EduardoNunesChiniMD

PubMed

• Ecto-CD38-NADase inhibition modulates cardiac metabolism and protects mice against doxorubicin-induced cardiotoxicity.
  Thais R Peclat, Guillermo Agorrody, Laura Colman, Sonu Kashyap, Julianna D Zeidler, Claudia C S Chini, Gina M Warner, Katie L Thompson, Pranjali Dalvi, Felipe Beckedor...> ;Cardiovascular Research. 2024 Mar 14
• Heavy-chain antibody targeting of CD38 NADhydrolase ectoenzyme to prevent fibrosis in multiple organs.
  Bo Shi, Asif Amin, Pranjali Dalvi, Wenxia Wang, Nicholas Lukacs, Li Kai, Paul Cheresh, Thais R Peclat, Claudia C Chini, Eduardo N Chini, Wim van Schooten, John Varga> ;Scientific Reports. 2023 Dec 12
• 1 citations
  Immunomodulatory properties of CD38 antibodies and their effect on anticancer efficacy in multiple myeloma.
  Kamlesh Bisht, Taro Fukao, Marielle Chiron, Paul Richardson, Djordje Atanackovic, Eduardo Chini, Wee Joo Chng, Helgi Van De Velde, Fabio Malavasi> ;Cancer Medicine. 2023 Oct 1
• 6 citations
  Evaluation of the Aging Effect on Peripheral Nerve Regeneration: A Systematic Review.
  Karla C Maita, John P Garcia, Francisco R Avila, Ricardo A Torres-Guzman, Olivia Ho, Claudia C S Chini, Eduardo N Chini, Antonio J Forte> ;The Journal of Surgical Research. 2023 Aug 1
• A nitroalkene derivative of salicylate alleviates diet-induced obesity by activating creatine metabolism and non-shivering thermogenesis.
  Karina Cal, Alejandro Leyva, Jorge Rodríguez-Duarte, Santiago Ruiz, Leonardo Santos, Lucía Colella, Mariana Ingold, Cecilia Vilaseca, German Galliussi, Lucía Ziegler, ...> ;Research Square. 2023 Jul 12
• 2 citations
  NAD metabolism: Role in senescence regulation and aging.
  Claudia Christiano Silva Chini, Heidi Soares Cordeiro, Ngan Le Kim Tran, Eduardo Nunes Chini> ;Aging Cell. 2024 Jan 1
• 3 citations
  An ERK5-NRF2 Axis Mediates Senescence-Associated Stemness and Atherosclerosis.
  Jun-Ichi Abe, Masaki Imanishi, Shengyu Li, Aijun Zhang, Kyung Ae Ko, Venkata S K Samanthapudi, Ling-Ling Lee, Angelica Paniagua Bojorges, Young Jin Gi, Brian P Hobbs, ...> ;Circulation Research. 2023 Jun 23
• 2 citations
  A stress-induced cilium-to-PML-NB route drives senescence initiation.
  Xiaoyu Ma, Yingyi Zhang, Yuanyuan Zhang, Xu Zhang, Yan Huang, Kai He, Chuan Chen, Jielu Hao, Debiao Zhao, Nathan K LeBrasseur, James L Kirkland, Eduardo N Chini, Qing ...> ;Nature Communications. 2023 Apr 3
• Premature senescence and cardiovascular disease following cancer treatments: mechanistic insights.
  Ashita Jain, Diego Casanova, Alejandra Valdivia Padilla, Angelica Paniagua Bojorges, Sivareddy Kotla, Kyung Ae Ko, Venkata S K Samanthapudi, Khanh Chau, Minh T H Nguye...> ;Frontiers in Cardiovascular Medicine. 2023 Jan 1
• 21 citations
  p21 induces a senescence program and skeletal muscle dysfunction.
  Davis A Englund, Alyssa Jolliffe, Zaira Aversa, Xu Zhang, Ines Sturmlechner, Ayumi E Sakamoto, Julianna D Zeidler, Gina M Warner, Colton McNinch, Thomas A White, Eduar...> ;Molecular Metabolism. 2023 Jan 1
• 2 citations
  Endogenous metabolism in endothelial and immune cells generates most of the tissue vitamin B3 (nicotinamide).
  Julianna D Zeidler, Claudia C S Chini, Karina S Kanamori, Sonu Kashyap, Jair M Espindola-Netto, Katie Thompson, Gina Warner, Fernanda S Cabral, Thais R Peclat, Lilian ...> ;Iscience. 2022 Nov 18
• Aging increases the risk of flap necrosis in murine models: A systematic review.
  John P Garcia, Francisco R Avila, Ricardo A Torres-Guzman, Karla C Maita, Abdullah S Eldaly, Luiza Palmieri, Omar Emam, Claudia C Chini, Eduardo N Chini, Antonio J Forte> ;Journal of Clinical and Translational Research. 2022 Oct 31
• 6 citations
  Senescent Cells Accumulate in Systemic Sclerosis Skin.
  Bo Shi, Pei-Suen Tsou, Feiyang Ma, Michael P Mariani, Megan N Mattichak, Nathan K LeBrasseur, Eduardo N Chini, Robert Lafyatis, Dinesh Khanna, Michael L Whitfield, Joh...> ;The Journal of Investigative Dermatology. 2023 Apr 1
• 6 citations
  TNB-738, a biparatopic antibody, boosts intracellular NAD+ by inhibiting CD38 ecto-enzyme activity.
  Harshad S Ugamraj, Kevin Dang, Laure-Hélène Ouisse, Benjamin Buelow, Eduardo N Chini, Giulia Castello, James Allison, Starlynn C Clarke, Laura M Davison, Roland Buelow...> ;Mabs. 2022 Jul 22
• 154 citations
  Mitochondrial dysfunction in cell senescence and aging.
  Satomi Miwa, Sonu Kashyap, Eduardo Chini, Thomas von Zglinicki> ;The Journal of Clinical Investigation. 2022 Jul 1
• 9 citations
  CD38-NADase is a new major contributor to Duchenne muscular dystrophic phenotype.
  Antoine de Zélicourt, Abdallah Fayssoil, Mbarka Dakouane-Giudicelli, Isley De Jesus, Ahmed Karoui, Faouzi Zarrouki, Florence Lefebvre, Arnaud Mansart, Jean-Marie Launa...> ;EMBO Molecular Medicine. 2022 May 9
• 10 citations
  Benefits in cardiac function by CD38 suppression: Improvement in NADlevels, exercise capacity, heart rate variability and protection against catecholamine-induced vent...
  Guillermo Agorrody, Thais R Peclat, Gonzalo Peluso, Luis A Gonano, Leonardo Santos, Wim van Schooten, Claudia C S Chini, Carlos Escande, Eduardo N Chini, Paola Contreras> ;Journal of Molecular and Cellular Cardiology. 2022 May 1
• 13 citations
  CD38 inhibitor 78c increases mice lifespan and healthspan in a model of chronological aging.
  Thais R Peclat, Katie L Thompson, Gina M Warner, Claudia C S Chini, Mariana G Tarragó, Delaram Z Mazdeh, Chunlian Zhang, Jose Zavala-Solorio, Ganesh Kolumam, Yao Liang...> ;Aging Cell. 2022 Apr 1
• 17 citations
  The CD38 glycohydrolase and the NAD sink: implications for pathological conditions.
  Julianna D Zeidler, Kelly A Hogan, Guillermo Agorrody, Thais R Peclat, Sonu Kashyap, Karina S Kanamori, Lilian Sales Gomez, Delaram Z Mazdeh, Gina M Warner, Katie L Th...> ;American Journal of Physiology. Cell Physiology. 2022 Mar 1
• 7 citations
  Dihydronicotinamide Riboside Is a Potent NADPrecursor Promoting a Pro-Inflammatory Phenotype in Macrophages.
  Claudia C S Chini, Thais R Peclat, Lilian S Gomez, Julianna D Zeidler, Gina M Warner, Sonu Kashyap, Delaram Z Mazdeh, Faisal Hayat, Marie E Migaud, Aneel Paulus, Asher...> ;Frontiers in Immunology. 2022 Jan 1
• 5 citations
  Cancer treatment-induced NAD+ depletion in premature senescence and late cardiovascular complications.
  Priyanka Banerjee, Elizabeth A Olmsted-Davis, Anita Deswal, Minh Th Nguyen, Efstratios Koutroumpakis, Nicholas L Palaskas, Steven H Lin, Sivareddy Kotla, Cielito Reyes...> ;The Journal of Cardiovascular Aging. 2022 Jan 1
• 3 citations
  Radiation therapy induces immunosenescence mediated by p90RSK.
  Masaki Imanishi, Haizi Cheng, Sivareddy Kotla, Anita Deswal, Nhat-Tu Le, Eduardo Chini, Kyung Ae Ko, Venkata S K Samanthapudi, Ling-Ling Lee, Joerg Herrmann, Xiaolei X...> ;Frontiers in Cardiovascular Medicine. 2022 Jan 1
• 3 citations
  Low NADLevels Are Associated With a Decline of Spermatogenesis in Transgenic ANDY and Aging Mice.
  Mirella L Meyer-Ficca, Alexie E Zwerdling, Corey A Swanson, Abby G Tucker, Sierra A Lopez, Miles K Wandersee, Gina M Warner, Katie L Thompson, Claudia C S Chini, Haoli...> ;Frontiers in Endocrinology. 2022 Jan 1
• 14 citations
  Implications of the NADase CD38 in COVID pathophysiology.
  Julianna D. Zeidler, Sonu Kashyap, Kelly A. Hogan, Eduardo N. Chini> ;Physiological Reviews. 2022 Jan 1
• 8 citations
  Critical Role of Astrocyte NAD+ Glycohydrolase in Myelin Injury and Regeneration.
  Monica R. Langley, Chan Il Choi, Thais Peclat, Yong Guo, Whitney L. Simon, Hyesook Yoon, Laurel S. Kleppe, Claudia F. Lucchinetti, Claudia C.S. Chini, Eduardo N. Chini...> ;The Journal of Neuroscience. 2021 Oct 13
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Journal Articles

• HMG-CoA reductase inhibitors decrease hyperglycemia on animal model of Systemic inflammatory response Syndrome (SIRS)  
  Aksoy P, Brown MJ, Chini EN, Journal of Anesthesia and Clinical Research, 1/1/2011
• Cyclic ADP-ribose signaling in sea urchin gametes - metabolism in spermatozoa  
  Chini EN, Thompson MA, Chini CCS, Dousa TP, Am J Physiol Cell Physiol, 1/1/1997
• Different thermostabilities of sarcoplasmic reticulum (Ca2+ + Mg2+)-ATPases from rabbit and trout muscles  
  de Toledo FG, Albuquerque MC, Goulart BH, Chini EN, Comparative Biochemistry & Physiology. Part C Pharmacology, Toxicology, Endocrinology, 1/1/1995

Books/Book Chapters

• Molecular mechanisms of parasite invasion. 
  Chapter: Calcium regulation and signaling in apicomplexan parasites. 
  Page 1 - 12Nagamune K, Moreno SN, Chini EN, Sibley DLEditors: Burleigh B, Soldati D.Landes Bioscience2007
• Cellular signaling and apoptosis research. 
  Chapter: Nuclear calcium signalling: the nuclear envelope store and the regulation of transcription. 
  Page 201 - 219Escande C, Arbildi P, Chini E, Benech JCEditors: Demasi AR.Nova Biomedical Books, New York, NY2007
• Critical care medicine : perioperative management. 
  Chapter: Transfusion medicine for the intensivist. 
  Page 566 - 576Chini EN, Dietz NM, Faust RJEditors: Murray MJ, et al.Lippincott Williams & Wilkins, Philadelphia, PAEdition 2,2002
• Recent Research Developments in Biophysics and Biochemistry 
  Chapter: The new calcium-mobilizing nucleotides cyclic ADP-ribose and NAADP 
  Chini EN, De Toledo FGSResearch Signposts, Trivandrum, India2001
• Methods in Renal Toxicology. 
  Chapter: Microdissection and microanalysis of specific nephron segments from mammalian kidney. 
  Page 97 - 107Chini EN, Dousa TPEditors: Zalups RK, Lash LH.CRC Press, Boca Raton, FL1996
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Abstracts/Posters

• A fatal case of fat embolism
  Schafer JE, Chini EN, MARC Conference, Cincinnati, OH, 1/1/2010
• The role of the CD38/cADPR signaling pathway in oxytocin-induced contraction in human myometrium.
  Zielinska W, Chini E, Vasdev GM, Anesthesiology, 1/1/2007
• Agonist-induced CADPR production in airway smooth muscle (Abstract 767.12)
  Kip SN, Smelter M, Thompson MA, Hunter LW, Iyanoye A, Chini EN, Pabelick CM, Sieck GC, FASEB J, 1/1/2006
• CD38 overexpression influences [Ca2+]i regulation in airway smooth muscle (Abstract 767.11)
  Soares SM, White TA, Bailey JP, Chini EN, Prakash YS, Pabelick CM, Sieck GC, FASEB J, 1/1/2006
• The levels of mRNA encoding plasma membrane calcium pump (pmca) isoforms 2 and 3 in rat kidney cortex is selectively decreased during hypercalciuria.
  Caride AJ, Chini EN, Penniston JT, Dousa TP, J Am Soc Nephrol, 1/1/1998
• Beta-estradiol (E2) stimulates synthesis of cyclic ADP ribose (CADPR) in rat uterus. (Abstract 1876)
  Chini EN, De Toledo FGS, Dousa TP, FASEB J, 1/1/1997
• Administration of beta-estradiol (E2) stimulates generation of cyclic ADP ribose from NAD in rat uterus.
  Chini EN, De Toledo FGS, Dousa TP, Journal of Investigative Medicine, 1/1/1997
• Thyroid hormone increases ADP/ribosyl cyclase activity in rat myocardium.
  Chini EN, De Toledo FGS, Dousa TP, Journal of Investigative Medicine, 1/1/1997
• Synthesis of cyclic-ADP-ribose, a putative new second messenger, in liver mitochondria.
  Liang M, Chini EN, Dousa TP, Journal of Investigative Medicine, 1/1/1997
• Compartmentalization of cAMP signaling in renal mesangial cells (mc) by cAMP phosphodiesterase (PDE) isozymes pde4 and pde3. (Abstract 57)
  Grande JP, Chini CSC, Chini EN, Dousa TP, Mol Biol Cell, 1/1/1996
• Diversity of plasma membrane calcium pump isoforms (RPMCAs) along the rat nephron. (Abstract M-POS264)
  Caride A, Chini E, Homma S, Penniston J, Dousa T, Biophys J, 1/1/1996
• Formation of reactive oxygen metabolites in rat mesangial cells (mc) is selectively suppressed by rolipram, inhibitor of cAMP phosphodiesterase isozyme IV (PDE-IV. (Ab...
  Chini CS, Grande JP, Chini EN, Dousa TP, FASEB J, 1/1/1996
• Enzymatic synthesis of naadp by ADP-ribosyl cyclases. (Abstract 822).
  Chini EN, Thompson M, Dousa TP, FASEB J, 1/1/1996
• Compartmentalization of cAMP-protein kinase a (pKA) signaling by isozymes PDE-IV and PDE-III in rat mesangial cells.
  Dousa TP, Chini CSC, Chini EN, Tsuboi Y, Grande JP, Biochem Soc Trans, 1/1/1996
• Plasma membrane CA pump (RPMCA) mRNAs encoding isoforms 1B and 2B in segments of rat cortical tubules and their change in decreased CA reabsorption.
  Caride AJ, Chini EN, Penniston JT, Dousa TP, J Am Soc Nephrol, 1/1/1996
• Isozymes of cAMP phosphodiesterase (PDE) compartmentalize cAMP signaling pathways in mesangial cells (mc).
  Chini CSC, Grande JP, Chini EN, Dousa TP, J Am Soc Nephrol, 1/1/1996
• Adrenomedullin (ADM) inhibits mesangial cell (MC) proliferation induced by PDGF but not by endothelin (ET-1)
  Chini EN, Chini CSC, Choi E, Burnett JCJ, Grande JP, Dousa TP, J Am Soc Nephrol, 1/1/1996
• Synthesis and localization of adrenomedullin (ADM) in rat mesangial cells (mc).
  Chini EN, Grande JP, Jougasaki M, Burnett JC, Dousa TP, J Am Soc Nephrol, 1/1/1996
• Relationship between proteinuria and histopathologic changes in glomeruli in mesangioproliferative glomerulonephritis (MSGN) elicited by anti-thy-1.1-Monoclonal antibo...
  Grande JP, Shankland SJ, Walker HJ, Chini EN, Tsuboi Y, Johnson RJ, Dousa TP, J Am Soc Nephrol, 1/1/1996
• Localization of mRNA encoding Ca2+ pump isoform gamma PMCA3 in the thin descending limb (DT1) of the Henle's loop from rat kidney. (Abstract 1099)
  Caride AJ, Chini EN, Yamaki M, Dousa TP, Penniston JT, FASEB J, 1/1/1995
• Specific modulation of cyclic ADP-ribose induced Ca2+ release by polyamines. (Abstract no. 730)
  Chini EN, Beers KW, Chini CS, Dousa TP, FASEB J, 1/1/1995
• Inhibitors of cAMP phosphodiesterase (PDE) isoenzymes block mesangial cell production of monocyte chemo-attractant protein-1 (MCP-1).
  Grande JP, Chini CS, Chini EN, Melder DC, Radford MG, Dousa TP, Journal of Investigative Medicine, 1/1/1995
• Nicotinic acid adenine dinucleotide phosphate: a novel calcium release messenger in sea urchin eggs. (Abstract TU-POS525)
  Chini E, Perez C, Beers K, Clapham DE, Dousa TP, Biophys J, 1/1/1995
• All trans-retinoic acid stimulates NA+-dependent phosphate (P) uptake and other NA+-dependent cotransporters in opossum kidney (OK) cells. (Abstract 1506)
  Beers KW, Toledo FGS, Chini EN, Dousa TP, FASEB J, 1/1/1995
• Suppression of rat mesangial cell (mc) proliferation by thyrphostins, the inhibitors of tyrosine protein kinase (PTK)
  Thompson MA, Chini EN, Grande JP, Dousa TP, J Am Soc Nephrol, 1/1/1995
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Lectures

• Cellular Metabolism in the Treatment of Pancreatic Cancer 
  1/1/2014
• New Experimental Concepts in Obesity and Age Related Metabolic 
  Mayo Clinic, Rochester, MN - 1/1/2013
• New Experimental Concepts in Obesity and Related Metabolic Dysfunction 
  Mayo Clinic, Rochester, MN - 1/1/2013
• Central Anesthesia M&M 
  Mayo Clinic, Rochester, MN - 1/1/2013
• Current and Future Perspectives in Metabolic Syndrome Therapy 
  Rio de Janeiro, Brazil - 1/1/2013
• Physiology of Metabolic Syndrome 
  Rio de Janeiro, Brazil - 1/1/2013
• Targeting NAD Metabolism in Pancreatic Cancer Cells: Role of SIRTUINS, CD38, and Nampt in Therapy of Pancreatic Cancer 
  Rochester, MN - 1/1/2013
• Targeting NAD Metabolism in Pancreatic Cancer Cells: Role of SIRT1, Nampt, and CD38 in Therapy of Pancreatic Cancer 
  Rochester, MN - 1/1/2013
• NAD Signaling Pathways: Key Roles in Metabolic Regulation in Health and Disease. 
  Rochester, MN - 1/1/2013
• Regulating the Regulator: Role of DBC1 in Epigenetics and Energy Metabolism 
  Yale University School of Medicine, New Haven, CT - 1/1/2013
• Is There a Role for Caloric Restriction (CR) and CR Mimetics for the Prevention and Treatment of Polycystic Kidney Disease? 
  Mayo Clinic, Rochester, MN - 1/1/2012
• Manipulating NAD Metabolism in Cancer 
  Rochester, MN - 1/1/2012
• Targeting NAD Metabolism in Cancer Cells 
  Rochester, MN - 1/1/2012
• Anesthesia for Liver Transplant 
  Salvador, Brazil - 1/1/2012
• Transfusion Medicine 
  Salvador, Brazil - 1/1/2012
• Role of CD38 and DBC1 in the Regulation of SIRT1 
  University of South Florida, Tampa, FL - 1/1/2012
• Role of CD38 and DBC1 in the Regulation of SIRT 1 
  Ventura, CA - 1/1/2012
• Research in Anesthesiology; Transfusion Medicine for the Anesthesiologist 
  Wayne State University, Detroit, MI - 1/1/2012
• NAD(P) in Cell Signaling: from Calcium to Epigenetics. A Tale of Life, Death, and Everything In Between 
  Federal University of Minas Gerais, Belo Horizonte, Brazil - 1/1/2012
• Role of the NAMPT-CD38-SIRT1-NAD Axis in Pancreatic Cancer 
  Rochester, MN - 1/1/2011
• Can We Stop Aging with NAD? 
  University of Rio de Janeiro, Rio de Janeiro, Brazil - 1/1/2011
• Molecular Biology of Aging for the Anesthesiologist 
  Walter Reed Medical Center, Washington, DC - 1/1/2011
• Role of NAD Metabolism in Regulation of Cell Function 
  Los Angeles, CA - 1/1/2011
• NAD Metabolism for Everyone 
  Mayo Clinic, Rochester, MN - 1/1/2011
• CD38 and DBC1 as Regulator of SIRT1: Regulating the Regulator 
  Northwestern University, Chicago, IL - 1/1/2010
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