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Dan Theodorescu, MD, Urology, Los Angeles, CA, Cedars-Sinai Medical Center

DanTheodorescuMDPhD

Urology • Los Angeles, CA

Minimally Invasive Surgery, Surgical Oncology, Clinical Informatics

Director, Cedars-Sinai Cancer Center

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Summary

  • Trained both as a urologic oncologist and cancer biologist, Theodorescu has emerged as a leading translational cancer researcher. Theodorescu is known for his work on the molecular mechanisms underlying bladder cancer and tools that determine drug response as well as discovery of new drugs for several cancer types. Examples include discovery of genes that regulate tumor growth and metastasis (RhoGDI2, CD24, AGL, GON4L) in bladder and other cancers and novel biomarkers (DNA/NGS, RNA and proteomic) and concepts for precision therapeutic approaches such as the COXEN principle, that are currently being tested in national (SWOG) clinical trials. He led the discovery and development of a "first in class" RalGTPase inhibitor as a new therapeutic in several human cancer types which is now in commercial development. Recent efforts in our lab have focused on understanding the biology of Telomerase reverse transcriptase (TERT) and using that knowledge to develop novel inhibitors to this critical protein in cancer. Finally, active efforts are currently aimed at identifying immune system agonists or antagonists that modulate tumor behavior in vivo as well as the identification of novel combination therapies that enhance the effectiveness of checkpoint and other immunotherapies.

Education & Training

  • Memorial Sloan Kettering Cancer Center
    Memorial Sloan Kettering Cancer CenterFellowship, Urology Service, 1994 - 1995
  • University of Toronto
    University of TorontoResidency, Urology, 1986 - 1994
  • University of Toronto
    University of TorontoPhD, Cancer Biology, 1989 - 1993
  • Queen's University at Kingston
    Queen's University at KingstonClass of 1986, MD

Certifications & Licensure

  • CA State Medical License
    CA State Medical License 2018 - 2024
  • CO State Medical License
    CO State Medical License 2010 - 2019
  • VA State Medical License
    VA State Medical License 1995 - 2012
  • NY State Medical License
    NY State Medical License 1994 - 1995
  • American Board of Urology Urology

Awards, Honors, & Recognition

  • Elected Member Association of American Physicians (AAP), 2019
  • Distinguished Professor University of Colorado, 2018
  • Barringer Medal American Association of Genitourinary Surgeons (AAGUS), 2015
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Publications & Presentations

PubMed

Journal Articles

  • Metastatic Cells Are Preferentially Vulnerable to Lysosomal Inhibition  
    Dan Theodorescu, MD, Proceedings of the National Academy of Sciences
  • RalA Controls Glucose Homeostasis by Regulating Glucose Uptake in Brown Fat  
    Dan Theodorescu, MD, Proceedings of the National Academy of Sciences

Press Mentions

  • Fatty Liver Promotes Colorectal Cancer Spread
    Fatty Liver Promotes Colorectal Cancer SpreadMay 13th, 2023
  • Study Shows How Fatty Liver Promotes the Spread of Colon Cancer
    Study Shows How Fatty Liver Promotes the Spread of Colon CancerMay 12th, 2023
  • Study Reveals How Fatty Liver Promotes Colorectal Cancer Spread
    Study Reveals How Fatty Liver Promotes Colorectal Cancer SpreadMay 11th, 2023
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Committees

  • Chairperson, Program Committee, 2019 AACR Bladder Cancer Special Conference 2018 - 2019

Professional Memberships

  • Society of Laparoendoscopic Surgeons - SLS
    Member
  • CSMC
    Executive Management Committee
  • SOCCI
    Executive Committee
  • European Academy for Tumor Immunology
    Member
  • National Academy of Medicine (NAM),
    Member
  • Brazilian Cancer Society
    Member
  • American Surgical Association
    Member
  • American Association of Genitourinary Surgeons (AAGUS)
    Member
  • American Society for Clinical Investigation (ASCI)
    Member

Other Languages

  • French

Hospital Affiliations

Dr. Dan Theodorescu, Dr. Dan Theodorescu, MD, Dr. D Theodorescu