DouglasJSchwartzentruberMD

General Surgery • Indianapolis, IN

Melanoma, Surgical Oncology (Other than Breast)

Physician

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Office
550 N University Blvd
AOC UH 6237
Indianapolis, IN 46202
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Education & Training

National Cancer InstituteFellowship, Complex General Surgical Oncology, 1987 - 1990
Indiana University School of MedicineResidency, Surgery, 1982 - 1987
Indiana University School of MedicineClass of 1982

Certifications & Licensure

IN State Medical License 1982 - 2025

Awards, Honors, & Recognition

America's Top Doctors Castle Connolly, 2007-2014
Indianapolis Monthly Castle Connolly, 2013
America's Top Doctors for Cancer Castle Connolly, 2006-2013
Fellow (FACS) American College of Surgeons
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Clinical Trials

Aldesleukin With or Without Vaccine Therapy in Treating Patients With Locally Advanced or Metastatic Melanoma Start of enrollment: 1999 Dec 01
Completed
Phase 3

Publications & Presentations

PubMed

115 citations
High dose interleukin-2 (Aldesleukin) - expert consensus on best management practices-2014
Janice P. Dutcher, Douglas J. Schwartzentruber, Howard L. Kaufman, Sanjiv S. Agarwala, Ahmad A. Tarhini, James N. Lowder, Michael B. Atkins> ;Journal for Immunotherapy of Cancer. 2014 Sep 16
535 citations
A Mosaic Activating Mutation in AKT1 Associated with the Proteus Syndrome
Marjorie J. Lindhurst, Julie C Sapp, Jamie K. Teer, Jennifer J. Johnston, Erin M Finn, Kathryn F. Peters, Joyce T. Turner, Jennifer L. Cannons, David P. Bick, Laurel C...> ;The New England Journal of Medicine. 2011 Aug 18
601 citations
gp100 peptide vaccine and interleukin-2 in patients with advanced melanoma.
Douglas J. Schwartzentruber, David H. Lawson, Jon M. Richards, Robert M. Conry, Donald M. Miller, Jonathan S. Treisman, Fawaz Gailani, Lee B. Riley, Kevin C. Conlon, B...> ;The New England Journal of Medicine. 2011 Jun 2
10 citations
Future perspectives in melanoma research. Meeting report from the "Melanoma Research: a bridge Naples-USA. Naples, December 6th-7th 2010".
Paolo A. Ascierto, Eleonora De Maio, Stefano Bertuzzi, Giuseppe Palmieri, Ruth Halaban, Mary J.C. Hendrix, Mohamed Kashani-sabet, Soldano Ferrone, Ena Wang, Alistair J...> ;Journal of Translational Medicine. 2011 Mar 26
7 citations
Morphological Characterization of the Breast in Proteus Syndrome Complicated by Ductal Carcinoma In Situ
Jabed Iqbal, Gary He, Leslie G. Biesecker, Peter Rosen, Paul H. Duray, Douglas J. Schwartzentruber, Mansor Beg, Ellen Kahn> ;Annals of Clinical and Laboratory Science. 2006 Sep 21
21 citations
Cardiac magnetic resonance appearance of myocarditis caused by high dose IL-2: similarities to community-acquired myocarditis.
W. Patricia Ingkanisorn, D. Ian Paterson, Katherine R. Calvo, Douglas R. Rosing, Douglas J. Schwartzentruber, Anthon R. Fuisz, Andrew E. Arai> ;Journal of Cardiovascular Magnetic Resonance. 2006 Jan 1
65 citations
Tumor progression can occur despite the induction of very high levels of self/tumor antigen-specific CD8+ T cells in patients with melanoma.
Steven A Rosenberg, Richard M Sherry, Kathleen E Morton, William J Scharfman, James C Yang, Suzanne L Topalian, Richard E Royal, Udai Kammula, Nicholas P Restifo, Mary...> ;Journal of Immunology. 2005 Nov 1
24 citations
Phase III randomized trial of patient-specific vaccination for previously untreated patients with follicular lymphoma in first complete remission: protocol summary and...
Sattva S. Neelapu, Barry L. Gause, Daniel A. Nikcevich, Stephen J. Schuster, Jane N. Winter, Jon P. Gockerman, Thomas P. Loughran, Ken Takeshita, Giorgio Inghirami, De...> ;Clinical Lymphoma. 2005 Jun 1
18 citations
Gastrointestinal perforations associated with interleukin-2 administration.
David M. Heimann, Douglas J. Schwartzentruber> ;Journal of Immunotherapy. 2004 May 1
50 citations
Cell transfer therapy for cancer: lessons from sequential treatments of a patient with metastatic melanoma.
Steven A. Rosenberg, James Chih-Hsin Yang, Paul F. Robbins, John R. Wunderlich, Patrick Hwu, Richard M. Sherry, Douglas J. Schwartzentruber, Suzanne L. Topalian, Nicho...> ;Journal of Immunotherapy. 2003 Jan 1
574 citations
Randomized Study of High-Dose and Low-Dose Interleukin-2 in Patients With Metastatic Renal Cancer
James Chih-Hsin Yang, Richard M. Sherry, Seth M. Steinberg, Suzanne L. Topalian, Douglas J. Schwartzentruber, Patrick Hwu, Claudia A. Seipp, Linda Rogers-Freezer, Kath...> ;Journal of Clinical Oncology. 2003 Aug 15
71 citations
Recombinant Fowlpox Viruses Encoding the Anchor-modified gp100 Melanoma Antigen Can Generate Antitumor Immune Responses in Patients with Metastatic Melanoma
Steven A. Rosenberg, James Chih-Hsin Yang, Douglas J. Schwartzentruber, Patrick Hwu, Suzanne L. Topalian, Richard M. Sherry, Nicholas P. Restifo, John R. Wunderlich, C...> ;Clinical Cancer Research. 2003 Aug 1
2082 citations
A Randomized Trial of Bevacizumab, an Anti–Vascular Endothelial Growth Factor Antibody, for Metastatic Renal Cancer
James Chih-Hsin Yang, Leah R. Haworth, Richard M. Sherry, Patrick Hwu, Douglas J. Schwartzentruber, Suzanne L. Topalian, Seth M. Steinberg, Helen X. Chen, Steven A. Ro...> ;The New England Journal of Medicine. 2003 Jul 31
1198 citations
Cancer regression and autoimmunity induced by cytotoxic T lymphocyte-associated antigen 4 blockade in patients with metastatic melanoma
Giao Q. Phan, James Chih-Hsin Yang, Richard M. Sherry, Patrick Hwu, Suzanne L. Topalian, Douglas J. Schwartzentruber, Nicholas P. Restifo, Leah R. Haworth, Claudia A. ...> ;Proceedings of the National Academy of Sciences of the United States of America. 2003 Jul 8
89 citations
Immunization of patients with metastatic melanoma using both class I- and class II-restricted peptides from melanoma-associated antigens
Giao Q. Phan, Christopher E. Touloukian, James Chih-Hsin Yang, Nicholas P. Restifo, Richard M. Sherry, Patrick Hwu, Suzanne L. Topalian, Douglas J. Schwartzentruber, C...> ;Journal of Immunotherapy. 2003 Jul 1
84 citations
Inability to immunize patients with metastatic melanoma using plasmid DNA encoding the gp100 melanoma-melanocyte antigen
Steven A. Rosenberg, James Chih-Hsin Yang, Richard M. Sherry, Patrick Hwu, Suzanne L. Topalian, Douglas J. Schwartzentruber, Nicholas P. Restifo, Leah R. Haworth, Clau...> ;Human Gene Therapy. 2003 May 20
244 citations
Presurgical Chemotherapy Compared With Immediate Surgery and Adjuvant Chemotherapy for Nonmetastatic Osteosarcoma: Pediatric Oncology Group Study POG-8651
Allen M. Goorin, Douglas J. Schwartzentruber, Meenakshi Devidas, Mark C. Gebhardt, Alberto G. Ayala, Michael E. Harris, Lee J. Helman, Holcombe E. Grier, Michael P. Link> ;Journal of Clinical Oncology. 2003 Apr 15
2121 citations
Cancer Regression and Autoimmunity in Patients After Clonal Repopulation with Antitumor Lymphocytes
Mark E. Dudley, John R. Wunderlich, Paul F. Robbins, James Chih-Hsin Yang, Patrick Hwu, Douglas J. Schwartzentruber, Suzanne L. Topalian, Richard M. Sherry, Nicholas P...> ;Science. 2002 Oct 25
21 citations
Principles for the surgical management of patients with Proteus syndrome and patients with overgrowth not meeting Proteus criteria.
Matthew Lublin, Douglas J. Schwartzentruber, Jeff Lukish, Caroline Chester, Leslie G. Biesecker, Kurt D. Newman> ;Journal of Pediatric Surgery. 2002 Jul 1
272 citations
A phase I study of nonmyeloablative chemotherapy and adoptive transfer of autologous tumor antigen-specific T lymphocytes in patients with metastatic melanoma.
Mark E. Dudley, John R. Wunderlich, James Chih-Hsin Yang, Patrick Hwu, Douglas J. Schwartzentruber, Suzanne L. Topalian, Richard M. Sherry, Francesco M. Marincola, Sus...> ;Journal of Immunotherapy. 2002 May 1
81 citations
Hepatic abscess in patients with chronic granulomatous disease.
Matthew Lublin, David L. Bartlett, David N. Danforth, Howard Kauffman, John I. Gallin, Harry L. Malech, Thomas H. Shawker, Peter L. Choyke, David E. Kleiner, Douglas J...> ;Annals of Surgery. 2002 Mar 1
491 citations
Phase I Study of the Intravenous Administration of Attenuated Salmonella typhimurium to Patients With Metastatic Melanoma
John F. Toso, Vee J. Gill, Patrick Hwu, Francesco M. Marincola, Nicholas P. Restifo, Douglas J. Schwartzentruber, Richard M. Sherry, Suzanne L. Topalian, James Chih-Hs...> ;Journal of Clinical Oncology. 2002 Jan 1
78 citations
Safety and efficacy of high-dose interleukin-2 therapy in patients with brain metastases.
Lisa M. Guirguis, James Chih-Hsin Yang, Donald E. White, Seth M. Steinberg, David J. Liewehr, Steven A. Rosenberg, Douglas J. Schwartzentruber> ;Journal of Immunotherapy. 2002 Jan 1
180 citations
Identification of dynamically distinct subpopulations of T lymphocytes that are differentially affected by HIV.
Joseph A. Kovacs, Richard A. Lempicki, Igor A. Sidorov, Joseph W. Adelsberger, Betsey Herpin, Julia A. Metcalf, Irini Sereti, Michael A. Polis, Richard T. Davey, Jorge...> ;The Journal of Experimental Medicine. 2001 Dec 17
121 citations
Guidelines for the safe administration of high-dose interleukin-2.
Douglas J. Schwartzentruber> ;Journal of Immunotherapy. 2001 Jul 1
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