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Office
3400 Spruce St
Philadelphia, PA 19104Phone+1 800-789-7366Fax+1 215-662-3953- Is this information wrong?
Summary
- Description of Research Expertise
"Abnormal Mitochondrial Bioenergetic and Motility Signatures in Acute Care Illness in a Translational Approach from Bench to Bedside."
We are interested in studying the interaction of mitochondrial bioenergetics and dynamics in the area of acute care that includes sepsis and acute toxicological poisoning. We are currently taking a translational approach studying the mitochondria at a cell-based level all the way to the clinical setting actively enrolling patients with these acute medical conditions with the goal to develop better prognostic measures with the potential for mitochondrial-directed therapy.
We have both the latest model of the O2k-FluoRespirometer (O2k-Series H) and Seahorse XFe24 to study mitochondrial respiration in both intact and permeabilized cells. In addition we also study mitochondrial dynamics examining both mitochondrial motility and fusion/fission events with microscopy while also examining other mitochondrial functions such as membrane potential and ROS. Combining these elements we aim to better understand the complex interactions of both bioenergetics and motility in issues of acute care to better improve patient care and outcomes.
Our other area of interest includes research objectives relevant to the Office of Naval Research (ONR) where we leverage our expertise in this area to study cellular dysfunction in response to decompression injuries from the cell to clinical in a translational fashion. Our research in this area is also to study more effective treatments directed at the mitochondrial-level to improve function which will result in better safety and performance in naval personnel.
Education & Training
- New York University CTSIMSc, Clinical Investigation, 2012 - 2014
- NYU Grossman School of MedicineFellowship, Medical Toxicology (Emergency Medicine), 2009 - 2011
- UPMC Medical Education (Pittsburgh)Residency, Emergency Medicine, 2006 - 2009
- Tufts University School of MedicineClass of 2006
Certifications & Licensure
- PA State Medical License 2006 - 2024
- NY State Medical License 2009 - 2016
- American Board of Emergency Medicine Emergency Medicine
- American Board of Emergency Medicine Medical Toxicology
Publications & Presentations
PubMed
- Anaerobic Lactate Production Is Associated With Decreased Microcirculatory Blood Flow and Decreased Mitochondrial Respiration Following Cardiovascular Surgery With Car...Fatima M Talebi, Frances S Shofer, Vladimir R Muzykantov, Jan Bakker, John C Greenwood, David H Jang, Audrey E Spelde, Emily K Gordon, Jiri Horak, Michael A Acker, Tod...> ;Critical Care Medicine. 2024 Apr 5
- Investigation of Cerebral Mitochondrial Injury in a Porcine Survivor Model of Carbon Monoxide Poisoning.Constantine D Mavroudis, Alistair Lewis, John C Greenwood, Matthew Kelly, Tiffany S Ko, Rodrigo M Forti, Samuel S Shin, Frances S Shofer, Johannes K Ehinger, Wesley B ...> ;Journal of Medical Toxicology. 2024 Jan 1
- Low postoperative perfused vessel density is associated with increased soluble endothelial cell adhesion molecules during circulatory shock after cardiac surgery.John C Greenwood, Fatima M Talebi, David H Jang, Audrey E Spelde, Emily K Gordon, Jiri Horak, Michael A Acker, Todd J Kilbaugh, Frances S Shofer, John G T Augoustides,...> ;Microvascular Research. 2023 Nov 1
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Grant Support
- ABNORMAL MITOCHONDRIAL BIOENERGETIC AND MOTILITY SIGNATURES IN HUMAN BLOOD CELLS AS INDICES OF ACUTE POISONING IN PATIENTSNational Institute of Health (NHLBI)2018–2021
Professional Memberships
- American College of Medical ToxicologyFellow
Hospital Affiliations
- Hospital of the University of PennsylvaniaPhiladelphia, Pennsylvania
- Penn Presbyterian Medical CenterPhiladelphia, Pennsylvania
- Children's Hospital of PhiladelphiaPhiladelphia, Pennsylvania
External Links
- Pennhttp://www.med.upenn.edu/apps/faculty/index.php/g321/p8749889
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