DeborahAnneLewinsohnMD

Pediatric Infectious Disease • Portland, OR

Professor, Pediatrics, Oregon Health and Science University School of Medicine

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Office
3181 SW Sam Jackson Park Rd
Portland, OR 97239
Phone+1 503-494-3023

Fax+1 503-346-8043
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Education & Training

University of WashingtonFellowship, Pediatric Infectious Diseases, 1992 - 1995
University of California (San Francisco)Residency, Pediatrics, 1989 - 1992
Stanford University School of MedicineClass of 1989

Certifications & Licensure

CA State Medical License 1990 - Present
OR State Medical License 1999 - 2025
WA State Medical License 1993 - 1999
American Board of Pediatrics Pediatric Infectious Diseases

Publications & Presentations

PubMed

Delivery of loaded MR1 monomer results in efficient ligand exchange to host MR1 and subsequent MR1T cell activation.
Corinna A Kulicke, Gwendolyn M Swarbrick, Nicole A Ladd, Meghan Cansler, Megan Null, Aneta Worley, Chance Lemon, Tania Ahmed, Joshua Bennett, Taylor N Lust, Chelsea M ...> ;Communications Biology. 2024 Feb 24
Production of Proinflammatory Cytokines by CD4+ and CD8+ T Cells in Response to Mycobacterial Antigens among Children and Adults with Tuberculosis.
Erin Morrow, Qijia Liu, Sarah Kiguli, Gwendolyn Swarbrick, Mary Nsereko, Megan D Null, Meghan Cansler, Harriet Mayanja-Kizza, W Henry Boom, Phalkun Chheng, Melissa R N...> ;Pathogens. 2023 Nov 14
Modulation of riboflavin biosynthesis and utilization in mycobacteria.
Melissa D Chengalroyen, Carolina Mehaffy, Megan Lucas, Niel Bauer, Mabule L Raphela, Nurudeen Oketade, Digby F Warner, Deborah A Lewinsohn, David M Lewinsohn, Karen M ...> ;Biorxiv. 2023 Sep 10
Mycobacterial-specific secretion of cytokines and chemokines in healthcare workers with apparent resistance to infection with.
Muki Shehu Shey, Avuyonke Balfour, Nomawethu Masina, Abulele Bekiswa, Charlotte Schutz, Rene Goliath, Rachel Dielle, Patrick Dmc Katoto, Katalin Andrea Wilkinson, Davi...> ;Frontiers in Immunology. 2023 Jan 1
3 citations
Deaza-modification of MR1 ligands modulates recognition by MR1-restricted T cells.
Haihong Jin, Nicole A Ladd, Andrew M Peev, Gwendolyn M Swarbrick, Meghan Cansler, Megan Null, Christopher T Boughter, Curtis McMurtrey, Aaron Nilsen, Karen M Dobos, Wi...> ;Scientific Reports. 2022 Dec 29
3 citations
The Missing Link in Correlates of Protective Tuberculosis Immunity: Recognizing the Infected Cell.
David Michael Lewinsohn, Deborah Anne Lewinsohn> ;Frontiers in Immunology. 2022 Jan 1
2 citations
Donor Unrestricted T Cells: Linking innate and adaptive immunity.
Shogo Soma, Deborah A. Lewinsohn, David M. Lewinsohn> ;Vaccine. 2021 Nov 2
5 citations
Functional and Activation Profiles of Mucosal-Associated Invariant T Cells in Patients With Tuberculosis and HIV in a High Endemic Setting.
Avuyonke Balfour, Charlotte Schutz, Rene Goliath, Katalin A. Wilkinson, Sumaya Sayed, Bianca Sossen, Jean Paul Kanyik, Amy Ward, Rhandzu Ndzhukule, Anele Gela, David M...> ;Frontiers in Immunology. 2021 Mar 22
7 citations
T cell receptor diversity, specificity and promiscuity of functionally heterogeneous human MR1-restricted T cells.
Marco Lepore, Deborah A. Lewinsohn, David M. Lewinsohn> ;Molecular Immunology. 2021 Feb 1
9 citations
Postnatal Expansion, Maturation, and Functionality of MR1T Cells in Humans.
Gwendolyn Swarbrick, Anele Gela, Meghan E. Cansler, Megan D. Null, Rowan B. Duncan, Elisa Nemes, Muki Shey, Mary Nsereko, Harriet Mayanja-Kizza, Sarah Kiguli, Jeffrey ...> ;Frontiers in Immunology. 2020 Sep 16
3 citations
Clonal enrichments of Vδ2- γδ T cells in Mycobacterium tuberculosis-infected human lungs
Corinna A. Kulicke, Deborah A. Lewinsohn, David M. Lewinsohn> ;The Journal of Clinical Investigation. 2019 Nov 25
13 citations
New Concepts in Tuberculosis Host Defense.
David M. Lewinsohn, Deborah A. Lewinsohn> ;Clinics in Chest Medicine. 2019 Dec 1
20 citations
The evolving research agenda for paediatric tuberculosis infection.
James A Seddon, Elizabeth Whittaker, Beate Kampmann, Deborah A. Lewinsohn, Muhammad Osman, Anneke C. Hesseling, Roxana Rustomjee, Farhana Amanullah> ;The Lancet. Infectious Diseases. 2019 Sep 1
6 citations
Recognition of CD8+ T-cell epitopes to identify adults with pulmonary tuberculosis
Christina Lancioni, Gwendolyn Swarbrick, Byung Park, Melissa Nyendak, Mary Nsereko, Harriet Mayanja-Kizza, Megan D. Null, Meghan E. Cansler, Rowan B. Duncan, Joy Basek...> ;The European Respiratory Journal. 2019 May 1
16 citations
Moving toward Tuberculosis Elimination. Critical Issues for Research in Diagnostics and Therapeutics for Tuberculosis Infection.
Salmaan Keshavjee, Farhana Amanullah, Adithya Cattamanchi, Richard E. Chaisson, Karen M. Dobos, Gregory J. Fox, Howard E. Gendelman, Richard Gordon, Anneke C. Hesselin...> ;American Journal of Respiratory and Critical Care Medicine. 2019 Mar 1
9 citations
Characterization of specific CD4 and CD8 T-cell responses in QuantiFERON TB Gold-Plus TB1 and TB2 tubes.
Nadia Pc. Allen, Gwendolyn Swarbrick, Meghan E. Cansler, Megan Null, Hiam Salim, Misato Miyamasu, Jenny Howard, Jeffrey Boyle, David M. Lewinsohn, Deborah A. Lewinsohn> ;Tuberculosis. 2018 Dec 1
87 citations
MR1 displays the microbial metabolome driving selective MR1-restricted T cell receptor usage
Melanie J. Harriff, Curtis McMurtrey, Cara A. Froyd, Haihong Jin, Meghan E. Cansler, Megan D. Null, Aneta H. Worley, Erin W. Meermeier, Gwendolyn Swarbrick, Aaron Nils...> ;Science Immunology. 2018 Jul 13
51 citations
Identification and Evaluation of Novel Protective Antigens for the Development of a Candidate Tuberculosis Subunit Vaccine.
Elena Stylianou, Rachel Harrington-Kandt, Julia Beglov, Naomi Bull, Nawamin Pinpathomrat, Gwendolyn Swarbrick, Deborah A. Lewinsohn, David M. Lewinsohn, Helen McShane> ;Infection and Immunity. 2018 Jul 1
32 citations
T cell recognition of Mycobacterium tuberculosis peptides presented by HLA-E derived from infected human cells.
Curtis McMurtrey, Melanie J. Harriff, Gwendolyn Swarbrick, Amanda Duncan, Meghan E. Cansler, Megan D. Null, Wilfried Bardet, Kenneth W. Jackson, Deborah A. Lewinsohn, ...> ;Plos One. 2017 Nov 27
107 citations
Polyfunctional CD4+ T Cells As Targets for Tuberculosis Vaccination
Deborah A. Lewinsohn, David M. Lewinsohn, Thomas J. Scriba> ;Frontiers in Immunology. 2017 Oct 5
36 citations
Comprehensive definition of human immunodominant CD8 antigens in tuberculosis.
Deborah A. Lewinsohn, Gwendolyn Swarbrick, Byung Park, Meghan E. Cansler, Megan D. Null, Katelynne Gardner Toren, Joy Baseke, Sarah Zalwango, Harriet Mayanja-Kizza, La...> ;NPJ Vaccines. 2017 Apr 3
29 citations
HLA-E Presents Glycopeptides from the Mycobacterium tuberculosis Protein MPT32 to Human CD8+ T cells.
Melanie J. Harriff, Lisa M. Wolfe, Gwendolyn Swarbrick, Megan D. Null, Meghan E. Cansler, Elizabeth T. Canfield, Todd M. Vogt, Katelynne Gardner Toren, Wei Li, Mary Ja...> ;Scientific Reports. 2017 Jul 4
76 citations
MR1-restricted mucosal-associated invariant T (MAIT) cells respond to mycobacterial vaccination and infection in nonhuman primates
Justin M. Greene, Pradyot Dash, Sobhan Roy, Curtis McMurtrey, Walid Awad, Jason S. Reed, Katherine B. Hammond, Shaheed A. Abdulhaqq, Helen L. Wu, Benjamin J. Burwitz, ...> ;Mucosal Immunology. 2017 May 1
188 citations
Official American Thoracic Society/Infectious Diseases Society of America/Centers for Disease Control and Prevention Clinical Practice Guidelines: Diagnosis of Tubercu...
David M Lewinsohn, Michael K Leonard, Philip A LoBue, David L Cohn, Charles L Daley, Ed Desmond, Joseph Keane, Deborah A Lewinsohn, Ann M Loeffler, Gerald H Mazurek, R...> ;Clinical Infectious Diseases. 2017 Jan 15
176 citations
Official American Thoracic Society/Infectious Diseases Society of America/Centers for Disease Control and Prevention Clinical Practice Guidelines: Diagnosis of Tubercu...
David M Lewinsohn, Michael K Leonard, Philip A LoBue, David L Cohn, Charles L Daley, Ed Desmond, Joseph Keane, Deborah A Lewinsohn, Ann M Loeffler, Gerald H Mazurek, R...> ;Clinical Infectious Diseases. 2017 Jan 15
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Grant Support

A CD8+ T Cell Diagnostic To Identify Children With Pulmonary TuberculosisNational Institute Of Allergy And Infectious Diseases2011–2012
Age-Related Changes In Primate Dendritic Cell FunctionNational Institute On Aging2004–2008
Infant Rhesus Macaque Model For SIV VaccinesNational Center For Research Resources2004–2006
Tuberculosis Immunity In Young ChildrenNational Institute Of Allergy And Infectious Diseases2003–2006
Evaluation Of Adoptive T Cell Therapy For HIVNational Institute Of Allergy And Infectious Diseases1998–2002

Hospital Affiliations

OHSU HospitalPortland, Oregon