DavidCWilliamsJr.MD

PubMed

• 24 citations
  The Nucleosome Remodeling and Deacetylase Complex Has an Asymmetric, Dynamic, and Modular Architecture.
  Jason Low, Ana P. G. Silva, Mehdi Sharifi Tabar, Mario Torrado, Sarah R. Webb, Benjamin L. Parker, Maryam Sana, Callum Smits, Jason W. Schmidberger, Lou Brillault, Mat...> ;Cell Reports. 2020 Dec 1
• 7 citations
  VE-1902-A direct thrombin inhibitor with reversible covalent mechanism of action shows efficacy with reduced bleeding in rodent models of thrombosis.
  Mohanram Sivaraja, Daniel M. Clemens, Sivan Sizikov, Subhadra Dash, Chengpei Xu, Matthew Rienzo, Bo Yang, Molly Ryan, Madhuri Chattopadhyay, Lev Igoudin, Stephanie S C...> ;Thrombosis Research. 2020 Apr 19
• 8 citations
  DNA looping by two 5-methylcytosine-binding proteins quantified using nanofluidic devices.
  Ming Liu, Saeid Movahed, Saroj Dangi, Hai Pan, Parminder Kaur, Stephanie M. Bilinovich, Edgar M. Faison, Gage O. Leighton, Hong Wang, David C. Williams, Robert Riehn> ;Epigenetics & Chromatin. 2020 Mar 16
• 26 citations
  The Methyl-CpG-Binding Domain 2 and 3 Proteins and Formation of the Nucleosome Remodeling and Deacetylase Complex.
  Gage O. Leighton, David C. Williams> ;Journal of Molecular Biology. 2020 Mar 13
• 6 citations
  Thermodynamic consequences of Tyr to Trp mutations in the cation–π-mediated binding of trimethyllysine by the HP1 chromodomain
  Mackenzie W. Krone, Katherine I. Albanese, Gage O. Leighton, Cyndi Qixin He, Ga Young Lee, Marc Garcia-Borràs, Alex J. Guseman, David C. Williams, K. N. Houk, Eric M. ...> ;Chemical Science. 2020 Mar 4
• 33 citations
  Disruption of the MBD2-NuRD complex but not MBD3-NuRD induces high level HbF expression in human adult erythroid cells
  Xiaofei Yu, Alexander Azzo, Stephanie M. Bilinovich, Xia Li, Mikhail Dozmorov, Ryo Kurita, Yukio Nakamura, David C. Williams, Gordon D. Ginder> ;Haematologica. 2019 Dec 1
• 4 citations
  Corrigendum to "Readers of DNA methylation, the MBD family as potential therapeutic targets" [Pharmacology & Therapeutics 184 (1) (2018) 98-111].
  Gordon D. Ginder, David C. Williams> ;Pharmacology & Therapeutics. 2018 Oct 1
• 12 citations
  Reversible covalent direct thrombin inhibitors.
  Mohanram Sivaraja, Nicola Pozzi, Matthew Rienzo, Kenneth Lin, Timothy Shiau, Daniel M. Clemens, Lev Igoudin, Piotr Zalicki, Stephanie S Chang, M. Angels Estiarte, Kevi...> ;Plos One. 2018 Aug 2
• 40 citations
  Refinement of the subunit interaction network within the nucleosome remodelling and deacetylase (NuRD) complex.
  Mario Torrado, Jason Low, Ana P. G. Silva, Jason W. Schmidberger, Maryam Sana, Mehdi Sharifi Tabar, Musa E. Isilak, Courtney S. Winning, Cherry Kwong, Max J. Bedward, ...> ;The FEBS Journal. 2017 Dec 1
• 45 citations
  Readers of DNA methylation, the MBD family as potential therapeutic targets
  Gordon D. Ginder, David C. Williams> ;Pharmacology & Therapeutics. 2017 Nov 8
• 17 citations
  CpG and methylation-dependent DNA binding and dynamics of the methylcytosine binding domain 2 protein at the single-molecule level
  Hai Pan, Stephanie M. Bilinovich, Parminder Kaur, Robert Riehn, Hong Wang, David C. Williams> ;Nucleic Acids Research. 2017 Sep 6
• 27 citations
  Structural Basis of MeCP2 Distribution on Non-CpG Methylated and Hydroxymethylated DNA
  M. Jeannette Sperlazza, Stephanie M. Bilinovich, Leander M. Sinanan, Fatima Razelle Javier, David C. Williams> ;Journal of Molecular Biology. 2017 May 19
• 19 citations
  Methylation specific targeting of a chromatin remodeling complex from sponges to humans.
  Jason M. Cramer, Deborah Pohlmann, Fernando Gomez, Leslie Mark, Benjamin Kornegay, Chelsea Hall, Edhriz Siraliev-Perez, Ninad M. Walavalkar, M. Jeannette Sperlazza, St...> ;Scientific Reports. 2017 Jan 17
• 11 citations
  Krüppel-Like Transcription Factor KLF1 Is Required for Optimal γ- and β-Globin Expression in Human Fetal Erythroblasts
  Divya S. Vinjamur, Yousef N. Alhashem, Safa F. Mohamad, Parth B. Amin, David C. Williams, Joyce A. Lloyd> ;Plos One. 2016 Feb 3
• 11 citations
  Dissecting the structural basis of MEIG1 interaction with PACRG
  Wei Li, Ninad M. Walavalkar, William A. Buchwald, Maria E. Teves, Ling Zhang, Hong Liu, Stephanie M. Bilinovich, Darrell L. Peterson, Jerome F. Strauss, David C. Willi...> ;Scientific Reports. 2016 Jan 4
• 17 citations
  Longitudinal trends in all healthcare-associated infections through comprehensive hospital-wide surveillance and infection control measures over the past 12 years: sub...
  Hajime Kanamori, David J. Weber, Lauren M. DiBiase, Emily E. Sickbert-Bennett, Rebecca H. Brooks, Lisa Teal, David C. Williams, Elizabeth Walters, William A. Rutala> ;Infection Control and Hospital Epidemiology. 2015 Jun 25
• 44 citations
  An intrinsically disordered region of methyl-CpG binding domain protein 2 (MBD2) recruits the histone deacetylase core of the NuRD complex
  Megha Desai, Heather D. Webb, Leander M. Sinanan, J. Neel Scarsdale, Ninad M. Walavalkar, Gordon D. Ginder, David C. Williams> ;Nucleic Acids Research. 2015 Mar 31
• 41 citations
  A MEIG1/PACRG complex in the manchette is essential for building the sperm flagella
  Wei Li, Waixing Tang, Maria E. Teves, Zhengang Zhang, Ling Zhang, Hongfei Li, Kellie J. Archer, Darrell L. Peterson, David C. Williams, Jerome F. Strauss, Zhibing Zhang> ;Development. 2015 Mar 1
• Peptide Library Approach to Uncover Phosphomimetic Inhibitors of the BRCA1 C-Terminal Domain.
  White, E. R.,Sun, L.,Ma, Z.,Beckta, J. M.,Danzig, B. A.,Hacker, D. E.,Huie, M.,Williams, D. C.,Edwards, R. A.,Valerie, K.,Glover, J. N.,Hartman, M. C.> ;ACS Chem. Biol.. 2015 Feb 06
• 23 citations
  Solution structure and intramolecular exchange of methyl-cytosine binding domain protein 4 (MBD4) on DNA suggests a mechanism to scan for mCpG/TpG mismatches
  Ninad M. Walavalkar, Jason M. Cramer, William A. Buchwald, J. Neel Scarsdale, David C. Williams> ;Nucleic Acids Research. 2014 Sep 29
• 42 citations
  Probing the Dynamic Distribution of Bound States for Methylcytosine-binding Domains on DNA
  Jason M. Cramer, J. Neel Scarsdale, Ninad M. Walavalkar, William A. Buchwald, Gordon D. Ginder, David C. Williams> ;The Journal of Biological Chemistry. 2014 Jan 17
• 117 citations
  Dual Inhibition of Bcl-2 and Bcl-xL Strikingly Enhances PI3K Inhibition-Induced Apoptosis in Human Myeloid Leukemia Cells through a GSK3- and Bim-Dependent Mechanism
  Mohamed Rahmani, Mandy Mayo Aust, Elisa Attkisson, David C. Williams, Andrea Ferreira-Gonzalez, Steven Grant> ;Cancer Research. 2013 Feb 15
• 26 citations
  Unique Features of the Anti-parallel, Heterodimeric Coiled-coil Interaction between Methyl-cytosine Binding Domain 2 (MBD2) Homologues and GATA Zinc Finger Domain Cont...
  Ninad M. Walavalkar, Nathaniel Gordon, David C. Williams> ;The Journal of Biological Chemistry. 2013 Feb 1
• 59 citations
  Mi2β-mediated silencing of the fetal γ-globin gene in adult erythroid cells
  Maria Laura Amaya, Megha Desai, Merlin Nithya Gnanapragasam, Shou Zhen Wang, Sheng Zu Zhu, David C. Williams, Gordon D. Ginder> ;Blood. 2012 Nov 16
• 35 citations
  Epigenetic induction of adaptive immune response in multiple myeloma: sequential azacitidine and lenalidomide generate cancer testis antigen‐specific cellular immunity
  Amir A. Toor, Kyle K. Payne, Harold M. Chung, Roy T. Sabo, Allison F. Hazlett, Maciej Kmieciak, Kimberly W. Sanford, David C. Williams, William B. Clark, Catherine H. ...> ;British Journal of Haematology. 2012 Sep 1
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