DavidLWirtaMD

PubMed

• Omidenepag Isopropyl Versus Timolol in Patients With Glaucoma or Ocular Hypertension: Two Randomized Phase 3 Trials (SPECTRUM 4 and 3).
  Jason Bacharach, Jacob W Brubaker, David G Evans, Fenghe Lu, Noriko Odani-Kawabata, Takaharu Yamabe, David L Wirta> ;American Journal of Ophthalmology. 2024 Feb 21
• Double-Masked, Vehicle-Controlled, Randomized, Phase II Study of the Ocular Hypotensive Activity and Safety of VVN539 Ophthalmic Solution.
  Li, X., Shen, W., Lu, C., Novack, G., , Wirta, D.> ;Ophthalmology Science. 2023 Nov 7
• 2 citations
  Single Administration of Bimatoprost Implant: Effects on 24-Hour Intraocular Pressure and 1-Year Outcomes.
  Robert N Weinreb, William C Christie, Felipe A Medeiros, E Randy Craven, Kimmie Kim, Ashley Nguyen, Marina Bejanian, David L Wirta> ;Ophthalmology. Glaucoma. 2023 Jun 19
• 3 citations
  Safety and Target Engagement of Complement C1q Inhibitor ANX007 in Neurodegenerative Eye Disease: Results from Phase I Studies in Glaucoma.
  Yang Sun, David Wirta, Wendy Murahashi, Vidhu Mathur, Sethu Sankaranarayanan, Lori K Taylor, Ted Yednock, Donald S Fong, Jeffrey L Goldberg> ;Ophthalmology Science. 2023 Jun 1
• 8 citations
  Efficacy and Safety of a Water-Free Topical Cyclosporine, 0.1%, Solution for the Treatment of Moderate to Severe Dry Eye Disease: The ESSENCE-2 Randomized Clinical Trial.
  Esen K Akpek, David L Wirta, Johnathon E Downing, Joseph Tauber, John D Sheppard, Joseph B Ciolino, Alice S Meides, Sonja Krösser> ;JAMA Ophthalmology. 2023 May 1
• 12 citations
  Lotilaner Ophthalmic Solution, 0.25%, for the Treatment of Demodex Blepharitis: Results of a Prospective, Randomized, Vehicle-Controlled, Double-Masked, Pivotal Trial ...
  Elizabeth Yeu, David L Wirta, Paul Karpecki, Stephanie N Baba, Mark Holdbrook> ;Cornea. 2023 Apr 1
• Two Randomized, Double-masked, Placebo-controlled Studies of the Local Anesthetic Effect of Articaine Ophthalmic Solution.
  Victor H Gonzalez, David L Wirta, Martin Uram, Audrey Schupp, Michelle Widmann, Gary D Novack> ;Clinical Ophthalmology. 2023 Jan 1
• 22 citations
  NOV03 for Dry Eye Disease Associated with Meibomian Gland Dysfunction: Results of the Randomized Phase 3 GOBI Study.
  Joseph Tauber, Gregg J Berdy, David L Wirta, Sonja Krösser, Jason L Vittitow> ;Ophthalmology. 2023 May 1
• 19 citations
  ONSET-1 Phase 2b Randomized Trial to Evaluate the Safety and Efficacy of OC-01 (Varenicline Solution) Nasal Spray on Signs and Symptoms of Dry Eye Disease.
  David Wirta, Gail L Torkildsen, Blair Boehmer, David A Hollander, Edward Bendert, Lijuan Zeng, Michael Ackermann, Jeffrey Nau> ;Cornea. 2022 Oct 1
• 7 citations
  A randomized, vehicle-controlled, Phase 2b study of two concentrations of the TRPM8 receptor agonist AR-15512 in the treatment of dry eye disease (COMET-1).
  David L Wirta, Michelle Senchyna, Amber E Lewis, David G Evans, Eugene B McLaurin, George W Ousler, David A Hollander> ;The Ocular Surface. 2022 Oct 1
• 11 citations
  Safety and Efficacy of AGN-190584 in Individuals With Presbyopia: The GEMINI 1 Phase 3 Randomized Clinical Trial.
  George O Waring 4th, Francis W Price Jr, David Wirta, Cathleen McCabe, Majid Moshirfar, Qiang Guo, Anu Gore, Haixia Liu, Eleonora Safyan, Robinson, M.> ;JAMA Ophthalmology. 2022 Apr 1
• 5 citations
  Phase 2b, Randomized, 3-Month, Dose-Finding Study of Sepetaprost in Patients with Primary Open-Angle Glaucoma or Ocular Hypertension: The ANGEL Study.
  David L Wirta, Yasuaki Kuwayama, Fenghe Lu, Hui Shao, Noriko Odani-Kawabata> ;Journal of Ocular Pharmacology and Therapeutics. 2022 Apr 1
• 1 citations
  A Comparison of TearCare and Lipiflow Systems in Reducing Dry Eye Disease Symptoms Associated with Meibomian Gland Disease.
  Edward J Holland, Jennifer Loh, Marc Bloomenstein, Vance Thompson, David Wirta, Kavita Dhamdhere> ;Clinical Ophthalmology. 2022 Jan 1
• 5 citations
  Combinations of Pilocarpine and Oxymetazoline for the Pharmacological Treatment of Presbyopia: Two Randomized Phase 2 Studies.
  Francis W Price Jr, Milton Hom, Majid Moshirfar, David Evans, Haixia Liu, Jeff Penzner, Sungwook Lee, David L Wirta, Robinson, M.> ;Ophthalmology Science. 2021 Dec 1
• 3 citations
  Noninferiority Study Comparing Latanoprost 0.005% Without Versus With Benzalkonium Chloride in Open-Angle Glaucoma or Ocular Hypertension
  David Wirta, Ranjan Malhotra, James H. Peace, Bridgitte Shen Lee, Brittany Mitchell, Kenneth N Sall, Matthew McMenemy> ;Eye & Contact Lens. 2021 Nov 17
• 40 citations
  Efficacy and Safety of OC-01 (Varenicline) Nasal Spray on Signs and Symptoms of Dry Eye Disease: the ONSET-2 Phase 3, Randomized Trial
  David Wirta, Patrick Vollmer, James Paauw, Kuei-Hsun Chiu, Eugenia Henry, Kristen Striffler, Jeffrey Nau> ;Ophthalmology. 2021 Nov 9
• 24 citations
  Phase 3, Randomized, 20-Month Study of the Efficacy and Safety of Bimatoprost Implant in Patients with Open-Angle Glaucoma and Ocular Hypertension (ARTEMIS 2)
  Jason Bacharach, Andrew J. Tatham, Gloria Ferguson, Sandra Belalcázar, Hagen Thieme, Margot L. Goodkin, Michelle Y. Chen, Qiang Guo, Jeen Liu, Michael R. Robinson, Mar...> ;Drugs. 2021 Nov 1
• 6 citations
  Repository Corticotropin Injection (Acthar® Gel) for Refractory Severe Noninfectious Keratitis: Efficacy and Safety from a Phase 4, Multicenter, Open-Label Study
  David Wirta, Eugene B McLaurin, George W Ousler, Jingyu Liu, R. Oktay Kacmaz, Joseph Grieco> ;Ophthalmology and Therapy. 2021 Oct 20
• 2 citations
  Safety of Once-Daily Oxymetazoline HCl Ophthalmic Solution, 0.1% in Patients with Acquired Blepharoptosis: Results from Four Randomized, Double-Masked Clinical Trials.
  David Wirta, Michael S Korenfeld, Shane Foster, Robert Smyth-Medina, Jason Bacharach, Shane R Kannarr, Mark Jaros, Charles B. Slonim> ;Clinical Ophthalmology. 2021 Oct 8
• 18 citations
  A Randomized Clinical Study (SEECASE) to Assess Efficacy, Safety, and Tolerability of NOV03 for Treatment of Dry Eye Disease.
  Joseph Tauber, David Wirta, Kenneth N Sall, Parag A. Majmudar, Daniela Willen, Sonja Krösser> ;Cornea. 2021 Sep 1
• 7 citations
  Rapid and Sustained Eyelid Elevation in Acquired Blepharoptosis with Oxymetazoline 0.1%: Randomized Phase 3 Trial Results.
  Jason Bacharach, David Wirta, Robert Smyth-Medina, Michael S Korenfeld, Shane R Kannarr, Shane Foster, Mark Jaros, Charles B. Slonim> ;Clinical Ophthalmology. 2021 Jun 25
• 1 citations
  Mydriasis with micro-array print touch-free tropicamide-phenylephrine fixed combination MIST: pooled randomized Phase III trials.
  David Wirta, Thomas R Walters, William J. Flynn, Siddarth Rathi, Tsontcho Ianchulev> ;Therapeutic Delivery. 2021 Mar 15
• 13 citations
  A Water-free 0.1% Cyclosporine A Solution for Treatment of Dry Eye Disease: Results of the Randomized Phase 2B/3 ESSENCE Study.
  John D. Sheppard, David Wirta, Eugene B McLaurin, Blair E. Boehmer, Joseph B. Ciolino, Meides Alice, Thomas Schlüter, George W Ousler, Dale W. Usner, Sonja Krösser> ;Cornea. 2021 Jan 11
• 7 citations
  A Prospective, Post-Market, Multicenter Trial (CHEETAH) Suggested TearCare ® System as a Safe and Effective Blink-Assisted Eyelid Device for the Treatment of Dry Eye D...
  Paul M. Karpecki, David Wirta, Smajo Osmanovic, Kavita Dhamdhere> ;Clinical Ophthalmology. 2020 Dec 30
• 16 citations
  Association of Oxymetazoline Hydrochloride, 0.1%, Solution Administration With Visual Field in Acquired Ptosis: A Pooled Analysis of 2 Randomized Clinical Trials
  Charles B. Slonim, Shane Foster, Mark Jaros, Shane R Kannarr, Michael S. Korenfeld, Robert Smyth-Medina, David L. Wirta> ;JAMA Ophthalmology. 2020 Nov 1
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Journal Articles

• Association of Oxymetazoline Hydrochloride, 0.1%, Solution Administration with Visual Field in Acquired Ptosis  
  Charles B Slonim, Michael S Korenfeld, Robert Smyth-Medina, David L Wirta, JAMA Ophthalmology