EugeneKhandrosMD

PubMed

• Ancestral β-globin gene haplotypes modify β-thalassemia severity in a mouse model.
  Christophe Lechauve, Julia Keith, Alfonso G Fernandez, Kalin Mayberry, Thiyagaraj Mayuranathan, Lance E Palmer, Xiaohui Qiu, Heather Sheppard, Rahul Telange, Hans-Mart...> ;Blood Advances. 2024 Mar 27
• Let-7 miRNAs repress HIC2 to regulate BCL11A transcription and hemoglobin switching.
  Peng Huang, Scott A Peslak, Vanessa Shehu, Cheryl A Keller, Belinda M Giardine, Junwei Shi, Ross C Hardison, Gerd A Blobel, Eugene Khandros> ;Blood. 2024 Feb 16
• Author Correction: HIC2 controls developmental hemoglobin switching by repressing BCL11A transcription.
  Peng Huang, Scott A Peslak, Ren Ren, Eugene Khandros, Kunhua Qin, Cheryl A Keller, Belinda Giardine, Henry W Bell, Xianjiang Lan, Malini Sharma, John R Horton, Osheiza...> ;Nature Genetics. 2023 Sep 1
• 2 citations
  Molecular basis of polycomb group protein-mediated fetal hemoglobin repression.
  Kunhua Qin, Xianjiang Lan, Peng Huang, Megan S Saari, Eugene Khandros, Cheryl A Keller, Belinda Giardine, Osheiza Abdulmalik, Junwei Shi, Ross C Hardison, Gerd A Blobel> ;Blood. 2023 Jun 1
• 3 citations
  Gene silencing dynamics are modulated by transiently active regulatory elements.
  Marit W Vermunt, Jing Luan, Zhe Zhang, A Josephine Thrasher, Anran Huang, Megan S Saari, Eugene Khandros, Robert A Beagrie, Shiping Zhang, Pranay Vemulamada, Matilda B...> ;Molecular Cell. 2023 Mar 2
• 15 citations
  HIC2 controls developmental hemoglobin switching by repressing BCL11A transcription.
  Peng Huang, Scott A Peslak, Ren Ren, Eugene Khandros, Kunhua Qin, Cheryl A Keller, Belinda Giardine, Henry W Bell, Xianjiang Lan, Malini Sharma, John R Horton, Osheiza...> ;Nature Genetics. 2022 Sep 1
• Publisher Correction: Dual function NFI factors control fetal hemoglobin silencing in adult erythroid cells.
  Kunhua Qin, Peng Huang, Ruopeng Feng, Cheryl A Keller, Scott A Peslak, Eugene Khandros, Megan S Saari, Xianjiang Lan, Thiyagaraj Mayuranathan, Phillip A Doerfler, Oshe...> ;Nature Genetics. 2022 Jun 1
• 13 citations
  Dual function NFI factors control fetal hemoglobin silencing in adult erythroid cells.
  Kunhua Qin, Peng Huang, Ruopeng Feng, Cheryl A Keller, Scott A Peslak, Eugene Khandros, Megan S Saari, Xianjiang Lan, Thiyagaraj Mayuranathan, Phillip A Doerfler, Oshe...> ;Nature Genetics. 2022 Jun 1
• 2 citations
  Identification and characterization of RBM12 as a novel regulator of fetal hemoglobin expression.
  Aoi Wakabayashi, Maryanne Kihiu, Malini Sharma, A Josephine Thrasher, Megan S Saari, Mathieu Quesnel-Vallières, Osheiza Abdulmalik, Scott A Peslak, Eugene Khandros, Ch...> ;Blood Advances. 2022 Dec 13
• 1 citations
  FACS and immunomagnetic isolation of early erythroid progenitor cells from mouse fetal liver.
  Tatum W Braun, Michael K Kuoch, Eugene Khandros, Hojun Li> ;STAR Protocols. 2022 Mar 18
• 21 citations
  ZMYND8-regulated IRF8 transcription axis is an acute myeloid leukemia dependency
  Zhendong Cao, Krista A. Budinich, Hua Huang, Diqiu Ren, Bin Lu, Zhen Zhang, Qingzhou Chen, Yeqiao Zhou, Yu-Han Huang, Fatemeh Alikarami, Molly C. Kingsley, Alexandra L...> ;Molecular Cell. 2021 Sep 2
• 4 citations
  Heterogeneity of fetal hemoglobin production in adult red blood cells.
  Eugene Khandros, Gerd A. Blobel> ;Current Opinion in Hematology. 2021 May 1
• 11 citations
  HRI depletion cooperates with pharmacologic inducers to elevate fetal hemoglobin and reduce sickle cell formation.
  Scott A. Peslak, Eugene Khandros, Peng Huang, Xianjiang Lan, Carly L. Geronimo, Jeremy D. Grevet, Osheiza Abdulmalik, Zhe Zhang, Belinda Giardine, Cheryl A. Keller, Ju...> ;Blood Advances. 2020 Sep 22
• 37 citations
  The HRI-regulated transcription factor ATF4 activates BCL11A transcription to silence fetal hemoglobin expression
  Scott A. Peslak, Xianjiang Lan, Eugene Khandros, Jennifer A. Yano, Malini Sharma, Cheryl A. Keller, Belinda Giardine, Kunhua Qin, Osheiza Abdulmalik, Ross C. Hardison,...> ;Blood. 2020 Jun 11
• 21 citations
  Understanding heterogeneity of fetal hemoglobin induction through comparative analysis of F and A erythroblasts.
  Eugene Khandros, Peng Huang, Scott A. Peslak, Malini Sharma, Osheiza Abdulmalik, Belinda Giardine, Zhe Zhang, Cheryl A. Keller, Ross C. Hardison, Gerd A. Blobel> ;Blood. 2020 May 28
• 3 citations
  Corrigendum: The Spectrum of SPTA1-Associated Hereditary Spherocytosis.
  Satheesh Chonat, Mary Risinger, Haripriya Sakthivel, Omar Niss, Jennifer A. Rothman, Loan Hsieh, Stella T. Chou, Janet L. Kwiatkowski, Eugene Khandros, Matthew F. Gorm...> ;Frontiers in Physiology. 2019 Oct 18
• 29 citations
  The autophagy-activating kinase ULK1 mediates clearance of free α-globin in β-thalassemia
  Christophe Lechauve, Julia Keith, Eugene Khandros, Stephanie Fowler, Kalin Mayberry, Abdullah Freiwan, Christopher S. Thom, Paola Delbini, Emilio Boada Romero, Jingjin...> ;Science Translational Medicine. 2019 Aug 21
• 32 citations
  The Spectrum of SPTA1-Associated Hereditary Spherocytosis.
  Satheesh Chonat, Mary Risinger, Haripriya Sakthivel, Omar Niss, Jennifer A. Rothman, Loan Hsieh, Stella T. Chou, Janet L. Kwiatkowski, Eugene Khandros, Matthew F. Gorm...> ;Frontiers in Physiology. 2019 Jul 3
• 22 citations
  Beta Thalassemia: Monitoring and New Treatment Approaches
  Eugene Khandros, Janet L. Kwiatkowski> ;Hematology/oncology Clinics of North America. 2019 Apr 2
• 21 citations
  The E3 ligase adaptor molecule SPOP regulates fetal hemoglobin levels in adult erythroid cells
  Xianjiang Lan, Eugene Khandros, Peng Huang, Scott A. Peslak, Saurabh K. Bhardwaj, Jeremy D. Grevet, Osheiza Abdulmalik, Hongxin Wang, Cheryl A. Keller, Belinda Giardin...> ;Blood Advances. 2019 May 28
• 64 citations
  Trim58 Degrades Dynein and Regulates Terminal Erythropoiesis
  Christopher S. Thom, Elizabeth A. Traxler, Eugene Khandros, Jenna M. Nickas, Olivia Y. Zhou, Jacob E. Lazarus, Ana P. G. Silva, Dolly Prabhu, Yu Yao, Chiaka Aribeana, ...> ;Developmental Cell. 2014 Sep 29
• 11 citations
  α-Hemoglobin-stabilizing Protein (AHSP) Perturbs the Proximal Heme Pocket of Oxy-α-hemoglobin and Weakens the Iron-Oxygen Bond *
  Claire F. Dickson, Anne M. Rich, W. d’Avigdor, Daniel A. T. Collins, Jason A. Lowry, Todd L. Mollan, Eugene Khandros, John S. Olson, Mitchell J. Weiss, Joel P. Mackay,...> ;The Journal of Biological Chemistry. 2013 Jul 5
• 24 citations
  The secreted lymphangiogenic factor CCBE1 is essential for fetal liver erythropoiesis
  Zhiying Zou, David Enis, Hung Bui, Eugene Khandros, Vinayak Kumar, Zoltán Jakus, Christopher S. Thom, Yiqing Yang, Veerpal Dhillon, Mei Chen, MinMin Lu, Mitchell J. We...> ;Blood. 2013 Apr 18
• 60 citations
  Integrated protein quality-control pathways regulate free α-globin in murine β-thalassemia
  Eugene Khandros, Christopher S. Thom, Janine D'Souza, Mitchell J. Weiss> ;Blood. 2012 May 31
• 19 citations
  Kinetics of α-globin binding to α-hemoglobin stabilizing protein (AHSP) indicate preferential stabilization of hemichrome folding intermediate.
  Todd L. Mollan, Eugene Khandros, Mitchell J. Weiss, John S. Olson> ;The Journal of Biological Chemistry. 2012 Mar 30
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Abstracts/Posters

• Heme-Regulated Inhibitor (HRI) Activates Transcription Factor ATF4 to Promote BCL11A Transcription and Fetal Hemoglobin Silencing
  Eugene Khandros, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/9/2019
• Heme-Regulated Inhibitor (HRI) Depletion Cooperates with Pharmacologic Inducers to Strongly Elevate Fetal Hemoglobin and Reduce Sickle Cell Formation
  Eugene Khandros, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/9/2019

Lectures

• Understanding Heterogeneity of Fetal Hemoglobin Induction through Comparative Analysis of Stage-Matched F- and a-Cells 
  61st Annual American Society of Hematology Meeting - Orlando, FL - 12/7/2019