DanielleDuffyMD

Cardiology • Philadelphia, PA

Adult Congenital Heart Disease, Preventive Cardiology

Assistant Professor, Medicine, Jefferson Medical College-Thos Jefferson Univ

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Office
925 Chestnut St Mezzanine Level
Philadelphia, PA 19107
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Education & Training

Sidney Kimmel Medical College at Thomas Jefferson University/TJUHFellowship, Cardiovascular Disease, 2006 - 2009
University of Pennsylvania Health SystemResidency, Internal Medicine, 2002 - 2005
Perelman School of Medicine at the University of PennsylvaniaClass of 2002

Certifications & Licensure

PA State Medical License 2002 - 2024
American Board of Internal Medicine Cardiovascular Disease

Awards, Honors, & Recognition

CMS Meaningful Use Stage 1 Certification Allscripts Enterprise EHR, Allscripts, 2012-2013
Fellow (FACC) American College of Cardiology

Clinical Trials

Comparison of 2 Beta Blocker Drugs on Peripheral Arterial Disease in Patients With High Blood Pressure Start of enrollment: 2011 Aug 01
Completed
Phase 3
A Study of CSL112 in Adults With Moderate Renal Impairment and Acute Myocardial Infarction Start of enrollment: 2016 Aug 01
Completed
Phase 2

Publications & Presentations

PubMed

Apolipoprotein A1 Infusions and Cardiovascular Outcomes after Acute Myocardial Infarction.
C Michael Gibson, Danielle Duffy, Serge Korjian, M Cecilia Bahit, Gerald Chi, John H Alexander, A Michael Lincoff, Mark Heise, Pierluigi Tricoci, Lawrence I Deckelbaum...> ;The New England Journal of Medicine. 2024 Apr 6
Effect of CSL112 on Recurrent Myocardial Infarction and Cardiovascular Death: Insights from the AEGIS-II Trial.
Thomas J Povsic, Serge Korjian, M Cecilia Bahit, Gerald Chi, Danielle Duffy, John H Alexander, Dragos Vinereanu, Pierluigi Tricoci, Sojaita Jenny Mears, Lawrence I Dec...> ;Journal of the American College of Cardiology. 2024 Mar 25
1 citations
Biological basis and proposed mechanism of action of CSL112 (apolipoprotein A-I [human]) for prevention of major adverse cardiovascular events in patients with myocard...
Serge Korjian, Syed Hassan A Kazmi, Gerald Chi, Arzu Kalayci, Jane J Lee, Usama Talib, Samuel D Wright, Danielle Duffy, Bronwyn A Kingwell, Roxana Mehran, Paul M Ridke...> ;European Heart Journal. Cardiovascular Pharmacotherapy. 2023 Jun 2
6 citations
CSL112 (Apolipoprotein A-I [Human]) Strongly Enhances Plasma Apoa-I and Cholesterol Efflux Capacity in Post-Acute Myocardial Infarction Patients: A PK/PD Substudy of t...
C Michael Gibson, Syed Hassan A Kazmi, Serge Korjian, Gerald Chi, Adam T Phillips, Sahar Memar Montazerin, Danielle Duffy, Bo Zheng, Mark Heise, Charles Liss, Lawrence...> ;Journal of Cardiovascular Pharmacology and Therapeutics. 2022 Oct 25
6 citations
ApoA-I Infusion Therapies Following Acute Coronary Syndrome: Past, Present, and Future.
Arzu Kalayci, C Michael Gibson, Paul M Ridker, Samuel D Wright, Bronwyn A Kingwell, Serge Korjian, Gerald Chi, Jane J Lee, Pierluigi Tricoci, S Hassan Kazmi, Clara Fit...> ;Current Atherosclerosis Reports. 2022 Jul 1
8 citations
Pharmacometric analyses to characterize the effect of CSL112 on apolipoprotein A-I and cholesterol efflux capacity in acute myocardial infarction patients.
Bo Zheng, Danielle Duffy, Pierluigi Tricoci, Helen Kastrissios, Marc Pfister, Samuel D. Wright, Andreas Gille, Michael A. Tortorici> ;British Journal of Clinical Pharmacology. 2021 Jun 1
19 citations
Cholesterol Efflux Capacity and Its Association With Adverse Cardiovascular Events: A Systematic Review and Meta-Analysis.
Jane J Lee, Gerald Chi, Clara Fitzgerald, Syed Hassan A Kazmi, Arzu Kalayci, Serge Korjian, Danielle Duffy, Alka Shaunik, Bronwyn Kingwell, Robert W Yeh, Deepak L Bhat...> ;Frontiers in Cardiovascular Medicine. 2021 Jan 1
43 citations
Rationale and design of ApoA-I Event Reducing in Ischemic Syndromes II (AEGIS-II): A phase 3, multicenter, double-blind, randomized, placebo-controlled, parallel-group...
C. Michael Gibson, John J.P. Kastelein, Adam T. Phillips, Philip E. Aylward, Megan K. Yee, Michal Tendera, Stephen J. Nicholls, Stuart J. Pocock, Shaun G. Goodman, Joh...> ;American Heart Journal. 2021 Jan 1
13 citations
Pharmacokinetics and Safety of CSL112 (Apolipoprotein A-I [Human]) in Adults With Moderate Renal Impairment and Normal Renal Function.
Michael A. Tortorici, Danielle Duffy, Rebecca Evans, John Feaster, Andreas Gille, Timothy G. K. Mant, Samuel D. Wright, Denise D'Andrea> ;Clinical Pharmacology in Drug Development. 2019 Jul 1
10 citations
Moderate Renal Impairment Does Not Impact the Ability of CSL112 (Apolipoprotein A-I [Human]) to Enhance Cholesterol Efflux Capacity.
Andreas Gille, Danielle Duffy, Michael A. Tortorici, Samuel D. Wright, Lawrence I. Deckelbaum, Denise D'Andrea> ;Journal of Clinical Pharmacology. 2019 Mar 1
20 citations
The CSL112-2001 trial: Safety and tolerability of multiple doses of CSL112 (apolipoprotein A-I [human]), an intravenous formulation of plasma-derived apolipoprotein A-...
C. Michael Gibson, Mathieu Kerneis, Megan K. Yee, Yazan Daaboul, Serge Korjian, Ali Poyan Mehr, Pierluigi Tricoci, John H. Alexander, John J.P. Kastelein, Roxana Mehra...> ;American Heart Journal. 2019 Feb 1
47 citations
Oral Apolipoprotein A-I Mimetic D-4F Lowers HDL-Inflammatory Index in High-Risk Patients: A First-in-Human Multiple-Dose, Randomized Controlled Trial
Richard L. Dunbar, Rajesh Movva, LeAnne T. Bloedon, Danielle Duffy, Robert B. Norris, Mohamad Navab, Alan M. Fogelman, Daniel J. Rader> ;Clinical and Translational Science. 2017 Aug 9
15 citations
Impact of the 2013 American College of Cardiology/American Heart Association cholesterol guidelines on the prescription of high-intensity statins in patients hospitali...
Michael A. Valentino, Jad Al Danaf, Andrew W. Panakos, Loheetha Ragupathi, Danielle Duffy, David J. Whellan> ;American Heart Journal. 2016 Nov 1
45 citations
US physician practices for diagnosing familial hypercholesterolemia: data from the CASCADE-FH registry.
Zahid Ahmad, Rolf Andersen, Lars Andersen, Emily C. O'Brien, Iris Kindt, Peter Shrader, Chandna Vasandani, Connie B. Newman, Emil M. deGoma, Seth J. Baum, Linda C. Hem...> ;Journal of Clinical Lipidology. 2016 Sep 1
148 citations
Treatment Gaps in Adults With Heterozygous Familial Hypercholesterolemia in the United States: Data From the CASCADE-FH Registry.
Emil M. deGoma, Zahid Ahmad, Emily C. O'Brien, Iris Kindt, Peter Shrader, Connie B. Newman, Yashashwi Pokharel, Seth J. Baum, Linda C. Hemphill, Lisa C. Hudgins, Cathe...> ;Circulation. Cardiovascular Genetics. 2016 Mar 24
3 citations
Pharmacogenetics in the Development of Lipid Lowering Medications: Lomitapide & Mipomersen in Clinical Practice.
Jeffrey A. Marbach, Jhapat Thapa, Edward M Goldenberg, Danielle Duffy> ;Delaware Medical Journal. 2015 Aug 1
16 citations
2013 ACC/AHA cholesterol treatment guideline: Paradigm shifts in managing atherosclerotic cardiovascular disease risk.
Jonathan B. Finkel, Danielle Duffy> ;Trends in Cardiovascular Medicine. 2015 May 1
12 citations
Modeled risk of ischemic heart disease following left breast irradiation with deep inspiration breath hold
Harriet Eldredge-Hindy, Danielle Duffy, Kosj Yamoah, Nicole L. Simone, Jenna Skowronski, Adam P. Dicker, Pramila R. Anne> ;Practical Radiation Oncology. 2015 May 1
8 citations
Targeting lipoprotein (a): an evolving therapeutic landscape.
Lillian C. Man, Erik Kelly, Danielle Duffy> ;Current Atherosclerosis Reports. 2015 Mar 4
2 citations
PA32540 for the secondary prevention of cardiovascular disease in patients at risk for aspirin-associated gastric ulcers
Danielle Duffy, Bridget Rooney, Suzanne Adams, David J. Whellan> ;Expert Review of Cardiovascular Therapy. 2014 Oct 23
25 citations
A pilot phase II Study of digoxin in patients with recurrent prostate cancer as evident by a rising PSA
Jianqing Lin, Tingting Zhan, Danielle Duffy, Jean H. Hoffman-Censits, Deborah Kilpatrick, Edouard J. Trabulsi, Costas D. Lallas, Inna Chervoneva, Kimberly Limentani, B...> ;American Journal of Cancer Therapy and Pharmacology. 2014 Sep 7
6 citations
Novel treatments for familial hypercholesterolemia: pharmacogenetics at work.
Jeffrey A. Marbach, Jessica L. McKeon, Joyce L. Ross, Danielle Duffy> ;Pharmacotherapy. 2014 Sep 1
21 citations
Pharmacokinetic interactions of the microsomal triglyceride transfer protein inhibitor, lomitapide, with drugs commonly used in the management of hypercholesterolemia.
Sony Tuteja, Danielle Duffy, Richard L. Dunbar, Rajesh Movva, Ram Gadi, LeAnne T. Bloedon, Marina Cuchel> ;Pharmacotherapy. 2014 Mar 1
14 citations
Aspirin for Cardioprotection and Strategies to Improve Patient Adherence
Danielle Duffy, Erik Kelly, Amanda Trang, David J. Whellan, Geoffrey Mills> ;Postgraduate Medicine. 2014 Jan 1
17 citations
The impact of high-density lipoprotein cholesterol levels on long-term outcomes after non-ST-elevation myocardial infarction.
Danielle Duffy, DaJuanicia N. Holmes, Matthew T. Roe, Eric D. Peterson> ;American Heart Journal. 2012 Apr 1
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Lectures

Optimizing Diabetes Management
59th Annual Scientific Session & Expo, Atlanta, Georgia, USA
Optimizing Diabetes Management
American College of Cardiology, 59th Annual Scientific Session & Expo, Atlanta, Georgia, USA