DavidMarshallGuidotMD

PubMed

• Ethanol-exposed lung fibroblasts cause airway epithelial barrier dysfunction.
  Viranuj Sueblinvong, Xian Fan, Craishun Hart, Samuel Molina, Michael Koval, David M Guidot> ;Alcohol, Clinical & Experimental Research. 2023 Oct 1
• MYOSIN LIGHT CHAIN KINASE DELETION WORSENS LUNG PERMEABILITY AND INCREASES MORTALITY IN PNEUMONIA-INDUCED SEPSIS.
  Deena B Chihade, Prestina Smith, David A Swift, Shunsuke Otani, Wenxiao Zhang, Ching-Wen Chen, Lauren A Jeffers, Zhe Liang, Takashi Shimazui, Eileen M Burd, Alton B Fa...> ;Shock. 2023 Apr 1
• 2 citations
  Alcohol impairs recognition and uptake of Mycobacterium tuberculosis by suppressing toll-like receptor 2 expression.
  Gregory W Wigger, Darya Khani, Mariam Ahmed, Layal Sayegh, Sara C Auld, Xian Fan, David M Guidot, Bashar S Staitieh> ;Alcoholism, Clinical and Experimental Research. 2022 Dec 1
• ARDS - Paradigms Lost and Found.
  David M. Guidot> ;The American Journal of the Medical Sciences. 2021 Oct 8
• 8 citations
  HIV Impairs Alveolar Macrophage Function via MicroRNA-144-Induced Suppression of Nrf2.
  Xian Fan, Shannon C. Murray, Bashar S. Staitieh, Paul Spearman, David M. Guidot> ;The American Journal of the Medical Sciences. 2021 Jan 1
• 3 citations
  HIV X4 Variants Increase Arachidonate 5-Lipoxygenase in the Pulmonary Microenvironment and are associated with Pulmonary Arterial Hypertension.
  Sharilyn Almodovar, Brandy E. Wade, Kristi M. Porter, Justin M. Smith, Robert Alexis Lopez-Astacio, Kaiser M. Bijli, Bum-Yong Kang, Sushma K. Cribbs, David M. Guidot, ...> ;Scientific Reports. 2020 Jul 16
• Correction: Chronic Alcohol Ingestion Increases Mortality and Organ Injury in a Murine Model of Septic Peritonitis.
  Benyam P Yoseph, Elise Breed, Christian E Overgaard, Christina J Ward, Zhe Liang, Maylene E Wagener, Daniel R Lexcen, Elizabeth R Lusczek, Greg J Beilman, Eileen M Bur...> ;Plos One. 2020 Jan 1
• SSCI Presidential Symposium Presented at the 2019 Southern Regional Meeting: HIV-Mediated Tissue Injury in the Era of Anti-Retroviral Therapy.
  David M. Guidot> ;The American Journal of the Medical Sciences. 2019 Oct 23
• 31 citations
  Macrophages exposed to HIV viral protein disrupt lung epithelial cell integrity and mitochondrial bioenergetics via exosomal microRNA shuttling.
  Zhihong Yuan, Jessica R. Petree, F. Eun-Hyung Lee, Xian Fan, Khalid Salaita, David M. Guidot, Ruxana T. Sadikot> ;Cell Death & Disease. 2019 Aug 2
• 18 citations
  MiR-144 mediates Nrf2 inhibition and alveolar epithelial dysfunction in HIV-1 transgenic rats
  Abiodun T. Kukoyi, Xian Fan, Bashar S. Staitieh, Brooks M. Hybertson, Bifeng Gao, Joe M. McCord, David M. Guidot> ;American Journal of Physiology. Cell Physiology. 2019 Aug 1
• 5 citations
  Alcohol-Induced Interleukin-17 Expression Causes Murine Lung Fibroblast-to-Myofibroblast Transdifferentiation via Thy-1 Down-Regulation.
  Wendy A. Neveu, Bashar S. Staitieh, Stephen T. Mills, David M. Guidot, Viranuj Sueblinvong> ;Alcoholism, Clinical and Experimental Research. 2019 Jul 1
• 6 citations
  HIV-1 Protein gp120 Induces Mouse Lung Fibroblast-to-Myofibroblast Transdifferentiation via CXCR4 Activation
  Lucian Marts, David M. Guidot, Viranuj Sueblinvong> ;The American Journal of the Medical Sciences. 2019 Jun 1
• 6 citations
  Endocannabinoid receptor CB2R is significantly expressed in aspirin-exacerbated respiratory disease: a pilot study.
  Alessia Corrado, Monica Battle, Sarah K. Wise, F. Eun-Hyung Lee, David M. Guidot, John M. DelGaudio, Samuel A. Molina, Joshua M. Levy> ;International Forum of Allergy & Rhinology. 2018 Oct 1
• 11 citations
  Chronic Alcohol Ingestion Impairs Rat Alveolar Macrophage Phagocytosis via Disruption of RAGE Signaling.
  Bashar S. Staitieh, Eduardo E. Egea, Xian Fan, Adaugo Amah, David M. Guidot> ;The American Journal of the Medical Sciences. 2018 May 1
• 15 citations
  Dysregulation of Alveolar Macrophage PPARγ, NADPH Oxidases, and TGFβ1 in Otherwise Healthy HIV-Infected Individuals.
  Samantha M. Yeligar, Janine M. Ward, Frank L. Harris, Lou Ann S. Brown, David M. Guidot, Sushma K. Cribbs> ;AIDS Research and Human Retroviruses. 2017 Oct 1
• 2017 Founders' Medal Acceptance.
  David M. Guidot> ;The American Journal of the Medical Sciences. 2017 Mar 15
• 35 citations
  HIV-1 decreases Nrf2/ARE activity and phagocytic function in alveolar macrophages
  Bashar S. Staitieh, Lingmei Ding, Wendy A. Neveu, Paul Spearman, David M. Guidot, Xian Fan> ;Journal of Leukocyte Biology. 2017 Aug 1
• 5 citations
  Pulmonary Innate Immune Dysfunction in Human Immunodeficiency Virus
  Bashar S. Staitieh, Eduardo E. Egea, David M. Guidot> ;American Journal of Respiratory Cell and Molecular Biology. 2017 May 1
• 33 citations
  HIV-related proteins prolong macrophage survival through induction of Triggering receptor expressed on myeloid cells-1.
  Zhihong Yuan, Xian Fan, Bashar S. Staitieh, Paul Spearman, David M. Guidot, Ruxana T. Sadikot> ;Scientific Reports. 2017 Feb 9
• 26 citations
  Alcohol and the Lung.
  Ashish J. Mehta, David M. Guidot> ;Alcohol Research. 2017 Jan 1
• 10 citations
  Maternal Alcohol Use During Pregnancy and Associated Morbidities in Very Low Birth Weight Newborns.
  Theresa W. Gauthier, David M. Guidot, Michael Kelleman, Courtney McCracken, Lou Ann S. Brown> ;The American Journal of the Medical Sciences. 2016 Oct 1
• 69 citations
  Regulation of claudin/zonula occludens-1 complexes by hetero-claudin interactions
  Barbara Schlingmann, Christian E. Overgaard, Samuel A. Molina, K. Sabrina Lynn, Leslie A. Mitchell, StevenClaude Dorsainvil White, Alexa L. Mattheyses, David M. Guidot...> ;Nature Communications. 2016 Jul 25
• 9 citations
  Nuclear Thioredoxin-1 Overexpression Attenuates Alcohol-Mediated Nrf2 Signaling and Lung Fibrosis.
  Viranuj Sueblinvong, Stephen T. Mills, David C. Neujahr, Young-Mi Go, Dean P. Jones, David M. Guidot> ;Alcoholism, Clinical and Experimental Research. 2016 Jul 20
• Only Jesus Can Call My Son.
  David M Guidot> ;The American Journal of the Medical Sciences. 2016 Jun 1
• 62 citations
  Correlation of the lung microbiota with metabolic profiles in bronchoalveolar lavage fluid in HIV infection
  Sushma K. Cribbs, Karan Uppal, Shuzhao Li, Dean P. Jones, Laurence Huang, Laura Tipton, Adam Fitch, Ruth M. Greenblatt, Lawrence A. Kingsley, David M. Guidot, Elodie G...> ;Microbiome. 2016 Jan 20
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Journal Articles

• Alveolar barrier function in alcoholic lung syndrome is impaired by tight junction destabilization  
  Schlingmann BL, Ward C, Molina SA, Overgaard CE, Guidot DM, Koval M, Ann Am Thorac Soc, 1/1/2015
• Presentation of the 2014 Founder's Medal Award  
  Guidot, D.M., Am J Med Sci, 1/1/2014
• Donor alcohol abuse and lung injury following allograft transplantation: a cautionary tale but also a call to action  
  Guidot DM, Alcoholism: Clin Exp Res, 1/1/2014
• Alcohol causes alveolar epithelial oxidative stress by inhibiting the Nrf2/ARE signaling pathway  
  Jensen, JS, Fan X and Guidot, DM, American Journal of Respiratory Cell Molecular Biology, 1/1/2013
• Alcohol ingestion disrupts alveolar epithelial barrier function by activation of macrophage-derived transforming growth factor beta1  
  Curry-McCoy TV, Venado A, Guidot DM, Joshi PC., Respir Res, 1/1/2013
• Nicotinic Acetylcholine Receptors are Sensors for Ethanol in Lung Fibroblasts  
  Ritzenthaler JD, Roser-Page S, Guidot DM, Roman J., Alcoholism: Clin Exp Res, 1/1/2013
• Chronic Alcohol Ingestion in Rats Decreases Krüppel-Like Factor 4 Expression and Intracellular Zinc in the Lung  
  Curry-McCoy TV, Guidot DM, Joshi PC, Alcoholism: Clin Exp Res, 1/1/2013
• Alcohol abuse, the alveolar macrophage, and pneumonia  
  Mehta AJ and Guidot, DM, American Journal of the Medical Sciences, 1/1/2012
• Recruitment and retention in academic medicine--what junior faculty and trainees want department chairs to know  
  Kubiak NT, Guidot DM, Trimm RF, Kamen DL, Roman J, Am J Med Sci, 1/1/2012
• Zinc supplementation restores PU1 and Nrf2 nuclear binding in alveolar macrophages and improves redox balance and bacterial clearance in the lungs of alcohol-fed rats  
  Mehta, A.J., Joshi, P.C., Fan, X, Brown, L.S., Ritzenthaler, J.D., Roman, J. and Guidot, D.M., Alcoholism: Clin Exp Res, 1/1/2011
• Chronic alcohol ingestion exacerbates lung epithelial barrier dysfunction in HIV-1 transgenic rats  
  Fan, X., Joshi, P,C., Koval, M. and Guidot, D.M., Alcoholism: Clin Exp Res, 1/1/2011
• HIV-1 transgene expression in rats induces differential expression of tumor necrosis factor alpha and zinc transporters in the liver and the lung  
  Joshi PC and Guidot DM, AIDS Research & Therapy, 1/1/2011
• Alterations in the immuno-skeletal interface drive bone destruction in HIV-1 transgenic rats  
  Vikulina T., Fan, X., Yamaguchi, M., Roser-Page S., Zayzafoon, M., Guidot, D.M., Ofotokun, I. and Weitzman, M.N., Proc Natl Acad Sci USA, 1/1/2010
• Procysteine increases alcohol-depleted glutathione stores in rat plantaris following a period of abstinence  
  Otis, J.S. and Guidot, D.M., Alcohol, 1/1/2010
• Modeling HIV and Alcohol’s Effects: Focus on the Lung  
  Quintero D. and Guidot, D.M., Alcohol Research & Health, 1/1/2010
• Lung Disease and HIV/AIDS in the HAART Era  
  Morris, A. and Guidot, D.M., Future Medicine - HIV Therapy, 1/1/2010
• HIV-1 transgene expression in rats causes oxidant stress and alveolar epithelial barrier dysfunction  
  Lassiter, C., Fan, X., Joshi, P.C., Jacob, B.A., Sutliff, R.L., Jones, D.P., Koval, M. and Guidot, D.M., AIDS Research & Therapy, 1/1/2009
• Alcohol primes the airway for increased interleukin-13 signaling  
  Mitchell. P.O., Jensen, J.S., Ritzenthaler, J.D., Roman, J., Pelaez, A. and Guidot, D.M., Alcoholism: Clin Exp Res, 1/1/2009
• Procysteine stimulates expression of key anabolic factors and reduces plantaris atrophy in alcohol-fed rats  
  Otis J.S. and Guidot, D.M., Alcoholism: Clin Exp Res, 1/1/2009
• Zinc deficiency mediates alcohol-induced alveolar epithelial and macrophage dysfunction in rats  
  Joshi, P.C., Mehta, A.J., Jabber, W., Fan, X., and Guidot, D.M., American Journal of Respiratory Cell and Molecular Biology, 1/1/2009
• Effect of HIV-1-related protein expression on cardiac and skeletal muscles from transgenic rats  
  Jeffrey S Otis, Yaroslav I Ashikhmin, Lou Ann S Brown and David M Guidot, AIDS Research and Therapy, 1/1/2008
• Alcoholic lung disease  
  Kershaw, C.D. and Guidot, D.M., Alcohol Research & Health, 1/1/2008
• Chronic ethanol ingestion increases aortic endothelial nitric oxide synthase expression and nitric oxide production in the rat  
  Kleinhenz, D.J., Sutliff, R.L., Polikandriotis, J.A., Walp, E.R., Dikalov, S.I., Guidot, D.M. and Hart, C.M., Alcoholism: Clin Exp Res, 1/1/2008
• Na/K-ATPase expression is increased in the lungs of alcohol-fed rats  
  Otis, J.S., Mitchell, P.O., Kershaw, C.D., Joshi, P.C., and Guidot, D.M., Alcoholism: Clin Exp Res, 1/1/2008
• Vascular oxidative stress and nitric oxide depletion in HIV-1 transgenic rats are reversed by glutathione restoration  
  Erik R. Kline, Dean J. Kleinhenz, Bill Liang, Sergey Dikalov, David M. Guidot, C. Michael Hart, Dean P. Jones and Roy L. Sutliff, Am J Physiol: Heart, 1/1/2008
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Books/Book Chapters

• Alcohol Use Disorders and the Lung: A Clinical and Pathophysiological Approach 
  Editors: Mehta, AJ and Guidot, DM.Springer Science, New York, NY2013
• Alcohol Use Disorders and the Lung: A Clinical and Pathophysiological Approach 
  Chapter: A brief history of alcohol use and abuse in human history. 
  Guidot, D.M.Editors: Mehta, AJ and Guidot, DM.Springer Science, New York, NY2013
• Alcohol Use Disorders and the Lung: A Clinical and Pathophysiological Approach 
  Chapter: Alcohol-mediated zinc deficiency within the alveolar space: a potential fundamental mechanism underlying oxidative stress and cellular dysfunction in the alcoholic lung. 
  Guidot, D.M. and Mehta, A.J.Editors: Mehta, AJ and Guidot, DM.Springer Science, New York, NY2013
• Alcohol Use Disorders and the Lung: A Clinical and Pathophysiological Approach 
  Chapter: Disruption in the dynamic balance between transforming growth factor-beta and granulocyte/macrophage colony-stimulating factor signaling within the alveolar space of the alcoholic lung: impact on epit 
  Guidot, D.M. and Mehta, A.J.Editors: Mehta, AJ and Guidot, DM.Springer Science, New York, NY2013
• Alcohol Use Disorders and the Lung: A Clinical and Pathophysiological Approach 
  Chapter: Overview of the evolving recognition of the health effects of excessive alcohol use over the past two centuries including the classic citations. 
  Guidot, D.M. and Mehta, A.J.Editors: Mehta, AJ and Guidot, DM.Springer Science, New York, NY2013
• Etiology and Treatment of Acute Lung Injury: From bench to bedside. Volume 336 in the NATO Science Series. 
  Chapter: Ethanol ingestion, via glutathione depletion, impairs alveolar epithelial function and renders the lung susceptible to acute injury during oxidative stress. 
  Guidot, D.M., Moss, M. and Brown, L.S.Editors: Matalon, S. and Sznajder, J.I..IOS Press, Amsterdam/ Berlin/ Oxford/ Tokyo/ Washington, DC2001
• Understanding the Process of Aging: The roles of mitochondria, free radicals, and antioxidants. 
  Chapter: Mitochondria generate and scavenge superoxide anion. 
  Guidot, D.M. and McCord J.M.Editors: Cadenas, E. and Packer, L..Marcel Dekker, Inc., New York, NY1999
• The Emory University Comprehensive Board Review in Internal Medicine. 
  Chapter: Pulmonary Diagnostic Techniques. 
  Guidot, D.M., Roman, J. and Francis, P.B.Editors: Stein, S.F. and Kokko, J.P..McGraw-Hill, New York, NY1997
• The Internal Medicine Casebook. 
  Chapter: Pleural Disease. 
  Guidot, D.M.Editors: Schrier, R.W..Little, Brown and Co., Boston/New York/Toronto/London1994
• Critical Care Secrets. 
  Chapter: AIDS in the Intensive Care Unit. 
  Guidot, D.M.Editors: Parsons, P.E., Wiener-Kronish, J.P..Hanley & Belfus, Philadelphia, PA1992
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Lectures

• When the Nrf2-ARE defenses fail: insights from studies of HIV and the alcoholic lung. 
  Medical University of South Carolina - 1/1/2014
• How to Successfully Compete For An Academic Job: What Division Directors Wants And Do Not Want in Candidates. 
  San Diego, CA - 1/1/2014
• HIV-related lung disease: a translational approach. 
  Emory University - 1/1/2013
• Elucidating the Mechanisms Underlying the Alcoholic Lung: An Emory Story 
  Wake Forest University, Winston-Salem, NC - 1/1/2013
• Immune enhancement in alcohol abuse and HIV 
  Case Western Reserve University and the Louis Stokes VA, Cleveland, OH - 1/1/2012
• The Alcoholic Lung. 
  San Francisco, CA - 1/1/2012
• The pulmonary complications of alcohol abuse: common and deadly. 
  San Francisco, CA - 1/1/2012
• Can we enhance lung health in people with alcohol use disorders and other forms of chronic oxidative stress? 
  University of Alabama at Birmingham - 1/1/2012
• Zinc and Nrf2: Getting to the source of redox stress in the alcoholic lung. 
  University of South Alabama - 1/1/2011
• Alcohol and Lung Disease: what have we learned thus far? 
  University of Louisville - 1/1/2010
• The Alcoholic Lung: A Physician’s Perspective. 
  University of Pittsburgh - 1/1/2009
• Alcohol Abuse and Pneumonia 
  Toronto, Canada - 1/1/2008
• Alcohol and lung injury; getting the signals crossed. 
  Chicago, IL - 1/1/2007
• Epithelial barrier dysfunction in the alcoholic lung: basic mechanisms and potential therapies. 
  Chicago, IL - 1/1/2007
• The pulmonary complications of alcohol abuse. 
  Miami, FL - 1/1/2007
• The effects of alcohol use in the critically ill: lessons from bench to bedside. 
  San Francisco, CA - 1/1/2007
• Alcohol abuse and lung injury. 
  Shanghai, China - 1/12/2005
• The role of GM-CSF signaling in acute lung injury. 
  Duke University - 1/1/2005
• Impaired cytokine regulation renders the alcoholic lung susceptible to injury from both aberrant immune activation and immune suppression. 
  Santa Barbara, CA - 1/1/2005
• Transfusion therapy: evidence-based approach to a common therapy. 
  1/1/2004
• A novel role for GM-CSF therapy in acute lung injury. 
  1/1/2004
• Transfusion therapy in the ICU. 
  Emory University - 1/1/2004
• Alcohol and alveolar epithelial dysfunction: Implications for acute lung injury and host defense in critically ill patients. 
  Mannheim, Germany - 1/1/2004
• Chronic alcohol abuse and the lung: epidemiology, toxicology, and potential new treatments. 
  University of Pennsylvania - 1/1/2004
• Alcohol abuse and ARDS: Epidemiology and underlying mechanisms. 
  University of Toronto - 1/1/2004
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