CraigJGerardMD

PubMed

• 301 citations
  THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: G protein-coupled receptors
  Stephen P.H. Alexander, Arthur Christopoulos, Anthony P. Davenport, Eamonn Kelly, Alistair Mathie, John A. Peters, Emma L. Veale, Jane F. Armstrong, Elena Faccenda, Si...> ;British Journal of Pharmacology. 2021 Oct 1
• 23 citations
  CFTR regulates B cell activation and lymphoid follicle development.
  Francesca Polverino, Bao Lu, Joselyn Rojas Quintero, Sara O. Vargas, Avignat S. Patel, Caroline A. Owen, Norma P. Gerard, Craig Gerard, Manuela Cernadas> ;Respiratory Research. 2019 Jul 1
• 29 citations
  CCL27/CCL28–CCR10 Chemokine Signaling Mediates Migration of Lymphatic Endothelial Cells
  Tara Karnezis, Rae H Farnsworth, Nicole C. Harris, Steven P. Williams, Carol Caesar, David J Byrne, Prad Herle, Maria L Macheda, Ramin Shayan, You-Fang Zhang, Sezer Ya...> ;Cancer Research. 2019 Apr 1
• 46 citations
  Complement Receptor C5aR1 Plays an Evolutionarily Conserved Role in Successful Cardiac Regeneration
  Niranjana Natarajan, Yamen Abbas, Donald M. Bryant, Juan Manuel González-Rosa, Michka Sharpe, Aysu Uygur, Lucas H. Cocco-Delgado, Nhi Ngoc Ho, Norma P. Gerard, Craig G...> ;Circulation. 2018 Jan 18
• 3 citations
  A putative lateral flagella of the cystic fibrosis pathogen Burkholderia dolosa regulates swimming motility and host cytokine production.
  Damien Roux, Matthew M. Schaefers, Bradley S. Clark, Molly Weatherholt, Diane E. Renaud, David A. Scott, John J. LiPuma, Gregory P. Priebe, Craig Gerard, Deborah R. Yo...> ;Plos One. 2018 Jan 18
• 23 citations
  The Epithelial Sodium Channel Is a Modifier of the Long-Term Nonprogressive Phenotype Associated with F508del CFTR Mutations.
  Pankaj B. Agrawal, Ruobing Wang, Hongmei Lisa Li, Klaus Schmitz-Abe, Chantelle Simone-Roach, Jingxin Chen, Jiahai Shi, Tin Louie, Shaohu Sheng, Meghan C. Towne, Christ...> ;American Journal of Respiratory Cell and Molecular Biology. 2017 Dec 1
• 2 citations
  Divergent Function of Programmed Death-Ligand 1 in Donor Tissue versus Recipient Immune System in a Murine Model of Bronchiolitis Obliterans.
  Katharina Schütte-Nütgen, Olaf Boenisch, Hakima Harrach, Alicia Casey, Indira Guleria, Nader Najafian, Mohamed H. Sayegh, Craig Gerard, Meera Subramaniam> ;The American Journal of Pathology. 2017 Jun 1
• 4 citations
  Immune Recognition of the Epidemic Cystic Fibrosis Pathogen Burkholderia dolosa
  Damien Roux, Molly Weatherholt, Bradley S. Clark, Mihaela Gadjeva, Diane E. Renaud, David A. Scott, David Skurnik, Gregory P. Priebe, Gerald B. Pier, Craig Gerard, Deb...> ;Infection and Immunity. 2017 Jun 1
• 6 citations
  Effect of Inhibition or Deletion of Neutral Endopeptidase on Neuropathic Endpoints in High Fat Fed/Low Dose Streptozotocin-Treated Mice.
  Matthew S. Yorek, Alexander Obrosov, Bao Lu, Craig John Gerard, Randy H. Kardon, Mark A. Yorek> ;Journal of Neuropathology and Experimental Neurology. 2016 Nov 1
• 23 citations
  C5L2, the Second C5a Anaphylatoxin Receptor, Suppresses LPS-Induced Acute Lung Injury
  Ruobing Wang, Bao Lu, Craig Gerard, Norma P. Gerard> ;American Journal of Respiratory Cell and Molecular Biology. 2016 Oct 31
• 2 citations
  Cloning of the Human C5a Anaphylatoxin Receptor, and More
  Norma P. Gerard, Craig Gerard> ;Frontiers in Immunology. 2015 Sep 1
• 64 citations
  Differential Interaction of the Staphylococcal Toxins Panton–Valentine Leukocidin and γ-Hemolysin CB with Human C5a Receptors
  András N. Spaan, Ariën Schiepers, Carla J. C. de Haas, Davy D. J. J. van Hooijdonk, Cédric Badiou, Hugues Contamin, François Vandenesch, Gerard Lina, Norma P. Gerard, ...> ;Journal of Immunology. 2015 Jun 19
• 15 citations
  Characterization of G protein coupling mediated by the conserved D1343.49 of DRY motif, M2416.34, and F2516.44 residues on human CXCR1
  Xinbing Han, Yan Feng, Xinhua Chen, Craig Gerard, William A. Boisvert> ;FEBS Open Bio. 2015 Jan 1
• 10 citations
  Bone Marrow-Derived Multipotent Stromal Cells Attenuate Inflammation in Obliterative Airway Disease in Mouse Tracheal Allografts
  Alicia Casey, Fabian Dirks, Olin D. Liang, Hakima Harrach, Katharina Schuette-Nuetgen, Kristen T. Leeman, Carla F. Kim, Craig Gerard, Meera Subramaniam> ;Stem Cells International. 2014 Sep 10
• 52 citations
  CXCR3-independent actions of the CXC chemokine CXCL10 in the infarcted myocardium and in isolated cardiac fibroblasts are mediated through proteoglycans.
  Amit Saxena, Marcin Bujak, Olga Frunza, Marcin Dobaczewski, Carlos Gonzalez-Quesada, Bao Lu, Craig Gerard, Nikolaos G. Frangogiannis> ;Cardiovascular Research. 2014 Jul 15
• 219 citations
  C5a Receptor (CD88) Blockade Protects against MPO-ANCA GN
  Hong Xiao, Daniel J. Dairaghi, Jay P. Powers, Linda S. Ertl, Trageen Baumgart, Yu Wang, Lisa Seitz, Mark E. T. Penfold, Lin Gan, Peiqi Hu, Bao Lu, Norma P. Gerard, Cra...> ;Journal of the American Society of Nephrology. 2014 Feb 1
• 38 citations
  Functional Roles for C5a and C5aR but Not C5L2 in the Pathogenesis of Human and Experimental Cerebral Malaria
  Hani Kim, Laura K. Erdman, Ziyue Lu, Lena Serghides, Kathleen Zhong, Aggrey Dhabangi, Charles Musoke, Craig Gerard, Christine Cserti-Gazdewich, W. Conrad Liles, Kevin ...> ;Infection and Immunity. 2014 Jan 1
• 102 citations
  Biased agonism as a mechanism for differential signaling by chemokine receptors.
  Sudarshan Rajagopal, Daniel Bassoni, James Campbell, Norma P. Gerard, Craig Gerard, Tom S. Wehrman> ;The Journal of Biological Chemistry. 2013 Dec 6
• 31 citations
  Disruption of the Complement Anaphylatoxin Receptor C5L2 Exacerbates Inflammation in Allergic Contact Dermatitis
  Ruobing Wang, Bao Lu, Craig Gerard, Norma P. Gerard> ;Journal of Immunology. 2013 Oct 15
• C3a receptor promotes viral containment in mice inoculated with vaccinia virus at sites of allergic skin inflammation.
  Lalit Kumar, Bao Lu, Craig Gerard, Raif S. Geha> ;The Journal of Allergy and Clinical Immunology. 2013 Sep 1
• 19 citations
  C5a Receptor Deficiency Alters Energy Utilization and Fat Storage
  Christian Roy, Abhishek Gupta, Alexandre Fisette, Marc Lapointe, Pegah Poursharifi, Denis Richard, HuiLing Lu, Bao Lu, Norma P. Gerard, Craig Gerard, Katherine Cianflone> ;Plos One. 2013 May 7
• 20 citations
  Intrarectal Immunization and IgA Antibody-Secreting Cell Homing to the Small Intestine
  Davide Agnello, Damien Denimal, Amandine Lavaux, Leslie Blondeau-Germe, Bao Lu, Norma P. Gerard, Craig Gerard, Pierre Pothier> ;Journal of Immunology. 2013 May 1
• 72 citations
  Mast cell anaphylatoxin receptor expression can enhance IgE-dependent skin inflammation in mice
  Beatrix Schäfer, Adrian M. Piliponsky, Tatsuya Oka, Chang Ho Song, Norma P. Gerard, Craig Gerard, Mindy Tsai, Janet Kalesnikoff, Stephen J. Galli> ;The Journal of Allergy and Clinical Immunology. 2013 Feb 1
• 10 citations
  Inhaled amiloride and tobramycin solutions fail to eradicate Burkholderia dolosa in patients with cystic fibrosis
  Ahmet Uluer, David A. Waltz, Leslie A. Kalish, Summer Adams, Craig Gerard, Dawn A. Ericson> ;Journal of Cystic Fibrosis. 2013 Jan 1
• 46 citations
  Th17 Cytokines Are Critical for Respiratory Syncytial Virus-Associated Airway Hyperreponsiveness through Regulation by Complement C3a and Tachykinins
  Monali M. Bera, Bao Lu, Thomas R. Martin, Shun Cui, Lawrence M. Rhein, Craig Gerard, Norma P. Gerard> ;Journal of Immunology. 2011 Oct 15
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Journal Articles

• Functional high efficiency expression of cloned leukocyte chemo attractant receptor cDNAs.  
  Didsbury JR, Uhing RJ, Tomhave E, GERARD C, Gerard NP, Snyderman R, FEBS Lett 1992; 297: 275-279
• The human leukocyte platelet activating factor receptor. cDNA cloning, cell surface expression, and construction of a novel epitope-bearing analog.  
  Kunz D, Gerard NP, GERARD C, J Biol Chem 1992; 267: 9101-9106
• Exon 16 del: a novel form of human neutral endopeptidase (CALLA).  
  Iijima H, Gerard NP, Squassoni C, Ewig J, Face D, Drazen JM, Kim YA, Shriver ß, Hersh LB, GERARD C, Am J Physiol 1992; 262(6 Pt 1): L725-L729
• Mapping of genes for the human C5a receptor (C5AR), human FMLP receptor (FPR), and two FMLP receptor homologue orphan receptors (FPRH1, FPRH2) to chromosome 19.  
  Bao L, Gerard NP, Eddy RL Jr., Shows TB, GERARD C, Genomics 1992; 13: 437-440
• Structural diversity in the extracellular faces of peptidergic G-protein-coupled receptors. Molecular cloning of the mouse C5a anaphylatoxin receptor.  
  GERARD C, Bao L, Orozco O, Pearson M, Kunz D, Gerard NP, J Immunol 1992; 149: 2600-2606
• Human chemotaxis receptor genes cluster at 19q13.3-13.4. Characterization of the human C5a receptor gene.  
  Gerard NP, Bao L, He Xiao-Ping H, Eddy Jr. R, Shows TB, GERARD C, Biochemistry 1993; 32: 1243-1250
• Specific interactions of chemoattractant factor receptors with G-proteins.  
  Amatruda TT 3d, Gerard NP, GERARD C, Simon MI, J Biol Chem 1993; 268: 10139-10144
• Human lung expresses unique -glutamyl transpeptidase transcripts.  
  Wetmore LA, GERARD C, Drazen JM, Proc Natl Acad Sci USA 1993; 90: 7461-7465
• Receptor-dependent internalization of platelet-activating factor.  
  Gerard NP, GERARD C, J Immunol 1994; 152: 793-800
• Constitutive and inducible nitric oxide synthase gene expression, regulation, and activity in human lung epithelial cells.  
  Asano K, Chee CB, Gaston B, Lilly CM, GERARD C, Drazen JM, Stamler JS, Proc Natl Acad Sci USA 1994; 91: 10089-10093
• The murine interleukin 8 type B receptor homologue and its ligands: Expression and biological characterization.  
  Bozic CR, Gerard NP, von Uexkull-Guldenband C, Kolakowski LF Jr., Conklyn MJ, Breslow R, Showell HJ, GERARD C, J Biol Chem 1994; 269: 29355-29358
• Expression and biological characterization of the murine chemokine KC.  
  Bozic CR, Kolakowksi LF Jr., Gerard NP, Garcia-Rodriguez C, von Uexkull-Guldenband C, Conklyn MJ, Breslow R, Showell HJ, GERARD C, J Immunol 1995; 154: 6048-6057
• Neutral endopeptidase modulation of septic shock.  
  Lu B, Gerard NP, Kolakowksi LF Jr., Bozza M, Zurakowski D, Finco O, Carroll MC, GERARD C, J Exp Med 1995; 181: 2271-2275
• Structural characterization and chromosomal location of the mouse macrophage migration inhibitory factor gene and pseudogenes.  
  Bozza M, Kolakowski LF Jr., Gilbert DJ, Jenkins NA, Copeland NG, David JR GERARD C, Genomics 1995; 27: 412-419
• Probing the “message:address” sites for chemoattractant binding to the C5a receptor. Mutagenesis of hydrophilic and proline residues within the transmembrane segments.  
  Kolakowski LF Jr, Lu B, GERARD C, Gerard NP, J Biol Chem 1995; 270: 18077-18082
• Streptococcus pneumoniae anchor to activated human cells by the receptor for platelet-activating factor.  
  Cundell DR, Gerard NP, GERARD C, Idanpaan-Heikkilla I, Toumanen EI, Nature 1995; 377: 435-438
• The role of N-glycosylation for functional expression of the human platelet-activating factor receptor. Glycosylation is required for efficient membrane trafficking.  
  Garcia Rodriguez C, Cundell DR, Tuomanen EI, Kolakowski LF Jr, GERARD C, Gerard NP, J Biol Chem 1995; 270: 25178-25184
• Comparison of the structure and expression of the human and rat neprilysin (endopeptidase 24.11) encoding genes.  
  Li C, Chen G, Gerard NP, GERARD C, Bozic C, Hersh LB, Gene 1996; 164: 363-366
• Molecular characterization of two murine eosinophil beta chemokine receptors.  
  Post TW, Bozic CR, Rothenberg ME, Luster AD, Gerard NP, GERARD C, J Immunol 1995; 155: 5299-5305
• PAf receptor anchors Streptococcus pneumoniae to activated human endothelial cells.  
  Cundell DR, GEARD C, Idanpaan-Heikkila I, Tuomanen EI, Gerard NP, Adv Exp Med Biol. 1996; 416: 89-94
• Receptor binding specificity and pulmonary gene expression of the neutrophil-activating peptide ENA-78.  
  Bozic CR, Gerard NP, GERARD C, Am J Respir Cell Mol Biol 1996; 14: 302-308
• Neutral endopeptidase modulates septic shock.  
  Lu B, Gerard NP, Kolakowski LF Jr, Finco O, Carroll MC, GERARD C, Ann N Y Acad Sci. 1996 Mar 22; 780: 156-63
• Molecular cloning and characterization of human eotaxin receptor expressed selectively on eosinophils.  
  Ponath PD, Qin S, Post TW, Wang J, Wu L, Gerard NP, Newman W, GERARD C, Mackay CR, J Exp Med 1996; 183: 2437-2448
• The chemokine receptors CCR-3 and CCR-5 facilitate infection by primary HIV-1 isolates.  
  Choe H, Farzan M, Sullivan N, Parolin C, Sun Y, Rollins B, Ponath P, Wu L, Mackay C, Mirabelli C, Newman W, Gerard NP, GERARD C, Sodroski J, Cell 1996; 85: 1135-1148
• Mouse astrocytes respond to the chemokines MCP-1 and KC, but reverse transcriptase-polymerase chain reaction does not detect mRNA for the KC or new MCP-1 receptor.  
  Heesen M, Tanabe S, Berman MA, Yoshizawa I, Luo Y, Kim RJ, Post TW, GERARD C, Dorf ME, J Neurosci Res. 1996 Aug 15; 45(4): 382-91
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Books/Book Chapters

•  
  Chapter: High performance liquid chromatography of polar and hydrophobic peptides of cytochromes from microsomal membranes. 
  Page 417 - 429Ozols J, Heineman FS, GERARD CEditors: Chr. Birr.Elsevier, North Holland Biomedical Press
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  Chapter: C5a: A mediator of chemotaxis and cellular release reactions. In: Biochemistry of Acute Allergic Reactions 
  GERARD C, Hugli TEEditors: KF Austen, EL Becker.Alan R. Liss, Inc, New York
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  Chapter: Possible role of serum anaphylatoxins in hypersensitivity reactions. 
  Page 113 - 120Hugli TE, Gerard NP, GERARD C, Moon KE
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  Chapter: Platelet-activating factor (AAGPC) contracts human lung tissues in vitro. 
  Page 195 - 204Stimler NP, GERARD C, O’Flaherty JTEditors: J. Benveniste, et al.Elsevier
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  Chapter: Molecular cloning of the human neurokinin-2 receptor cDNA by polymerize chain reaction and isolation of the gene 
  Page 389 - 390Gerard NP, GERARD CNew York Acad Sci
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  Chapter: Molecular biology of human neutrophil chemo tactic receptors. 
  Page 115 - 131GERARD C, Gerard NPEditors: C. Page.Academic Press, London
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  Chapter: Neutral endopeptidase modulates septic shock. 
  Page 156 - 163Lu B, Gerard NP, Kolakowski LF, Finco O, Carroll MC, GERARD CNew York Acad. Sci
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  Chapter: Transgenic mice for study of pulmonary disease. 
  Page 383 - 391Whitsett J, GERARD CEditors: R. Crystal, J. West, E. Weibel, P. Barnes.Raven Press New YorkEdition 2,
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  Chapter: Receptor Anchors Streptococcus Pneumoniae to Activated Human Endothelial Cells. 
  Page 89 - 94Cundell DR, GERARD C, Ildanpanaan-Heikkila I, Tuomanen El, and Gerard NPEditors: S. Nigam, G. Kunkel, S.M. Prescott, and B.B. Vargaftig.Plenum Publishing Co, New York
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  Chapter: Understanding Chemokine Biology through Mouse Genetics: Riddles and Answers. 
  Page 1 - 17GERARD CEditors: C. Herbert.
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  Chapter: Complement anaphylatoxin receptors in asthma 
  Gerard, NP, and Gerard, CEditors: NT Eissa and DP Huston.Marcel Dekker, New York
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Lectures

• Seven Transmembrane Domain Receptors and Inflammation. 
  Children’s Hospital, Boston, MA
• Chemoattractants, Chemokines and Granulocyte Trafficking. 
  Pulmonary/Critical Care Conference, Beth Israel Hospital, Boston, MA (1994)
• Cystic Fibrosis. 
  Cambridge Hospital, Boston, MA
• Chemokines: from Chemotaxis to HIV. 
  Department of Immunology, Boston University, Boston, MA
• Chemoattractant Receptors in Host Defense and Inflammation. 
  Children’s Hospital Research Seminar, Boston, MA
• Revisiting Biochemical Sciences and Pathology. 
  Harvard Medical School, Boston, MA
• Cystic Fibrosis: Progress in the Last Decade. 
  Harvard Medical School, Department of Pathology, Boston, MA
• Chemokine Receptors in Asthma And Transplant Rejection. 
  Children’s Hospital, Boston, MA
• Clinical and Molecular Aspects of CF. 
  Harvard Medical School, Boston, MA
• Receptor Mediated Signaling in Inflammatory Cells. 
  The Scripps Research Institute, LaJolla, CA
• Seven Transmembrane receptors of the Leukocyte. 
  Cardiovascular, Lung and Blood Diseases Frontiers Symposium, NIH, Rockville, MD
• Targeted Disruption of CD/10 Neutral Endopeptidase. 
  American Society of Hematology, Nashville, TN
• C-X-C Chemokine Signal Transduction and C-C Chemokine Receptors. 
  Fourth International Chemokine Symposium, University of Bath, Bath, United Kingdom
• Cell Biology of the Host Response to Injury. 
  Medical College of New Jersey, Newark, NJ
• Chemoattractants, Chemokines and White Cell Trafficking. 
  Pulmonary/Critical Care Conference, Beth Israel Hospital, Boston, MA
• C-C Chemokine Receptors. 
  International Chemokine Symposium, Brighton, UK
• Eosinophil Chemoattractant Receptors. 
  Fifth Annual Lung Cell Biology Symposium, Woods Hole, MA
• PAF Receptor Anchors Streptococcus Pneumoniae To Activated Human Endothelial Cells. 
  5th International Congress on Platelet-Activating Factor and Related Lipid Medicators, Berlin, FRG
• Transgenic Models in the Study of Inflammatory Disease. 
  University of Cincinnati Medical Center, Cincinnati, OH
• Signaling Pathways in Lung Inflammation. 
  American Physiological Society Symposium, FASEB Meeting, Atlanta, GA
• Chemotactic cytokines in Inflammation. 
  National Jewish Center for Immunology and Respiratory Medicine, Denver, CO
• Early Disease-How does it Start? 
  Cystic Fibrosis Foundation, Williamsburg Conference, Williamsburg, VA
• HIV and Chemokines. 
  NIH, Washington, DC
• Symposium, New Drugs for Inflammatory, Allergic, and Immunologic Diseases. 
  Hershey, PA
• Chemoattractant Receptors and Host Defense. 
  Inflammation Research Society, Woods Hole, MA
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Other

• AIDS vaccine development. 
  Agosto M, Allan J, Benson C, Berger EA, Blumenthal R, Burton D, Clements J, Coffin J, Connor R, Cullen B, Desrosiers R, Dimitrov D, Doms R, Emerman M, Feinberg M, Fult..., Science 1998; 280: 803
• For whom the bell tolls. 
  GERARD C, Nature 1998; 395: 217-219