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David Whitcomb, MD, Gastroenterology, Pittsburgh, PA

David C Whitcomb MD

Pancreas Disease


Professor, Medicine, University of Pittsburgh School of Medicine

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  • 200 Lothrop St# DigestivPittsburgh, PA 15213

  • Phone+1 412-647-8666

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Summary

  • Professor David C. Whitcomb MD, PhD is a pioneer in using mathematics, genetics, neurosciences, immunology, epidemiology, and clinical sciences to study complex inflammatory disorders and cancer risks, with a focus on the pancreas (i.e. pancreatitis, pancreatic cancer and diabetes mellitus) and gastrointestinal disorders. He served as Chief of the Division of Gastroenterology, Hepatology and Nutrition at the University of Pittsburgh from 1999 to 2016, building it into a Top 5 ranked program by US News & World Report. He founded PancreasFest, an annual international translational research meeting that became the world’s leading pancreatic research conference for over two decades. Professor Whitcomb has published over 400 papers, reviews, and book chapters, with >40,000 citations, an h-index of >100, and an i10-index of >300.

    Professor Whitcomb completed an MS and a PhD in Physiology and received his MD, all from The Ohio State University. This was followed by postdoctoral training at Duke University, including internal medicine residency and a gastroenterology fellowship. He joined the University of Pittsburgh and UPMC as a physician-scientist in 1991, eventually holding the Giant Eagle Foundation Professor of Cancer Genetics endowed chair, and served as Professor of Medicine, Professor of Cell Biology & Molecular Physiology, and Professor of Human Genetics until 2022.

    Professor Whitcomb is currently Adjunct Professor of Biomedical Engineering at Carnegie Mellon University in Pittsburgh, where he teaches precision medicine, and Adjunct Professor of Gastroenterology, Christian Medical College, Vellore, India. As co-founder of Ariel Precision Medicine Inc. and SMART-MD Publishing LLC, he continues to advance precision medicine in pancreatic diseases, focusing on genetic risk stratification, personalized therapies, drug development, clinical trials, and clinical decision support systems.

Education & Training

  • Duke University Hospital
    Duke University HospitalFellowship, Gastroenterology, 1988 - 1990
  • Duke University Hospital
    Duke University HospitalResidency, Internal Medicine, 1985 - 1988
  • Ohio State University College of Medicine
    Ohio State University College of MedicineClass of 1985

Certifications & Licensure

  • PA State Medical License
    PA State Medical License 1991 - 2026
  • NC State Medical License
    NC State Medical License 1986 - 1998
  • Internal Medicine
    American Board of Internal Medicine Internal Medicine

Awards, Honors, & Recognition

  • Fellow (AGAF) American Gastroenterological Association, 2011
  • Elected Member The American Society for Clinical Investigation, 2000
  • Fellow (FACG) American College of Gastroenterology

Clinical Trials

Publications & Presentations

PubMed

Journal Articles

  • Protease-Sensitive Pancreatic Lipase Variants Are Associated with Early Onset Chronic Pancreatitis  
    David C Whitcomb, M Michael Barmada, The American Journal of Gastroenterology
  • Hereditary Pancreatitis in the United States: Survival and Rates of Pancreatic Cancer  
    Chandraprakash Umapathy, David C Whitcomb, Dhiraj Yadav, Nature
  • Recurrent Acute Pancreatitis Significantly Reduces Quality of Life Even in the Absence of Overt Chronic Pancreatitis  
    Dhiraj Yadav, Bimaljit S Sandhu, Nalini M Guda, Vikesh K Singh, John Baillie, Randall Brand, Andres Gelrud, David C Whitcomb, Darwin Conwell, Stuart Sherman, Adam Sliv..., Nature

Lectures

  • PancreasFest 2012: Pancreatic Cancer Risk, Early Detection, Diagnosis & Treatment 
    UPMC Life Changing Medicine, Pittsburgh, Pennsylvania - 7/26/2012

Other

Press Mentions

  • Diagnosis and Management of Exocrine Pancreatic Insufficiency
    Diagnosis and Management of Exocrine Pancreatic InsufficiencyNovember 19th, 2024
  • Guideline Rewind: 10 Clinical Updates That Revamped GI, Hepatology Practice in 2023
    Guideline Rewind: 10 Clinical Updates That Revamped GI, Hepatology Practice in 2023December 29th, 2023
  • Chutes & Ladders—Pfizer Taps McKinsey U.S. Managing Partner as New M&a Leader
    Chutes & Ladders—Pfizer Taps McKinsey U.S. Managing Partner as New M&a LeaderAugust 27th, 2021

Grant Support

  • Feeding And Pancreatic REST In Acute PancreatitisNational Institute Of Diabetes And Digestive And Kidney Diseases2007–2012
  • NAPS2 Continuation Genome Wide Association Study Of PancreatitisNational Institute Of Diabetes And Digestive And Kidney Diseases2011
  • Digestive Diseases Training ProgramNational Institute Of Diabetes And Digestive And Kidney Diseases2003–2011
  • Pancreasfest 2010: Defining &Classifying Disease To Enhance Research &CareNational Institute Of Diabetes And Digestive And Kidney Diseases2010
  • Naps2-As: RACE Dependent Risk For PancreatitisNational Institute Of Diabetes And Digestive And Kidney Diseases2010

Professional Memberships

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