George Muschler, MD, Orthopaedic Surgery, Cleveland, OH, Cleveland Clinic


Orthopaedic Surgery Cleveland, OH

Orthopedic Spine Surgery

Professor of Orthopedic Surgery, Cleveland Cl College of Medicine/Case West Res Director, Regenerative Medicine Laboratory

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  • Dr. Muschler's clinical practice is specialized in adult reconstructive surgery of the hip and knee. He is exceptionally skilled in: assessment of arthritic conditions of the hip and knee, hip and knee replacement, revision of hip and knee replacement due to pain, loosening or instability; and in regenerative medicine approaches to the hip and knee preservation.
    He has an exceptional bedside manner. Patients are people, whose problems come first.

    Dr. Muschler is an Orthopaedic Surgeon and a Clinician-Scientist at the Cleveland Clinic. Building upon an MD from Northwestern, a residency at UT Southwestern, and fellowships in musculoskeletal oncology and metabolic bone disease at the Hospital for Special Surgery and Memorial Sloan Kettering in NY (1986-1988), Dr. Muschler evolved into an equally balanced clinical and research career that integrates adult reconstructive surgery, treatment of fracture non-union, and cartilage repair with research focusing on adult stem and progenitor cell biology, quantitative clinical diagnostics, aging, gender variation, tissue engineering and regenerative medicine. His laboratory has earned continuous federal funding for 18 years.

    As an institutional leader, Dr. Muschler served as Vice Chair of the Cleveland Clinic Department of Bioengineering (2004-2013); Director, Orthopaedic Research Center (2005-2013, embracing musculoskeletal research across 13 departments); and as Vice Chair, Orthopaedic and Rheumatologic Institute (2007-2013).

    As an inter-institutional leader, Dr. Muschler founded and led the translational Ohio-based Clinical Tissue Engineering Center (2005-2012). He also served as the founding Co-Director of the Armed Forces Institute of Regenerative Medicine (AFIRM) (2008-2011), funded by the Department of Defense and dedicated to the accelerated development of therapies for war injuries. In addition to 27 years of clinical trainees, Dr. Muschler has mentored over 29 research post-docs and graduate students.

Education & Training

  • Memorial Sloan-Kettering Cancer Center
    Memorial Sloan-Kettering Cancer CenterFellowship, Musculoskeletal Oncology, 1986 - 1988
  • The Hospital for Specal SurgeryFellowship, Musculoskeletal Research and Metboloic Bone Disease, 1986 - 1988
  • University of Texas Southwestern - Parkland Health & Hospital SystemResidency, Orthopedic Surgery, 1982 - 1986
  • University of Texas Southwestern Medical Center Affiliated HospitalsInternship, Transitional Year, 1981 - 1982
  • Northwestern University Feinberg School of Medicine
    Northwestern University Feinberg School of MedicineClass of 1981
  • University of IllinoisB.S., Chemistry, 1974 - 1977

Certifications & Licensure

  • OH State Medical License
    OH State Medical License 1988 - 2022
  • TX State Medical License
    TX State Medical License 1982 - 1992
  • American Board of Orthopaedic Surgery Orthopaedic Surgery

Awards, Honors, & Recognition

  • America's Top Doctors Castle Connolly, 2006-2016
  • Carl Spangler Award La Trappe Creek Ecological and Historical Society, 2014
  • CMS Meaningful Use Stage 1 Certification EpicCare Ambulatory EMR, Epic Systems Corporation, 2011, 2013
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Publications & Presentations


Journal Articles

  • Evaluation of rhBMP-2/ACS/TCP-HA bone graft with addition of Bone Marrow Cells in the Canine Femoral Multi Defect Model  
    Luangphakdy, V., Shinohara, K., Pan, H., Boehm, C., Samaranska, A., Walker, E. A., Hefferan, T. E., Muschler, G. F, Eur Cell Mater, 1/1/2015
  • Modeling and Experimental Methods to Predict Oxygen Distribution in Bone Defects Following Cell Transplantation  
    Heylman CM, Santoso S, Krebs MD, Saidel GM, Alsberg E, Muschler GF, Medical & Biological Engineering & Computing, 1/1/2014
  • Slowing the onset of hypoxia increases colony forming efficiency of connective tissue progenitor cells in vitro  
    Heylman CM, Caralla TN, Boehm CA, Patterson TE, Muschler GF, J Reg Med and Tissue Eng, 1/1/2013
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Books/Book Chapters

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  • Development of a Caprine Chronic Tibial Defect Model.
    Pluhar G, Nicholson A, Muschler GF, Luangphakdy V, Bechtold J, Boehm C, Carlson C, Pan H, Shinohara K, Wenke J, ORS Annual Meeting, San Antonio, TX, 1/26/2013
  • Development of Scaffolds with Tethered Epidermal Growth Factor to Improve Performance of Human Adult Stem and Progenitor Cells for Orthopaedic Tissue Engineering.
    Raut, VP, Alvarez, L A; Rivera, J A; Stockdale, L A; Boehm, C A; Patterson, T E; Griffith, L G; Muschler, G F, Orthopaedic Research Society Annual Meeting, San Fransisco, CA, 1/4/2012
  • Concentration and Selection of Osteogenic Progenitors using Magnetic Labeling based on Hyaluronan Expression for Immediate Transplantation into a Canine Femoral Multid...
    Caralla T, Joshi P, Boehm C, Hefferan T, Herrick J, Luangphakdy V, Fleury S, Yaszemski M, Zborowski M, Muschler G, TERMIS, Houston, TX, 1/11/2011
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  • Quantitative Assays of Chondrogenic connective tissue progenitors in human knee articular cartilage – Correlation with histological grade and structure 
    San Francisco, CA - 1/22/2016
  • Optimizing soft tissue management and spacer design in caprine segmental bone defects 
    Orlando/ Kissimmee, FL - 1/15/2016
  • University of Texas at Houston 
    Cleveland Clinic Lerner College of Medicine - 1/11/2016
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  • Clinical Use of Platelet Rich Plasma in Orthopaedics. 
    Boyan BD, Schwartz, Z, Patterson TE, Muschler GF, AAOS Bulletin Summer
  • The Fundamentals of Tissue Engineering – Concepts and Strategies. DVD published Slide and Audio Lecture Presentation 
    Muschler GF, Midura R, Commissioned by ORS/AAOS, AAOS for AAOS Education Program and Board Review
  • Focus on Bone Graft Substitutes for Spinal Arthrodesis: A Case-Based Monograph 
    Lauryssen C, Bauer T, Muschler GF, Bio-Continum Group, Inc.
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Press Mentions

  • New Omaha-Area Clinic Touts Stem Cells' 'Remarkable Potential' as Some Experts Urge Caution
    New Omaha-Area Clinic Touts Stem Cells' 'Remarkable Potential' as Some Experts Urge CautionJune 01, 2018 18:04
  • The Stem Cell Treatment Hysteria for Knee Arthritis
    The Stem Cell Treatment Hysteria for Knee ArthritisMarch 23, 2018 11:49
  • Stem Cell Clinics Pitch Pricey, Bogus 'Cures' for Knee Pain
    Stem Cell Clinics Pitch Pricey, Bogus 'Cures' for Knee PainMarch 08, 2018 10:49
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Grant Support

  • Cleveland Clinic Orthopaedic And Rheumatology Care -- Quality Innovation Summit 2National Institute Of Arthritis And Musculoskeletal And Skin Diseases2009
  • Extended Learning Curriculum For The Cleveland Clinic Orthopaedic &RheumatologyAgency For Healthcare Research And Quality2009
  • Optimizing Assays Of Human Stem Cells In Bone MarrowNational Institute On Aging2004–2007
  • Epidemiology Of Connective Tissue Progenitor PopulationsNational Institute Of Arthritis And Musculoskeletal And Skin Diseases2003–2006
  • Optimizing Bone Marrow As A Bone GraftNational Institute Of Arthritis And Musculoskeletal And Skin Diseases2003–2005
  • Optimizing Bone Marrow As A Bone GraftNational Institute Of Arthritis And Musculoskeletal And Skin Diseases2002
  • Epidemiology Of Connective Tissue Progenitor PopulationsNational Institute Of Arthritis And Musculoskeletal And Skin Diseases2002
  • Optimizing Aspirated Bone Marrow As A Bone GraftNational Institute Of Arthritis And Musculoskeletal And Skin Diseases1996–1999

Hospital Affiliations