ElizabethMarionJaffeeMD

PubMed

• Transfer Learning Reveals Cancer-Associated Fibroblasts Are Associated with Epithelial-Mesenchymal Transition and Inflammation in Cancer Cells in Pancreatic Ductal Ade...
  Samantha Guinn, Benedict Kinny-Köster, Joseph A Tandurella, Jacob T Mitchell, Dimitrios N Sidiropoulos, Melanie Loth, Melissa R Lyman, Alexandra B Pucsek, Daniel J Zab...> ;Cancer Research. 2024 May 2
• Mesothelin CAR T Cells Secreting Anti-FAP/Anti-CD3 Molecules Efficiently Target Pancreatic Adenocarcinoma and its Stroma.
  Marc Wehrli, Samantha Guinn, Filippo Birocchi, Adam Kuo, Yi Sun, Rebecca C Larson, Antonio J Almazan, Irene Scarfò, Amanda A Bouffard, Stefanie R Bailey, Praju Vikas A...> ;Clinical Cancer Research. 2024 May 1
• 1 citations
  Fibroblasts in the Aged Pancreas Drive Pancreatic Cancer Progression.
  Daniel J Zabransky, Yash Chhabra, Mitchell E Fane, Emma Kartalia, James M Leatherman, Laura Hüser, Jacquelyn W Zimmerman, Daniel Delitto, Song Han, Todd D Armstrong, S...> ;Cancer Research. 2024 Apr 15
• Personalized neoantigen vaccine and pembrolizumab in advanced hepatocellular carcinoma: a phase 1/2 trial.
  Mark Yarchoan, Edward J Gane, Thomas U Marron, Renzo Perales-Linares, Jian Yan, Neil Cooch, Daniel H Shu, Elana J Fertig, Luciane T Kagohara, Gabor Bartha, Josette Nor...> ;Nature Medicine. 2024 Apr 1
• 1 citations
  An orientation to the US National Cancer plan for the research community.
  Geiger, A., Brown, C., Rathmell, W., Bertagnolli, M., Jaffee, E., Berger, M.> ;Journal of the National Cancer Institute. 2024 Mar 1
• Entinostat, nivolumab and ipilimumab for women with advanced HER2-negative breast cancer: a phase Ib trial.
  Roussos Torres, E., Ho, W., Danilova, L., Tandurella, J., Leatherman, J., Rafie, C., Wang, C., Brufsky, A., LoRusso, P., Chung, V., Yuan, Y., Downs, M., O'Connor, A., ...> ;Nature Cancer. 2024 Feb 14
• 1 citations
  Neoadjuvant radioimmunotherapy in pancreatic cancer enhances effector T cell infiltration and shortens their distances to tumor cells.
  Wang, J., Gai, J., Zhang, T., Niu, N., Qi, H., Thomas, D., Li, K., Xia, T., Rodriguez, C., Parkinson, R., Durham, J., McPhaul, T., Narang, A., Anders, R., Osipov, A., ...> ;Science Advances. 2024 Feb 9
• Systems immunology spanning tumors, lymph nodes, and periphery.
  Dimitrios N Sidiropoulos, Won Jin Ho, Elizabeth M Jaffee, Luciane T Kagohara, Elana J Fertig> ;Cell Reports Methods. 2023 Dec 18
• Inferring cellular and molecular processes in single-cell data with non-negative matrix factorization using Python, R and GenePattern Notebook implementations of CoGAPS.
  Jeanette A I Johnson, Ashley P Tsang, Jacob T Mitchell, David L Zhou, Julia Bowden, Emily Davis-Marcisak, Thomas Sherman, Ted Liefeld, Melanie Loth, Loyal A Goff, Jacq...> ;Nature Protocols. 2023 Dec 1
• 3 citations
  Immune landscape of tertiary lymphoid structures in hepatocellular carcinoma (HCC) treated with neoadjuvant immune checkpoint blockade.
  Daniel H Shu, Won Jin Ho, Luciane T Kagohara, Alexander Girgis, Sarah M Shin, Ludmila Danilova, Jae W Lee, Dimitrios N Sidiropoulos, Sarah Mitchell, Kabeer Munjal, Kat...> ;Biorxiv. 2023 Oct 26
• Molecular signature incorporating the immune microenvironment enhances thyroid cancer outcome prediction.
  Xu, G., Loberg, M., Gallant, J., Sheng, Q., Chen, S., Lehmann, B., Shaddy, S., Tigue, M., Phifer, C., Wang, L., Saab-Chalhoub, M., Dehan, L., Wei, Q., Chen, R., Li, B....> ;Cell Genomics. 2023 Oct 11
• Barcoding intracellular reverse transcription enables high-throughput phenotype-coupled T cell receptor analyses.
  Sahana Jayaraman, Janelle M Montagne, Thomas R Nirschl, Emily Marcisak, Jeanette Johnson, Amanda Huff, Meng-Hsuan Hsiao, Julie Nauroth, Thatcher Heumann, Jelani C Zari...> ;Cell Reports Methods. 2023 Oct 23
• 4 citations
  Digitize your Biology! Modeling multicellular systems through interpretable cell behavior.
  Jeanette A I Johnson, Genevieve L Stein-O'Brien, Max Booth, Randy Heiland, Furkan Kurtoglu, Daniel R Bergman, Elmar Bucher, Atul Deshpande, André Forjaz, Michael Getz,...> ;Biorxiv. 2023 Nov 5
• 3 citations
  Informing virtual clinical trials of hepatocellular carcinoma with spatial multi-omics analysis of a human neoadjuvant immunotherapy clinical trial.
  Shuming Zhang, Atul Deshpande, Babita K Verma, Hanwen Wang, Haoyang Mi, Long Yuan, Won Jin Ho, Elizabeth M Jaffee, Qingfeng Zhu, Robert A Anders, Mark Yarchoan, Lucian...> ;Biorxiv. 2023 Aug 15
• 8 citations
  A platform trial of neoadjuvant and adjuvant antitumor vaccination alone or in combination with PD-1 antagonist and CD137 agonist antibodies in patients with resectabl...
  Thatcher Heumann, Carol Judkins, Keyu Li, Su Jin Lim, Jessica Hoare, Rose Parkinson, Haihui Cao, Tengyi Zhang, Jessica Gai, Betul Celiker, Qingfeng Zhu, Thomas McPhaul...> ;Nature Communications. 2023 Jun 20
• 4 citations
  Uncovering the spatial landscape of molecular interactions within the tumor microenvironment through latent spaces.
  Atul Deshpande, Melanie Loth, Dimitrios N Sidiropoulos, Shuming Zhang, Long Yuan, Alexander T F Bell, Qingfeng Zhu, Won Jin Ho, Cesar Santa-Maria, Daniele M Gilkes, St...> ;Cell Systems. 2023 Apr 19
• 5 citations
  Achieving the Goals of the Cancer Moonshot Requires Progress against All Cancers.
  Monica M Bertagnolli, Danielle Carnival, Elizabeth M Jaffee> ;Cancer Discovery. 2023 May 4
• 4 citations
  Multiomics Empowers Predictive Pancreatic Cancer Immunotherapy.
  Janelle M Montagne, Elizabeth M Jaffee, Elana J Fertig> ;Journal of Immunology. 2023 Apr 1
• Utilization of cancer immunotherapy in sub-Saharan Africa.
  Olatunji, E., Patel, S., Graef, K., Joseph, A., Lasebikan, N., Mallum, A., Chigbo, C., Ngwa, W., Jaffee, E.> ;Frontiers in Oncology. 2023 Jan 1
• Colorectal cancer in patients of advanced age is associated with increased incidence ofp.V600E mutation and mismatch repair deficiency.
  Eric S Christenson, Hua-Ling Tsai, Dung T Le, Elizabeth M Jaffee, Jonathan Dudley, Rena R Xian, Christopher D Gocke, James R Eshleman, Ming-Tseh Lin> ;Frontiers in Oncology. 2023 Jan 1
• Solid Organ Transplantation Is Associated with an Increased Rate of Mismatch Repair Deficiency and PIK3CA Mutations in Colorectal Cancer.
  Eric S Christenson, Valerie Lee, Hao Wang, Mark Yarchoan, Ana De Jesus-Acosta, Nilo Azad, Ahmet Gurakar, Ming-Tseh Lin, Dung T Le, Daniel C Brennan, Elizabeth M Jaffee...> ;Current Oncology. 2022 Dec 21
• 26 citations
  Multi-omic analyses of changes in the tumor microenvironment of pancreatic adenocarcinoma following neoadjuvant treatment with anti-PD-1 therapy.
  Keyu Li, Joseph A Tandurella, Jessica Gai, Qingfeng Zhu, Su Jin Lim, Dwayne L Thomas 2nd, Tao Xia, Guanglan Mo, Jacob T Mitchell, Janelle Montagne, Melissa Lyman, Ludm...> ;Cancer Cell. 2022 Nov 14
• 16 citations
  Quantitative Spatial Profiling of Immune Populations in Pancreatic Ductal Adenocarcinoma Reveals Tumor Microenvironment Heterogeneity and Prognostic Biomarkers.
  Haoyang Mi, Shamilene Sivagnanam, Courtney B Betts, Shannon M Liudahl, Elizabeth M Jaffee, Lisa M Coussens, Aleksander S Popel> ;Cancer Research. 2022 Dec 2
• 10 citations
  Profiling of syngeneic mouse HCC tumor models as a framework to understand anti-PD-1 sensitive tumor microenvironments.
  Daniel J Zabransky, Ludmila Danilova, James M Leatherman, Tamara Y Lopez-Vidal, Jessica Sanchez, Soren Charmsaz, Nicole E Gross, Sarah Shin, Xuan Yuan, Alexei Hernande...> ;Hepatology. 2023 May 1
• 173 citations
  Pancreatic Cancer: Pathogenesis, Screening, Diagnosis, and Treatment.
  Laura D Wood, Marcia Irene Canto, Elizabeth M Jaffee, Diane M Simeone> ;Gastroenterology. 2022 Aug 1
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Journal Articles

• Development of Tumor Mutation Burden as an Immunotherapy Biomarker: Utility for the Oncology Clinic  
  Mark Yarchoan, Elizabeth Jaffee, Annals of Oncology