLC) Treatment Strategy in the Age of Immunotherapy.
Melina E Marmarelis, Yu-Xiao Yang, Wei-Ting Hwang, Ronac Mamtani, Aditi Singh, Christine Ciunci, Charu Aggarwal, Roger B Cohen, Corey J Langer> ;Clinical Lung Cancer. 2022 Jun 1
9 citations
Plasma Genotyping at the Time of Diagnostic Tissue Biopsy Decreases Time-to-Treatment in Patients With Advanced NSCLC-Results From a Prospective Pilot Study.
Jeffrey C Thompson, Charu Aggarwal, Janeline Wong, Vivek Nimgaonkar, Wei-Ting Hwang, Michelle Andronov, David M Dibardino, Christoph T Hutchinson, Kevin C Ma, Anthony ...> ;JTO Clinical and Research Reports. 2022 Apr 1
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Journal Articles

Cisplatin Versus Cetuximab with Definitive Concurrent Radiotherapy for Head and Neck Squamous Cell Carcinoma: An Analysis of Veterans Health Affairs Data
Ravi Vinnakota, Keith Sigel, Joshua M Bauml, Roger B Cohen, Nevena Damjanov, Corey J Langer, Ronac Mamtani, Charu Aggarwal, Christina Knepley, Juan Wisnivesky, Cancer
Predictive Biomarkers for Response to EGFR-Directed Monoclonal Antibodies for Advanced Squamous Cell Lung Cancer
D R Spigel, E S Kim, S S Ramalingam, M A Socinski, C Obasaju, C J Langer, R B Natale, P D Bonomi, H Wakelee, Annals of Oncology
Thoracic Imaging of Non-Small Cell Lung Cancer Treated with Anti-Programmed Death Receptor-1 Therapy
Sharyn I Katz, Arun C Nachiappan, Joshua Bauml, Stephen Bagley, Charu Aggarwal, Corey Langer, ScienceDirect

Lectures

What’s the Role for Immunotherapy With and Without Chemotherapy in Oncogene Mutated NSCLC?
ASCO Annual Meeting 2019 - Chicago, IL - 6/1/2019
PD-L1, CTLA4, Cyclin D, Oh, My!
2018 ASCO Annual Meeting - Chicago, Illinois - 06/3/2018
2013 Updates in Oncology
Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania - 6/25/2013
7th Community Oncology Conference
Global Academy for Medical Education (Elsevier), Las Vegas, Nevada - 3/30/2012
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Press Mentions

Party with a Purpose Benefits AACR and Supports Lung Cancer ResearchOctober 27th, 2022
Oncocyte Launches First Real-World Evidence (RWE) Registry to Evaluate Biomarker Impact on Early-Stage Lung Cancer Treatment Decisions and OutcomesAugust 17th, 2021
Novocure Announces FDA IDE Approval and Steering Committee for KEYNOTE-B36 Trial Evaluating Tumor Treating Fields Together with Pembrolizumab in Non-Small Cell Lung CancerApril 22nd, 2021
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Committees

Member, Definitive and Adjuvant Radiotherapy in Locally Advanced Non-small Cell Lung Cancer Guideline Panel, American Society for Radiation Oncology 2015 - Present