DonaldGrayHeppnerJr.MD

PubMed

• Current Strategic Thinking for the Development of a Trivalent Alphavirus Vaccine for Human Use.
  Wolfe, D. N.,Heppner, D. G.,Gardner, S. N.,Jaing, C.,Dupuy, L. C.,Schmaljohn, C. S.,Carlton, K.> ;Am. J. Trop. Med. Hyg.. 2014 May 21
• First-in-human evaluation of genetically attenuated Plasmodium falciparum sporozoites administered by bite of Anopheles mosquitoes to adult volunteers.
  Spring, M.,Murphy, J.,Nielsen, R.,Dowler, M.,Bennett, J. W.,Zarling, S.,Williams, J.,de la Vega, P.,Ware, L.,Komisar, J.,Polhemus, M.,Richie, T. L.,Epstein, J.,Tamming...> ;Vaccine. 2013 Oct 9
• The malaria vaccine - Status quo 2013.
  Heppner, D. G.> ;Travel Med Infect Dis. 2013 Mar 05
• 134 citations
  Preerythrocytic, live-attenuated Plasmodium falciparum vaccine candidates by design
  Kelley M. VanBuskirk, Matthew T. O'Neill, Patricia de la Vega, Alexander G. Maier, Urszula Krzych, Jack Williams, Megan Dowler, John B. Sacci, Niwat Kangwanrangsan, Ta...> ;Proceedings of the National Academy of Sciences of the United States of America. 2009 Aug 4
• 265 citations
  Blood stage malaria vaccine eliciting high antigen-specific antibody concentrations confers no protection to young children in Western Kenya.
  Bernhards Ogutu, Odika J. Apollo, Denise McKinney, Willis Okoth, Joram Siangla, Filip Dubovsky, Kathryn Tucker, John N. Waitumbi, Carter L. Diggs, Janet Wittes, Elissa...> ;Plos One. 2009 Mar 5
• 107 citations
  Phase 2a trial of 0, 1, and 3 month and 0, 7, and 28 day immunization schedules of malaria vaccine RTS,S/AS02 in malaria-naïve adults at the Walter Reed Army Institute...
  Kent E. Kester, James F. Cummings, Christian F. Ockenhouse, Robin Nielsen, B. Ted Hall, Daniel M. Gordon, Robert Schwenk, Urszula Krzych, Carolyn A. Holland, Gregory R...> ;Vaccine. 2008 Apr 24
• 88 citations
  A phase I/IIa safety, immunogenicity, and efficacy bridging randomized study of a two-dose regimen of liquid and lyophilized formulations of the candidate malaria vacc...
  Kent E. Kester, Denise McKinney, Nadia Tornieporth, Christian F. Ockenhouse, D. Gray Heppner, Ted Hall, Bruce T. Wellde, Katherine White, Peifang Sun, Robert Schwenk, ...> ;Vaccine. 2007 Jul 20
• 73 citations
  Phase 1 randomized double-blind safety and immunogenicity trial of Plasmodium falciparum malaria merozoite surface protein FMP1 vaccine, adjuvanted with AS02A, in adul...
  José A. Stoute, Joash Gombe, Mark R. Withers, Joram Siangla, Denise McKinney, Melanie Onyango, James F. Cummings, Jessica Milman, Kathryn Tucker, Lorraine Soisson, V. ...> ;Vaccine. 2007 Jan 2
• 146 citations
  Towards an RTS,S-based, multi-stage, multi-antigen vaccine against falciparum malaria: progress at the Walter Reed Army Institute of Research.
  D. Gray Heppner, Kent E. Kester, Christian F. Ockenhouse, Nadia Tornieporth, Opokua Ofori, Jeffrey A. Lyon, V. Ann Stewart, Patrice M. Dubois, David E. Lanar, Urszula ...> ;Vaccine. 2005 Mar 18
• Safety and Comparability of Controlled Human Plasmodium falciparum Infection by Mosquito Bite in Malaria-Naïve Subjects at a New Facility for Sporozoite Challenge.
  Talley, A. K.,Healy, S. A.,Finney, O. C.,Murphy, S. C.,Kublin, J.,Salas, C. J.,Lundebjerg, S.,Gilbert, P.,Van Voorhis, W. C.,Whisler, J.,Wang, R.,Ockenhouse, C. F.,Hep...> ;PLoS ONE. 2014 Nov 19
• Extended safety, immunogenicity and efficacy of a blood-stage malaria vaccine in malian children: 24-month follow-up of a randomized, double-blinded phase 2 trial.
  Laurens, M. B.,Thera, M. A.,Coulibaly, D.,Ouattara, A.,Kone, A. K.,Guindo, A. B.,Traore, K.,Traore, I.,Kouriba, B.,Diallo, D. A.,Diarra, I.,Daou, M.,Dolo, A.,Tolo, Y.,...> ;PLoS ONE. 2013 Nov 22
• A field trial to assess a blood-stage malaria vaccine.
  Thera, M. A., Doumbo, O. K., Coulibaly, D., Laurens, M. B., Ouattara, A., Kone, A. K., Guindo, A. B., Traore, K., Traore, I., Kouriba, B., Diallo, D. A., Diarra, I., D...> ;N Engl J Med. 2011 Sep 15
• Safety and immunogenicity of an AMA-1 malaria vaccine in Malian adults: results of a phase 1 randomized controlled trial.
  Thera, M. A., Doumbo, O. K., Coulibaly, D., Diallo, D. A., Kone, A. K., Guindo, A. B., Traore, K., Dicko, A., Sagara, I., Sissoko, M. S., Baby, M., Sissoko, M., Diarra...> ;PLoS One. 2008
• Impact of RTS,S/AS02(A) and RTS,S/AS01(B) on genotypes of P. falciparum in adults participating in a malaria vaccine clinical trial.
  Waitumbi, J. N., Anyona, S. B., Hunja, C. W., Kifude, C. M., Polhemus, M. E., Walsh, D. S., Ockenhouse, C. F., Heppner, D. G., Leach, A., Lievens, M., Ballou, W. R., C...> ;PLoS One. 2009 Jan 01
• Safety, tolerability, and antibody responses in humans after sequential immunization with a PfCSP DNA vaccine followed by the recombinant protein vaccine RTS,S/AS02A.
  Epstein, J. E., Charoenvit, Y., Kester, K. E., Wang, R., Newcomer, R., Fitzpatrick, S., Richie, T. L., Tornieporth, N., Heppner, D. G., Ockenhouse, C., Majam, V., Holl...> ;Vaccine. 2004 Apr 16
• Pre-clinical evaluation of the malaria vaccine candidate P. falciparum MSP1(42) formulated with novel adjuvants or with alum.
  Pichyangkul, S., Gettayacamin, M., Miller, R. S., Lyon, J. A., Angov, E., Tongtawe, P., Ruble, D. L., Heppner, D. G., Kester, K. E., Ballou, W. R., Diggs, C. L., Voss,...> ;Vaccine. 2004 Sep 28
• Safety and immunogenicty of RTS,S/AS02A candidate malaria vaccine in Gambian children.
  Bojang, K. A., Olodude, F., Pinder, M., Ofori-Anyinam, O., Vigneron, L., Fitzpatrick, S., Njie, F., Kassanga, A., Leach, A., Milman, J., Rabinovich, R., McAdam, K. P.,...> ;Vaccine. 2005 Jul 14
• Cutaneous delayed-type hypersensitivity (DTH) in a multi-formulation comparator trial of the anti-falciparum malaria vaccine candidate RTS,S in rhesus macaques.
  Stewart, V. A., Walsh, D. S., McGrath, S. M., Kester, K. E., Cummings, J. F., Voss, G., Delchambre, M., Garçon, N., Cohen, J. D., Heppner, D. G.> ;Vaccine. 2006 Oct 30
• Pre-clinical evaluation of new adjuvant formulations to improve the immunogenicity of the malaria vaccine RTS,S/AS02A.
  Stewart, V. A., McGrath, S. M., Walsh, D. S., Davis, S., Hess, A. S., Ware, L. A., Kester, K. E., Cummings, J. F., Burge, J. R., Voss, G., Delchambre, M., Garçon, N., ...> ;Vaccine. 2006 Oct 30
• Malaria treatment with atovaquone-proguanil in malaria-immune adults: implications for malaria intervention trials and for pre-exposure prophylaxis of malaria.
  Polhemus, M. E., Remich, S., Ogutu, B., Waitumbi, J., Lievens, M., Ballou, W. R., Heppner, D. G.> ;Antimicrob Agents Chemother. 2008 Apr
• The dog that did not bark: malaria vaccines without antibodies.
  Heppner, D. G., Schwenk, R. J., Arnot, D., Sauerwein, R. W., Luty, A. J.> ;Trends Parasitol. 2007 Jul
• Murine immune responses to liver-stage antigen 1 protein FMP011, a malaria vaccine candidate, delivered with adjuvant AS01B or AS02A.
  Brando, C., Ware, L. A., Freyberger, H., Kathcart, A., Barbosa, A., Cayphas, S., Demoitie, M. A., Mettens, P., Heppner, D. G., Lanar, D. E.> ;Infect Immun. 2007 Feb
• Adenovirus 5 and 35 vectors expressing Plasmodium falciparum circumsporozoite surface protein elicit potent antigen-specific cellular IFN-gamma and antibody responses ...
  Shott, J. P., McGrath, S. M., Pau, M. G., Custers, J. H., Ophorst, O., Demoitié, M. A., Dubois, M. C., Komisar, J., Cobb, M., Kester, K. E., Dubois, P., Cohen, J., Gou...> ;Vaccine. 2008 Jun 2
• Phase 1 safety and immunogenicity trial of malaria vaccine RTS,S/AS02A in adults in a hyperendemic region of western Kenya.
  Stoute, J. A., Heppner, D. G., Mason, C. J., Siangla, J., Opollo, M. O., Kester, K. E., Vigneron, L., Voss, G., Walter, M. J., Tornieporth, N., Cohen, J. D., Ballou, W...> ;Am J Trop Med Hyg. 2006 Jul
• Safety and immunogenicity of rts,s+trap malaria vaccine, formulated in the as02a adjuvant system, in infant rhesus monkeys.
  Walsh, D. S., Pichyangkul, S., Gettayacamin, M., Tongtawe, P., Siegrist, C. A., Hansukjariya, P., Kester, K. E., Holland, C. A., Voss, G., Cohen, J., Stewart, A. V., M...> ;Am J Trop Med Hyg. 2004 May
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