GiselleLopezMD

PubMed

• 8 citations
  Expanded analysis of high-grade astrocytoma with piloid features identifies an epigenetically and clinically distinct subtype associated with neurofibromatosis type 1.
  Patrick J Cimino, Courtney Ketchum, Rust Turakulov, Omkar Singh, Zied Abdullaev, Caterina Giannini, Peter Pytel, Giselle Yvette Lopez, Howard Colman, MacLean P Nasrall...> ;Acta Neuropathologica. 2023 Jan 1
• 1 citations
  Papillary Glioneuronal Tumor With a Novel GPR37L1-PRKCA Fusion.
  Janice S Ahn, John F. Ervin, Thomas J. Cummings, Giselle Y. Lopez, Shih-Hsiu Wang> ;Journal of Neuropathology and Experimental Neurology. 2021 Oct 26
• Eosinophilic globules in a classic ependymoma: evidence of a possible secretory role.
  Janice S Ahn, Maureen Petersen, Allan H. Friedman, Edward M López, Thomas J. Cummings, Anne F. Buckley, Giselle Y. Lopez> ;Ultrastructural Pathology. 2020 Nov 5
• 3 citations
  Proinflammatory cytokines and ARDS pulmonary edema fluid induce CD40 on human mesenchymal stromal cells-A potential mechanism for immune modulation.
  Erin M. Wilfong, Roxanne H. Croze, Xiaohui Fang, Matthew Schwede, Eréne C. Niemi, Giselle Y. Lopez, Jae-Woo Lee, Mary C. Nakamura, Michael A. Matthay> ;Plos One. 2020 Oct 6
• 797 citations
  Management of glioblastoma: State of the art and future directions.
  Aaron C. Tan, David M. Ashley, Giselle Y. Lopez, Michael D. Malinzak, Henry S. Friedman, Mustafa Khasraw> ;CA. 2020 Jul 1
• 5 citations
  Frequent Mutations of POT1 Distinguish Pulmonary Sarcomatoid Carcinoma From Other Lung Cancer Histologies.
  Erica Shen, Joanne Xiu, Rex C. Bentley, Giselle Y. Lopez, Kyle M. Walsh> ;Clinical Lung Cancer. 2020 Apr 15
• 3 citations
  Catastrophic stroke burden in a patient with uncontrolled psoriasis and psoriatic arthritis: a case report.
  Joline M. Fan, David A. Solomon, Giselle Y. Lopez, Jeffrey W. Hofmann, Rene A. Colorado, Anthony S. Kim, Karl Meisel, Cathra Halabi> ;BMC Neurology. 2020 Mar 21
• 25 citations
  POT1 mutation spectrum in tumour types commonly diagnosed among POT1-associated hereditary cancer syndrome families.
  Erica Shen, Joanne Xiu, Giselle Y. Lopez, Rex C. Bentley, Ali Jalali, Amy B. Heimberger, Matthew N. Bainbridge, Melissa L. Bondy, Kyle M. Walsh> ;Journal of Medical Genetics. 2020 Jan 14
• 17 citations
  CDKN2A/B Loss Is Associated with Anaplastic Transformation in a Case of NTRK2 Fusion-positive Pilocytic Astrocytoma.
  Giselle Y. Lopez, Arie Perry, Brian Harding, Marilyn M. Li, Mariarita Santi> ;Neuropathology and Applied Neurobiology. 2019 Feb 1
• 52 citations
  The genetic landscape of gliomas arising after therapeutic radiation
  Giselle Y. Lopez, Jessica Van Ziffle, Courtney Onodera, James P. Grenert, Iwei Yeh, Boris C. Bastian, Jennifer Clarke, Nancy Ann Oberheim Bush, Jennie Taylor, Susan M....> ;Acta Neuropathologica. 2019 Jan 1
• 6 citations
  Perilesional edema associated with an intracranial calcifying pseudoneoplasm of the neuraxis in a child: case report and review of imaging features.
  Michael Safaee, Soren Jonzzon, Giselle Y. Lopez, Shailesh Asaikar, Tarik Tihan, Orit A. Glenn, Nalin Gupta> ;Journal of Neurosurgery. Pediatrics. 2018 Nov 1
• 14 citations
  Autoimmune pancerebellitis associated with pembrolizumab therapy.
  Jeffrey R. Vitt, Collin J. Kreple, Nausheen F. Mahmood, Elliot Dickerson, Giselle Y. Lopez, Megan B. Richie> ;Neurology. 2018 Jul 10
• 1 citations
  Metastatic cervical paravertebral solitary fibrous tumor detected by fluorodeoxyglucose positron emission tomography-computed tomography
  Hoiwan Cheung, Courtney Lawhn-Heath, Giselle Y. Lopez, Maya Vella, Carina Mari Aparici> ;Radiology Case Reports. 2018 Mar 6
• 6 citations
  Occipital Headache in Chronic Lymphocytic Inflammation With Pontine Perivascular Enhancement Responsive to Steroids (CLIPPERS)
  Christian Cordano, Giselle Y. Lopez, Andrew W. Bollen, Bardia Nourbakhsh> ;Headache. 2018 Mar 1
• 14 citations
  Diffuse midline gliomas with subclonal H3F3A K27M mutation and mosaic H3.3 K27M mutant protein expression
  Giselle Y. Lopez, Nancy Ann Oberheim Bush, Joanna J. Phillips, John Paul Bouffard, Yaron A. Moshel, Kurt A. Jaeckle, Bette K. Kleinschmidt-DeMasters, Marc K. Rosenblum...> ;Acta Neuropathologica. 2017 Oct 23
• 37 citations
  Diffuse non-midline glioma with H3F3A K27M mutation: a prognostic and treatment dilemma.
  Giselle Y. Lopez, Nancy Ann Oberheim Bush, Mitchel S. Berger, Arie Perry, David A. Solomon> ;Acta Neuropathologica Communications. 2017 May 15
• 1 citations
  Supratentorial tanycytic ependymoma in an adult male: case report and review of literature.
  Giselle Y. Lopez, Roger E. McLendon, Katherine B. Peters> ;Case Reports in Oncology. 2015 Mar 12
• 65 citations
  EGFR phosphorylation of DCBLD2 recruits TRAF6 and stimulates AKT-promoted tumorigenesis
  Haizhong Feng, Giselle Y. Lopez, Chung Kwon Kim, Angel Alvarez, Christopher G. Duncan, Ryo Nishikawa, Motoo Nagane, An Jey A. Su, Philip E. Auron, Matthew L. Hedberg, ...> ;The Journal of Clinical Investigation. 2014 Sep 2
• 3 citations
  Clinico-pathological description of three paediatric medulloblastoma cases with MLL2/3 gene mutations.
  Giselle Y. Lopez, Gerald A. Grant, Herbert E. Fuchs, Linda G. Leithe, Sridharan Gururangan, Darell D. Bigner, Hai Yan, Roger E. McLendon, Yiping He> ;Neuropathology and Applied Neurobiology. 2014 Feb 1
• 97 citations
  Disruption of wild type IDH1 suppresses D-2-hydroxyglutarate production in IDH1-mutated gliomas
  Genglin Jin, Zachary J. Reitman, Christopher G. Duncan, Ivan Spasojevic, David M. Gooden, B.K. Ahmed Rasheed, Rui Yang, Giselle Y. Lopez, Yiping He, Roger E. McLendon,...> ;Cancer Research. 2013 Jan 15
• 35 citations
  Mutant IDH1 is required for IDH1 mutated tumor cell growth
  Genglin Jin, Christopher J. Pirozzi, Lee H. Chen, Giselle Y. Lopez, Christopher G. Duncan, Jie Feng, Ivan Spasojevic, Darell D. Bigner, Yiping He, Hai Yan> ;Oncotarget. 2012 Aug 11
• 439 citations
  Frequent ATRX, CIC, FUBP1 and IDH1 mutations refine the classification of malignant gliomas.
  Yuchen Jiao, Patrick J. Killela, Zachary J. Reitman, B.K. Ahmed Rasheed, Christopher M. Heaphy, Roeland F. de Wilde, Fausto J. Rodriguez, Sergio Rosemberg, Sueli Mieko...> ;Oncotarget. 2012 Aug 4
• 563 citations
  Transformation by the R Enantiomer of 2-Hydroxyglutarate Linked to EglN Activation
  Peppi Koivunen, Sungwoo Lee, Christopher G. Duncan, Giselle Y. Lopez, Gang Lu, Shakti Ramkissoon, Julie-Aurore Losman, Päivi Joensuu, Ulrich Bergmann, Stefan Gross, Je...> ;Nature. 2012 Mar 22
• 21 citations
  Transcriptional regulation of N-acetylglutamate synthase.
  Sandra Kirsch Heibel, Giselle Y. Lopez, Maria Panglao, Sonal Sodha, Leonardo Mariño-Ramírez, Mendel Tuchman, Ljubica Caldovic> ;Plos One. 2012 Feb 27
• 62 citations
  Isocitrate dehydrogenase mutations in gliomas: mechanisms, biomarkers and therapeutic target
  Changcun Guo, Christopher J. Pirozzi, Giselle Y. Lopez, Hai Yan> ;Current Opinion in Neurology. 2011 Dec 1
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Journal Articles

• The genetic landscape of gliomas arising after therapeutic radiation  
  Lopez GY, Van Ziffle J, Onodera C, Grenert JP, Yeh I, Bastian BC, Clarke J, Oberheim Bush NA, Taylor J, Chang S, Butowski N, Banerjee A, Mueller S, Kline C, Torkildson..., Acta Neuropathol, 1/8/2018
• Occipital headache in chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids (CLIPPERS)  
  Cordano C, Lopez GY, Bollen AW, Nourbakhsh B, Headache, 1/1/2018
• Metastatic cervical paravertebral solitary fibrous tumor detected by fluorodeoxyglucose positron emission tomography-computed tomography  
  Cheung H, Lawhn-Heath C, Lopez G, Vella M, Aparici CM, Radiol Case Rep, 1/1/2018
• CDKN2A/B Loss is Associated with Anaplastic Transformation in a Case of NTRK2 Fusion-positive Pilocytic Astrocytoma  
  Lopez GY, Perry A, Harding B, Li M, Santi M, Neuropathol Appl Neurobiol, 1/1/2018
• Autoimmune pancerebellitis associated with pembrolizumab therapy  
  Vitt JR, Kreple C, Mahmood N, Dickerson E, Lopez GY, Richie MB, Neurology, 1/1/2018
• Perilesional edema associated with an intracranial calcifying pseudoneoplasm of the neuraxis in a child: case report and review of imaging features  
  Safaee MM, Jonzzon S, Lopez GY, Asaikar S, Tihan T, Glenn OA, Gupta N, J Neurosurg Pediatr, 1/1/2018
• Diffuse non-midline gliomas with H3F3A K27M mutation: a prognostic and treatment dilemma  
  Lopez G, Oberheim Bush NA, Berger MS, Perry A, Solomon DA, Acta Neuropathol Commun, 1/1/2017
• Diffuse midline gliomas with subclonal H3F3A K27M mutation and mosaic H33 K27M mutant protein expression  
  Lopez GY, Oberheim Bush NA, Phillips JJ, Bouffard JP, Moshel YA, Jaeckle K, Kleinschmidt-DeMasters BK, Rosenblum MK, Perry A, Solomon DA, Acta Neuropathol, 1/1/2017
• Supratentorial tanycytic ependymoma in an adult male: case report and review of the literature  
  Lopez G, McLendon RE, Peters KB, Case Rep Oncol, 1/1/2015
• Clinic-pathological description of three paediatric medulloblastoma cases with MLL2/3 gene mutations  
  Lopez GY, Grant GA, Fuchs HE, Liethe LG, Gururangan S, Bigner DD, Yan H, McLendon RE, He Y, Neuropathol Appl Neurobiol, 1/1/2014
• EGFR phosphorylation of DCBLD2 recruits TRAF6 and stimulates AKT-promoted tumorigenesis  
  Feng H, Lopez GY, Kim CK, Alvarez A, Duncan CG, Nishikawa R, Nagane M, Su AJ, Auron PE, Hedberg ML, Wang L, Raizer JJ, Kessler JA, Parsa AT, Gao WQ, Kim SH, Minata M, ..., J Clin Invest, 1/1/2014
• Disruption of wild-type IDH1 suppresses D-2-hydroxyglutarate production in IDH1-mutated gliomas  
  Jin, G, Reitman ZJ, Duncan CG, Spasojevic I Gooden DM, Rasheed BA, Yang R, Lopez GY, He Y, McLendon RE, Bigner DD, Yan H, Cancer Res, 1/1/2013
• Transformation by the (R)-enantiomer of 2-hydroxyglutarate linked to EGLN activation  
  Koivunen P, Lee S, Duncan CG, Lopez G, Lu G, Ramkissoon S, Losman JA, Joensuu P, Bergmann U, Gross S, Travins J, Weiss S, Looper R, Ligon KL, Verhaak RGW, Yan H, Kaeli..., Nature, 1/1/2012
• Transcriptional regulation of N-acetylglutamate synthase  
  Heibel SK, Lopez GY, Panglao M, Sodha S, Marino-Ram�rez L, Tuchman M, Caldovic L, PLoS One, 1/1/2012
• Frequent ATRX, CIC, and FUBP1 mutations refine the classification of malignant gliomas  
  Jiao Y, Killela PJ, Reitman ZJ, Rasheed AB, Heaphy CM, de Wilde RF, Rodriguez FJ, Rosemberg S, Oba-Shinjo SM, Marie SK, Bettegowda C, Agrawal N, Lipp E, Pirozzi C, Lop..., Oncotarget, 1/1/2012
• Mutant IDH1 is required for IDH1 mutated tumor cell growth  
  Jin G, Pirozzi CJ, Chen LH, Lopez GY, Duncan CG, Feng J, Spasojevic I, Bigner DD, He Y, Yan H, Oncotarget, 1/1/2012
• Isocitrate dehydrogenase mutations in gliomas: mechanisms, biomarkers, and therapeutic target  
  Guo C, Pirozzi CJ, Lopez GY, Yan H, Curr Opin Neurol, 1/1/2011
• IDH1 mutation identified in one human melanoma metastasis, but not correlated with metastases to the brain  
  Lopez GY, Reitman ZJ, Solomon D, Waldman T, Bigner DD, McLendon R, Rosenberg SA, Samuels Y, Yan H, Biochem Biophys Res Commun, 1/1/2010
• Gastrin-releasing peptide, immune responses, and lung disease  
  Degan S, Lopez GY, Kevill K, Sunday ME, Ann NY Acad Sci, 1/1/2008
• Biochemical properties of recombinant human and mouse N-acetylglutamate synthase  
  Caldovic L, Lopez GY, Haskins N, Panglao M, Shi D, Morizono H, Tuchman M, Mol Genet Metab, 1/1/2006
• Late onset N-acetylglutamate synthase deficiency caused by hypomorphic alleles  
  Caldovic L, Morizono H, Panglao MG, Lopez GY, Shi D, Summar ML, Tuchman M, Hum Mutat, 1/1/2005
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Books/Book Chapters

• eLS 
  Chapter: Brain Tumours 
  Lopez GY, Cummings TJ, Bigner DD, McLendon REJohn Wiley & Sons, Ltd., Chichester2016
• Systems Biology of Cancer 
  Chapter: Genetic alterations in glioblastoma multiforme. 
  Lopez GY, Samsky M, Jones R, Adamson DC, Yan HYEditors: Sam Thiagalingam.Cambridge University Press2015

Abstracts/Posters

• "Anaplastic transformation in a Pilocytic Astrocytoma."
  Lopez GY, American Association of Neuropathologists' Annual Meeting, 1/1/2017
• "SSTR2a status and response to somatostatin analogues in acromegaly."
  Lopez GY, United States and Canadian Academy of Pathology, Annual Meeting, 1/1/2016
• "The role of IDH1 and IDH2 mutations in gliomagenesis."
  Lopez GY, Duke Pathology Graduate Retreat, 1/1/2012
• "Histopathological description of medulloblastomas with MLL2/3 gene mutations."
  Lopez GY, Pediatric Neuro-oncology Basic and Translational Research Conference, New Orleans, LA, 1/1/2011
• "Metabolism and IDH1/2 mutations."
  Lopez GY, Duke Medical Scientist Training Program Annual Symposium, 1/1/2011
• "IDH mutations as potential biomarkers in gliomas."
  Lopez GY, Duke Medical Scientist Training Program Annual Symposium, 1/1/2010
• "DCBLD2 in glioblastoma multiforme."
  Lopez GY, Duke 18th Annual Biomedical Science Graduate Student Symposium, 1/1/2009
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Lectures

• "Genetic Landscape of Gliomas Arising after Therapeutic Radiation for Childhood Cancer." 
  1/1/2018
• "Multiple sclerosis." 
  1/1/2016
• "PNET classification." 
  1/1/2016
• "Connecting the dots in neurodegenerative disease." 
  1/1/2015
• "TERT and ATRX mutations in gliomas." 
  1/1/2015
• "IDH mutations in gliomas." 
  1/1/2014
• "Biochemical characterization and genetic modeling of IDH1 mutations in progressive gliomas." 
  1/1/2013
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