DavidJShapiroDO

PubMed

• Estrogen-Independent Myc Overexpression Confers Endocrine Therapy Resistance on Breast Cancer Cells Expressing ERαY537S and ERαD538G Mutations.
  Yu, L.,Wang, L.,Mao, C.,Duraki, D.,Kim, J. E.,Huang, R.,Helferich, W. G.,Nelson, E. R.,Park, B. H.,Shapiro, D. J.> ;Cancer Lett.. 2018 Nov 13
• A New Role for Estrogen Receptor α in Cell Proliferation and Cancer: Activating the Anticipatory Unfolded Protein Response.
  Livezey, M.,Kim, J. E.,Shapiro, D. J.> ;Front Endocrinol (Lausanne). 2018 Jul 03
• Estrogen receptor-α and aryl hydrocarbon receptor involvement in the actions of botanical estrogens in target cells.
  Gong P, Madak-Erdogan Z, Flaws JA, Shapiro DJ, Katzenellenbogen JA, Katzenellenbogen BS> ;Mol. Cell. Endocrinol.. 2016-12-05
• Interplay between steroid hormone activation of the unfolded protein response and nuclear receptor action.
  Zheng, X.,Andruska, N.,Yu, L.,Mao, C.,Kim, J. E.,Livezey, M.,Helferich, W. G.,Shapiro, D. J.> ;Steroids. 1900 Jan 01
• Anticipatory activation of the unfolded protein response by epidermal growth factor is required for immediate early gene expression and cell proliferation.
  Yu, L.,Andruska, N.,Zheng, X.,Shapiro, D. J.> ;Mol. Cell. Endocrinol.. 2015 Nov 10
• 56 citations
  Estrogen receptor α inhibitor activates the unfolded protein response, blocks protein synthesis, and induces tumor regression.
  Neal Andruska, Xiaobin Zheng, Xujuan Yang, Chengjian Mao, Mathew M. Cherian, Lily Mahapatra, William G. Helferich, David J. Shapiro> ;Proceedings of the National Academy of Sciences of the United States of America. 2015 Apr 14
• Anticipatory estrogen activation of the unfolded protein response is linked to cell proliferation and poor survival in estrogen receptor α-positive breast cancer.
  Andruska, N.,Zheng, X.,Yang, X.,Helferich, W. G.,Shapiro, D. J.> ;Oncogene. 2014 Sep 30
• The immune system and inflammation in breast cancer.
  Jiang, X.,Shapiro, D. J.> ;Mol. Cell. Endocrinol.. 2013 Jun 25
• High-Throughput Fluorescence Anisotropy Screen for Inhibitors of the Oncogenic mRNA Binding Protein, IMP-1.
  Mahapatra, L.,Mao, C.,Andruska, N.,Zhang, C.,Shapiro, D. J.> ;J Biomol Screen. 2013 Oct 11
• Fluorescence anisotropy microplate assay to investigate the interaction of full-length steroid receptor coactivator-1a with steroid receptors.
  Zhang, C.,Nordeen, S. K.,Shapiro, D. J.> ;Methods Mol. Biol.. 2013
• Evaluation of a luciferase-based reporter assay as a screen for inhibitors of estrogen-ERα-induced proliferation of breast cancer cells.
  Andruska N, Mao C, Cherian M, Zhang C, Shapiro DJ> ;J Biomol Screen. 2012-08-01
• A competitive inhibitor that reduces recruitment of androgen receptor to androgen-responsive genes.
  Cherian MT, Wilson EM, Shapiro DJ> ;J. Biol. Chem.. 2012-07-06
• Cellular pregnenolone esterification by acyl-CoA:cholesterol acyltransferase.
  Rogers MA, Liu J, Kushnir MM, Bryleva E, Rockwood AL, Meikle AW, Shapiro D, Vaisman BL, Remaley AT, Chang CCY, Chang T> ;J. Biol. Chem.. 2012-05-18
• 8-alkylthio-6-thio-substituted theophylline analogues as selective noncompetitive progesterone receptor antagonists.
  Aninye IO, Berg KC, Mollo AR, Nordeen SK, Wilson EM, Shapiro DJ> ;Steroids. 2012-05-01
• Small molecule inhibitors as probes for estrogen and androgen receptor action.
  Shapiro, D.J., Mao, C., Cherian, M.T.> ;J Biol Chem. 2011 Feb 11
• Posttranscriptional suppression of proto-oncogene c-fms expression by vigilin in breast cancer.
  Woo, H., Yi, X., Lamb, T., Menzl, I., Baker, T., Shapiro, D.J., Chambers, S.K.> ;Mol Cell Biol. 2011 Jan
• A noncompetitive small molecule inhibitor of estrogen-regulated gene expression and breast cancer cell growth that enhances proteasome-dependent degradation of estroge...
  Kretzer, N.M., Cherian, M.T., Mao, C., Aninye, I.O., Reynolds, P.D., Schiff, R., Hergenrother, P.J., Nordeen, S.K., Wilson, E.M., Shapiro, D.J.> ;J Biol Chem. 2010 Dec 31
• Differential requirements of Hsp90 and DNA for the formation of estrogen receptor homodimers and heterodimers.
  Powell, E., Wang, Y., Shapiro, D.J., Xu, W.> ;J Biol Chem. 2010 May 21
• High-resolution x-ray diffraction microscopy of specifically labeled yeast cells.
  Nelson J, Huang X, Steinbrener J, Shapiro D, Kirz J, Marchesini S, Neiman AM, Turner JJ, Jacobsen C> ;Proc. Natl. Acad. Sci. U.S.A.. 2010-04-20
• Low concentrations of the soy phytoestrogen genistein induce proteinase inhibitor 9 and block killing of breast cancer cells by immune cells.
  Jiang, X., Patterson, N.M., Ling, Y., Xie, J., Helferich, W.G., Shapiro, D.J.> ;Endocrinology. 2008 Nov
• A new small molecule inhibitor of estrogen receptor alpha binding to estrogen response elements blocks estrogen-dependent growth of cancer cells.
  Mao, C., Patterson, N.M., Cherian, M.T., Aninye, I.O., Zhang, C., Montoya, J.B., Cheng, J., Putt, K.S., Hergenrother, P.J., Wilson, E.M., Nardulli, A.M., Nordeen, S.K....> ;J Biol Chem. 2008 May 9
• Tamoxifen induction of CCAAT enhancer-binding protein alpha is required for tamoxifen-induced apoptosis.
  Cheng, J., Yu, D.V., Zhou, J., Shapiro, D.J.> ;J Biol Chem. 2007 Oct 19
• A functional serine 118 phosphorylation site in estrogen receptor-alpha is required for down-regulation of gene expression by 17beta-estradiol and 4-hydroxytamoxifen.
  Cheng, J., Zhang, C., Shapiro, D.J.> ;Endocrinology. 2007 Oct
• Delayed and persistent ERK1/2 activation is required for 4-hydroxytamoxifen-induced cell death.
  Zhou, J., Yu, D.V., Cheng, J., Shapiro, D.J.> ;Steroids. 2007 Oct
• In vitro fluorescence anisotropy analysis of the interaction of full-length SRC1a with estrogen receptors alpha and beta supports an active displacement model for core...
  Wang, S., Zhang, C., Nordeen, S.K., Shapiro, D.J.> ;J Biol Chem. 2007 Feb 2
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