DrewWeissmanMD

PubMed

• 16 citations
  Adjuvant lipidoid-substituted lipid nanoparticles augment the immunogenicity of SARS-CoV-2 mRNA vaccines.
  Xuexiang Han, Mohamad-Gabriel Alameh, Kamila Butowska, James J Knox, Kendall Lundgreen, Majed Ghattas, Ningqiang Gong, Lulu Xue, Ying Xu, Marc Lavertu, Paul Bates, Jun...> ;Nature Nanotechnology. 2023 Sep 1
• 1 citations
  Lipid nanoparticles (LNP) induce activation and maturation of antigen presenting cells in young and aged individuals.
  Jennifer Connors, David Joyner, Nathan J Mege, Gina M Cusimano, Matthew R Bell, Jennifer Marcy, Bhavani Taramangalam, Kenneth M Kim, Paulo J C Lin, Ying K Tam, Drew We...> ;Communications Biology. 2023 Feb 17
• 28 citations
  Ionizable Lipid Nanoparticles formRNA Delivery to the Placenta during Pregnancy.
  Kelsey L Swingle, Hannah C Safford, Hannah C Geisler, Alex G Hamilton, Ajay S Thatte, Margaret M Billingsley, Ryann A Joseph, Kaitlin Mrksich, Marshall S Padilla, Adit...> ;Journal of the American Chemical Society. 2023 Mar 1
• 32 citations
  Ionizable lipid nanoparticles deliver mRNA to pancreatic β cells via macrophage-mediated gene transfer.
  Jilian R Melamed, Saigopalakrishna S Yerneni, Mariah L Arral, Samuel T LoPresti, Namit Chaudhary, Anuradha Sehrawat, Hiromi Muramatsu, Mohamad-Gabriel Alameh, Norbert ...> ;Science Advances. 2023 Jan 27
• 25 citations
  Ligand-tethered lipid nanoparticles for targeted RNA delivery to treat liver fibrosis.
  Xuexiang Han, Ningqiang Gong, Lulu Xue, Margaret M Billingsley, Rakan El-Mayta, Sarah J Shepherd, Mohamad-Gabriel Alameh, Drew Weissman, Michael J Mitchell> ;Nature Communications. 2023 Jan 17
• 4 citations
  Nucleoside-Modified mRNA-Based Influenza Vaccines Circumvent Problems Associated with H3N2 Vaccine Strain Egg Adaptation.
  Sigrid Gouma, Colleen Furey, Jefferson J S Santos, Kaela Parkhouse, Madison Weirick, Hiromi Muramatsu, Norbert Pardi, Steven H Y Fan, Drew Weissman, Scott E Hensley> ;Journal of Virology. 2023 Jan 31
• 12 citations
  mRNA-LNP expressing PfCSP and Pfs25 vaccine candidates targeting infection and transmission of Plasmodium falciparum.
  Clifford T H Hayashi, Yi Cao, Leor C Clark, Abhai K Tripathi, Fidel Zavala, Garima Dwivedi, James Knox, Mohamad-Gabriel Alameh, Paulo J C Lin, Ying K Tam, Drew Weissma...> ;NPJ Vaccines. 2022 Dec 1
• 77 citations
  A multivalent nucleoside-modified mRNA vaccine against all known influenza virus subtypes.
  Claudia P Arevalo, Marcus J Bolton, Valerie Le Sage, Naiqing Ye, Colleen Furey, Hiromi Muramatsu, Mohamad-Gabriel Alameh, Norbert Pardi, Elizabeth M Drapeau, Kaela Par...> ;Science. 2022 Nov 25
• 7 citations
  Lipid Nanoparticles Delivering Constitutively Active STING mRNA to Stimulate Antitumor Immunity.
  Wei Liu, Mohamad-Gabriel Alameh, June F Yang, Jonathan R Xu, Paulo J C Lin, Ying K Tam, Drew Weissman, Jianxin You> ;International Journal of Molecular Sciences. 2022 Nov 22
• 3 citations
  Safety and immunogenicity of a prefusion non-stabilized spike protein mRNA COVID-19 vaccine: a phase I trial.
  Sivaporn Gatechompol, Wonngarm Kittanamongkolchai, Chutitorn Ketloy, Eakchai Prompetchara, Arunee Thitithanyanont, Anan Jongkaewwattana, Supranee Buranapraditkun, Moha...> ;Nature Microbiology. 2022 Dec 1
• 32 citations
  Breadth of SARS-CoV-2 neutralization and protection induced by a nanoparticle vaccine.
  Dapeng Li, David R Martinez, Alexandra Schäfer, Haiyan Chen, Maggie Barr, Laura L Sutherland, Esther Lee, Robert Parks, Dieter Mielke, Whitney Edwards, Amanda Newman, ...> ;Nature Communications. 2022 Oct 23
• SARS-CoV-2 mRNA-based vaccines in the Aicardi Goutières Syndrome.
  Asako Takanohashi, Mohamad-Gabriel Alameh, Sarah Woidill, Julia Hacker, Benjamin Davis, Guy Helman, Francesco Gavazzi, Laura Adang, Russell D'Aiello, Patrick Winters, ...> ;Molecular Genetics and Metabolism. 2022 Dec 1
• 1 citations
  Nucleoside-modified mRNA vaccines yield robust blocking antibody responses against major house dust mite allergens.
  Sirikarn Jitthamstaporn, Rueangsit Inthong, Dittaya Audomsun, Supapich Chanasit, Chanatip Thanasarnthungcharoen, Paulo J C Lin, Drew Weissman, Norbert Pardi, Alain Jac...> ;Allergy. 2023 Jan 1
• 45 citations
  Dual spike and nucleocapsid mRNA vaccination confer protection against SARS-CoV-2 Omicron and Delta variants in preclinical models.
  Renee L Hajnik, Jessica A Plante, Yuejin Liang, Mohamad-Gabriel Alameh, Jinyi Tang, Srinivasa Reddy Bonam, Chaojie Zhong, Awadalkareem Adam, Dionna Scharton, Grace H R...> ;Science Translational Medicine. 2022 Sep 14
• 131 citations
  Respiratory mucosal immunity against SARS-CoV-2 after mRNA vaccination.
  Jinyi Tang, Cong Zeng, Thomas M Cox, Chaofan Li, Young Min Son, In Su Cheon, Yue Wu, Supriya Behl, Justin J Taylor, Rana Chakaraborty, Aaron J Johnson, Dante N Shiavo,...> ;Science Immunology. 2022 Oct 28
• 35 citations
  Rational Design of Bisphosphonate Lipid-like Materials for mRNA Delivery to the Bone Microenvironment.
  Lulu Xue, Ningqiang Gong, Sarah J Shepherd, Xinhong Xiong, Xueyang Liao, Xuexiang Han, Gan Zhao, Chao Song, Xisha Huang, Hanwen Zhang, Marshall S Padilla, Jingya Qin, ...> ;Journal of the American Chemical Society. 2022 Jun 8
• 4 citations
  Modified E2 Glycoprotein of Hepatitis C Virus Enhances Proinflammatory Cytokines and Protective Immune Response.
  Vijayamahantesh Vijayamahantesh, Tapas Patra, Keith Meyer, Mohamad-Gabriel Alameh, Erin K Reagan, Drew Weissman, Ranjit Ray> ;Journal of Virology. 2022 Jun 22
• 25 citations
  Hydroxycholesterol substitution in ionizable lipid nanoparticles for mRNA delivery to T cells.
  Savan K Patel, Margaret M Billingsley, Caitlin Frazee, Xuexiang Han, Kelsey L Swingle, Jingya Qin, Mohamad-Gabriel Alameh, Karin Wang, Drew Weissman, Michael J Mitchell> ;Journal of Controlled Release. 2022 Jul 1
• 22 citations
  Rational design of anti-inflammatory lipid nanoparticles for mRNA delivery.
  Hanwen Zhang, Xuexiang Han, Mohamad-Gabriel Alameh, Sarah J Shepherd, Marshall S Padilla, Lulu Xue, Kamila Butowska, Drew Weissman, Michael J Mitchell> ;Journal of Biomedical Materials Research. Part A. 2022 May 1
• 32 citations
  Development of mRNA manufacturing for vaccines and therapeutics: mRNA platform requirements and development of a scalable production process to support early phase cli...
  Jill Whitley, Christopher Zwolinski, Christian Denis, Maureen Maughan, Leonie Hayles, David Clarke, Meghan Snare, Hong Liao, Sean Chiou, Tina Marmura, Holly Zoeller, B...> ;Translational Research. 2022 Apr 1
• 44 citations
  Added to pre-existing inflammation, mRNA-lipid nanoparticles induce inflammation exacerbation (IE).
  Hamideh Parhiz, Jacob S Brenner, Priyal N Patel, Tyler E Papp, Hamna Shahnawaz, Qin Li, Ruiqi Shi, Marco E Zamora, Amir Yadegari, Oscar A Marcos-Contreras, Ambika Nate...> ;Journal of Controlled Release. 2022 Apr 1
• 28 citations
  The Unexpected Importance of the Primary Structure of the Hydrophobic Part of One-Component Ionizable Amphiphilic Janus Dendrimers in Targeted mRNA Delivery Activity.
  Dapeng Zhang, Elena N Atochina-Vasserman, Juncheng Lu, Devendra S Maurya, Qi Xiao, Matthew Liu, Jasper Adamson, Nathan Ona, Erin K Reagan, Houping Ni, Drew Weissman, V...> ;Journal of the American Chemical Society. 2022 Mar 23
• 18 citations
  mRNA-encoded HIV-1 Env trimer ferritin nanoparticles induce monoclonal antibodies that neutralize heterologous HIV-1 isolates in mice.
  Zekun Mu, Kevin Wiehe, Kevin O Saunders, Rory Henderson, Derek W Cain, Robert Parks, Diana Martik, Katayoun Mansouri, Robert J Edwards, Amanda Newman, Xiaozhi Lu, Shi-...> ;Cell Reports. 2022 Mar 15
• 5 citations
  Antibodies to Crucial Epitopes on HSV-2 Glycoprotein D as a Guide to Dosing an mRNA Genital Herpes Vaccine.
  Lauren M Hook, Sita Awasthi, Tina M Cairns, Mohamad-Gabriel Alameh, Bernard T Fowler, Kevin P Egan, Molly M H Sung, Drew Weissman, Gary H Cohen, Harvey M Friedman> ;Viruses. 2022 Mar 5
• 19 citations
  Breadth of SARS-CoV-2 Neutralization and Protection Induced by a Nanoparticle Vaccine.
  Dapeng Li, David R Martinez, Alexandra Schäfer, Haiyan Chen, Maggie Barr, Laura L Sutherland, Esther Lee, Robert Parks, Dieter Mielke, Whitney Edwards, Amanda Newman, ...> ;Biorxiv. 2022 Feb 14
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