CynthiaLSearsMD

PubMed

• Unraveling the Oral-Gut axis: Interconnection between Periodontitis and IBD, Current Challenges, and Future Perspective.
  Tanwar, H., Gnanasekaran, J., Allison, D., Chuang, L., He, X., Aimetti, M., Baima, G., Costalonga, M., Thumbigere-Math, V., Cross, R., Sears, C., Mehandru, S., Cho, J....> ;Journal of Crohn's & Colitis. 2024 Feb 28
• Enrichment of Bacteroides fragilis and enterotoxigenic Bacteroides fragilis in CpG island methylator phenotype-high colorectal carcinoma.
  Takashima, Y., Kawamura, H., Okadome, K., Ugai, S., Haruki, K., Arima, K., Mima, K., Akimoto, N., Song, M., Ugai, T., Nowak, J., Giannakis, M., Garrett, W., Sears, C.,...> ;Clinical Microbiology and Infection. 2024 Jan 22
• 7 citations
  Molecular cartography uncovers evolutionary and microenvironmental dynamics in sporadic colorectal tumors.
  Cody N Heiser, Alan J Simmons, Frank Revetta, Eliot T McKinley, Marisol A Ramirez-Solano, Jiawei Wang, Harsimran Kaur, Justin Shao, Gregory D Ayers, Yu Wang, Sarah E G...> ;Cell. 2023 Dec 7
• The Role of the Gut Microbiome in Cancer: A Review, With Special Focus on Colorectal Neoplasia and Clostridioides difficile.
  Sean M Anderson, Cynthia L Sears> ;Clinical Infectious Diseases. 2023 Dec 5
• 1 citations
  Subtle, persistent shaping of the gut microbiome by host genes: A critical determinant of host biology.
  Lindsey Dzierozynski, Jessica Queen, Cynthia L Sears> ;Cell Host & Microbe. 2023 Oct 11
• 6 citations
  The microbial landscape of colorectal cancer.
  Maxwell T White, Cynthia L Sears> ;Nature Reviews. Microbiology. 2024 Apr 1
• Longitudinal Bile Acid Composition Changes Following Faecal Microbiota Transplantation for Clostridioides difficile Infection in Children With and Without Underlying I...
  Lea Ann Chen, Maria Oliva-Hemker, Arielle Radin, Melissa Weidner, Brynn D O'Laughlin, Cynthia L Sears, Norman B Javitt, Suchitra K Hourigan, Chen, L. A.> ;Journal of Crohn's & Colitis. 2023 Aug 21
• 3 citations
  Unraveling the Link between Periodontitis and Inflammatory Bowel Disease: Challenges and Outlook.
  Himanshi Tanwar, Jeba Mercy Gnanasekaran, Devon Allison, Ling-Shiang Chuang, Xuesong He, Mario Aimetti, Giacomo Baima, Massimo Costalonga, Raymond K Cross, Cynthia Sea...> ;Arxiv. 2023 Aug 19
• 2 citations
  Understanding the mechanisms and translational implications of the microbiome for cancer therapy innovation.
  Jessica Queen, Fyza Shaikh, Cynthia L Sears> ;Nature Cancer. 2023 Aug 1
• Introducing the New Journal of Infectious Diseases Editorial Board, Part IV.
  Cynthia Sears> ;The Journal of Infectious Diseases. 2023 Mar 1
• Introducing the New Journal of Infectious Diseases Editorial Board, Part III.
  Cynthia L Sears> ;The Journal of Infectious Diseases. 2023 Feb 14
• Introducing the New Journal of Infectious Diseases Editorial Board, Part II.
  Cynthia L Sears> ;The Journal of Infectious Diseases. 2023 Feb 1
• Introducing the New Journal of Infectious Diseases Editorial Board, Part I.
  Cynthia L Sears> ;The Journal of Infectious Diseases. 2023 Jan 11
• Turning the page: a welcome from the new leadership of the Journal of Infectious Diseases.
  Cynthia L Sears, Jonathan Z Li, Upinder Singh> ;The Journal of Infectious Diseases. 2022 Dec 28
• Diet-Related and Gut-Derived Metabolites and Health Outcomes: A Scoping Review.
  Yuanxi Jia, Xuhao Yang, Lisa M Wilson, Noel T Mueller, Cynthia L Sears, Glenn J Treisman, Karen A Robinson> ;Metabolites. 2022 Dec 14
• 2 citations
  Microbial metabolites damage DNA.
  Jens Puschhof, Cynthia L Sears> ;Science. 2022 Oct 28
• 33 citations
  Western-Style Diet, pks Island-Carrying Escherichia coli, and Colorectal Cancer: Analyses From Two Large Prospective Cohort Studies.
  Kota Arima, Rong Zhong, Tomotaka Ugai, Melissa Zhao, Koichiro Haruki, Naohiko Akimoto, Mai Chan Lau, Kazuo Okadome, Raaj S Mehta, Juha P Väyrynen, Junko Kishikawa, Tyl...> ;Gastroenterology. 2022 Oct 1
• 11 citations
  Phage display of environmental protein toxins and virulence factors reveals the prevalence, persistence, and genetics of antibody responses.
  Julia W Angkeow, Daniel R Monaco, Athena Chen, Thiagarajan Venkataraman, Sahana Jayaraman, Cristian Valencia, Brandon M Sie, Thomas Liechti, Payam N Farhadi, Gabriela ...> ;Immunity. 2022 Jun 14
• 30 citations
  Human Colon Cancer-Derived Clostridioides difficile Strains Drive Colonic Tumorigenesis in Mice.
  Julia L Drewes, Jie Chen, Nicholas O Markham, Reece J Knippel, Jada C Domingue, Ada J Tam, June L Chan, Lana Kim, Madison McMann, Courtney Stevens, Christine M Dejea, ...> ;Cancer Discovery. 2022 Aug 5
• 2 citations
  Microbes and cancer: disease drivers, passengers, biomarkers, or therapeutics?
  Cynthia L Sears> ;Cancer Metastasis Reviews. 2022 Jun 1
• 4 citations
  Label-Free Vibrational and Quantitative Phase Microscopy Reveals Remarkable Pathogen-Induced Morphomolecular Divergence in Tumor-Derived Cells.
  Zhenhui Liu, Sheetal Parida, Shaoguang Wu, Cynthia L Sears, Dipali Sharma, Ishan Barman> ;ACS Sensors. 2022 May 27
• 16 citations
  Colon Tumors in Enterotoxigenic Bacteroides fragilis (ETBF)-Colonized Mice Do Not Display a Unique Mutational Signature but Instead Possess Host-Dependent Alterations ...
  Jawara Allen, Axel Rosendahl Huber, Cayetano Pleguezuelos-Manzano, Jens Puschhof, Shaoguang Wu, Xinqun Wu, Charelle Boot, Aurelia Saftien, Heather M O'Hagan, Hao Wang,...> ;Microbiology Spectrum. 2022 Jun 29
• 85 citations
  Next-generation sequencing: insights to advance clinical investigations of the microbiome.
  Caroline R Wensel, Jennifer L Pluznick, Steven L Salzberg, Cynthia L Sears> ;The Journal of Clinical Investigation. 2022 Apr 1
• 1 citations
  Adult-Attained Height and Colorectal Cancer Risk: A Cohort Study, Systematic Review, and Meta-Analysis.
  Elinor Zhou, Lin Wang, Celina N Santiago, Julie Nanavati, Samara Rifkin, Emma Spence, Linda M Hylind, Joell J Gills, Louis La Luna, David R Kafonek, David M Cromwell, ...> ;Cancer Epidemiology, Biomarkers & Prevention. 2022 Apr 1
• 9 citations
  Murine fecal microbiota transfer models selectively colonize human microbes and reveal transcriptional programs associated with response to neoadjuvant checkpoint inhi...
  Fyza Y Shaikh, Joell J Gills, Fuad Mohammad, James R White, Courtney M Stevens, Hua Ding, Juan Fu, Ada Tam, Richard L Blosser, Jada C Domingue, Tatianna C Larman, Jami...> ;Cancer Immunology, Immunotherapy. 2022 Oct 1
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Journal Articles

• The Contributions of Physician-Scientists Within Divisions of Infectious Diseases  
  Cynthia Sears, MD, The Journal of Infectious Diseases
• High-speed, ultrahigh-resolution distal scanning OCT endoscopy at 800 nm for in vivo imaging of colon tumorigenesis on murine models  
  Mavadia-Shukla J, Fathi P, Liang W, Wu S, Sears CL, and Li X., Biomedical Optics Express., 1/1/2018
• A Blueprint to Advance Colorectal Cancer Immunotherapies  
  Le DT, Hubbard-Lucey VM, Morse MA, Heery CR, Dwyer A, Marsilje TH, Brodsky AN, Chan E, Deming DA, Diaz LA Jr, Fridman WH, Goldberg RM, Hamilton SR, Housseau F, Jaffee ..., Cancer Immunol Res., 1/1/2017
• High-resolution bacterial 16S rRNA gene profile meta-analysis and biofilm status reveal common colorectal cancer consortia  
  Drewes JL, White JR, Dejea CM, Fathi P, Iyadorai T, Vadivelu J, Roslani AC, Wick EC, Mongodin EF, Loke MF, Thulasi K, Gan HM, Goh KL, Chong HY, Kumar T, Wanyiri JW, an..., NPJ Biofilms Microbiomes., 1/1/2017
• Clostridium difficile in Pediatric Inflammatory Bowel Disease  
  Hourigan SK, Sears CL, Oliva-Hemker M., Inflamm Bowel Dis., 1/1/2016
• Redundant Innate and Adaptive Sources of IL17 Production Drive Colon Tumorigenesis  
  Housseau F, Wu S, Wick EC, Fan H, Wu X, Llosa NJ, Smith KN, Tam A, Ganguly S, Wanyiri JW, Iyadorai T, Malik AA, Roslani AC, Vadivelu JS, Van Meerbeke S, Huso DL, Pardo..., Cancer Res, 1/1/2016
• Brief Report: Intestinal Microbiota-Produced Trimethylamine-N-Oxide and Its Association With Coronary Stenosis and HIV Serostatus  
  Miller PE, Haberlen SA, Brown TT, Margolick JB, DiDonato JA, Hazen SL, Witt MD, Kingsley LA, Palella FJ Jr, Budoff M, Jacobson LP, Post WS, Sears CL., J Acquir Immune Defic Syndr., 1/1/2016
• Next-generation sequencing in neuropathologic diagnosis of infections of the nervous system  
  Salzberg SL, Breitwieser FP, Kumar A, Hao H, Burger P, Rodriguez FJ, Lim M, Qui�ones-Hinojosa A, Gallia GL, Tornheim JA, Melia MT, Sears CL, Pardo CA, Neurol Neuroimmunol Neuroinflamm., 1/1/2016
• Reduction of Murine Colon Tumorigenesis Driven by Enterotoxigenic Bacteroides fragilis Using Cefoxitin Treatment  
  DeStefano Shields CE, Van Meerbeke SW, Housseau F, Wang H, Huso DL, Casero RA Jr, O'Hagan HM, Sears CL., J Infect Dis, 1/1/2016
• Sam68/KHDRBS1 is critical for colon tumorigenesis by regulating genotoxic stress-induced NF-kappaB activation  
  Fu K, Sun X, Wier EM, Hodgson A, Liu Y, Sears CL, Wan F., eLife, 1/1/2016
• Do biofilms confer a pro-carcinogenic state?  
  Dejea CM, Sears CL, Gut Microbes, 1/1/2016
• Sporadic colorectal cancer: microbial contributors to disease prevention, development and therapy  
  Drewes JL, Housseau F, Sears CL, Br J Cancer., 1/1/2016
• The vigorous immune microenvironment of microsatellite instable colon cancer is balanced by multiple counter-inhibitory checkpoints  
  Llosa NJ, Cruise M, Tam A, Wick EC, Hechenbleikner EM, Taube JM, Blosser L, Fan H, Wang H, Luber B, Zhang M, Papadopoulos N, Kinzler KW, Vogetlstein B, Sears CL, Ander..., Cancer Discovery., 1/1/2015
• The Bacteroides fragilis toxin gene is prevalent in the colon mucosa of colorectal cancer patients  
  Boleij A, Heckenbleikner EM, Goodwin AC, Badani R, Stein EM, Lazarev MG, Ellis B, Carroll KC, Albesiano E, Wick EC, Platz EE, Pardoll DM, Sears CL., Clin Infect Dis, 1/1/2015
• Metabolism links bacterial biofilms and colon carcinogenesis  
  Johnson CH, Dejea CM, Edler D, Hoang LT, Santidrian AF, Felding BH, Ivanisevic J, Cho K, Wick EC, Hechenbleikner EM, Uriboonthai W, Goetz L, Casero RA, Pardoll DM, Whi..., Cell Metab., 1/1/2015
• Fecal detection of enterotoxigenic Bacteroides fragilis  
  Chen LA, Van Meerbeke S, Albesiano E, Goodwin A, Wu S, Yu H, Carroll K, Sears C., Eur J Clin Microbiol Infet Dis., 1/1/2015
• Microbiome changes associated with sustained eradication of Clostridium difficile after single faecal microbiota transplantation in children with and without inflammat...  
  Hourigan SK, Chen LA, Grigoryan Z, Laroche G, Weidner M, Sears CL, Oliva-Hemker M, Aliment Pharmacol Ther., 1/1/2015
• Regulatory T cell response to enterotoxigenic Bacteroides fragilis colonization triggers IL-17-dependent colon carcinogenesis  
  Geis AL, Fan H, Wu X, Wu S, Huso DL, Wolfe JL, Sears CL, Pardoll DM, Housseau F, Cancer Discov., 1/1/2015
• The intestinal microbiome and health  
  Tuddenham S, Sears CL, Curr Opin Infect Dis, 1/1/2015
• Oncogenic Kras activates a hematopoietic-to-epithelial IL-17 signaling axis in preinvasive pancreatic neoplasia  
  McAllister F, Bailey JM, Alsina J, Nirschl CJ, Sharma R, Fan H, Rattigan Y, Roeser JC, Lankapalli RH, Zhang H, Jaffee EM, Drake CG, Housseau F, Maitra A, Kolls JK, Sea..., Cancer Cell., 1/1/2014
• Microbiota organization is a distinct feature of proximal colorectal cancers  
  Dejea CM, Wick EC, Hechenbleikner EM, White JR, Mark Welch JL, Rosetti, BJ, Peterson SN, Snesrud EC, Borisy GG, Lazarev M, Stein E, Vadivelu J, Roslani AC, Malik A, Wa..., Proc Natl Acad Sci USA., 1/1/2014
• Microbiota and immune responses in colon cancer: more to learn  
  McAllister F, Housseau F, Sears CL., Cancer J., 1/1/2014
• Microbes, Microbiota and Colon Cancer  
  Sears CL, Garrett WS., Cell Host Microbe., 1/1/2014
• Bacteroides fragilis subverts mucosal biology: from symbiont to colon carcinogenesis  
  Sears CL, Geis AL, Housseau F., J Clin Invest., 1/1/2014
• Bartlett: a transformative, visionary leader of Johns Hopkins Infectious Diseases  
  Auwaerter PG, Quinn TC, Sears CL, Thomas DL. John G., Clin Infect Dis, 1/1/2014
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Books/Book Chapters

• Sleisenger and Fordtran 
  Chapter: Infectious Enteritis and Proctocolitis 
  Haines CF and Sears CLElsevierEdition 10th,2014
• Principles and Practices of Infectious Diseases 
  Chapter: Prebiotics, Probiotics and Synbiotics 
  Rabizadeh S, Miller M, Sears CLEditors: Mandell GL, Douglas G, Bennett J.Elsevier Inc2009
• Encyclopedia of Public Health 
  Chapter: Infectious Diseases: Escherichia coli 
  Wanke CA, Sears CLEditors: Heggenhougen K.Elsevier Inc2008
• Sourcebook of Bacterial Protein Toxins 
  Chapter: The Toxins of Bacteroides fragilis. 
  Sears CLEditors: Alouf JE, Freer JH.Academic Press, NYEdition 3rd,2005
• Osler Handbook for House Officers 
  Chapter: Diarrhea 
  Ang GB, Donowitz M, Sears CLJohns Hopkins University2003
• Microbial Pathogenesis and the Intestinal Epithelial Cell 
  Chapter: Enteric Microbial Toxins and the Intestinal Epithelial Cytoskeleton. 
  Nataro JP, Sears CL, Fasano A, Block R.Editors: Hecht G.ASM Press2003
• Principles and Practice of Clinical Parasitology 
  Chapter: Cryptosporidium/Isospora. 
  Sears CL, Kirkpatrick B.Editors: Gillespie, Pearson RD.John Wiley and Sons, Susset, England2001
• Sexually Transmitted Diseases 
  Chapter: Intestinal Protozoa: Giardia lamblia, Entamoeba histolytica and Cryptosporidium. 
  Guerrant RL, Sears CL, Ravdin JI.Editors: Holmes KK, Sparling PF, Mardh PA, Lemon SM, Stamm WE, Piot P, Wasserheit JN.McGraw-Hill Inc, New York, NYEdition 3rd,1999
• Cecil Textbook of Medicine 
  Chapter: Giardia 
  Sears CLEditors: Goldman L, Bennett JC.WB Saunders CoEdition 21st,1999
• Cecil Textbook of Medicine 
  Chapter: Cryptosporidium 
  Kirkpatrick B and Sears CL.Editors: Goldman L, Bennett JC.WB Saunders CoEdition 21st,1999
• Sourcebook of Bacterial Protein Toxins 
  Chapter: The Toxins of Bacteroides fragilis 
  Sears CLEditors: Alouf JE, Freer JH.Academic Press, NYEdition 2nd,1999
• Infections of the Gastrointestinal Tract 
  Chapter: Bacterial Toxins. 
  Page 617.0 - 634.0Sears CL, Guerrant RL, Kaper JB.Editors: Blaser MJ, Smith PD, Ravdin JI, Greenberg HB, Guerrant RL.Raven Press, New York, NY1995
• Principles and Practices of Infectious Diseases 
  Chapter: Isospora belli, Sarcocystis species, Balantidium coli, Blastocystis huminis, and Cyclospora 
  Page 2510. - 2513.Sears CLEditors: Mandell GL, Dolin R, Bennett JE.Churchill Livingstone Inc, New York, NY1995
• Medical and Environmental Aspects of Anaerobes 
  Chapter: Enterotoxin as a Virulence Factor in Bacteroides fragilis - associated Diarrheal Disease 
  Page 90.0 - 100.0Myers LL, Weikel CS.Editors: Duerden BI, Brazier JS, Seddon SV, Wade WG.Wrightson Biomedical Publishing Ltd, Great Britain1992
• Pathophysiology of Secretory Diarrhea 
  Chapter: Parasitic Causes of Diarrhea: An Overview. 
  Page 273.0 - 280.0Guerrant RL, Petri WA, Weikel CSEditors: Lebenthal E, Duffey M.Raven Press1990
• Principles and Practice of Infectious Diseases 
  Chapter: Other Protozoa; Including Cryptosporidium, Microsporidia, Sarcocystis, Isospora, and Balantidium coli. 
  Page 2122. - 2130.Soave R., Weikel CS.Editors: John Wiley and Sons Inc.New York, NY1989
• Sexually Transmitted Diseases 
  Chapter: Intestinal Protozoa: Giardia lamblia, Entamoeba histolytica and Cryptosporidium 
  Guerrant RL, Weikel CS, Ravdin JI.Editors: Holmes KK, Mardh P-A, Sparling PF, Wiesner PJ.McGraw-Hill Book Co, New York, NYEdition 2nd,1988
• Advances in Research on Cholera and Related Diarrheas 
  Chapter: Intestinal Secretion Stimulated by Protein Kinase C Activators. 
  Page 181.0 - 190.0Weikel CS, Sando JJ, Guerrant RL.Editors: Kuwahara S, Pierce NF.KTK Scientific Publishers, Tokyo1988
• Advances in Research on Cholera and Related Diarrheas 
  Chapter: Pharmacologic Pathways Leading to Intestinal Secretion: Stimulation by Enterotoxins and by C-Kinase Activators. 
  Page 181.0 - 188.0Guerrant RL, Weikel CSEditors: S Kuwahara and Pierce NF.KTK Scientific Publishers, Tokyo, Japan1988
• Conn's Current Therapy 
  Chapter: Salmonellosis (other than Typhoid Fever) 
  Page 104.0 - 106.0Weikel CS, Guerrant RLEditors: RE Rakel.Little, Brown and Co1987
• Internal Medicine 
  Chapter: Rotaviruses 
  Page 1603. - 1605.Weikel CS, Guerrant RL.Editors: JH Stein.Little, Brown and Co1987
• Internal Medicine 
  Chapter: Norwalk-like Agents 
  Page 1620. - 1621.Weikel CS, Guerrant RLEditors: JH Stein.Little, Brown and Co1987
• Medical Care of Refugees 
  Chapter: Dengue Fever and Rickettsial Diseases 
  Page 287.0 - 294.0Weikel CSEditors: TC Jones R Sandler.Oxford University Press1987
• Years of Horror, Days of Hope: Responding to the Cambodian Refugee Crisis. 
  Chapter: The Cornell Medical Team 
  Page 332.0 - 341.0Weikel CS, Armstrong DEditors: Levy BS, Susott DC.Associated Faculty Press Inc1986
• Advances in Research on Cholera and Related Diarrheas 
  Chapter: E. coli STb: A New Mechanism for Secretory Diarrhea? 
  Page 333.0 - 341.0Weikel CS, Long-Krug S, Guerrant RL.Editors: Kuwahara S and Pierce NF.KTK Scientific Publishers, Tokyo, Japan1986
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Lectures

• The Human Microbiome: Emerging Themes at the Horizon of the 21st Century 
  Bethesda, MD - 1/1/2017
• From Initiation to Outcomes 
  Tampa, TL - 1/1/2016
• Colon Cancer and Microbiota 
  1/1/2015
• Fight CRC 
  1/1/2015
• Biofilms and Microbes in Colon Cancer 
  1/1/2015
• Colonic Commensals, B. fragilis and Colorectal Cancer 
  British Columbia, Canada - 1/1/2014
• Bacterial Instigators of Colon Cancer 
  1/1/2014
• Microbiota: Biofilms vs Composition in Colon Cancer: Will There Be a Victor? 
  Chicago, IL - 1/1/2014
• Biofilms in Colon Cancer 
  Waterville Valley, New Hampshire - 1/1/2014
• Colon Cancer: How your microbiome may do you wrong 
  Vanderbilt University, SOM, Nashville, TN - 1/1/2013
• Colon Cancer: A Community Conspires in Disease 
  Louisiana State University, SOM, New Orleans, LA - 1/1/2013
• The Role of Inflammation during Carcinogenesis 
  Dublin, Ireland - 1/1/2012
• Probiotics, Intestinal Microbiota and the Host: Physiological and Clinical Implications 
  Carefree, AZ - 1/1/2011
• Your Flora: Your Destiny? 
  New York, NY, 2007; University of Virginia, Charlottesville, VA, 2007 - 1/1/2007
• Enterotoxigenic Bacteroides fragilis stimulate colonic hyperplasia and inflammation in mice 
  Petersburg, FL - 1/1/2006
• Intestinal Flora: New Lessons about Physiology, Immunity and Disease 
  1/1/2006
• Toxigenic Bacteroides fragilis: A Commensal Launches a Diverse Attack on the Gut 
  Prague, Czech Republic - 1/1/2004
• Toxigenic Bacteroides fragilis: A Rogue Among Commensals 
  New Orleans, LA - 1/1/2004
• Enterotoxigenic Bacteroides fragilis: Can this organism instigate chronic colonic disease 
  1/1/2004
• Toxin attack on epithelial tight junctions 
  Atlanta, GA - 1/1/2001
• Mechanisms of Action of Bacterial Toxins 
  Salt Lake City, UT - 1/1/2001
• Enterotoxigenic Bacteroides fragilis: A New View of Pathogenesis 
  Manchester, England - 1/1/2000
• Pathogenesis of Enterotoxigenic Bacteroides fragilis 
  Rocky Mountain Laboratories, NIH/NIAID - 1/1/1999
• Cryptosporidium parvum: miniscule but mighty 
  1/1/1999
• The Toxins of Bacteroides fragilis - A story in evolution 
  Nice, France - 1/1/1998
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Other

• Drive out the �bad bugs� to prevent colon cancers 
  Sears CL, Microbiology
  TheScienceBreaker.org
  1/1/2018
• Microbiota dysbiosis in select human cancers: Evidence of association and causality. 
  Chen J, Domingue JC, Sears CL., Semin Immunol, on-line
  1/16/2017