EdwardJHollandMD

Ophthalmology • Blue Ash, OH

Cataract Related, Cornea & External Disease

Clinical Professor of Ophthalmology, University Cincinnati

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Office
1945 Cei Dr
Blue Ash, OH 45242
Phone+1 513-984-5133

Fax+1 513-984-4240
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Education & Training

National Capital ConsortiumResidency, Ophthalmology, 1986 - 1987
University of Iowa Hospitals and ClinicsResidency, Ophthalmology, 1985 - 1986
University of MinnesotaResidency, Ophthalmology, 1982 - 1985
Henry Ford HospitalInternship, Transitional Year, 1981 - 1982
Loyola University Chicago Stritch School of MedicineClass of 1981

Certifications & Licensure

CA State Medical License 2007 - Present
KY State Medical License 2000 - 2025
OH State Medical License 1999 - 2024
MN State Medical License 1987 - 2007
IA State Medical License 1985 - 1988
MI State Medical License Active through 1982
American Board of Ophthalmology Ophthalmology

Awards, Honors, & Recognition

America's Top Doctors Castle Connolly, 2002-2014
CMS Meaningful Use Stage 1 Certification NextGen Ambulatory EHR, NextGen Healthcare, 2012-2013
Fellow (FAAO) American Academy of Ophthalmology

Clinical Trials

Cornea Donor Study Start of enrollment: 2000 Jan 10
Completed
Not Applicable
Study of Difluprednate vs. Prednisolone Acetate on Visual Acuity, and Corneal Edema Following Cataract Surgery. Start of enrollment: 2009 Mar 01
Completed
Phase 4
A Comparison of 0.5% Loteprednol Etabonate Versus 1% Prednisolone Acetate Following Cataract Surgery Start of enrollment: 2010 May 01
Completed
A Phase 2 Single-Masked, Randomized Study of Latanoprost PPDS in Ocular Hypertension or Open-Angle Glaucoma Start of enrollment: 2013 Dec 01
Completed
Phase 2
A Phase IV, Randomized, Parallel Group, Investigator-Masked Evaluation of the Effect of Loteprednol Etabonate Ophthalmic Gel 0.5% on the Initiation of Dry Eye Treatment With Restasis® Start of enrollment: 2014 Jan 01
Withdrawn
Phase 4
Safety and Efficacy Study of SJP-0035 Ophthalmic Solution in Patients With Moderate to Severe Corneal Epithelial Disorders Start of enrollment: 2014 Apr 08
Completed
Phase 2
Phase 3 Study of OTX-101 in the Treatment of Keratoconjunctivitis Sicca Start of enrollment: 2016 Feb 01
Completed
Phase 3
First in Human (FIH) Study to Assess Safety and Efficacy of the CorNeat KPro for the Treatment of Corneal Blindness Start of enrollment: 2021 Jan 03
Terminated
Not Applicable
A Research Study To See How Well an Eye Drop, SURF-100 (A Mycophenolic Acid/Betamethasone Sodium Phosphate Combination), Works and What Side Effects There Are in Subjects With Dry Eye Disease Start of enrollment: 2021 Jan 11
Completed
Phase 2
Research Study To See How Well An Eye Drop (SURF-200) Works, What Side Effects There Are, And To Compare It With Vehicle In Subjects With An Episodic Flare-Up of Dry Eye Disease Start of enrollment: 2021 Jan 07
Completed
Phase 2
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Publications & Presentations

PubMed

Phase IV Multicenter, Prospective, Open-Label Clinical Trial of Cenegermin (rhNGF) for Stage 1 Neurotrophic Keratopathy (DEFENDO).
Massaro-Giordano, M., Goisis, G., Pasedis, G., Mantelli, F., Hamrah, P., Schanzlin, D., Holland, E., Berdy, G.> ;Ophthalmology and Therapy. 2024 Feb 1
Reply.
Edward J Holland, Albert Y Cheung, Ali R Djalilian> ;Cornea. 2024 Feb 1
Why Are Corneal Specialists Resistant to Treating Patients Who Have Severe Ocular Surface Disease With Limbal Stem Cell Deficiency?
Edward J Holland, Albert Y Cheung, Ali R Djalilian, Marjan Farid, Mark J Mannis> ;Cornea. 2023 Sep 1
12 citations
Clinical diagnosis and management of Demodex blepharitis: the Demodex Expert Panel on Treatment and Eyelid Health (DEPTH).
Brandon D Ayres, Eric Donnenfeld, Marjan Farid, Ian Benjamin Gaddie, Preeya K Gupta, Edward Holland, Paul M Karpecki, Richard Lindstrom, Kelly K Nichols, Stephen C Pfl...> ;Eye. 2023 Oct 1
2 citations
Allogeneic Ocular Surface Stem Cell Transplantation Outcomes With Decreased or No Systemic Immunosuppression in the Elderly.
Albert Y Cheung, Joseph H Jeffrey, Amit Govil, Elizabeth Kinosz, Enrica Sarnicola, Matthew R Denny, Cameron B Reinisch, Edward J Holland> ;Cornea. 2023 Dec 1
1 citations
Perioperative management of high-risk corneal transplantation using basiliximab and mycophenolate mofetil.
Cameron B Reinisch, Asma M Azam, Albert Y Cheung, Amit Govil, Edward J Holland> ;Canadian Journal of Ophthalmology. Journal Canadien D'ophtalmologie. 2023 Aug 1
3 citations
Delphi Panel Consensus Regarding Current Clinical Practice Management Options for.
Marjan Farid, Brandon D Ayres, Eric Donnenfeld, Ian Benjamin Gaddie, Preeya K Gupta, Edward Holland, Richard Lindstrom, Stephen C Pflugfelder, Paul M Karpecki, Kelly K...> ;Clinical Ophthalmology. 2023 Jan 1
1 citations
Comparison of Persistent Epithelial Defect Treatment With Sutureless Cryopreserved and Dehydrated Amniotic Membrane.
Shawn Sell, Martin de la Presa, Medi Eslani, Joseph Jeffrey, John D Sheppard, Edward J Holland, Albert Y Cheung, Shambhawi Thakur> ;American Journal of Ophthalmology. 2023 Jul 1
2 citations
Phase 2, Randomized, Open-Label Parallel-Group Study of Two Dosing Regimens of Netarsudil for the Treatment of Corneal Edema Due to Fuchs Corneal Dystrophy.
Richard L Lindstrom, Amber E Lewis, Edward J Holland, John D Sheppard, John A Hovanesian, Michelle Senchyna, David A Hollander> ;Journal of Ocular Pharmacology and Therapeutics. 2022 Dec 1
2 citations
Presence of Panel-reactive Antibodies after Penetrating Keratoplasty.
Albert Y Cheung, Joseph H Jeffrey, Khaliq H Kurji, Matthew R Denny, Amit Govil, Edward J Holland> ;Ocular Immunology and Inflammation. 2023 May 1
1 citations
A Comparison of TearCare and Lipiflow Systems in Reducing Dry Eye Disease Symptoms Associated with Meibomian Gland Disease.
Edward J Holland, Jennifer Loh, Marc Bloomenstein, Vance Thompson, David Wirta, Kavita Dhamdhere> ;Clinical Ophthalmology. 2022 Jan 1
Peripheral hypertrophic subepithelial corneal degeneration versus Salzmann's nodular degeneration: A clinical and surgical comparison.
Nicholas J Auteri, Martin de la Presa, Kasey L. Pierson, Khaliq H. Kurji, Albert Y. Cheung, Edward J. Holland> ;The Ocular Surface. 2022 Jan 1
5 citations
Meibomian Gland Dysfunction: A Dermatological Perspective on Pathogenesis and Treatment Outlook
Preeya K. Gupta, Laura M Periman, Edward Lain, Eric D. Donnenfeld, John A. Hovanesian, Terry Kim, William Trattler, Elizabeth Yeu, Edward J. Holland> ;Clinical Ophthalmology. 2021 Nov 9
12 citations
Acute Corneal Epithelial Rejection of LR-CLAL After SARS-CoV-2 Vaccination.
Martin de la Presa, Amit Govil, Winston Chamberlain, Edward J. Holland> ;Cornea. 2021 Nov 4
12 citations
Efficacy of Lifitegrast Ophthalmic Solution, 5.0%, in Patients With Moderate to Severe Dry Eye Disease: A Post Hoc Analysis of 2 Randomized Clinical Trials.
Edward J. Holland, Mitchell Jackson, Eric D. Donnenfeld, Rebecca Piccolo, Alisa Cohen, Stefano Barabino, Maurizio Rolando, Francisco C Figueiredo> ;JAMA Ophthalmology. 2021 Nov 1
6 citations
TearCare for the Treatment of Meibomian Gland Dysfunction in Adult Patients With Dry Eye Disease: A Masked Randomized Controlled Trial
Preeya K. Gupta, Edward J. Holland, John A. Hovanesian, Jennifer Loh, Mitchell A Jackson, Paul M. Karpecki, Kavita Dhamdhere> ;Cornea. 2021 Sep 29
2 citations
Anterior Scleral and Limbal Inflammatory Necrosis After Adjuvant Miltefosine for Recalcitrant Acanthamoeba Keratitis.
Martin de la Presa, Mitch Ibach, John P. Berdahl, Edward J. Holland> ;Cornea. 2021 Sep 4
15 citations
The corneal endothelium: clinical review of endothelial cell health and function.
Preeya K. Gupta, John P. Berdahl, Clara C. Chan, Karolinne Maia Rocha, Elizabeth Yeu, Brandon D. Ayres, Marjan Farid, W. Barry Lee, Kenneth A Beckman, Terry Kim, Edwar...> ;Journal of Cataract and Refractive Surgery. 2021 Sep 1
8 citations
Dry eye disease flares: A rapid evidence assessment
Christopher E. Starr, Reza Dana, Stephen C. Pflugfelder, Edward J. Holland, Steven Zhang, Desiree V Owen, Kim Brazzell> ;The Ocular Surface. 2021 Jul 22
3 citations
Use of Cenegermin in the Presence of Bandage Contact Lenses
Albert Y. Cheung, Amar P Shah, Kasey L. Pierson, Matthew R. Denny, Michael L. Nordlund, Edward J. Holland> ;Cornea. 2021 Jun 16
9 citations
Limbal Stem Cell Deficiency: Demographics and Clinical Characteristics of a Large Retrospective Series at a Single Tertiary Referral Center.
Albert Y. Cheung, Enrica Sarnicola, Matthew R. Denny, Lorena Sepsakos, Nicholas J Auteri, Edward J. Holland> ;Cornea. 2021 May 27
4 citations
Posterior lamellar keratoplasty: techniques, outcomes, and recent advances.
Elizabeth Yeu, José Álvaro Pereira Gomes, Brandon D. Ayres, Clara C. Chan, Preeya K. Gupta, Kenneth A Beckman, Marjan Farid, Edward J. Holland, Terry Kim, Christopher ...> ;Journal of Cataract and Refractive Surgery. 2021 Mar 5
8 citations
Safety and efficacy of nepafenac punctal plug delivery system in controlling postoperative ocular pain and inflammation after cataract surgery.
Eric D. Donnenfeld, Edward J. Holland, Kerry D Solomon> ;Journal of Cataract and Refractive Surgery. 2021 Feb 1
3 citations
Clinical Outcomes of Allogeneic Ocular Surface Stem Cell Transplantation in Pediatric Patients
Albert Y. Cheung, Enrica Sarnicola, Medi Eslani, Elizabeth Wright, Jens Goebel, David K. Hooper, Amit Govil, Khaliq H. Kurji, Edward J. Holland> ;Cornea. 2021 Jan 1
Reply to comment on: Safety and efficacy of a nepafenac punctal plug delivery system in controlling postoperative ocular pain and inflammation after cataract surgery.
Eric D. Donnenfeld, Kerry D Solomon, Edward J. Holland> ;Journal of Cataract and Refractive Surgery. 2021 Jan 1
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Lectures

ASCRS/ASOA Winter Update 2013
American Society of Cataract and Refractive Surgery (ASCRS), Aventura, Florida - 2/14/2013

Press Mentions

Elite Stem-Cell Transplant Program for Eye Surface Damage Opens at UCI HealthFebruary 1st, 2023
Cracking the Cornea ConundrumSeptember 2nd, 2022
Masters of the OphthoverseAugust 4th, 2022
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