DavidJBearssMD

PubMed

• 2 citations
  Development of High-Throughput Screening Assays for Inhibitors of ETS Transcription Factors:
  Simon L. Currie, Stephen L. Warner, Hariprasad Vankayalapati, Xiao-Hui Liu, Sunil Sharma, David J. Bearss, Barbara J. Graves> ;SLAS Discovery. 2019 Jan 1
• 9 citations
  Fragment-based design, synthesis, biological evaluation, and SAR of 1H-benzo[d]imidazol-2-yl)-1H-indazol derivatives as potent PDK1 inhibitors.
  Ting Chen, Venkataswamy Sorna, Susie Choi, Lee T. Call, Jared Bearss, Kent J. Carpenter, Steven L. Warner, Sunil Sharma, David J. Bearss, Hariprasad Vankayalapati> ;Bioorganic & Medicinal Chemistry Letters. 2017 Dec 15
• 58 citations
  Combined venetoclax and alvocidib in acute myeloid leukemia.
  James M Bogenberger, Clifford J. Whatcott, Nanna Hansen, Devora Delman, Chang Xin Shi, Wontak Kim, Hillary Haws, Katherine K. Soh, Ye Sol Lee, Peter Peterson, Adam Sid...> ;Oncotarget. 2017 Nov 4
• Mechanism and relevance of EWS/FLI-mediated transcriptional repression in Ewing sarcoma.
  Sankar S, Bell R, Stephens B, Zhuo R, Sharma S, Bearss DJ, Lessnick SL> ;Oncogene. 2016-11-24
• 14 citations
  Axl activates fibroblast growth factor receptor pathway to potentiate survival signals in B-cell chronic lymphocytic leukemia cells
  Sutapa Sinha, Justin C. Boysen, Michael Nelson, Steven L. Warner, David J. Bearss, Neil E. Kay, Asish K. Ghosh> ;Leukemia. 2016 Jun 1
• 109 citations
  Receptor tyrosine kinase Axl is required for resistance of leukemic cells to FLT3-targeted therapy in acute myeloid leukemia.
  Il-Kyoo Park, Bethany L. Mundy-Bosse, Susan P. Whitman, Xulang Zhang, Steven L. Warner, David J. Bearss, William Blum, G. Marcucci, Michael A. Caligiuri> ;Leukemia. 2015 Jun 19
• 56 citations
  Targeted Axl Inhibition Primes Chronic Lymphocytic Leukemia B Cells to Apoptosis and Shows Synergistic/Additive Effects in Combination with BTK Inhibitors.
  Sutapa Sinha, Justin C. Boysen, Michael Nelson, Charla R. Secreto, Steven L. Warner, David J. Bearss, Connie Lesnick, Tait D. Shanafelt, Neil E. Kay, Asish K. Ghosh> ;Clinical Cancer Research. 2015 Feb 11
• Highly effective combination of LSD1 (KDM1A) antagonist and pan-histone deacetylase inhibitor against human AML cells.
  Fiskus, W.,Sharma, S.,Shah, B.,Portier, B. P.,Devaraj, S. G.,Liu, K.,Iyer, S. P.,Bearss, D.,Bhalla, K. N.> ;Leukemia. 2014 Apr 05
• 19 citations
  Different expression of placental pyruvate kinase in normal, preeclamptic and intrauterine growth restriction pregnancies.
  Brigham L. Bahr, M.D. Price, Daniel Merrill, Camilo Mejia, L. Call, David J. Bearss, Juan A. Arroyo> ;Placenta. 2014 Nov 1
• 15 citations
  Inhibition of Nek2 by Small Molecules Affects Proteasome Activity
  Lingyao Meng, Kent J. Carpenter, Alexis Mollard, Hariprasad Vankayalapati, Steven L. Warner, Sunil Sharma, Guido Tricot, Fenghuang Zhan, David J. Bearss> ;Biomed Research International. 2014 Sep 17
• 2 citations
  Mitochondrial priming of chronic lymphocytic leukemia patients associates Bcl-xL dependence with alvocidib response.
  William E. Pierceall, Steven L. Warner, Ryan Lena, Camille Doykan, Noel Blake, Michael Elashoff, Daniel D. Von Hoff, David J. Bearss, Michael H. Cardone, Leslie A. And...> ;Leukemia. 2014 Jul 3
• 50 citations
  A Small-Molecule Inhibitor of PIM Kinases as a Potential Treatment for Urothelial Carcinomas
  Jason M. Foulks, Kent J. Carpenter, Bai Luo, Yong Xu, Anna Senina, Rebecca N. Nix, Ashley Chan, Adrianne Clifford, Marcus Wilkes, David Vollmer, Benjamin Brenning, Sha...> ;Neoplasia. 2014 May 1
• 11 citations
  Discovery of Novel Putative Inhibitors of UDP-GlcNAc 2-Epimerase as Potent Antibacterial Agents
  Yong Xu, Benjamin Brenning, Adrianne Clifford, David Vollmer, Jared Bearss, Carissa Jones, Virgil McCarthy, Chongtie Shi, Bradley Wolfe, Bhasker Aavula, Steve Warner, ...> ;ACS Medicinal Chemistry Letters. 2013 Dec 12
• 138 citations
  High-throughput virtual screening identifies novel N'-(1-phenylethylidene)-benzohydrazides as potent, specific, and reversible LSD1 inhibitors
  Venkataswamy Sorna, Emily R. Theisen, Bret Stephens, Steven L. Warner, David J. Bearss, Hariprasad Vankayalapati, Sunil Sharma> ;Journal of Medicinal Chemistry. 2013 Nov 23
• 32 citations
  The tumor suppressor axis p53/miR-34a regulates Axl expression in B-cell chronic lymphocytic leukemia: implications for therapy in p53-defective CLL patients.
  Justin C. Boysen, Sutapa Sinha, Tammy Price-Troska, Steven L. Warner, David J. Bearss, David S. Viswanatha, Tait D. Shanafelt, Neil E. Kay, Asish K. Ghosh> ;Leukemia. 2014 Feb 1
• 58 citations
  TIG1 Promotes the Development and Progression of Inflammatory Breast Cancer through Activation of Axl Kinase
  Xiaoping Wang, Hitomi Saso, Takayuki Iwamoto, Weiya Xia, Yun Gong, Lajos Pusztai, Wendy A. Woodward, James M. Reuben, Steven L. Warner, David J. Bearss, Gabriel N. Hor...> ;Cancer Research. 2013 Nov 1
• 35 citations
  Mechanism and relevance of EWS/FLI-mediated transcriptional repression in Ewing sarcoma.
  S Sankar, R Bell, B Stephens, R Zhuo, S Sharma, D J Bearss, S L Lessnick> ;Oncogene. 2013 Oct 17
• 37 citations
  Use of a bacteriophage lysin to identify a novel target for antimicrobial development.
  Raymond Schuch, Adam J. Pelzek, Assaf Raz, Chad W. Euler, Patricia Ryan, Benjamin Y. Winer, Andrew Farnsworth, Bhaskaran Shyam S, C. Erec Stebbins, Yong Xu, Adrienne C...> ;Plos One. 2013 Apr 10
• 3 citations
  Discovery of Biologically Active Oncologic and Immunologic Small Molecule Therapies using Zebrafish: Overview and Example of Modulation of T Cell Activation
  Nikolaus S. Trede, William L. Heaton, Suzanne Ridges, Hossein Sofla, Matthew F. Cusick, David J. Bearss, David A. Jones, Robert S. Fujinami> ;Current Protocols in Pharmacology. 2013 Mar 1
• 216 citations
  NEK2 Induces Drug Resistance Mainly through Activation of Efflux Drug Pumps and Is Associated with Poor Prognosis in Myeloma and Other Cancers
  Wen Zhou, Ye Yang, Jiliang Xia, He Wang, Mohamed E. Salama, Wei Xiong, Hongwei Xu, Shashirekha Shetty, Tiehua Chen, Zhaoyang Zeng, Lei Shi, Maurizio Zangari, Rodney R....> ;Cancer Cell. 2013 Jan 14
• 721 citations
  An Epithelial–Mesenchymal Transition Gene Signature Predicts Resistance to EGFR and PI3K Inhibitors and Identifies Axl as a Therapeutic Target for Overcoming EGFR Inhi...
  Lauren Averett Byers, Lixia Diao, Jing Wang, Pierre Saintigny, Luc Girard, Michael Peyton, Li Shen, Youhong Fan, Uma Giri, Praveen K. Tumula, Monique B. Nilsson, Jayan...> ;Clinical Cancer Research. 2013 Jan 1
• 18 citations
  Chemical Genetic Screen Reveals a Role for Desmosomal Adhesion in Mammary Branching Morphogenesis
  Kaitlin J. Basham, Collin Kieffer, Dawne N. Shelton, Christopher J. Leonard, Vasudev R. Bhonde, Hariprasad Vankayalapati, Brett Milash, David J. Bearss, Ryan E. Looper...> ;The Journal of Biological Chemistry. 2013 Jan 25
• 60 citations
  Design, Synthesis and Biological Evaluation of a Series of Novel Axl Kinase Inhibitors.
  Alexis Mollard, Steven L. Warner, Lee T. Call, Mark Wade, Anupam Verma, Sunil Sharma, Hariprasad Vankayalapati, David J. Bearss> ;ACS Medicinal Chemistry Letters. 2011 Dec 8
• 46 citations
  The Pim kinases: New targets for drug development
  Ronan T. Swords, Kevin R. Kelly, Jennifer S. Carew, Steffan T. Nawrocki, Devalingam Mahalingam, John Sarantopoulos, David J. Bearss, Francis J. Giles> ;Current Drug Targets. 2011 Nov 30
• 23 citations
  Targeting PIM kinase enhances the activity of sunitinib in renal cell carcinoma.
  Devalingam Mahalingam, Claudia M. Espitia, Ernest Medina, Juan A. Esquivel, Kevin R. Kelly, David J. Bearss, Gavin Choy, Pietro Taverna, Jennifer S. Carew, Francis J. ...> ;British Journal of Cancer. 2011 Nov 8
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