CorneliaDekkerMD

Pediatric Infectious Disease • Half Moon Bay, CA

Pediatric Vaccinology and Vaccine Preventable Diseases, Perinatal Infections

Professor Emerita, Pediatrics - Infectious Diseases, Stanford University

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Office
24 Jenna Lane
Half Moon Bay, CA 94019
Phone+1 510-501-6323
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Education & Training

Duke University HospitalFellowship, Pediatric Infectious Diseases, 1979 - 1982
Duke University HospitalResidency, Pediatrics, 1976 - 1979
Michigan State University College of Human MedicineClass of 1976

Certifications & Licensure

CA State Medical License 1998 - 2026
NC State Medical License 1977 - 1998
American Board of Pediatrics Pediatrics

Clinical Trials

B-cell Immunity to Influenza (SLVP017)- Year 1, 2009 Start of enrollment: 2009 Jul 01
Completed
Phase 4
The Influence of Chronic CMV Infection on Influenza Vaccine Responses Start of enrollment: 2012 Oct 01
Completed
Phase 4
Plasmablast Trafficking and Antibody Response in Influenza Vaccination (SLVP021 2011-2014) Start of enrollment: 2011 Aug 01
Completed
Phase 4
Pilot Study in Young Adults to Examine the Kinetics of Changes in the B-cell Repertoire Following TIV Immunization Start of enrollment: 2012 May 01
Completed
Phase 4
Kinetics of B-Cell Responses to Live, Attenuated Influenza Vaccine (LAIV) in Young Children Two Years of Age Start of enrollment: 2008 Nov 01
Terminated
Phase 4
B-cell Immunity to Influenza (SLVP017) - Years 2 (2010) & 3 (2011) Start of enrollment: 2010 Sep 01
Completed
Phase 4
B-cell Immunity to Influenza (SLVP017)- Year 5, 2013 Start of enrollment: 2013 Oct 01
Completed
Phase 4
T-cell And General Immune Response to Seasonal Influenza Vaccine (SLVP018) Year 2, 2010 Start of enrollment: 2010 Sep 01
Completed
Phase 4
T-cell And General Immune Response to Seasonal Influenza Vaccine (SLVP018) Year 3, 2011 Start of enrollment: 2011 Sep 01
Completed
Phase 4
T-cell And General Immune Response to Seasonal Influenza Vaccine (SLVP018) Year 4, 2012 Start of enrollment: 2012 Oct 01
Completed
Phase 4
T-cell And General Immune Response to Seasonal Influenza Vaccine (SLVP018) Year 5, 2013 Start of enrollment: 2013 Sep 01
Completed
Phase 4
The Human Mucosal Immune Responses to Influenza Virus (SLVP026) Start of enrollment: 2012 Dec 01
Completed
Phase 4
Protective Mechanisms Against a Pandemic Respiratory Virus (SLVP024) Start of enrollment: 2012 Oct 01
Completed
Phase 4
Tissue-specific Responses to Influenza Immunization and Their Relation to Blood Biomarkers (SLVP032) Start of enrollment: 2015 Sep 01
Terminated
Phase 4
Innate and Acquired Immunity to Influenza Infection and Immunization (SLVP029) Start of enrollment: 2014 Sep 17
Completed
Phase 4
Adaptive Immune Responses and Repertoire in Influenza Vaccination and Infection (SLVP031) Start of enrollment: 2014 Nov 19
Terminated
Phase 4
Genetic and Environmental Factors in the Response to Influenza Vaccination Start of enrollment: 2014 Oct 03
Completed
Phase 1
Effects of Aging on Primary and Secondary Vaccine Responses in a 15-Year Longitudinal Cohort Start of enrollment: 2017 Sep 19
Completed
Phase 1
The Role of CD4+ Memory Phenotype, Memory, and Effector T Cells in Vaccination and Infection Start of enrollment: 2014 Sep 30
Completed
Phase 1
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Publications & Presentations

PubMed

Acute Respiratory Illness Is Associated with Memory T Cell Differentiation and Other Immune Cell Changes in an Age-Associated Manner.
Shreya S Ugale, Tyson H Holmes, Sofia Maysel-Auslender, Scott D Boyd, Cornelia L Dekker, Mark M Davis, Holden T Maecker> ;Immunohorizons. 2023 Sep 1
Considerations for unblinding individual study participants during vaccine trials.
Neal Halsey, Stephen Evans, Mathuram Santosham, Adam Hacker, Kathryn M Edwards, Rebecca E Chandler, Matthew Z Dudley, Cornelia L Dekker, , Seif Al-Abri, Narendra Arora...> ;Vaccine. 2023 May 22
89 citations
KIRCD8T cells suppress pathogenic T cells and are active in autoimmune diseases and COVID-19.
Jing Li, Maxim Zaslavsky, Yapeng Su, Jing Guo, Michael J Sikora, Vincent van Unen, Asbjørn Christophersen, Shin-Heng Chiou, Liang Chen, Jiefu Li, Xuhuai Ji, Julie Wilh...> ;Science. 2022 Apr 15
1 citations
Author Correction: An inflammatory aging clock (iAge) based on deep learning tracks multimorbidity, immunosenescence, frailty and cardiovascular aging.
Nazish Sayed, Yingxiang Huang, Khiem Nguyen, Zuzana Krejciova-Rajaniemi, Anissa P Grawe, Tianxiang Gao, Robert Tibshirani, Trevor Hastie, Ayelet Alpert, Lu Cui, Tatian...> ;Nature Aging. 2021 Aug 1
155 citations
An inflammatory aging clock (iAge) based on deep learning tracks multimorbidity, immunosenescence, frailty and cardiovascular aging
Nazish Sayed, Yingxiang Huang, Khiem Van Nguyen, Zuzana Krejciova-Rajaniemi, Anissa P. Grawe, Tianxiang Gao, Robert Tibshirani, Trevor Hastie, Ayelet Alpert, Lu Cui, T...> ;Nature Aging. 2021 Jul 1
43 citations
The critical role of background rates of possible adverse events in the assessment of COVID-19 vaccine safety.
Steven Black, Barbara Law, Robert T. Chen, Cornelia L. Dekker, Miriam C. J. M. Sturkenboom, Wan-Ting Huang, Marc Gurwith, G.A. Poland> ;Vaccine. 2021 May 6
14 citations
Signatures of immune dysfunction in HIV and HCV infection share features with chronic inflammation in aging and persist after viral reduction or elimination
Cesar J. Lopez Angel, Edward A. Pham, Huixun Du, Francesco Vallania, Benjamin Fram, Kevin Perez, Thai Nguyen, Yael Rosenberg-Hasson, Aijaz Ahmed, Cornelia L. Dekker, P...> ;Proceedings of the National Academy of Sciences of the United States of America. 2021 Apr 6
58 citations
Vaccine-associated enhanced disease: Case definition and guidelines for data collection, analysis, and presentation of immunization safety data.
Flor M. Munoz, Jakob P. Cramer, Cornelia L. Dekker, Matthew Z. Dudley, Barney S. Graham, Marc Gurwith, Barbara Law, Stanley Perlman, Fernando P. Polack, Jonathan M. Sp...> ;Vaccine. 2021 Feb 23
77 citations
Consensus summary report for CEPI/BC March 12-13, 2020 meeting: Assessment of risk of disease enhancement with COVID-19 vaccines.
Paul-Henri Lambert, Donna M. Ambrosino, Svein Rune Andersen, Ralph S. Baric, Steven Black, Robert T. Chen, Cornelia L. Dekker, Arnaud M. Didierlaurent, Barney S. Graha...> ;Vaccine. 2020 Jun 26
93 citations
Memory B Cell Activation, Broad Anti-influenza Antibodies, and Bystander Activation Revealed by Single-Cell Transcriptomics
Felix Horns, Cornelia L. Dekker, Stephen R. Quake> ;Cell Reports. 2020 Jan 21
29 citations
Determinants governing T cell receptor α/β-chain pairing in repertoire formation of identical twins
Hidetaka Tanno, Timothy M. Gould, Jonathan R. McDaniel, Wenqiang Cao, Yuri Tanno, Russell E. Durrett, Daechan Park, Steven Cate, William H. Hildebrand, Cornelia L. Dek...> ;Proceedings of the National Academy of Sciences of the United States of America. 2020 Jan 7
30 citations
Pregnancy-Induced Alterations in NK Cell Phenotype and Function
Mathieu Le Gars, Christof Seiler, Alexander W. Kay, Nicholas L. Bayless, Elina Starosvetsky, Lindsay Moore, Shai S. Shen-Orr, Natali Aziz, Purvesh Khatri, Cornelia L. ...> ;Frontiers in Immunology. 2019 Oct 23
9 citations
The FluPRINT dataset, a multidimensional analysis of the influenza vaccine imprint on the immune system.
Adriana Tomic, Ivan Tomic, Cornelia L. Dekker, Holden T. Maecker, Mark M. Davis> ;Scientific Data. 2019 Oct 21
15 citations
Safety and immunogenicity of investigational seasonal influenza hemagglutinin DNA vaccine followed by trivalent inactivated vaccine administered intradermally or intra...
Cristina Carter, Katherine V. Houser, Galina Yamshchikov, Abbie R. Bellamy, Jeanine May, Mary E. Enama, Uzma N. Sarwar, Brenda Larkin, Robert T. Bailer, Richard A. Kou...> ;Plos One. 2019 Sep 18
28 citations
SIMON, an Automated Machine Learning System, Reveals Immune Signatures of Influenza Vaccine Responses.
Adriana Tomic, Ivan Tomic, Yael Rosenberg-Hasson, Cornelia L. Dekker, Holden T. Maecker, Mark M. Davis> ;Journal of Immunology. 2019 Aug 1
27 citations
Diminished B-Cell Response After Repeat Influenza Vaccination.
Mrinmoy Sanyal, Tyson H. Holmes, Holden T. Maecker, Randy A. Albrecht, Cornelia L. Dekker, Xiao-Song He, Harry B. Greenberg> ;The Journal of Infectious Diseases. 2019 Apr 19
91 citations
Distinct phenotype of CD4 + T cells driving celiac disease identified in multiple autoimmune conditions
Asbjørn Christophersen, Eivind G. Lund, Omri Snir, Elsa Sola, Chakravarthi Kanduri, Shiva Dahal-Koirala, Stephanie Zühlke, Øyvind Molberg, Paul J. Utz, Mina Rohani-Pic...> ;Nature Medicine. 2019 Mar 25
18 citations
The Kawasaki Disease Comparative Effectiveness (KIDCARE) trial: A phase III, randomized trial of second intravenous immunoglobulin versus infliximab for resistant Kawa...
Samantha C. Roberts, Sonia Jain, Adriana H. Tremoulet, Katherine K. Kim, Jane C. Burns, Vikram Anand, Marsha S. Anderson, Jocelyn Y. Ang, Emily Ansusinha, Moshe Arditi...> ;Contemporary Clinical Trials. 2019 Mar 3
222 citations
A clinically meaningful metric of immune age derived from high-dimensional longitudinal monitoring
Ayelet Alpert, Yishai Pickman, Michael D. Leipold, Yael Rosenberg-Hasson, Xuhuai Ji, Renaud Gaujoux, Hadas Rabani, Elina Starosvetsky, Ksenya Kveler, Steven Schaffert,...> ;Nature Medicine. 2019 Mar 1
43 citations
Signatures of selection in the human antibody repertoire: Selective sweeps, competing subclones, and neutral drift
Felix Horns, Christopher Vollmers, Cornelia L. Dekker, Stephen R. Quake> ;Proceedings of the National Academy of Sciences of the United States of America. 2019 Jan 8
17 citations
Plasmablast antibody repertoires in elderly influenza vaccine responders exhibit restricted diversity but increased breadth of binding across influenza strains.
Chia-Hsin Ju, Lisa K. Blum, Sarah Kongpachith, Nithya Lingampalli, Rong Mao, Petter Brodin, Cornelia L. Dekker, Mark M. Davis, William H. Robinson> ;Clinical Immunology. 2018 Aug 1
202 citations
Single-Cell Chromatin Modification Profiling Reveals Increased Epigenetic Variations with Aging
Peggie Cheung, Francesco Vallania, Hayley Warsinske, Michele Donato, Steven Schaffert, Sarah E. Chang, Mai Dvorak, Cornelia L. Dekker, Mark M. Davis, Paul J. Utz, Purv...> ;Cell. 2018 May 31
47 citations
Accuracy and Discomfort of Different Types of Intranasal Specimen Collection Methods for Molecular Influenza Testing in Emergency Department Patients.
Bradley W. Frazee, Amparo Rodríguez-Hoces de la Guardia, Harrison J. Alter, Carol G. Chen, Eugenia L. Fuentes, Alison K. Holzer, Macarena Lolas, Debkishore Mitra, Jasp...> ;Annals of Emergency Medicine. 2017 Nov 24
34 citations
Dynamics of the human antibody repertoire after B cell depletion in systemic sclerosis.
Charles F. A. de Bourcy, Cornelia L. Dekker, Mark M. Davis, Mark R. Nicolls, Stephen R. Quake> ;Science Immunology. 2017 Sep 29
79 citations
Continuous immunotypes describe human immune variation and predict diverse responses
Kevin J. Kaczorowski, Karthik Shekhar, Dieudonné Nkulikiyimfura, Cornelia L. Dekker, Holden T. Maecker, Mark M. Davis, Arup K. Chakraborty, Petter Brodin> ;Proceedings of the National Academy of Sciences of the United States of America. 2017 Jul 25
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Press Mentions

Immune System “Clock” Predicts Illness and MortalityJuly 12th, 2021
Caffeine May Counter Age-Related InflammationJanuary 17th, 2017
T-cell and General Immune Response to Seasonal Influenza Vaccine (SLVP018) Year 2, 2010January 13th, 2017
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Professional Memberships

American Academy of Pediatrics - AAP
Fellow
Infectious Disease Society of America - IDSA
Fellow
Pediatric Infectious Diseases Society
Fellow