
David J Tweardy MD
Head, Division of Internal Medicine, Professor of Infectious Diseases and Molecular & Cellular Oncology, University of Texas MD Anderson Cancer Center
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1515 Holcombe BlvdHouston, TX 77030
Phone+1 713-792-6161
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Education & Training
Case Western Reserve University/University Hospitals Cleveland Medical CenterResidency, Internal Medicine, 1978 - 1983
Case Western Reserve University/University Hospitals Cleveland Medical CenterFellowship, Infectious Disease, 1980 - 1982
Harvard Medical SchoolClass of 1978
Princeton UniversityA.B., Chemistry, Cum Laude, 1970 - 1974
Certifications & Licensure
FL State Medical License 2021 - Present
TX State Medical License 2000 - 2028
PA State Medical License 1984 - 2000
OH State Medical License 1982 - 1986
American Board of Internal Medicine Internal Medicine
American Board of Internal Medicine Infectious Disease
Awards, Honors, & Recognition
- Who’s Who in America Marquis, 2007
- Who's Who in Medicine and Healthcare Marquis, 2006
- Who's Who in Science and Engineering Marquis, 2006
Publications & Presentations
PubMed
- Colitis-Associated Colorectal Cancer-STAT3 Inhibition as a Preventive Strategy.Prema Robinson, Tan Hoang, Zara Italia, Zal Italia, Chia-Chi Chang
International Journal of Molecular Sciences. 2026-09-20 - BCM-MD Anderson onco-medicine track: a novel internal medicine residency pathway to strengthen the supportive cancer care workforce.Ellen F Manzullo, Saadia A Faiz, Richard J Hamill, David J Tweardy, Charity A Sembera
Supportive Care in Cancer. 2025-12-18 - 3 citationsSTAT3 Inhibition to Treat Ulcerative Colitis-Associated Colorectal Cancer.Prema Robinson, Zal Italia, Zara Italia, Tan Hoang, Emma Rodriguez
International Journal of Molecular Sciences. 2025-11-06
Journal Articles
- Adult Intracranial Tuberculoma Case Series from Houston, Texas: a report of 13 consecutive patientsKelly JD, Teeter LD, Graviss EA and Tweardy DJ, Scand J Infect Dis, 10/1/2011
- IL-6-Mediated Activation of Stat3 alpha Prevents Trauma/Hemorrhagic Shock-Induced Liver InflammationMoran A, Thacker SA, Arikan AA, Mastrangelo MA, Wu Y, Yu B and Tweardy DJ, PLoS ONE, 6/29/2011
- Stat5: From Breast Development to Cancer Prognosis, Prediction, and ProgressionTweardy DJ and Chang JC, J Clin Oncol, 6/1/2011
Books/Book Chapters
Lectures
- Drugging STAT proteins to treat inflammation and cancerInternal Medicine and Cancer Survivorship Grand Rounds, UT M.D. Anderson Cancer Center, Houston, TX - 11/16/2012
- Drugging STAT proteins to treat cancer and inflammatory disordersVerna and Marrs McLean Department of Biochemistry and Molecular Biology Research Seminar, Baylor Col - 4/26/2012
- Contributions of Abnormal Proteostasis to Cellular DysfunctionPlenary Symposium Presentation, 34th Annual Conference on Shock, Norfolk, VA - 6/12/2011
Press Mentions
Biopharmaceutical Co. Tvardi Therapeutics Raises $74M to Advance Clinical Pipeline, Grow TeamJune 23rd, 2021
Tvardi Snags $74M to Weed the Tumor Garden with STAT3 InhibitorJune 23rd, 2021
12 COVID-19 Vaccine Questions, AnsweredAugust 11th, 2020
Grant Support
- Targeting head and neck cancer cells and the adverse tumor microenvironment with a novel small-molecule STAT3 inhibitorUNIVERSITY OF TX MD ANDERSON CAN CTR2022–2027
- Targeting non-small cell lung cancer cells and the adverse tumor microenvironment with a small-molecule STAT3 inhibitorUNIVERSITY OF TX MD ANDERSON CAN CTR2023–2026
- STAT3 Probes That Target Breast Cancer Stem CellsNational Cancer Institute2010–2011
- Research Training In Infections And ImmunityNational Institute Of Allergy And Infectious Diseases2003–2011
- Reversal Of Hypovolemic Circulatory Collapse By IL-6National Heart, Lung, And Blood Institute2004–2007
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