Eddy Shih-HsinYangMDPhD

Breast Cancer, Head & Neck, Urologic Cancer

Professor and Vice Chair for Translational Sciences, Department of Radiation Oncology Deputy Director and Associate Director of Precision Oncology Hugh Kaul Precision Medicine Institute, University of Alabama School of Medicine

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Office
1700 6th Ave S
Ste 2232
Birmingham, AL 35233
Phone+1 205-934-5670

Fax+1 205-975-0784
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Education & Training

Vanderbilt University Medical CenterResidency, Radiation Oncology, 2006 - 2010
Mount Sinai Medical Center of FloridaInternship, Internal Medicine, 2005 - 2006
University of Miami Leonard M. Miller School of MedicineClass of 2005

Certifications & Licensure

KY State Medical License 2023 - 2025
AL State Medical License 2010 - 2024
American Board of Radiology Radiation Oncology

Clinical Trials

TAPUR: Testing the Use of Food and Drug Administration (FDA) Approved Drugs That Target a Specific Abnormality in a Tumor Gene in People With Advanced Stage Cancer Start of enrollment: 2016 Mar 14
Recruiting
Phase 2
International Registry for Men With Advanced Prostate Cancer (IRONMAN) Start of enrollment: 2017 Jul 21
Recruiting
Niraparib in Combination With Trastuzumab in Metastatic HER2+ Breast Cancer Start of enrollment: 2019 Sep 06
Recruiting
Phase 1, Phase 2
⁸⁹Zr-Df-IAB22M2C (CD8 PET Tracer) for PET/CT in Patients With Metastatic Solid Tumors Start of enrollment: 2018 Dec 18
Completed
Phase 2
Abemaciclib and Pembrolizumab in Metastatic or Recurrent Head and Neck Cancer Start of enrollment: 2019 Oct 08
Terminated
Phase 2
A Study of Selpercatinib (LY3527723) in Participants With RET-Mutant Medullary Thyroid Cancer Start of enrollment: 2020 Feb 11
Active, not recruiting
Phase 3
Abemaciclib in Combination With Androgen Deprivation Therapy for Locally Advanced Prostate Cancer Start of enrollment: 2021 Feb 25
Active, not recruiting
Phase 2
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Publications & Presentations

PubMed

A Novel Translational PET Imaging Approach to Quantifying Distal Tumor Immune Activation After Targeted Radiation Therapy and Checkpoint Blockade.
Yujun Zhang, Jessy S Deshane, Eddy S Yang, Benjamin Larimer> ;International Journal of Radiation Oncology, Biology, Physics. 2024 Apr 1
Two novel stereotactic radiotherapy methods for locally advanced, previously irradiated head and neck cancers patients.
Damodar Pokhrel, Josh Misa, Shane McCarthy, Eddy S Yang> ;Medical Dosimetry. 2023 Oct 20
1 citations
Combination Therapy with Trastuzumab and Niraparib: Quantifying Early Proliferative Alterations in HER2+ Breast Cancer Models.
Ameer Mansur, Patrick N Song, Yun Lu, Andrew C Burns, Luke Sligh, Eddy S Yang, Anna G Sorace> ;Biomedicines. 2023 Jul 25
Validation of Immunotherapy Response Score as Predictive of Pan-solid Tumor Anti-PD-1/PD-L1 Benefit.
Benjamin J Bulen, Nickolay A Khazanov, Daniel H Hovelson, Laura E Lamb, Marc Matrana, Mark E Burkard, Eddy Shih-Hsin Yang, William J Edenfield, Elizabeth Claire Dees, ...> ;Cancer Research Communications. 2023 Jul 1
2 citations
Prostate Stereotactic Body Radiation Therapy With a Focal Simultaneous Integrated Boost: 5-Year Toxicity and Biochemical Recurrence Results From a Prospective Trial.
Jared A Maas, Michael C Dobelbower, Eddy S Yang, Grant M Clark, Rojymon Jacob, Robert Y Kim, Rex A Cardan, Richard Popple, Jeffrey W Nix, Soroush Rais-Bahrami, John B ...> ;Practical Radiation Oncology. 2023 Jun 1
7 citations
Development and validation of an integrative pan-solid tumor predictor of PD-1/PD-L1 blockade benefit.
Tomlins, S., Khazanov, N., Bulen, B., Hovelson, D., Shreve, M., Lamb, L., Matrana, M., Burkard, M., Yang, E., Edenfield, W., Dees, E., Onitilo, A., Thompson, M., Buchs...> ;Communications Medicine. 2023 Feb 7
1 citations
A phase I/II study of preoperative letrozole, everolimus, and carotuximab in stage 2 and 3 hormone receptor-positive and Her2-negative breast cancer.
Christos Vaklavas, Erica M Stringer-Reasor, Ahmed M Elkhanany, Kevin J Ryan, Yufeng Li, Charles P Theuer, Edward P Acosta, Shi Wei, Eddy S Yang, William E Grizzle, And...> ;Breast Cancer Research and Treatment. 2023 Apr 1
1 citations
Olaparib in Patients With Metastatic Prostate Cancer With/Mutation: Results From the TAPUR Study.
Eddy S Yang, Susan Halabi, Michael Rothe, Elizabeth Garrett-Mayer, Pam K Mangat, Evan Pisick, Elie Dib, Earle F Burgess, Michael Zakem, Nitin Rohatgi, Mehmet A Bilen, ...> ;JCO Precision Oncology. 2023 Feb 1
1 citations
Therapeutic Targeting of DNA Damage Repair in the Era of Precision Oncology and Immune Checkpoint Inhibitors.
Curtis A Clark, Eddy S Yang> ;Journal of Immunotherapy and Precision Oncology. 2023 Feb 1
9 citations
An Assessment of the Feasibility and Utility of an ACCC-ASCO Implicit Bias Training Program to Enhance Racial and Ethnic Diversity in Cancer Clinical Trials.
Nadine J Barrett, Leigh Boehmer, Janelle Schrag, Al B Benson 3rd, Sybil Green, Leila Hamroun-Yazid, Alexandra Howson, Khalid Matin, Randall A Oyer, Lori Pierce, Sanfor...> ;JCO Oncology Practice. 2023 Apr 1
5 citations
Phase I Study of Niraparib in Combination with Radium-223 for the Treatment of Metastatic Castrate-Resistant Prostate Cancer.
Zachary Quinn, Benjamin Leiby, Guru Sonpavde, Atish D Choudhury, Christopher Sweeney, David Einstein, Russell Szmulewitz, Oliver Sartor, Karen Knudsen, Eddy Shih-Hsin ...> ;Clinical Cancer Research. 2023 Jan 4
3 citations
Body composition and mortality in men receiving prostate radiotherapy: A pooled analysis of NRG/RTOG 9406 and NRG/RTOG 0126.
Andrew M McDonald, Lyudmila DeMora, Eddy S Yang, John M Hoyle, Andrew Lenzie, Grant R Williams, Jeff M Michalski, Don Yee, Jean-Paul Bahary, Robert B Den, Mack Roach 3...> ;Cancer. 2023 Mar 1
10 citations
Selective suppression of melanoma lacking IFN-γ pathway by JAK inhibition depends on T cells and host TNF signaling.
Hongxing Shen, Fengyuan Huang, Xiangmin Zhang, Oluwagbemiga A Ojo, Yuebin Li, Hoa Quang Trummell, Joshua C Anderson, John Fiveash, Markus Bredel, Eddy S Yang, Christop...> ;Nature Communications. 2022 Aug 25
4 citations
An in vivo model of glioblastoma radiation resistance identifies long noncoding RNAs and targetable kinases.
Christian T Stackhouse, Joshua C Anderson, Zongliang Yue, Thanh Nguyen, Nicholas J Eustace, Catherine P Langford, Jelai Wang, James R Rowland 4th, Chuan Xing, Fady M M...> ;JCI Insight. 2022 Aug 22
6 citations
Phase II Study of Afatinib in Patients With Tumors With Human Epidermal Growth Factor Receptor 2-Activating Mutations: Results From the National Cancer Institute-Molec...
Philippe L Bedard, Shuli Li, Kari B Wisinski, Eddy S Yang, Sewanti A Limaye, Edith P Mitchell, James A Zwiebel, Jeffrey A Moscow, Robert J Gray, Victoria Wang, Lisa M ...> ;JCO Precision Oncology. 2022 Jul 1
47 citations
Increasing Racial and Ethnic Diversity in Cancer Clinical Trials: An American Society of Clinical Oncology and Association of Community Cancer Centers Joint Research S...
Randall A Oyer, Patricia Hurley, Leigh Boehmer, Suanna Steeby Bruinooge, Kathryn Levit, Nadine Barrett, Al Benson, Lea Ann Bernick, Leslie Byatt, Marjory Charlot, Jenn...> ;Journal of Clinical Oncology. 2022 Jul 1
7 citations
A 10-miRNA risk score-based prediction model for pathological complete response to neoadjuvant chemotherapy in hormone receptor-positive breast cancer.
Chang Gong, Ziliang Cheng, Yaping Yang, Jun Shen, Yingying Zhu, Li Ling, Wanyi Lin, Zhigang Yu, Zhihua Li, Weige Tan, Chushan Zheng, Wenbo Zheng, Jiajie Zhong, Xiang Z...> ;Science China. Life Sciences. 2022 Nov 1
9 citations
Poly(-vinylpyrrolidone)--Poly(dimethylsiloxane)--Poly(-vinylpyrrolidone) Triblock Copolymer Polymersomes for Delivery of PARP1 siRNA to Breast Cancers.
Yiming Yang, Veronika Kozlovskaya, Zhuo Zhang, Chuan Xing, Steve Zaharias, Maksim Dolmat, Shuo Qian, Jun Zhang, Jason M Warram, Eddy S Yang, Eugenia Kharlampieva> ;ACS Applied Bio Materials. 2022 Apr 18
6 citations
Modulation of the Tumor Microenvironment with Trastuzumab Enables Radiosensitization in HER2+ Breast Cancer.
Patrick N Song, Ameer Mansur, Yun Lu, Deborah Della Manna, Andrew Burns, Sharon Samuel, Katherine Heinzman, Suzanne E Lapi, Eddy S Yang, Anna G Sorace> ;Cancers. 2022 Feb 17
2 citations
The BET Inhibitor JQ1 Potentiates the Anticlonogenic Effect of Radiation in Pancreatic Cancer Cells.
Patrick L Garcia, Aubrey L Miller, Ling Zeng, Robert C A M van Waardenburg, Eddy S Yang, Karina J Yoon> ;Frontiers in Oncology. 2022 Jan 1
10 citations
RNF2 ablation reprograms the tumor-immune microenvironment and stimulates durable NK and CD4+ T-cell-dependent antitumor immunity
Zhuo Zhang, Lin Luo, Chuan Xing, Yu Chen, Peng Xu, Mao Li, Ling Zeng, Chao Li, Sadashib Ghosh, Deborah L. Della Manna, Tim M. Townes, William J. Britt, Narendra Wajape...> ;Nature Cancer. 2021 Oct 1
9 citations
Harnessing DNA Repair Defects to Augment Immune-Based Therapies in Triple-Negative Breast Cancer.
Curtis A. Clark, Eddy S. Yang> ;Frontiers in Oncology. 2021 Sep 24
13 citations
Real-World Performance of a Comprehensive Genomic Profiling Test Optimized for Small Tumor Samples.
Scott A. Tomlins, Daniel H. Hovelson, Jennifer Marie Suga, Daniel M. Anderson, Han A. Koh, Elizabeth Claire Dees, Brendan McNulty, Mark E. Burkard, Michael Guarino, Ja...> ;JCO Precision Oncology. 2021 Aug 19
13 citations
Anti-CD47 Monoclonal Antibody-Drug Conjugate: A Targeted Therapy to Treat Triple-Negative Breast Cancers.
Yingnan Si, Ya Zhang, Jia-Shiung Guan, Hanh Giai Ngo, Angela Totoro, Ajeet Pal Singh, Kai Chen, Yuanxin Xu, Eddy S. Yang, Lufang Zhou, Runhua Liu, Xiaoguang Margaret Liu> ;Vaccines. 2021 Aug 10
10 citations
Targeted Liposomal Chemotherapies to Treat Triple-Negative Breast Cancer
Yingnan Si, Ya Zhang, Hanh Giai Ngo, Jia-Shiung Guan, Kai Chen, Qing Wang, Ajeet Pal Singh, Yuanxin Xu, Lufang Zhou, Eddy S. Yang, Xiaoguang Margaret Liu> ;Cancers. 2021 Jul 26
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Lectures

Incorporating Transcriptomics to Guide Precision Therapeutics. Innovative Immune and Genomic Biomarkers for Solid Tumors
2018 ASCO Annual Meeting - Chicago, Illinois - 06/4/2018

Hospital Affiliations

University of Alabama HospitalBirmingham, Alabama
Birmingham VA Medical CenterBirmingham, Alabama
USA Health University HospitalMobile, Alabama
University of Kentucky Albert B. Chandler HospitalLexington, Kentucky