DimitriKraincMD

PubMed

• 1 citations
  VPS13C regulates phospho-Rab10-mediated lysosomal function in human dopaminergic neurons.
  Schrӧder, L., Peng, W., Gao, G., Wong, Y., Schwake, M., Krainc, D.> ;The Journal of Cell Biology. 2024 May 6
• Key genes and convergent pathogenic mechanisms in Parkinson disease.
  Robert Coukos, Dimitri Krainc> ;Nature Reviews. Neuroscience. 2024 Apr 10
• Twelve Years of Drug Prioritization to Help Accelerate Disease Modification Trials in Parkinson's Disease: The International Linked Clinical Trials initiative.
  Richard K Wyse, Tom Isaacs, Roger A Barker, Mark R Cookson, Ted M Dawson, David Devos, David T Dexter, Joy Duffen, Howard Federoff, Brian Fiske, Thomas Foltynie, Susan...> ;Journal of Parkinson's Disease. 2024 Apr 5
• De novo FRMD5 Missense Variants in Patients with Childhood-Onset Ataxia, Prominent Nystagmus, and Seizures.
  Ignacio J Keller Sarmiento, Bernabe I Bustos, Matthea Monroe, Lisa Kinsley, Megan Li, Vincenzo Silani, Steven J Lubbe, Niccolò E Mencacci, Joanna Blackburn, Nicholas E...> ;Movement Disorders. 2024 Apr 4
• Alterations in Blood Methylome as Potential Epigenetic Biomarker in Sporadic Parkinson's Disease.
  Paulina Gonzalez-Latapi, Bernabe Bustos, Siyuan Dong, Steven Lubbe, Tanya Simuni, Dimitri Krainc> ;Annals of Neurology. 2024 Apr 2
• Fostering Academia-Industry Partnerships to Facilitate Therapeutic Discoveries in Neurology: The Role of ANA as a Catalyst.
  Ross, M., Guo, M., Mouradian, M., Ratan, R., Krainc, D.> ;Annals of Neurology. 2024 Mar 4
• A GNAI1 Pathogenic Variant in a Case with GNAO1-Isolated Dystonia: A Modifier of Disease Severity?
  Mariana H G Monje, Joanna Sarah Blackburn, Lisa Kinsley, Dimitri Krainc, Niccolò E Mencacci> ;Movement Disorders. 2024 Feb 28
• Protocol to investigate Parkinson's patient-derived dopaminergic neurons by live-cell microscopy and oxidized dopamine assays.
  Pingping Song, Dimitri Krainc> ;STAR Protocols. 2024 Mar 15
• Inhibition of cysteine protease cathepsin Lincreases the level and activity of lysosomal glucocerebrosidase.
  Myung Jong Kim, Soojin Kim, Thomas Reinheckel, Dimitri Krainc> ;JCI Insight. 2024 Feb 8
• 1 citations
  Cell biology of Parkinson's disease: Mechanisms of synaptic, lysosomal, and mitochondrial dysfunction.
  Naylor, G., Brooker, S., Krainc, D.> ;Current Opinion in Neurobiology. 2024 Apr 1
• Shifting the trajectory of therapeutic development for neurological and psychiatric disorders.
  Martin, W., Casey, B., Tishkoff, S., Potter, W., Hyman, S., Krainc, D., Jensen, F.> ;Science Translational Medicine. 2023 Nov 1
• 1 citations
  Misregulation of mitochondria-lysosome contact dynamics in Charcot-Marie-Tooth Type 2B disease Rab7 mutant sensory peripheral neurons.
  Yvette C Wong, Nirupa D Jayaraj, Tayler B Belton, George C Shum, Hannah E Ball, Dongjun Ren, Abigail L D Tadenev, Dimitri Krainc, Robert W Burgess, Daniela M Menichella> ;Proceedings of the National Academy of Sciences of the United States of America. 2023 Oct 31
• 5 citations
  Parkinson's disease-linked parkin mutation disrupts recycling of synaptic vesicles in human dopaminergic neurons.
  Pingping Song, Wesley Peng, Veronique Sauve, Rayan Fakih, Zhong Xie, Daniel Ysselstein, Talia Krainc, Yvette C Wong, Niccolò E Mencacci, Jeffrey N Savas, D James Surme...> ;Neuron. 2023 Dec 6
• 10 citations
  Parkin regulates amino acid homeostasis at mitochondria-lysosome (M/L) contact sites in Parkinson's disease.
  Wesley Peng, Leonie F Schröder, Pingping Song, Yvette C Wong, Dimitri Krainc> ;Science Advances. 2023 Jul 21
• 3 citations
  Octopamine metabolically reprograms astrocytes to confer neuroprotection against α-synuclein.
  Andrew Shum, Sofia Zaichick, Gregory S McElroy, Karis D'Alessandro, Milad J Alasady, Michaela Novakovic, Wesley Peng, Ekaterina A Grebenik, Daayun Chung, Margaret E Fl...> ;Proceedings of the National Academy of Sciences of the United States of America. 2023 Apr 25
• 1 citations
  Variants in ATP5F1B are associated with dominantly inherited dystonia.
  Alessia Nasca, Niccolò E Mencacci, Federica Invernizzi, Michael Zech, Ignacio J Keller Sarmiento, Andrea Legati, Chiara Frascarelli, Bernabe I Bustos, Luigi M Romito, ...> ;Brain. 2023 Jul 3
• 6 citations
  Mechanisms of Glucocerebrosidase Dysfunction in Parkinson's Disease.
  Diptaman Chatterjee, Dimitri Krainc> ;Journal of Molecular Biology. 2023 Jun 15
• 4 citations
  Investigation of Shared Genetic Risk Factors Between Parkinson's Disease and Cancers.
  Pierre-Emmanuel Sugier, Elise A Lucotte, Cloé Domenighetti, Matthew H Law, Mark M Iles, Kevin Brown, Christopher Amos, James D McKay, Rayjean J Hung, Mojgan Karimi, De...> ;Movement Disorders. 2023 Apr 1
• 2 citations
  Extracellular transportation of α-synuclein by HLA class II molecules.
  Tatsuhiko Ozono, Yasuyoshi Kimura, Tadahiro Suenaga, Goichi Beck, Jyunki Jinno, César Aguirre, Kensuke Ikenaka, Dimitri Krainc, Hideki Mochizuki, Hisashi Arase> ;Biochemical and Biophysical Research Communications. 2023 Feb 12
• 10 citations
  Genome-wide contribution of common short-tandem repeats to Parkinson's disease genetic risk.
  Bernabe I Bustos, Kimberley Billingsley, Cornelis Blauwendraat, J Raphael Gibbs, Ziv Gan-Or, Dimitri Krainc, Andrew B Singleton, Steven J Lubbe> ;Brain. 2023 Jan 5
• Gene-based burden analysis of damaging private variants in PRKN, PARK7 and PINK1 in Parkinson's disease cohorts of European descent.
  Jing Hu, Cheryl H Waters, Dan Spiegelman, Edward A Fon, Eric Yu, Farnaz Asayesh, Lynne Krohn, Prabhjyot Saini, Roy N Alcalay, Sharon Hassin-Baer, Ziv Gan-Or, Dimitri K...> ;Neurobiology of Aging. 2022 Nov 1
• Novel THAP1 missense variant with incomplete penetrance in a case of generalized young onset dystonia showing good response to deep brain stimulation.
  Ignacio J Keller Sarmiento, Avram Fraint, Lisa Kinsley, Rizwan S Akhtar, Vincenzo Silani, Steven J Lubbe, Dimitri Krainc, Niccolò E Mencacci> ;Parkinsonism & Related Disorders. 2022 Dec 1
• 2 citations
  Novel bi-allelic FBXO7 variants in a family with early-onset typical Parkinson's disease.
  Ignacio J Keller Sarmiento, Mitra Afshari, Lisa Kinsley, Vincenzo Silani, Rizwan S Akhtar, Tanya Simuni, Steven J Lubbe, Dimitri Krainc, Niccolò E Mencacci> ;Parkinsonism & Related Disorders. 2022 Nov 1
• 12 citations
  Mid51/Fis1 mitochondrial oligomerization complex drives lysosomal untethering and network dynamics.
  Yvette C Wong, Soojin Kim, Jasmine Cisneros, Catherine G Molakal, Pingping Song, Steven J Lubbe, Dimitri Krainc> ;The Journal of Cell Biology. 2022 Oct 3
• 1 citations
  Expanding the spectrum of KCNJ6-related disorders: Milder phenotype with pathological startle responses.
  Vesna Marija van Midden, Lisa Kinsley, Avram Fraint, Dimitri Krainc, Niccolò E Mencacci> ;Clinical Genetics. 2023 Jan 1
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