DavidRobertsonMD

Cardiology

Elton Yates Professorship in Autonomic Disorders Professor of Clinical Pharmacology Professor of Neurology Professor of Medicine Vanderbilt University School of Medicine

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Office
AA 3228 Medical Center North
Nashville, TN 37232
Phone+1 615-343-6499
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Education & Training

Johns Hopkins UniversityChief Residency, Internal Medicine, 1978 - 1979
Johns Hopkins UniversityInternship, Internal Medicine, 1973 - 1975
Johns Hopkins UniversityInternship, Internal Medicine, 1973 - 1974
Vanderbilt University School of MedicineClass of 1973

Certifications & Licensure

TN State Medical License 1975 - 2019

Awards, Honors, & Recognition

Elected Member The American Society for Clinical Investigation, 1987

Clinical Trials

Treatment of Orthostatic Hypotension in Autonomic Failure Start of enrollment: 2002 Mar 01
Completed
Phase 1
Treatment of Supine Hypertension in Autonomic Failure Start of enrollment: 2001 Jan 01
Completed
Phase 1
Treatment of Orthostatic Hypotension Start of enrollment: 2004 Jan 01
Terminated
Phase 2, Phase 3
Pathophysiology of Orthostatic Intolerance Start of enrollment: 1996 Dec 01
Recruiting
Not Applicable
Peripheral Dopamine in Postural Tachycardia Syndrome Start of enrollment: 2008 May 01
Completed
Phase 2, Phase 3
Autonomic Failure Patients for RNA Blood Sampling Start of enrollment: 2008 Jul 01
Completed
The Pathophysiology of Orthostatic Hypotension Start of enrollment: 1996 Dec 01
Completed
Phase 1
Long Term Treatment With L-DOPS Start of enrollment: 2004 Sep 01
Approved for marketing
The Renin-Aldosterone Axis in Postural Tachycardia Syndrome Start of enrollment: 2009 Apr 01
Completed
Phase 1
The Role of Endothelin in the Supine Hypertension of Autonomic Failure Start of enrollment: 2010 May 01
Withdrawn
Phase 1
Study of Rifampicin in Multiple System Atrophy Start of enrollment: 2011 Mar 01
Terminated
Phase 3
Contribution of Angiotensin II to Supine Hypertension in Autonomic Failure Start of enrollment: 2011 Mar 01
Terminated
Phase 1
Evaluating the Effectiveness of Intravenous Immunoglobulin Therapy in Autoimmune Autonomic Ganglionopathy Start of enrollment: 2012 Feb 01
Completed
Phase 2, Phase 3
Magnetic Resonance Spectroscopy in Autonomic Failure Start of enrollment: 2012 Jul 01
Terminated
Modafinil and Cognitive Function in POTS Start of enrollment: 2014 Oct 01
Active, not recruiting
Early Phase 1
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Publications & Presentations

PubMed

Management of supine hypertension in patients with neurogenic orthostatic hypotension: scientific statement of the American Autonomic Society, European Federation of A...
Jordan, J.,Fanciulli, A.,Tank, J.,Calandra-Buonaura, G.,Cheshire, W. P.,Cortelli, P.,Eschlboeck, S.,Grassi, G.,Hilz, M. J.,Kaufmann, H.,Lahrmann, H.,Mancia, G.,Mayer, ...> ;J. Hypertens.. 2019 Mar 19
Moving from the present to the future of Postural Tachycardia Syndrome - What we need.
Raj, S. R.,Robertson, D.> ;Auton Neurosci. 2018 Dec 13
5 citations
Hepatic and renal mechanisms underlying the osmopressor response
Tu H. Mai, Emily M. Garland, André Diedrich, David Robertson> ;Autonomic Neuroscience. 2017 Mar 1
Respiratory modulation of human autonomic function: long-term neuroplasticity in space.
Eckberg DL, Diedrich A, Cooke WH, Biaggioni I, Buckey JC, Pawelczyk JA, Ertl AC, Cox JF, Kuusela TA, Tahvanainen KUO, Mano T, Iwase S, Baisch FJ, Levine BD, Adams-Huet...> ;J. Physiol. (Lond.). 2016-10-01
16 citations
Defective Wnt Signaling: A Potential Contributor to Cardiometabolic Disease?
Amy C. Arnold, David Robertson> ;Diabetes. 2015 Oct 1
Neurogenic hyperadrenergic orthostatic hypotension: a newly recognized variant of orthostatic hypotension in older adults with elevated norepinephrine (noradrenaline).
Mar PL, Shibao CA, Garland EM, Black BK, Biaggioni I, Diedrich A, Paranjape SY, Robertson D, Raj SR> ;Clin. Sci.. 2015-07-01
The pain interactome: connecting pain-specific protein interactions.
Jamieson DG, Moss A, Kennedy M, Jones S, Nenadic G, Robertson DL, Sidders B> ;Pain. 2014-11-01
20 citations
Acute volume loading and exercise capacity in postural tachycardia syndrome.
Rocio A. Figueroa, Amy C. Arnold, Victor C. Nwazue, Luis E. Okamoto, Sachin Y. Paranjape, Bonnie K. Black, André Diedrich, David Robertson, Italo Biaggioni, Satish R. ...> ;Journal of Applied Physiology. 2014 Sep 15
30 citations
Calcitonin gene-related peptide (CGRP) in autonomic cardiovascular regulation and vascular structure.
Tu H. Mai, Jing Wu, André Diedrich, Emily M. Garland, David Robertson> ;Journal of the American Society of Hypertension. 2014 May 1
Melatonin reduces tachycardia in Postural Tachycardia Syndrome (POTS): A Randomized, Crossover Trial.
Green, E. A.,Black, B. K.,Biaggioni, I.,Paranjape, S. Y.,Bagai, K.,Shibao, C.,Okoye, M. C.,Dupont, W. D.,Robertson, D.,Raj, S. R.> ;Cardiovasc Ther. 2014 Feb 06
5 citations
Human baroreflex rhythms persist during handgrip and muscle ischaemia
Dwain L. Eckberg, William H. Cooke, André Diedrich, Benjamin D. Levine, James A. Pawelczyk, Jay C. Buckey, Andrew C. Ertl, Italo Biaggioni, James F. Cox, David Roberts...> ;Acta Physiologica. 2013 Oct 1
Pediatric Ptosis as a Sign of Treatable Autonomic Dysfunction
Lara Phillips, Mark R Melson, David Robertson, Karen M Joos> ;Elsevier.
An Increase in Renal Dopamine Does Not Stimulate Natriuresis After Fava Bean Ingestion
David Robertson, Tericka S Cesar> ;The American Journal of Clinical Nutrition.
Influences of Donepezil on Cardiovascular System - Possible Therapeutic Benefits for Heart Failure - DOnepezil Cardiac TEst Registry (DOCTER) Study.
Kubo, T., Sato, T., Noguchi, T., Kitaoka, H., Yamasaki, F., Kamimura, N., Shimodera, S., Iiyama, T., Kumagai, N., Kakinuma, Y., Diedrich, A., Jordan, J., Robertson, D....> ;J Cardiovasc Pharmacol. 2012 Sep
35 citations
A cross-sectional study contrasting olfactory function in autonomic disorders.
Emily M. Garland, Satish R. Raj, Amanda C. Peltier, David Robertson, Italo Biaggioni> ;Neurology. 2011 Feb 1
Orthostatic hypertension: the last hemodynamic frontier.
Robertson D> ;Hypertension. 2011-02-01
Association between albuminuria and duration of diabetes and myocardial dysfunction and peripheral arterial disease among patients with stable coronary artery disease ...
Escobedo J, Rana JS, Lombardero MS, Albert SG, Davis AM, Kennedy FP, Mooradian AD, Robertson DG, Srinivas VS, Gebhart SSP> ;Mayo Clin. Proc.. 2010-01-01
A common biosynthetic pathway governs the dimerization and secretion of inhibin and related transforming growth factor beta (TGFbeta) ligands.
Walton KL, Makanji Y, Wilce MC, Chan KL, Robertson DM, Harrison CA> ;J. Biol. Chem.. 2009-04-03
Suppression of inhibin A biological activity by alterations in the binding site for betaglycan.
Makanji Y, Walton KL, Wilce MC, Chan KL, Robertson DM, Harrison CA> ;J. Biol. Chem.. 2008-06-13
103 citations
The pathophysiology and diagnosis of orthostatic hypotension.
David Robertson> ;Clinical Autonomic Research. 2008 Mar 27
A method for introducing non-silencing siRNA into the guinea pig cochlea in vivo.
Sellick P, Layton MG, Rodger J, Robertson D> ;J. Neurosci. Methods. 2008-01-30
25 citations
Fragile X gene premutation in multiple system atrophy
Emily M. Garland, Cindy L. Vnencak-Jones, Italo Biaggioni, Thomas L. Davis, Thomas J. Montine, David Robertson> ;Journal of the Neurological Sciences. 2004 Dec 15
Anxiolytic-like effects of the corticotropin-releasing factor1 (CRF1) antagonist DMP904 [4-(3-pentylamino)-2,7-dimethyl-8-(2-methyl-4-methoxyphenyl)-pyrazolo-[1,5-a]-p...
Lelas S, Wong H, Li Y, Heman KL, Ward KA, Zeller KL, Sieracki KK, Polino JL, Godonis HE, Ren SX, Yan X, Arneric SP, Robertson DW, Hartig PR, Grossman S, Trainor GL, Ta...> ;J. Pharmacol. Exp. Ther.. 2004-04-01
5 citations
Human Phenotypes and Animal Knockout Models of Genetic Autonomic Disorders
Phillip C. Usera, Simi Vincent, David Robertson> ;Journal of Biomedical Science. 2004 Jan 1
What kind of evidence do we need to justify humanitarian medical aid?
Robertson DW, Bedell R, Lavery JV, Upshur R> ;Lancet. 2002-07-27
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Press Mentions

VUMC Team Discovers New Genetic DiseaseJune 3rd, 2021
Beloved VUMC Colleague and Acclaimed Scientist David Robertson MournedJanuary 24th, 2024

Grant Support

Cardiovascular Regulation: Pathophysiology Of Orthostatic IntoleranceNational Heart, Lung, And Blood Institute2012
Administrative CoreNational Heart, Lung, And Blood Institute2007–2012
Dopamine-B-Hydroxylase In Human Cardiovascular ControlNational Heart, Lung, And Blood Institute2003–2012
Autonomic Cardiovascular RegulationNational Heart, Lung, And Blood Institute1997–2012
Training - Autonomic RARE Diseases Clinical Research ConsortiumNational Institute Of Neurological Disorders And Stroke2009–2011
Autonomic RARE Diseases Clinical Research ConsortiumNational Institute Of Neurological Disorders And Stroke2009–2011
Administrative Unit - Autonomic RARE Diseases Clinical Research ConsortiumNational Institute Of Neurological Disorders And Stroke2009–2011
Autonomic Determinants Of Orthostatic ToleranceNational Heart, Lung, And Blood Institute2007–2011
Echocardiograph And Vascular DopplerNational Center For Research Resources2010
The Genetic Basis Of Autonomic DysfunctionNational Center For Research Resources2005–2008
Autonomic ScreeningNational Center For Research Resources2005–2008
Dynamic Hypovolemia In Orthostatic IntoleranceNational Center For Research Resources2004–2006
Core- AdminNational Heart, Lung, And Blood Institute2003–2006
The Treatment Of Orthostatic TachycardiaNational Center For Research Resources2005
The Treatment Of Orthostatic HypotensionNational Center For Research Resources2005
The Pathophysiology Of Orthostatic HypotensionNational Center For Research Resources2005
Bionic Baroreflex System For Blod Pressure ControlNational Center For Research Resources2005
Yohimbine As A Model Of Orthostatic IntoleranceNational Center For Research Resources2004–2005
The Genetic Basis For Variable Response To YohimbineNational Center For Research Resources2004–2005
Autonomic Effects Of ModafinilNational Center For Research Resources2004–2005
Treatment Of Orthostatic TachycardiaNational Center For Research Resources1998–2005
Structual Genomics Of Norepinephrine TransportersNational Heart, Lung, And Blood Institute2004
Pathophysiology Of Orthostatic IntoleranceNational Heart, Lung, And Blood Institute2002
Physiological Determinants Of Dynamic Postural Blood Volume ChangesNational Center For Research Resources1999–2002
Fluid Balance In Orthostatic IntoleranceNational Center For Research Resources1998–2002
Autonomic Neurophysiology In MicrogravityNational Center For Research Resources1997–2002
Medical Scientist Training ProgramNational Institute Of General Medical Sciences1993–2002
Autonomic Caridovascular RegulationNational Heart, Lung, And Blood Institute1998–2001
Autonomic Pathophysiology Of Orthostatic IntoleranceNational Heart, Lung, And Blood Institute1997–2001
Sympathetic Nervous System In The Anemia Of WeightlessnessNational Center For Research Resources1996–2000
Pathophysiology, Pharmacology, And Treatment Of Orthostatic TachycardiaNational Center For Research Resources1996–2000
Autonomic Neurophysiology In MicrogravityNational Institute Of Neurological Disorders And Stroke1995–1998
Clinical Pharmacology Of Dopamine-Beta-HydroxylaseNational Heart, Lung, And Blood Institute1990–1994
Insulin Signal Transduction And Insulin ResistanceNational Institute Of Diabetes And Digestive And Kidney Diseases1988–1992
Adenosine And Cardiovascular Homeostasis In ManNational Heart, Lung, And Blood Institute1987–1990
Insulin Signal Transduction: Modulation And RegulationNational Institute Of Diabetes And Digestive And Kidney Diseases1988
Adenosine And Cardiovascular Hemeostasis In ManNational Heart, Lung, And Blood Institute1986
Clinical Pharmacology Of Cardiovascular ControlNational Institute Of General Medical Sciences1985