EricScottHalsteadMDPhD

PubMed

• 1 citations
  Multi-Omic Factors Associated with Frequency of Upper Respiratory Infections in Developing Infants.
  E Scott Halstead, Bryan Cusack, Steven D Hicks, Beheshti, R.> ;International Journal of Molecular Sciences. 2023 Jan 4
• 3 citations
  Immunocompromised Children With Acute Respiratory Distress Syndrome Possess a Distinct Circulating Inflammatory Profile.
  John Nguyen, Jill M Thompson, Daniel R Balcarcel, Matthew N Alder, Daniel J McKeone, E Scott Halstead, Courtney M Rowan, Robert B Lindell, Nadir Yehya> ;Critical Care Explorations. 2023 Jan 1
• 4 citations
  Inhaled Sargramostim (Recombinant Human Granulocyte-Macrophage Colony-Stimulating Factor) for COVID-19-Associated Acute Hypoxemia: Results of the Phase 2, Randomized, ...
  Robert Paine, Robert Chasse, E Scott Halstead, Jay Nfonoyim, David J Park, Timothy Byun, Bela Patel, Guido Molina-Pallete, Estelle S Harris, Fiona Garner, Lorinda Simm...> ;Military Medicine. 2022 Dec 2
• 3 citations
  Multi-omic factors associated with future wheezing in infants.
  E Scott Halstead, Daniel McKeone, Steven D Hicks, Beheshti, R.> ;Pediatric Research. 2023 Feb 1
• 1 citations
  Integrated machine learning approaches for flow cytometric quantification of myeloid-derived suppressor cells in acute sepsis.
  Anthony S Bonavia, Abigail Samuelsen, Joshua Luthy, E Scott Halstead> ;Frontiers in Immunology. 2022 Jan 1
• 4 citations
  Comparison of Rapid Cytokine Immunoassays for Functional Immune Phenotyping.
  Anthony S Bonavia, Abigail Samuelsen, Zissis C Chroneos, Eric Scott Halstead> ;Frontiers in Immunology. 2022 Jan 1
• 2 citations
  Biomarkers associated with mortality in pediatric patients with cardiac arrest and acute respiratory distress syndrome.
  Monique M Gardner, Matthew P Kirschen, Hector R Wong, Daniel J McKeone, E Scott Halstead, Jill M Thompson, Adam S Himebauch, Alexis A Topjian, Nadir Yehya> ;Resuscitation. 2022 Jan 1
• 5 citations
  Case Report: Rapid Recognition and Immune Modulation of Secondary HLH Due to Disseminated HSV Infection.
  Daniel J. McKeone, Theodore K. M. DeMartini, Robert P. Kavanagh, E. Scott Halstead> ;Frontiers in Pediatrics. 2021 Jul 2
• 6 citations
  Extracellular matrix-inspired inhalable aerogels for rapid clearance of pulmonary tuberculosis.
  Andrew W. Simonson, Todd M. Umstead, Atip Lawanprasert, Bailey Klein, Sarah Almarzooqi, E. Scott Halstead, Scott H. Medina> ;Biomaterials. 2021 Apr 22
• 4 citations
  Higher serum PD-L1 level predicts increased overall survival with lapatinib versus trastuzumab in the CCTG MA.31 phase 3 trial.
  Prashanth Reddy Moku, Lois E. Shepherd, Suhail M. Ali, Kim Leitzel, Wendy R. Parulekar, Liting Zhu, Shakeel Virk, Dora Nomikos, Samuel Aparicio, Karen A. Gelmon, Josep...> ;Cancer. 2020 Nov 15
• 4 citations
  Cytokine Panels and Pediatric Acute Respiratory Distress Syndrome: A Translational Investigation.
  Daniel J. McKeone, Margaret Mathewson, Priti G. Dalal, Debbie Spear, Todd M. Umstead, Steven D. Hicks, Zissis C. Chroneos, Ming Wang, Neal J. Thomas, E. Scott Halstead> ;Pediatric Critical Care Medicine. 2020 Dec 1
• 17 citations
  Lower respiratory tract delivery, airway clearance, and preclinical efficacy of inhaled GM-CSF in a postinfluenza pneumococcal pneumonia model
  Todd M. Umstead, Eranda Mangala K. Kurundu Hewage, Margaret Mathewson, Sarah Beaudoin, Zissis C. Chroneos, Ming Wang, E. Scott Halstead> ;American Journal of Physiology. Lung Cellular and Molecular Physiology. 2020 Apr 1
• 13 citations
  DNA Viremia Is Associated with Hyperferritinemia in Pediatric Sepsis
  Dennis W. Simon, E. Scott Halstead, Sam Davila, Kate F. Kernan, Robert S. B. Clark, Gregory A. Storch, Joseph A. Carcillo> ;The Journal of Pediatrics. 2019 Oct 1
• Advances in Pediatric Sepsis and Shock.
  E. Scott Halstead> ;Journal of Pediatric Intensive Care. 2019 Mar 1
• 5 citations
  No Requirement for Targeted Theophylline Levels for Diuretic Effect of Aminophylline in Critically Ill Children.
  Katie Park, Lindsay C. Trout, Cong Xu, Ming Wang, Robert F. Tamburro, E. Scott Halstead> ;Pediatric Critical Care Medicine. 2018 Aug 1
• 69 citations
  Racial and Ethnic Disparities and Bias in the Evaluation and Reporting of Abusive Head Trauma.
  Kent P. Hymel, Antoinette L. Laskey, Kathryn Crowell, Ming Wang, Veronica Armijo-Garcia, Terra N. Frazier, Kelly S. Tieves, Robin Foster, Kerri Weeks, Mark S. Dias, E....> ;The Journal of Pediatrics. 2018 Jul 1
• 29 citations
  Differential effects of innate immune variants of surfactant protein-A1 (SFTPA1) and SP-A2 (SFTPA2) in airway function after Klebsiella pneumoniae infection and sex di...
  Nithyananda Thorenoor, Xuesheng Zhang, Todd M. Umstead, E. Scott Halstead, David S. Phelps, Joanna Floros> ;Respiratory Research. 2018 Feb 3
• 49 citations
  GM-CSF overexpression after influenza a virus infection prevents mortality and moderates M1-like airway monocyte/macrophage polarization
  E. Scott Halstead, Todd M. Umstead, Michael L. Davies, Yuka Imamura Kawasawa, Patricia Silveyra, Judie Howyrlak, Linlin Yang, Weichao Guo, Sanmei Hu, Eranda Mangala K....> ;Respiratory Research. 2018 Jan 5
• 16 citations
  Viral DNAemia and Immune Suppression in Pediatric Sepsis.
  Samuel Z. Davila, E. Scott Halstead, Mark W. Hall, Allan Doctor, Russell Telford, Richard Holubkov, Joseph A. Carcillo, Gregory A. Storch> ;Pediatric Critical Care Medicine. 2018 Jan 1
• 7 citations
  An Electrochemical Biosensor for Rapid Detection of Pediatric Bloodstream Infections.
  Eranda Mangala K. Kurundu Hewage, Debbie Spear, Todd M. Umstead, Sanmei Hu, Ming Wang, Pak Kin Wong, Zissis C. Chroneos, E. Scott Halstead, Neal J. Thomas> ;SLAS Technology. 2017 Aug 29
• 14 citations
  SH3GLB2/endophilin B2 regulates lung homeostasis and recovery from severe influenza A virus infection
  Kristin Fino, Linlin Yang, Patricia Silveyra, Sanmei Hu, Todd M. Umstead, Susan L. DiAngelo, E. Scott Halstead, Timothy K. Cooper, Thomas Abraham, Yoshinori Takahashi,...> ;Scientific Reports. 2017 Aug 4
• 63 citations
  Three Hypothetical Inflammation Pathobiology Phenotypes and Pediatric Sepsis-Induced Multiple Organ Failure Outcome.
  Joseph A. Carcillo, E. Scott Halstead, Mark W. Hall, Trung C. Nguyen, Ron W Reeder, Rajesh K. Aneja, Bita Shakoory, Dennis W. Simon> ;Pediatric Critical Care Medicine. 2017 Jun 1
• 3 citations
  Intrapulmonary Percussive Ventilation as an Airway Clearance Technique during Venoarterial Extracorporeal Life Support in an Infant with Pertussis.
  Conrad Krawiec, Ken Ballinger, E. Scott Halstead> ;Frontiers in Pediatrics. 2017 Apr 27
• 54 citations
  A Systemic Inflammation Mortality Risk Assessment Contingency Table for Severe Sepsis.
  Joseph A. Carcillo, Katherine A. Sward, E. Scott Halstead, Russell Telford, Adria Jimenez-Bacardi, Bita Shakoory, Dennis W. Simon, Mark W. Hall> ;Pediatric Critical Care Medicine. 2017 Feb 1
• 8 citations
  Hyperferritinemic Sepsis: An Opportunity for Earlier Diagnosis and Intervention?
  E. Scott Halstead, Surender Rajasekaran, Julie C. Fitzgerald, Scott L. Weiss> ;Frontiers in Pediatrics. 2016 Aug 2
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Journal Articles

• No Requirement for Targeted Theophylline Levels for Diuretic Effect of Aminophylline in Critically Ill Children  
  Park, K., Trout, L. C., Xu, C., Wang, M., Tamburro, R. F. & Halstead, E. S., Pediatr Crit. Care Med., 1/1/2018
• Racial and Ethnic Disparities and Bias in the Evaluation and Reporting of Abusive Head Trauma  
  Hymel, K. P., et al, J. Pediatr., 1/1/2018
• Differential effects of innate immune variants of surfactant protein-A1 (SFTPA1) and SP-A2 (SFTPA2) in airway function after Klebsiella pneumoniae infection and sex di...  
  Thorenoor, N., Zhang, X., Umstead, T. M., Halstead, E. S., Phelps, D. S. & Floros, J., Respir. Res., 1/1/2018
• GM-CSF overexpression after influenza a virus infection prevents mortality and moderates M1-like airway monocyte/macrophage polarization  
  Halstead, E. S., Umstead, T. M., Davies, M. L., Kawasawa, Y. I., Silveyra, P., Howyrlak, J., Yang, L., Guo, W., Hu, S., Hewage, E. K. & Chroneos, Z. C., Respir. Res., 1/1/2018
• Viral DNAemia and Immune Suppression in Pediatric Sepsis  
  Davila, S., Halstead, E. S., Hall, M. W., Doctor, A., Telford, R., Holubkov, R., Carcillo, J. A. & Storch, G. A., Pediatr Crit. Care Med., 1/1/2018
• An Electrochemical Biosensor for Rapid Detection of Pediatric Bloodstream Infections  
  Kurundu Hewage, E. M. K., Spear, D., Umstead, T. M., Hu, S., Wang, M., Wong, P. K., Chroneos, Z. C., Halstead, E. S. & Thomas, N. J., SLAS Technol, 1/1/2017
• SH3GLB2/endophilin B2 regulates lung homeostasis and recovery from severe influenza A virus infection  
  Fino, K. K., Yang, L., Silveyra, P., Hu, S., Umstead, T. M., DiAngelo, S., Halstead, E. S., Cooper, T. K., Abraham, T., Takahashi, Y., Zhou, Z., Wang, H. G. & Chroneos..., Sci. Rep., 1/1/2017
• Intrapulmonary Percussive Ventilation as an Airway Clearance Technique during Venoarterial Extracorporeal Life Support in an Infant with Pertussis  
  Krawiec, C., Ballinger, K. & Halstead, E. S., Front. Pediatr., 1/1/2017
• Three Hypothetical Inflammation Pathobiology Phenotypes and Pediatric Sepsis-Induced Multiple Organ Failure Outcome  
  Carcillo, J. A., Halstead, E. S., Hall, M. W., Nguyen, T. C., Reeder, R., Aneja, R., Shakoory, B., Simon, D. & Eunice Kennedy Shriver National Institute of Child Healt..., Pediatr Crit Care Med, 1/1/2017
• Hyperferritinemic Sepsis: An Opportunity for Earlier Diagnosis and Intervention?  
  Halstead, E. S., Rajasekaran, S., Fitzgerald, J. C. & Weiss, S. L., Front. Pediatr., 1/1/2016
• Plasma mitochondrial DNA - A novel DAMP in pediatric sepsis  
  Di Caro, V., Walko, T. D., Bola, R. A., Hong, J. D., Pang, D., Hsue, V., Au, A. K., Halstead, E. S., Carcillo, J. A., Clark, R. S. B. & Aneja, R. K., Shock, 1/1/2016
• Lethal influenza infection: Is a macrophage to blame?  
  Halstead, E. S. & Chroneos, Z. C., Expert Rev Anti Infect Ther, 1/1/2015
• SP-R210 (Myo18A) isoforms as intrinsic modulators of macrophage priming and activation  
  Yang, L., Carrillo, M., Wu, Y. M., DiAngelo, S. L., Silveyra, P., Umstead, T. M., Halstead, E. S., Davies, M. L., Hu, S., Floros, J., McCormack, F. X., Christensen, N...., PLoS One, 1/1/2015
• Plasma Exchange, Methylprednisolone, IV Immune Globulin, and Now Anakinra Support Continued PICU Equipoise in Management of Hyperferritinemia-Associated Sepsis/Multipl...  
  Simon, D. W., Rajesh Aneja, Carcillo, J. A. & Halstead, E. S., Pediatr Crit Care Med, 1/1/2014
• Severe Cardiomyopathy in an Infant After Iatrogenic Fosphenytoin Overdose  
  Grageda, M., Saini, A. P., Trout, L. C., Cyran, S. E. & Halstead, E. S., Clin. Pediatr. (Phila), 1/1/2014
• Reduced frequency of CD56dim CD16pos natural killer cells in pediatric systemic inflammatory response syndrome/sepsis patients  
  Halstead, E. S., Carcillo, J. A., Schilling, B., Greiner, R. J. & Whiteside, T. L., Pediatr Res., 1/1/2013
• Rapid Onset of Hippocampal Atrophy in Febrile-Infection Related Epilepsy Syndrome (FIRES)  
  Byler, D. L., Grageda, M. R., Halstead, E. S. & Kanekar, S., J. Child Neurol, 1/1/2013
• IRX-2, a novel immunotherapeutic, enhances and protects NK-cell functions in cancer patients  
  Schilling, B., Halstead, E. S., Schuler, P., Harasymczuk, M., Egan, J. E. & Whiteside, T. L., Cancer Immunol. Immunother., 1/1/2012
• Enantioselective synthesis of (S)- and (R)- fluoxetine hydrochloride  
  Miles, W. H., Fialcowitz, E. J. & Halstead, E. S., Tetrahedron, 1/1/2001
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Books/Book Chapters

• Rogers' Textbook of Pediatric Intensive Care 
  Chapter: "Immune Deficiency Disorders." 
  Fausnight T, McArthur J, Halstead ES, Jogal SEdition 5th,

Abstracts/Posters

• The Use of Bronchoalveolar Lavage Chemokines for Prediction of Persistent Pediatric Acute Respiratory Distress Syndrome (PARDS).
  Mathewson MM, McKeone D, Spear D, Umstead TM, Halstead ES, Eastern Society of Pediatric Research (ESPR), Philadelphia, PA, 1/17/2018
• The Use of Bronchoalveolar Lavage Chemokines for Prediction of Persistent Pediatric Acute Respiratory Distress Syndrome (PARDS).
  Mathewson MM, McKeone D, Spear D, Umstead TM, Halstead ES, Pediatric Academic Society (PAS), Toronto, 1/6/2018
• Serum PD-L1 and outcomes in CCTG MA.31 phase 3 trial of anti-HER2 therapy in first-line HER2+ metastatic breast cancer patients (trastuzumab arm only).
  Leitzel K, Ali SM, Shepherd LE, Parulekar WR, Zhu L, Virk S, Nomikos D, Aparicio S, Gelmon KA, Drabick JJ, Cream L, Halstead ES, Polimera HV, Maddukuri, Ali A, Patel U..., American Society of Clinical Oncology (ASCO), Chicago, IL, 1/2/2018
• Continous Low-dose Heparin Infusion for Catheter-related Thrombosos Prophylaxis in Critically Ill Children.
  Bujold K, Halstead ES, Xavier F, American Society of Pediatric Hematology/Oncology (ASPHO), Pittsburgh, PA, 1/2/2018
• The PPARgamma Agonist, Pioglitazone, Confers Sex-Specific Protection from Influenza Virus Infection in Mice.
  Halstead ES, Amin S, Umstead TM, Hu S, Chroneos ZC, Annual NIH BIRCWH (Building Interdisciplinary Research Careers in Women's Health) Meeting, Bethesda, MD, 1/1/2017
• Chroneos ZC. Mucosal GM-CSF overexpression limits lung immunopathology during severe influenza infection by altering airway macrophage M1/M2 polarization.
  Halstead ES, Umstead TM, Davies ML, Yang L, Guo W, Hu S, Zissis C, International Conference of Mucosal Immunology, Washington, DC, 1/1/2017
• GM-CSF confers protection from severe influenza infection through accelerated recovery of lung homeostasis.
  Halstead ES, Umstead TM, Davies ML, Guo W, Hu S, Chroneos ZC, Society of Critical Care Medicine, Honolulu, HI, 1/1/2017
• Female mice are more susceptible to influenza A virus infection and demonstrate increased inflammation and lung elastance.
  Halstead ES, Umstead TM, Davies ML, Yang L, Hu S, Chroneos ZC, Annual BIRCWH (Building Interdisciplinary Research Careers in Women's Health) Meeting, 1/1/2016
• GM-CSF confers protection from severe influenza infection through accelerated recovery of lung homeostasis.
  Halstead ES, Davies ML, Umstead TM, Yang L, Guo W, Hu S, Myers R, White M, Hartshorn KL, Chroneos ZC, American Thoracic Society, San Francisco, CA, 1/1/2016
• GM-CSF confers sex-dependent protection from severe influenza infection through accelerated recovery of lung homeostasis.
  Halstead ES, Davies ML, Umstead TM, Yang L, Guo W, Hu S, Myers R, White M, Hartshorn KL, Chroneos ZC, PSU Women's Health Day, 1/1/2016
• Influenza Induces GM-CSF Deficiency: Lung-specific Overexpression After Infection Confers Protection.
  Halstead ES, Guo W, Yang L, Hu S, Umstead T, Hartshorn KL, White MR, Chroneos ZC, American Association Immunologists, New Orleans, LA, 1/1/2015
• Enhanced cell surface phenotyping and functional characterization of murine pulmonary leukocyte populations.
  Halstead ES, Yang L, Chroneos ZC, American Thoracic Society, San Diego, CA, 1/1/2014
• Functional Characterization of Murine Pulmonary Leukocyte Populations.
  Halstead ES, Yang L, Chroneos ZC, Pediatric Critical Care Colloquium, Washington, DC, 1/1/2013
• Functional Characterization of Murine Pulmonary Monocyte/Macrophage and Dendritic cell Populations.
  Halstead ES, Yang L, Chroneos ZC, Gordon Research Conference: Lung Development, Injury and Repair, Andover, NH, 1/1/2013
• Natural Killer Cell Cytotoxicity is Reduced in Pediatric SIRS/Sepsis Patients.
  Halstead ES, Carcillo JA, Schilling B, Whiteside TL, Society of Critical Care Medicine, Houston, TX, 1/1/2012
• Elevated soluble CD163 levels are associated with thrombocytopenia-associated multiple organ failure (TAMOF) in pediatric sepsis patients.
  Halstead ES, Hall MW, Aneja RK, Jones J, Springs L, Carcillo JA, Society of Critical Care Medicine, San Diego, CA, 1/1/2011
• Is it just sepsis? Characteristics and outcomes of patients diagnosed with hemophagocytic lymphohistiocytosis (HLH): a review of published data.
  Halstead ES, Aneja RK, Vehovic W, Carcillo JA, Society of Critical Care Medicine, Miami, FL, 1/1/2010
• Use of Q-dots in Flow Cytometry-Direct conjugation to antibodies.
  Horsch EA, Halstead ES, Papazoglou E, Tyagi S, Katsikis PD, Drexel University Research Day 2004, 1/4/2004
• In vivo Stimulation of CD137 (4-1BB) Enhances Antiviral CD8+ T Cell Responses.
  Halstead ES, Mueller YM, Altman JD, Katsikis PD, Infection and Immunity Forum, 1/31/2002
• CD30-CD30L interactions inhibit the CD8(+) T cell response to Influenza type A virus in mice.
  D'Ortone JM, Halstead ES, Dolfi DV, Katsikis PD, Discovery 2002, Drexel University College of Medicine, Philadelphia, PA, 1/1/2002
• Tracking of CD8(+) T lymphocyte cell division and expression by CFSE labeling.
  Dolfi DV, Halstead ES, Katsikis PD, Discovery 2001, Drexel University College of Medicine, Philadelphia, PA, 1/1/2001
• 4-1BB (CD137) stimulation enhances antiviral CD8(+) T cell responses in vivo.
  Halstead ES, Altman JD, Katsikis PD, Drexel University Research Day 2001, Philadelphia, PA, 1/1/2001
• 4-1BB stimulation can restore the primary CD8(+) T cell response to Influenza type A virus in CD28(-/-) mice.
  Halstead ES, Altman JD, Katsikis PD, 34th Midwinter Conference of Immunologists, Asilomar, Pacific Grove, CA, 1/1/2001
• Costimulation through 4-1BB modulates the immune response to Influenza virus in the absence of B7/CD28 interaction.
  Halstead ES, Altman JD, Smith CA, Katsikis PD, Discovery 2000, Drexel University College of Medicine, Philadelphia, PA, 1/1/2000
• Costimulation through 4-1BB antagonizes the effect of blocking CD28 and restores the primary CD8(+) T cell immune response to Influenza virus in mice.
  Halstead ES, Po JL, Mueller YM, Kim AH, Altman JD, Smith CA, Katsikis PD, Drexel University Research Day 2000, Philadelphia, PA, 1/1/2000
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Lectures

• "Novel Diagnostics and Therapeutics of Respiratory Viral Pneumonia" 
  1/1/2018
• "Transplant Immunology" 
  1/1/2018
• "Plasma Therapies in the PICU" 
  1/1/2018
• "Sex Differences in the Immune Response to Influenza." 
  1/1/2017
• "HLH vs. MAS vs. HFS: Does it acutely matter?" 
  1/1/2017
• "Shock" 
  1/1/2017
• "Respiratory Physiology" 
  1/1/2017
• "Current Understandings of Sepsis" 
  1/1/2017
• "Neuromonitoring" 
  1/1/2017
• "Pediatric Sedation" 
  1/1/2016
• "What Would You Do (WWYD)?" 
  1/1/2016
• "GM-CSF: Giving the lung what it wants." 
  1/1/2015
• "Fluids and Electrolytes" 
  1/1/2015
• "Functional characterization of the pulmonary myeloid immune response to influenza." 
  1/1/2014
• "Research Methodology" 
  1/1/2013
• "Antimicrobials: PK, PD and microbial resistance." 
  1/1/2011
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