
David C Whitcomb MD
Pancreas Disease
Professor, Medicine, University of Pittsburgh School of Medicine
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200 Lothrop St# DigestivPittsburgh, PA 15213
Phone+1 412-647-8666
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Summary
- Professor David C. Whitcomb MD, PhD is a pioneer in using mathematics, genetics, neurosciences, immunology, epidemiology, and clinical sciences to study complex inflammatory disorders and cancer risks, with a focus on the pancreas (i.e. pancreatitis, pancreatic cancer and diabetes mellitus) and gastrointestinal disorders. He served as Chief of the Division of Gastroenterology, Hepatology and Nutrition at the University of Pittsburgh from 1999 to 2016, building it into a Top 5 ranked program by US News & World Report. He founded PancreasFest, an annual international translational research meeting that became the world’s leading pancreatic research conference for over two decades. Professor Whitcomb has published over 400 papers, reviews, and book chapters, with >40,000 citations, an h-index of >100, and an i10-index of >300.
Professor Whitcomb completed an MS and a PhD in Physiology and received his MD, all from The Ohio State University. This was followed by postdoctoral training at Duke University, including internal medicine residency and a gastroenterology fellowship. He joined the University of Pittsburgh and UPMC as a physician-scientist in 1991, eventually holding the Giant Eagle Foundation Professor of Cancer Genetics endowed chair, and served as Professor of Medicine, Professor of Cell Biology & Molecular Physiology, and Professor of Human Genetics until 2022.
Professor Whitcomb is currently Adjunct Professor of Biomedical Engineering at Carnegie Mellon University in Pittsburgh, where he teaches precision medicine, and Adjunct Professor of Gastroenterology, Christian Medical College, Vellore, India. As co-founder of Ariel Precision Medicine Inc. and SMART-MD Publishing LLC, he continues to advance precision medicine in pancreatic diseases, focusing on genetic risk stratification, personalized therapies, drug development, clinical trials, and clinical decision support systems.
Education & Training
Duke University HospitalFellowship, Gastroenterology, 1988 - 1990
Duke University HospitalResidency, Internal Medicine, 1985 - 1988
Ohio State University College of MedicineClass of 1985
Certifications & Licensure
PA State Medical License 1991 - 2026
NC State Medical License 1986 - 1998
American Board of Internal Medicine Internal Medicine
Awards, Honors, & Recognition
- Fellow (AGAF) American Gastroenterological Association, 2011
- Elected Member The American Society for Clinical Investigation, 2000
- Fellow (FACG) American College of Gastroenterology
Clinical Trials
Publications & Presentations
PubMed
- Circulating Molecular Drivers of Bone Remodeling in Pancreatitis.Rachel L Hill, Dhiraj Yadav, Phil A Hart, David C Whitcomb, Kristen J McQuerry
Clinical and Translational Gastroenterology. 2025-12-01 - Recurrent Acute Pancreatitis: Many Faces(/Facets) of a Challenging Disease.Dhiraj Yadav, Nicholas J Zyromski, David C Whitcomb, Melena D Bellin, Gregory A Cote
Gastroenterology. 2025-07-01 - 1 citationsProtocol and Study Population of a Prospective Study of Patients With Chronic Pancreatitis and Exocrine Pancreatic Insufficiency: Preliminary Findings From the PACT-CP...Jodie A Barkin, Samer Al-Kaade, Rahul Pannala, Yasmin Hernandez-Barco, Janine Twal
Pancreas. 2025-04-01
Journal Articles
- Protease-Sensitive Pancreatic Lipase Variants Are Associated with Early Onset Chronic PancreatitisDavid C Whitcomb, M Michael Barmada, The American Journal of Gastroenterology
- Hereditary Pancreatitis in the United States: Survival and Rates of Pancreatic CancerChandraprakash Umapathy, David C Whitcomb, Dhiraj Yadav, Nature
- Recurrent Acute Pancreatitis Significantly Reduces Quality of Life Even in the Absence of Overt Chronic PancreatitisDhiraj Yadav, Bimaljit S Sandhu, Nalini M Guda, Vikesh K Singh, John Baillie, Randall Brand, Andres Gelrud, David C Whitcomb, Darwin Conwell, Stuart Sherman, Adam Sliv..., Nature
Lectures
- PancreasFest 2012: Pancreatic Cancer Risk, Early Detection, Diagnosis & TreatmentUPMC Life Changing Medicine, Pittsburgh, Pennsylvania - 7/26/2012
Other
- Hereditary pancreatitisWhitcomb DC
http://www.uptodate.com/contents/hereditary-pancreatitis
UpToDate, Wolters Kluwer Health - 2012-08-08 - Hypertriglyceridemia-induced acute pancreatitisWhitcomb DC, Gelrud A
http://www.uptodate.com/contents/hypertriglyceridemia-induced-acute-pancreatitis
UpToDate, Wolters Kluwer Health - 2013-03-01
Press Mentions
Diagnosis and Management of Exocrine Pancreatic InsufficiencyNovember 19th, 2024
Guideline Rewind: 10 Clinical Updates That Revamped GI, Hepatology Practice in 2023December 29th, 2023
Chutes & Ladders—Pfizer Taps McKinsey U.S. Managing Partner as New M&a LeaderAugust 27th, 2021
Grant Support
- Feeding And Pancreatic REST In Acute PancreatitisNational Institute Of Diabetes And Digestive And Kidney Diseases2007–2012
- NAPS2 Continuation Genome Wide Association Study Of PancreatitisNational Institute Of Diabetes And Digestive And Kidney Diseases2011
- Digestive Diseases Training ProgramNational Institute Of Diabetes And Digestive And Kidney Diseases2003–2011
- Pancreasfest 2010: Defining &Classifying Disease To Enhance Research &CareNational Institute Of Diabetes And Digestive And Kidney Diseases2010
- Naps2-As: RACE Dependent Risk For PancreatitisNational Institute Of Diabetes And Digestive And Kidney Diseases2010
Professional Memberships
- Fellow
- Fellow
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