DeborahLStoneMD

Pediatrics • Bethesda, MD

Physician

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Office
10 Center Drive Room 9n248c
Bethesda, MD 20892
Phone+1 301-451-9766

Fax+1 301-480-4436
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Summary

Dr. Deborah Stone, MD is a board certified pediatrician in Bethesda, Maryland. She is currently licensed to practice medicine in Maryland, District of Columbia, and Virginia.

Education & Training

UPMC Children's Hospital of PittsburghResidency, Pediatrics, 1991 - 1994
University of Florida College of MedicineClass of 1991

Certifications & Licensure

MD State Medical License 1995 - 2025
VA State Medical License 1997 - 2022
DC State Medical License 2003 - 2004
PA State Medical License 1991 - 1996
American Board of Pediatrics Pediatrics

Publications & Presentations

PubMed

20 citations
TNF-inhibition in vasculitis management in adenosine deaminase 2 deficiency (DADA2).
Ombrello, A. K., Natalie Deuitch, Dan Yang, Pui Y. Lee, Xiaomin Yu, Natalia Sampaio Moura, Oskar Schnappauf, Amanda K. Ombrello, Deborah L. Stone, Hye Sun Kuehn, Sergi...> ;The Journal of Allergy and Clinical Immunology. 2021 Nov 12
8 citations
Single-cell profiling of T lymphocytes in deficiency of adenosine deaminase 2
Zhijie Wu, Shouguo Gao, Naoki Watanabe, Sachiko Kajigaya, Carrie Diamond, Lemlem Alemu, Diego Quinones Raffo, Xingmin Feng, Patrycja Hoffmann, Deborah L. Stone, Amanda...> ;Journal of Leukocyte Biology. 2021 Nov 3
18 citations
Excess Serum Interleukin-18 Distinguishes Patients with Pathogenic Mutations in PSTPIP1
Deborah L. Stone, Amanda K. Ombrello, Juan I. Aróstegui, Corinne Schneider, Vinh Dang, Adriana de Jesus, Charlotte Girard-Guyonvarc'h, Cem Gabay, Jae Jin Chae, Ivona A...> ;Arthritis & Rheumatology. 2021 Sep 7
12 citations
Analysis of deficiency of adenosine deaminase 2 pathogenesis based on single-cell RNA sequencing of monocytes.
Naoki Watanabe, Shouguo Gao, Zhijie Wu, Sachiko Kajigaya, Carrie Diamond, Lemlem Alemu, Diego Quinones Raffo, Patrycja Hoffmann, Deborah L. Stone, Neal S. Young, Ombre...> ;Journal of Leukocyte Biology. 2021 Sep 1
10 citations
Systematic evaluation of nine monogenic autoinflammatory diseases reveals common and disease-specific correlations with allergy-associated features
Ombrello, A. K., Daniella M. Schwartz, Moses M. Kitakule, Brian Dizon, Cristhian A Gutierrez-Huerta, Sarah A Blackstone, Aarohan M Burma, Aran Son, Natalie Deuitch, So...> ;Annals of the Rheumatic Diseases. 2021 Feb 22
4 citations
The systemic autoinflammatory diseases: Coming of age with the human genome.
Deborah L. Stone, David B. Beck, Kalpana Manthiram, Yong Hwan Park, Jae Jin Chae, Elaine F. Remmers, Daniel L. Kastner> ;The Journal of Allergy and Clinical Immunology. 2020 Sep 25
28 citations
Deficiency of Adenosine Deaminase 2 (DADA2): Hidden Variants, Reduced Penetrance, and Unusual Inheritance.
Oskar Schnappauf, Qing Zhou, Natalia Sampaio Moura, Amanda K. Ombrello, Drew G. Michael, Natalie Deuitch, Karyl S. Barron, Deborah L. Stone, Patrycja Hoffmann, Michael...> ;Journal of Clinical Immunology. 2020 Jul 8
64 citations
Ancient familial Mediterranean fever mutations in human pyrin and resistance to Yersinia pestis.
Yong Hwan Park, Elaine F. Remmers, Wonyong Lee, Amanda K. Ombrello, Lawton K. Chung, Zhao Shilei, Deborah L. Stone, Maya I. Ivanov, Nicole A. Loeven, Karyl S. Barron, ...> ;Nature Immunology. 2020 Jun 29
22 citations
Type I interferon signature predicts response to JAK inhibition in haploinsufficiency of A20
Daniella M. Schwartz, Sarah A Blackstone, Natalia Sampaio-Moura, Sofia Rosenzweig, Aarohan M Burma, Deborah L. Stone, Patrycja Hoffmann, Anne Jones, Tina Romeo, Karyl ...> ;Annals of the Rheumatic Diseases. 2020 Mar 1
176 citations
Mutations that prevent caspase cleavage of RIPK1 cause autoinflammatory disease
Najoua Lalaoui, Steven E. Boyden, Hirotsugu Oda, Geryl Wood, Deborah L. Stone, Diep Chau, Lin Liu, Monique Stoffels, Tobias Kratina, Kate E. Lawlor, Kristien J. M. Zaa...> ;Nature. 2020 Jan 2
100 citations
Deficiency of adenosine deaminase 2 triggers adenosine-mediated NETosis and TNF production in patients with DADA2
Carmelo Carmona-Rivera, Sami S. Khaznadar, Kyawt Win Shwin, Jorge A Irizarry-Caro, Liam J. O’Neil, Yudong Liu, Kenneth A. Jacobson, Amanda K. Ombrello, Deborah L. Ston...> ;Blood. 2019 Jul 25
99 citations
Treatment Strategies for Deficiency of Adenosine Deaminase 2.
Amanda K. Ombrello, Jing Qin, Patrycja Hoffmann, Parag Kumar, Deborah L. Stone, Anne Jones, Tina Romeo, Beverly K. Barham, Gineth Pinto-Patarroyo, Camilo Toro, Ariane ...> ;The New England Journal of Medicine. 2019 Apr 17
62 citations
Dysregulated neutrophil responses and neutrophil extracellular trap formation and degradation in PAPA syndrome.
Pragnesh Mistry, Carmelo Carmona-Rivera, Amanda K. Ombrello, Patrycja Hoffmann, Nickie L Seto, Anne Jones, Deborah L. Stone, Faiza Naz, Philip M. Carlucci, Stefania De...> ;Annals of the Rheumatic Diseases. 2018 Dec 1
297 citations
JAK1/2 inhibition with baricitinib in the treatment of autoinflammatory interferonopathies
Gina A. Montealegre Sanchez, Adam L Reinhardt, Suzanne E. Ramsey, Helmut Wittkowski, Philip J. Hashkes, Yackov Berkun, Susanne Schalm, Sara Murias, Jason Dare, Diane B...> ;The Journal of Clinical Investigation. 2018 Jul 2
40 citations
Aberrant tRNA processing causes an autoinflammatory syndrome responsive to TNF inhibitors.
Angeliki Giannelou, Hongying Wang, Qing Zhou, Yong Hwan Park, Mones Abu-Asab, Kris Ylaya, Deborah L. Stone, Anna Sediva, Rola Sleiman, Lucie Sramkova, Deepika Bhatla, ...> ;Annals of the Rheumatic Diseases. 2018 Jan 22
143 citations
A20 haploinsufficiency (HA20): clinical phenotypes and disease course of patients with a newly recognised NF-kB-mediated autoinflammatory disease
Florence A. Aeschlimann, Ezgi Deniz Batu, Scott W. Canna, Ellen Go, Ahmet Gül, Patrycja Hoffmann, Helen L. Leavis, Seza Ozen, Daniella M. Schwartz, Deborah L. Stone, A...> ;Annals of the Rheumatic Diseases. 2018 May 1
158 citations
Biallelic hypomorphic mutations in a linear deubiquitinase define otulipenia, an early-onset autoinflammatory disease
Qing Zhou, Xiaomin Yu, Erkan Demirkaya, Natalie Deuitch, Deborah L. Stone, Wanxia Li Tsai, Hye Sun Kuehn, Hongying Wang, Dan Yang, Yong Hwan Park, Amanda K. Ombrello, ...> ;Proceedings of the National Academy of Sciences of the United States of America. 2016 Sep 6
4 citations
Early-onset stroke, polyarteritis nodosa (PAN), and livedo racemosa
Dominique C. Pichard, Amanda K. Ombrello, Patrycja Hoffmann, Deborah L. Stone, Edward W. Cowen> ;Journal of the American Academy of Dermatology. 2016 Aug 1
91 citations
Erratum: Additive loss-of-function proteasome subunit mutations in CANDLE/PRAAS patients promote type i IFN production (Journal of Clinical Investigation (2015) 125:11...
Anja Brehm, Yin Liu, Afzal Sheikh, Bernadette Marrero, Ebun Omoyinmi, Qing Zhou, G Montealegre, Angelique Biancotto, Adam L Reinhardt, Adriana Almeida de Jesus, Martin...> ;The Journal of Clinical Investigation. 2016 Feb 1
373 citations
Loss-of-function mutations in TNFAIP3 leading to A20 haploinsufficiency cause an early-onset autoinflammatory disease
Qing Zhou, Hongying Wang, Daniella M. Schwartz, Monique Stoffels, Yong Hwan Park, Yuan Zhang, Dan Yang, Erkan Demirkaya, Masaki Takeuchi, Wanxia Li Tsai, Jonathan J. L...> ;Nature Genetics. 2016 Jan 1
62 citations
Additive loss-of-function proteasome subunit mutations in CANDLE/PRAAS patients promote type I IFN production.
Anja Brehm, Yin Liu, Afzal Sheikh, Bernadette Marrero, Ebun Omoyinmi, Qing Zhou, Gina Montealegre, Angelique Biancotto, Adam Reinhardt, Adriana Almeida de Jesus, Marti...> ;The Journal of Clinical Investigation. 2015 Nov 2
44 citations
A 24-month open-label study of canakinumab in neonatal-onset multisystem inflammatory disease
Cailin H. Sibley, Andrea Chioato, SD Felix, Laurence Colin, Abhijit Chakraborty, N. Plass, Jackeline Rodriguez-Smith, Carmen C. Brewer, Kelly A. King, Christopher K. Z...> ;Annals of the Rheumatic Diseases. 2015 Sep 1
58 citations
Anakinra use during pregnancy in patients with cryopyrin-associated periodic syndromes (CAPS).
Zenas Chang, Catherine Y. Spong, Adriana Almeida de Jesus, Michael A. Davis, Nicole Plass, Deborah L. Stone, Dawn Chapelle, Patrycja Hoffmann, Daniel L. Kastner, Karyl...> ;Arthritis & Rheumatology. 2014 Nov 1
839 citations
Activated STING in a Vascular and Pulmonary Syndrome
Yongmei Liu, A Almeida de Jesus, B Marrero, Dan Yang, Suzanne E. Ramsey, G.A. Montealegre Sanchez, Klaus Tenbrock, Helmut Wittkowski, Olcay Y. Jones, Hye Sun Kuehn, Ch...> ;The New England Journal of Medicine. 2014 Aug 6
511 citations
Early-Onset Stroke and Vasculopathy Associated with Mutations in ADA2
Qing Zhou, Dan Yang, Amanda K. Ombrello, Andrey Zavialov, Camilo Toro, Anton V. Zavialov, Deborah L. Stone, Jae Jin Chae, Sergio D. Rosenzweig, Kevin Bishop, Karyl S. ...> ;The New England Journal of Medicine. 2014 Mar 5
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Press Mentions

Suicides Rise Again in the US, Increases Highest Among MinoritiesFebruary 13th, 2023
COVID‐19, Public Health, and the Politics of PreventionNovember 6th, 2020
Why US Suicide Rate Is on the RiseJune 11th, 2018
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