EricCStrainMD

Addiction

Professor of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine; Section Head, JHB Psychiatry Substance Abuse Programs, Medical Director, Behavioral Pharmacology Research Unit, Johns Hopkins Bayview Medical Center, Director, Center for Substance Abuse Treatment and Research

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Office
4940 Eastern Avenue
Baltimore, MD 21224
Phone+1 410-550-0016

Fax+1 410-550-0030
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Education & Training

Johns Hopkins UniversityResidency, Psychiatry, 1984 - 1988
Ohio State University College of MedicineClass of 1984

Certifications & Licensure

MD State Medical License 1986 - 2025
American Board of Psychiatry and Neurology Psychiatry
American Board of Psychiatry and Neurology Addiction Psychiatry

Awards, Honors, & Recognition

America's Top Doctors Castle Connolly, 2007-2014
Top Doctors:Baltimore Area Castle Connolly, 2012

Clinical Trials

Effects of Buprenorphine/Naloxone in Treating Opioid Dependent Individuals Who Are Maintained on Methadone Start of enrollment: 2002 Sep 01
Terminated
Not Applicable
Tryptophan and Behavior Therapy for Cocaine Abuse - 1 Start of enrollment: 1997 Mar 01
Completed
Phase 2
Assessing Abuse Potential of Parenteral Buprenorphine/Naloxone in Non-Dependent Opioid Abusers Start of enrollment: 2000 Dec 01
Terminated
Not Applicable
Blockade Efficacy of Buprenorphine/Naloxone For Opioid Dependence Start of enrollment: 2000 Dec 01
Completed
Not Applicable
Effects of Buprenorphine/Naloxone Administered in Different Ways For Treating Opioid Dependence Start of enrollment: 1996 Aug 01
Completed
Not Applicable
Opioid Agonist and Antagonist Effects on Opioid Dependence Start of enrollment: 2004 Jan 01
Terminated
Phase 2
Fluoxetine to Reduce Cocaine Use in Cocaine and Opioid Addicts Start of enrollment: 2001 Apr 01
Completed
Not Applicable
Tramadol to Reduce Opioid Withdrawal Symptoms Start of enrollment: 2005 Feb 01
Completed
Phase 2
Abuse Potential of Buprenorphine/Naloxone Start of enrollment: 2004 Jun 01
Terminated
Phase 2
Abuse Potential of Buprenorphine and Naloxone in Non-Dependent Opioid Users Start of enrollment: 1997 Jan 01
Completed
Not Applicable
Assessment of Tramadol as a Treatment for Opioid Addiction Start of enrollment: 2006 Jan 01
Completed
Phase 1, Phase 2
Buprenorphine's Dose Response Curve Start of enrollment: 2007 Jan 01
Completed
Phase 2
The Discriminative Effects of Tramadol in Humans Start of enrollment: 2007 Nov 01
Completed
Phase 1, Phase 2
Induction of Opioid-Dependent Individuals Onto Buprenorphine and Buprenorphine/Naloxone Start of enrollment: 2008 Mar 01
Completed
Phase 2
Medications Development for Drug Abuse Disorders Start of enrollment: 2010 Oct 01
Completed
Phase 1, Phase 2
ABT-436 for Alcohol Dependence Start of enrollment: 2013 Feb 01
Completed
Phase 2
Treatment Engagement With Technology-assisted Treatment Start of enrollment: 2016 Feb 29
Completed
Not Applicable
An Innovative Intervention for OUD Treatment Start of enrollment: 2020 Nov 15
Recruiting
Phase 2, Phase 3
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Publications & Presentations

PubMed

Establishing a research agenda for the study and assessment of opioid withdrawal.
Kelly E Dunn, Eric C Strain> ;The Lancet. Psychiatry. 2024 Mar 20
Suvorexant alters dynamics of the sleep-EEG power spectrum and depressive symptom trajectories during inpatient opioid withdrawal.
Reid, M., Dunn, K., Abraham, L., Ellis, J., Hunt, C., Coon, W., Mun, C., Smith, M., Finan, P., Huhn, A., Gamaldo, C., Strain, E.> ;Sleep. 2024 Jan 30
Virtual focus groups among individuals with use disorders: assessing feasibility and acceptability in an underserved clinical population.
Cecilia L Bergeria, Brandon Park, Prem Umang Satyavolu, Kelly E Dunn, Robert H Dworkin, Eric C Strain> ;Frontiers in Psychiatry. 2024 Jan 1
Polymorphisms in the A118G SNP of the OPRM1 gene produce different experiences of opioids: A human laboratory phenotype-genotype assessment.
Kelly E Dunn, Andrew S Huhn, Patrick H Finan, Ami Mange, Cecilia L Bergeria, Brion S Maher, Jill A Rabinowitz, Eric C Strain, Denis Antoine> ;Addiction Biology. 2024 Jan 1
Reply to "Capturing Synergy Holistically in Psychedelic Clinical Trials".
Dworkin, R., McDermott, M., Nayak, S., Strain, E.> ;Clinical Pharmacology and Therapeutics. 2024 Mar 1
Increases in primary opioid use disorder diagnoses co-occurring with anxiety or depressive disorder diagnoses in mental health treatment in the United States, 2015-2019.
Orrin D Ware, Jennifer D Ellis, Eric C Strain, Denis G Antoine, Suky Martinez, Cecelia L Bergeria> ;Drug and Alcohol Dependence. 2023 Dec 1
2 citations
Psychedelics and Psychotherapy: Is the Whole Greater than the Sum of its Parts?
Robert H Dworkin, Michael P McDermott, Sandeep M Nayak, Eric C Strain> ;Clinical Pharmacology and Therapeutics. 2023 Dec 1
Functional imaging studies of acute administration of classic psychedelics, ketamine, and MDMA: Methodological limitations and convergent results.
Sophia Linguiti, Jacob W Vogel, Valerie J Sydnor, Adam Pines, Nick Wellman, Allan Basbaum, Claudia R Eickhoff, Simon B Eickhoff, Robert R Edwards, Bart Larsen, Andrew ...> ;Neuroscience and Biobehavioral Reviews. 2023 Nov 1
5 citations
Control Conditions in Randomized Trials of Psychedelics: An ACTTION Systematic Review.
Sandeep M Nayak, Melissa K Bradley, Bethea A Kleykamp, Eric C Strain, Robert H Dworkin, Matthew W Johnson> ;The Journal of Clinical Psychiatry. 2023 May 10
3 citations
Operational definition of precipitated opioid withdrawal.
Kelly E Dunn, H Elizabeth Bird, Cecilia L Bergeria, Orrin D Ware, Eric C Strain, Andrew S Huhn> ;Frontiers in Psychiatry. 2023 Jan 1
2 citations
Clinical Trial Design Challenges and Opportunities for Emerging Treatments for Opioid Use Disorder: A Review.
Brian D Kiluk, Bethea A Kleykamp, Sandra D Comer, Roland R Griffiths, Andrew S Huhn, Matthew W Johnson, Kyle M Kampman, Marco Pravetoni, Kenzie L Preston, Ryan Vandrey...> ;JAMA Psychiatry. 2023 Jan 1
2 citations
Opioid Use Disorder: Pernicious and Persistent.
Cecilia L Bergeria, Strain, E.> ;The American Journal of Psychiatry. 2022 Oct 1
A comparison of registered and published primary outcomes in clinical trials of opioid use disorder: ACTTION review and recommendations.
Bethea A Kleykamp, McKenzie C Ferguson, Ewan McNicol, Ida Bixho, Michele Matthews, Dennis C Turk, Robert H Dworkin, Eric C Strain> ;Drug and Alcohol Dependence. 2022 Jul 1
Gender parity and homophily in the Drug and Alcohol Dependence editorial process.
Melissa R Schick, Rachel L Tomko, Anna M Maralit, Zubair Afzal, Lindsay M Squeglia, Agnieszka Freda, Linda Porrino, Jennifer Dahne, Erin A McClure, Eric C Strain> ;Drug and Alcohol Dependence. 2022 Jul 1
18 citations
Suvorexant ameliorated sleep disturbance, opioid withdrawal, and craving during a buprenorphine taper.
Andrew S Huhn, Patrick H Finan, Charlene E Gamaldo, Alexis S Hammond, Annie Umbricht, Cecilia L Bergeria, Eric C Strain, Kelly E Dunn> ;Science Translational Medicine. 2022 Jun 22
3 citations
Objective sleep outcomes in randomized-controlled trials in persons with substance use disorders: A systematic review.
Andrew S Huhn, Kelly E Dunn, Jennifer D Ellis, Dennis J Sholler, Paula Tabaschek, Rachel Burns, Eric C Strain> ;Drug and Alcohol Dependence. 2022 Aug 1
8 citations
Patient-reported sleep outcomes in randomized-controlled trials in persons with substance use disorders: A systematic review.
Andrew S Huhn, Jennifer D Ellis, Kelly E Dunn, Dennis J Sholler, Paula Tabaschek, Rachel Burns, Eric C Strain> ;Drug and Alcohol Dependence. 2022 Aug 1
5 citations
If the Doors of Perception Were Cleansed, Would Chronic Pain be Relieved? Evaluating the Benefits and Risks of Psychedelics.
Robert H Dworkin, Brian T Anderson, Nick Andrews, Robert R Edwards, Charles S Grob, Stephen Ross, Theodore D Satterthwaite, Eric C Strain> ;The Journal of Pain. 2022 Oct 1
4 citations
Characterization of basal ganglia volume changes in the context of HIV and polysubstance use.
Andrew J Monick, Michelle R Joyce, Natasha Chugh, Jason A Creighton, Owen P Morgan, Eric C Strain, Cherie L Marvel> ;Scientific Reports. 2022 Mar 14
Fare well.
Eric C Strain> ;Drug and Alcohol Dependence. 2022 Feb 1
The Defining Characteristic of Substance Use Disorders
Eric C. Strain> ;Drug and Alcohol Dependence. 2021 Nov 1
2 citations
Methadone maintenance patients lack analgesic response to a cumulative intravenous dose of 32 mg of hydromorphone.
Gabrielle Agin-Liebes, Andrew S. Huhn, Eric C. Strain, George E. Bigelow, Michael T. Smith, Robert R. Edwards, Valerie A. Gruber, D. Andrew Tompkins> ;Drug and Alcohol Dependence. 2021 Sep 1
5 citations
Wireless electroencephalography (EEG) to monitor sleep among patients being withdrawn from opioids: Evidence of feasibility and utility.
Kelly E. Dunn, Patrick H. Finan, Andrew S. Huhn, Charlene E. Gamaldo, Cecilia L. Bergeria, Eric C. Strain> ;Experimental and Clinical Psychopharmacology. 2021 Jun 7
4 citations
Moving Beyond Medications That Act at the μ Receptor in the Treatment of Opioid Use Disorder.
Eric C. Strain, Kyle M. Kampman, Roger D. Weiss> ;JAMA Psychiatry. 2021 Jul 1
18 citations
Research approaches for evaluating opioid sparing in clinical trials of acute and chronic pain treatments: Initiative on Methods, Measurement, and Pain Assessment in C...
Jennifer S. Gewandter, Shannon M. Smith, Robert H. Dworkin, Dennis C. Turk, Tong J. Gan, Ian Gilron, Sharon Hertz, Nathaniel P. Katz, John D. Markman, Srinivasa N. Raj...> ;Pain. 2021 Nov 1
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Press Mentions

Weed and Depression: Does Marijuana Make for Depressed Brains?September 30th, 2021
Effects of Psilocybin-Assisted Therapy on Major Depressive DisorderNovember 4th, 2020
Fighting the Opioid Crisis with Medication-Assisted TherapyMarch 14th, 2019
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