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David Knopman, MD, Neurology, Rochester, MN

David S Knopman MD

Neurodegenerative, Dementia & Geriatrics


Professor, Neurology, Mayo Medical School

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  • 200 1st St SwRochester, MN 55905

  • Phone+1 507-284-2511

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Summary

  • Dr. David Knopman is a neurologist at the Mayo Clinic, Rochester. He received his medical degree from University of Minnesota Medical School and has been in practice 42 years. He specializes in neurodegenerative and dementia & geriatrics.

Education & Training

  • University of Minnesota
    University of MinnesotaResidency, Neurology, 1976 - 1979
  • Hennepin Healthcare
    Hennepin HealthcareInternship, Transitional Year, 1975 - 1976
  • University of Minnesota Medical School
    University of Minnesota Medical SchoolClass of 1975
  • Dartmouth College
    Dartmouth CollegeA.B., Biology, 1972

Certifications & Licensure

  • MN State Medical License
    MN State Medical License 1978 - 2026
  • Neurology
    American Board of Psychiatry and Neurology Neurology

Awards, Honors, & Recognition

  • CMS Meaningful Use Stage 1 Certification Centricity Enterprise, GE Healthcare, 2014-2016
  • CMS Meaningful Use Stage 1 Certification Centricity Patient Online, GE Healthcare, 2014-2016
  • CMS Meaningful Use Stage 2 Certification Centricity Patient Online, GE Healthcare, 2014-2016

Clinical Trials

Publications & Presentations

PubMed

Journal Articles

  • Association of Initial Β-amyloid Levels with Subsequent Flortaucipir Positron Emission Tomography Changes in Persons Without Cognitive Impairment  
    David S Knopman, Bradley F Boeve, Ronald C Petersen, Clifford R Jack, JAMA Neurology
  • Rates of Brain Atrophy Across Disease Stages in Familial Frontotemporal Dementia Associated with MAPT, GRN, and C9orf72 Pathogenic Variants  
    Nupur Ghoshal, Neill R Graff-Radford, David S Knopman, Zbigniew K Wszolek, Joel H Kramer, Bradley F Boeve, Howard J Rosen, JAMA Network Open
  • Association Between Functional Performance and Alzheimer's Disease Biomarkers in Individuals Without Dementia  
    Mary M Machulda, Ronald C Petersen, David S Knopman, Yonas E Geda, Journal of the American Geriatrics Society

Books/Book Chapters

Abstracts/Posters

  • Tdp-43 influences cognition, memory loss and hippocampal atrophy in Alzheimer's disease.
    Josephs K, Whitwell J, Weigand S, Murray M, Tosakulwong N, Liesinger A, Petrucelli L, Knopman D, Boeve B, Ivnik R, Smith G, Jack C, Parisi J, Petersen R, Dickson D, J Neuropathol Exp Neurol, 6/1/2014
  • Antemortem characterization of a kindred carrying the non-coding GGGGCC hexanucleotide repeat expansion in C9ORF72.
    Adeli A, Boeve B, DeJesus-Hernandez M, Baker M, Rutherford N, Knopman D, Ivnik R, Fields J, Petersen R, Rademakers R, Neurology, 4/1/2012
  • Characterization of the neuropsychiatric features associated with mutations in C9ORF72'MAPT and PGRN.
    Adeli A, Geda Y, Boeve B, Graff-Radford N, DeJesus-Hernandez M, Knopman D, Josephs K, Pedraza O, Rush B, Fields J, Rutherford N, Baker M, Smith G, Ivnik R, Pankratz V,..., Neurology, 4/1/2012

Lectures

  • Alzheimers Disease 
    Curitiba, Brazil - 4/1/2004
  • Symptoms of Dementia 
    University of Colorado - 3/1/2004
  • 7th International Conference on Alzheimer's Disease 
    7/1/2000

Press Mentions

  • Long COVID Cognitive Symptoms: RECOVER-NEURO Trial Results
    Long COVID Cognitive Symptoms: RECOVER-NEURO Trial ResultsNovember 10th, 2025
  • First Guideline on Alzheimer’s Blood-Based Biomarker Tests Released
    First Guideline on Alzheimer’s Blood-Based Biomarker Tests ReleasedJuly 31st, 2025
  • United States Dementia Cases Estimated to Double by 2060
    United States Dementia Cases Estimated to Double by 2060January 13th, 2025

Grant Support

  • Validating The New Criteria For Preclinical Alzheimer'S DiseaseNational Institute On Aging2012
  • Frontotemporal Degeneration: A Basis For Clinical TrialsNational Institute On Aging2004–2006
  • Frontotemporal Degeneration: A Basis For Clinical TrialsNational Institute On Aging2003
  • Epidemiology Of Alzheimer Disease In A Total PopulationNational Institute On Aging1992–1994
  • Scientific Evaluation And PlanningNational Institute Of Mental Health1991–1994

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