DavidFreemanKerenMD

Pathology • Ann Arbor, MI

Transplantation Immunology, Anatomic Pathology, Clinical Pathology, Surgical Pathology

Professor of Pathology

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Office
The University of Michigan, 1301 Catherine Street, Ann Arbor, MI
Ann Arbor, MI 48109
Phone+1 734-936-1873

Fax+1 734-936-2756
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Education & Training

Johns Hopkins UniversityResidency, Pathology-Anatomic and Clinical, 1971 - 1976
University of Illinois College of MedicineClass of 1971

Certifications & Licensure

MI State Medical License 1978 - 2026
MD State Medical License 1973 - 1978
American Board of Pathology Anatomic Pathology & Clinical Pathology
American Board of Pathology Immunopathology

Publications & Presentations

PubMed

Retrospective analysis of serum free light chain reference intervals and risk for monoclonal gammopathy suggests different limits than those in international guidelines.
Lee F Schroeder, David M Manthei, David F Keren> ;Clinical Biochemistry. 2023 Aug 1
3 citations
Implementation of INHERET, an Online Family History and Cancer Risk Interpretation Program for Primary Care and Specialty Clinics.
Lynn A McCain, Kara J Milliron, Amanda M Cook, Robert Paquette, Jasmine B Parvaz, Susan D Ernst, Diane M Harper, Philip Zazove, Jim Arthurs, Jerry A Tippie, Bailey Hul...> ;Journal of the National Comprehensive Cancer Network. 2022 Jan 1
1 citations
Reflexing Suspicious β-Region Findings on Capillary Serum Protein Electrophoresis to Immunofixation or Immunosubtraction for Detecting Monoclonal Proteins.
Amanda L Kitson, Alexander S. Taylor, Donald A. Giacherio, David F. Keren> ;American Journal of Clinical Pathology. 2021 Sep 14
2 citations
Prenatal Hemoglobinopathy Evaluation.
David M Manthei, Shih-Hon Li, David F. Keren, Carmen Gherasim> ;Clinical Chemistry. 2021 Sep 1
2 citations
Accurate Quantification of Monoclonal Immunoglobulins Migrating in the Beta Region on Protein Electrophoresis.
Nivin Omar, Kiran Madwani, Pramila Moideen, David M Manthei, David F. Keren, Gurmukh Singh> ;Laboratory Medicine. 2021 Aug 13
12 citations
Laboratory Detection and Initial Diagnosis of Monoclonal Gammopathies: Guideline From the College of American Pathologists in Collaboration With the American Associati...
David F. Keren, Gregary Bocsi, Brooke L. Billman, Joan Etzell, James D Faix, Shaji Kumar, Brea Lipe, Christopher R. McCudden, Roberta Montgomery, David L. Murray, Alex...> ;Archives of Pathology & Laboratory Medicine. 2021 Aug 4
Incorrect Migration of Hemoglobin after Capillary Electrophoresis Software Update Complicates Diagnosis of an Infant with Hemoglobin S/Beta+ Thalassemia
David M Manthei, David Harro, David F. Keren> ;The Journal of Applied Laboratory Medicine. 2021 Sep 1
2 citations
Multiple myeloma presenting as cryoglobulinemic vasculitis.
John S. Runge, Tracie L. Pearson, David F. Keren, Scott D. Gitlin, Erica L. Campagnaro, Lori Lowe, Johann E. Gudjonsson, Alexandra C. Hristov> ;JAAD Case Reports. 2021 Mar 29
27 citations
An international multi-center serum protein electrophoresis accuracy and M-protein isotyping study. Part II: limit of detection and follow-up of patients with small M-...
Joannes F M Jacobs, Katherine A Turner, Maria Stella Graziani, Jody L. Frinack, Michael W Ettore, Jillian R Tate, Ronald A. Booth, Christopher R. McCudden, David F. Ke...> ;Clinical Chemistry and Laboratory Medicine. 2020 Mar 26
3 citations
Expression of Daratumumab and Elotuzumab Migration by Capillary Electrophoresis Relative to Transferrin Improves Precision of Their Identification
Forest Huls, Lee F. Schroeder, David F. Keren> ;The Journal of Applied Laboratory Medicine. 2020 Mar 1
30 citations
An international multi-center serum protein electrophoresis accuracy and M-protein isotyping study. Part I: factors impacting limit of quantitation of serum protein el...
Katherine A Turner, Jody L. Frinack, Michael W Ettore, Jillian R Tate, Maria Stella Graziani, Joannes F M Jacobs, Ronald A. Booth, Christopher R. McCudden, David F. Ke...> ;Clinical Chemistry and Laboratory Medicine. 2020 Mar 26
Commentary.
David F Keren> ;Clinical Chemistry. 2019 May 1
Effect of Diabetes Mellitus on Sickle Hemoglobin Quantitation in Sickle Cell Trait.
Shih-Hon Li, David Harro, John Alfsen, Janet Bolterman, Hemamalini Ketha, Lee F. Schroeder, Donald A. Giacherio, David F. Keren> ;American Journal of Clinical Pathology. 2018 Jul 3
3 citations
A Novel Approach to Estimating M-Protein Concentration: Capillary Electrophoresis Quantitative Immunosubtraction
Lee F. Schroeder, Forest Huls, Christopher L Williams, Shih-Hon Li, David F. Keren> ;The Journal of Applied Laboratory Medicine. 2018 May 1
1 citations
The Lifecycle of an Evidence-Based Laboratory Practice Guideline: Origin, Update, Affirmation, and Impact!
Raouf E. Nakhleh, Patrick L. Fitzgibbons, Jan A. Nowak, Robert M. Najarian, David F. Keren, Terence J. Colgan, Carol Colasacco, Lisa A. Fatheree> ;Archives of Pathology & Laboratory Medicine. 2018 Mar 22
Commentary.
David F Keren> ;Clinical Chemistry. 2018 Feb 1
23 citations
Recognition and management of common, rare, and novel serum protein electrophoresis and immunofixation interferences
Christopher R. McCudden, Joannes F M Jacobs, David F. Keren, Hélène Caillon, Thomas Dejoie, Kristian Thidemann Andersen> ;Clinical Biochemistry. 2018 Jan 1
1 citations
Editorial on laboratory diagnosis and management of plasma cell dyscrasias special issue
David F. Keren, Christopher R. McCudden, Ronald A. Booth> ;Clinical Biochemistry. 2018 Jan 1
19 citations
Screening and Diagnosis of Monoclonal Gammopathies: An International Survey of Laboratory Practice.
Jonathan R. Genzen, David L. Murray, Gyorgy Abel, Qing H. Meng, Richard J. Baltaro, Daniel D. Rhoads, Julio C. Delgado, Rhona J. Souers, Christine Bashleben, David F. ...> ;Archives of Pathology & Laboratory Medicine. 2017 Dec 21
18 citations
A global call to arms for clinical laboratories - Harmonised quantification and reporting of monoclonal proteins.
Jillian R. Tate, David F. Keren, Peter Mollee> ;Clinical Biochemistry. 2018 Jan 1
27 citations
Transforming Laboratory Utilization Review into Laboratory Stewardship: Guidelines by the PLUGS National Committee for Laboratory Stewardship
Jane A. Dickerson, Andrew H. Fletcher, Gary W. Procop, David F. Keren, Joaquin J. Garcia, Robert B. Carpenter, Joe Miles, Brian R. Jackson, Michael L. Astion, Ila R. S...> ;The Journal of Applied Laboratory Medicine. 2017 Sep 1
4 citations
Therapeutic Complications: A Caveat for M-Protein Detection.
David F. Keren> ;The Journal of Applied Laboratory Medicine. 2017 Jan 1
14 citations
Detection of Polyclonal Increases in Immunoglobulin G4 Subclass by Distinct Patterns on Capillary Serum Protein Electrophoresis: Diagnostic Pitfalls and Clinical Obser...
William G. Finn, Ronald Gulbranson, Sondra Fisher, Lynn Rae Sample, Renee Shalhoub, Deborah Hedstrom, David F. Keren> ;American Journal of Clinical Pathology. 2016 Sep 1
4 citations
Multiple myeloma and multiple plasmacytomas associated with free gamma heavy chain, free kappa light chain and IgGk paraproteins: an unusual triple gammopathy
William I Deighan, Maurice O'Kane, Feargal P McNicholl, David F. Keren> ;Annals of Clinical Biochemistry. 2016 May 10
48 citations
Challenges of measuring monoclonal proteins in serum
David F. Keren, Lee F. Schroeder> ;Clinical Chemistry and Laboratory Medicine. 2016 Jun 1
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Journal Articles

Effect of Diabetes Mellitus on Sickle Hemoglobin Quantitation in Sickle Cell Trait
David F Keren, Lee F Schroeder, American Journal of Clinical Pathology

Press Mentions

College of American Pathologists Honors 31 Members/Residents at CAP21 Annual MeetingSeptember 26th, 2021
New CAP Guideline Improves Diagnoses of Patients with Monoclonal GammopathiesAugust 10th, 2021

Hospital Affiliations

University of Michigan Medical CenterAnn Arbor, Michigan
Aleda E. Lutz Department of Veterans Affairs Medical CenterSaginaw, Michigan