DaphneJHoltMDPhD

Psychiatry • Charlestown, MA

Associate Professor of Psychiatry, Harvard Medical School, Massachusetts General Hospital

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Office
149 13th St
Mgh East
Charlestown, MA 02129
Phone(617) 726-7618
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Education & Training

Massachusetts General HospitalResidency, Psychiatry, 1998 - 2002
University of Chicago Pritzker School of MedicineClass of 1998

Certifications & Licensure

MA State Medical License 2001 - 2022
American Board of Psychiatry and Neurology Psychiatry

Publications & Presentations

PubMed

Neural abnormalities in fear generalization in schizophrenia and associations with negative symptoms
Lauri Tuominen, Stephanie N. DeCross, Emily A. Boeke, Clifford M. Cassidy, Oliver Freudenreich, Ann K. Shinn, Roger B. H. Tootell, Daphne J. Holt> ;Biological Psychiatry: Cognitive Neuroscience and Neuroimaging. 2021 Jan 29
Altered temporal, but intact spatial, features of transient network dynamics in psychosis.
Danhong Wang, Xiaolong Peng, Andrea Pelletier-Baldelli, Natasza Orlov, Amy Farabaugh, Shahin Nasr, Hamdi Eryilmaz, Maurizio Fava, Avram J. Holmes, Joshua L. Roffman, H...> ;Molecular Psychiatry. 2021 Jan 18
Launching a resiliency group program to assist frontline clinicians in meeting the challenges of the COVID-19 pandemic: Results of a hospital-based systems trial.
Elyse R. Park, Louisa G. Sylvia, Joanna M. Streck, Christina M. Luberto, Amelia M. Stanton, Giselle K. Perez, Margaret Baim, Cayley C. Bliss, Mary Susan Convery, Sydne...> ;General Hospital Psychiatry. 2021 Jan 1
Air pollution and hippocampal atrophy in first episode schizophrenia.
Michelle A. Worthington, Eva Petkova, Oliver Freudenreich, Corrine Cather, Daphne J. Holt, Iruma Bello, Erica D. Diminich, Yingying Tang, Babak A. Ardekani, Botao Zeng...> ;Schizophrenia Research. 2020 Mar 10
4 citations
Are Negative Symptoms Merely the "Real World" Consequences of Deficits in Social Cognition?
Andrea Pelletier-Baldelli, Daphne J. Holt> ;Schizophrenia Bulletin. 2020 Feb 26
1 citations
Rationale, Methods, Feasibility, and Preliminary Outcomes of a Transdiagnostic Prevention Program for At-Risk College Students.
Anne S Burke, Benjamin G. Shapero, Andrea Pelletier-Baldelli, Wisteria Y. Deng, Maren Nyer, Logan Leathem, Leah Namey, Carrie E. Landa, Corinne Cather, Daphne J. Holt> ;Frontiers in Psychiatry. 2020 Feb 25
1 citations
Elevated Amygdala Activity in Young Adults With Familial Risk for Depression: A Potential Marker of Low Resilience.
Tracy Barbour, Avram J. Holmes, Amy Farabaugh, Stephanie N. DeCross, Garth Coombs, Emily A. Boeke, Rick P. F. Wolthusen, Maren Nyer, Paola Pedrelli, Maurizio Fava, Dap...> ;Biological Psychiatry: Cognitive Neuroscience and Neuroimaging. 2020 Feb 1
1 citations
Increased amygdala-visual cortex connectivity in youth with persecutory ideation.
Stephanie N. DeCross, Amy Farabaugh, Avram J. Holmes, Maeve Ward, Emily A. Boeke, Rick P. F. Wolthusen, Garth Coombs, Maren Nyer, Maurizio Fava, Randy L. Buckner, Daph...> ;Psychological Medicine. 2020 Jan 1
Deficient Hippocampal Habituation in Psychosis: A Manifestation of Hippocampal Overactivity?
Daphne J. Holt> ;Biological Psychiatry: Cognitive Neuroscience and Neuroimaging. 2019 Nov 1
Correction: Progressive decline in hippocampal CA1 volume in individuals at ultra-high-risk for psychosis who do not remit: findings from the longitudinal youth at ris...
New Fei Ho, Daphne J Holt, Mike Cheung, Juan Eugenio Iglesias, Alex Goh, Mingyuan Wang, Joseph K W Lim, Joshua de Souza, Joann S Poh, Yuen Mei See, R Alison Adcock, St...> ;Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 2019 Nov 1
5 citations
The Shared Genetic Basis of Educational Attainment and Cerebral Cortical Morphology.
Tian Ge, Chia-Yen Chen, Alysa E. Doyle, Richard Vettermann, Lauri Tuominen, Daphne J. Holt, Mert R. Sabuncu, Jordan W. Smoller> ;Cerebral Cortex. 2019 Jul 22
12 citations
Neuroepigenetic signatures of age and sex in the living human brain.
Tonya M. Gilbert, Nicole R. Zürcher, Mary C. Catanese, Chieh-En Jane Tseng, Maria A. Di Biase, Amanda E. Lyall, Baileigh G Hightower, Anjali J. Parmar, Anisha Bhanot, ...> ;Nature Communications. 2019 Jul 3
3 citations
Citalopram in first episode schizophrenia: The DECIFER trial.
Donald C. Goff, Oliver Freudenreich, Corrine Cather, Daphne J. Holt, Iruma Bello, Erica D. Diminich, Yingying Tang, Babak A. Ardekani, Michelle A. Worthington, Botao Z...> ;Schizophrenia Research. 2019 Jun 1
5 citations
The relationship of perceptual discrimination to neural mechanisms of fear generalization.
Lauri Tuominen, Emily A. Boeke, Stephanie N. DeCross, Rick P. F. Wolthusen, Shahin Nasr, Mohammed R. Milad, Mark Vangel, Roger B. H. Tootell, Daphne J. Holt> ;NeuroImage. 2019 Mar 1
10 citations
Understanding the effects of emotional reactivity on depression and suicidal thoughts and behaviors: Moderating effects of childhood adversity and resilience.
Benjamin G. Shapero, Amy Farabaugh, Olga Terechina, Stephanie N. DeCross, Joey C. Cheung, Maurizio Fava, Daphne J. Holt> ;Journal of Affective Disorders. 2019 Feb 15
14 citations
PET neuroimaging reveals histone deacetylase dysregulation in schizophrenia.
Tonya M. Gilbert, Nicole R. Zürcher, Christine J. Wu, Anisha Bhanot, Baileigh G Hightower, Minhae Kim, Daniel S. Albrecht, Hsiao-Ying Wey, Frederick A. Schroeder, Anai...> ;Journal of Clinical Investigation. 2018 Dec 10
7 citations
Regional GABA Concentrations Modulate Inter-network Resting-state Functional Connectivity
Xi Chen, Xiaoying Fan, Yuzheng Hu, Chun S. Zuo, Susan Whitfield-Gabrieli, Daphne J. Holt, Qiyong Gong, Yihong Yang, Diego A. Pizzagalli, Fei Du, Dost Öngür> ;Cerebral Cortex. 2019 Apr 1
10 citations
The Genetics of Endophenotypes of Neurofunction to Understand Schizophrenia (GENUS) consortium: A collaborative cognitive and neuroimaging genetics project
Gabriëlla A.M. Blokland, Elisabetta del Re, Raquelle I. Mesholam-Gately, Jorge Jovicich, Joey W. Trampush, Matcheri S. Keshavan, Lynn E. DeLisi, James T.R. Walters, Je...> ;Schizophrenia Research. 2017 Oct 3
5 citations
Correlation Between Levels of Delusional Beliefs and Perfusion of the Hippocampus and an Associated Network in a Non–Help-Seeking Population
Rick P. F. Wolthusen, Garth Coombs, Emily A. Boeke, Stefan Ehrlich, Stephanie N. DeCross, Shahin Nasr, Daphne J. Holt> ;Biological Psychiatry: Cognitive Neuroscience and Neuroimaging. 2017 Jul 13
Progressive Decline in Hippocampal CA1 Volume in Individuals at Ultra-High-Risk for Psychosis Who do not Remit: Findings from the Longitudinal Youth at Risk Study.
Ho, N. F.,Holt, D. J.,Cheung, M.,Iglesias, J. E.,Goh, A.,Wang, M.,Lim, J. K.,de Souza, J.,Poh, J. S.,See, Y. M.,Adcock, A. R.,Wood, S. J.,Chee, M. W.,Lee, J.,Zhou, J.> ;Neuropsychopharmacology. 2017 Jan 13
A Pathway to Understanding Emotional Dysfunction in Schizophrenia.
Daphne J. Holt> ;JAMA Psychiatry. 2016 Jun 1
7 citations
The Core Brain Region for Face Processing in Schizophrenia Lacks Face Selectivity
Stephen Maher, Tor Ekstrom, Daphne J. Holt, Dost Öngür, Yue Chen> ;Schizophrenia Bulletin. 2016 May 1
Corrigendum to abnormalities in personal space and parietal-frontal function in schizophrenia.
Daphne J. Holt, Emily A. Boeke, Garth Coombs, Stephanie N. DeCross, Brittany S. Cassidy, Steven M. Stufflebeam, Scott L. Rauch, Roger B. H. Tootell> ;NeuroImage: Clinical. 2016 Apr 3
58 citations
Progression from Selective to General Involvement of Hippocampal Subfields in Schizophrenia
Daphne Holt, MD> ;Nature. 2017 Jan 1
5 citations
Alterations of lateral temporal cortical gray matter and facial memory as vulnerability indicators for schizophrenia: An MRI study in youth at familial high-risk for s...
Benjamin K. Brent, Isabelle M. Rosso, Heidi W. Thermenos, Daphne J. Holt, Stephen V. Faraone, Nikos Makris, Ming T. Tsuang, Larry J. Seidman> ;Schizophrenia Research. 2016 Jan 1
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Journal Articles

The Shared Genetic Basis of Educational Attainment and Cerebral Cortical Morphology
Jordan W Smoller, Daphne J Holt, Alysa E Doyle, Cerebral Cortex

Press Mentions

How to Maintain Your Mental Well-Being During the COVID-19 CrisisMay 4th, 2020
Why We Need 'Personal Space' and Ways to Deal When People Ignore ItAugust 19th, 2019
Increasing Advancement Opportunities for Women in Science and MedicineJuly 17th, 2018
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Grant Support

The Neural Basis Of Deficits In Acquisition And Extinction Of FEAR In SchizophrenNational Institute Of Mental Health2012
The Neural Basis Of Delusions In Schizophrenia: Studies Of Emotional PerceptionNational Institute Of Mental Health2007–2010
Neural Basis Of Delusions In Schizophrenia: EmotionalNational Institute Of Mental Health2006
Neurochemical Organization Of The Human StriatumNational Institute Of Mental Health1994–1995
The Neurochemical Organization Of The Human StriatumNational Institute Of Mental Health1993

Hospital Affiliations

Massachusetts General HospitalBoston, Massachusetts