GlennBubleyMD

Oncology • Boston, MA

Associate Professor of Medicine, Beth Israel Deaconess Medical Center

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Office
330 Brookline Ave
Him-1049
Boston, MA 02215
Phone+1 617-667-5288

Fax+1 617-667-1009
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Education & Training

Beth Israel Deaconess Medical CenterFellowship, Hematology and Medical Oncology, 1980 - 1985
University of ConnecticutResidency, Internal Medicine, 1977 - 1980
Michigan State University College of Human MedicineClass of 1977

Certifications & Licensure

MA State Medical License 1980 - 2025
American Board of Internal Medicine Internal Medicine
American Board of Internal Medicine Medical Oncology

Awards, Honors, & Recognition

America's Top Doctors Castle Connolly, 2010-2014
America's Top Doctors for Cancer Castle Connolly, 2009-2013
Boston Magazine Castle Connolly, 2008-2013
Meaningful Use Stage 1 Certification Centers for Medicare & Medicaid Services, 2012
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Clinical Trials

Ketoconazole, Hydrocortisone, Dutasteride and Lapatinib (KHAD-L) in Prostate Cancer Start of enrollment: 2009 Sep 29
Terminated
Phase 1, Phase 2
Docetaxel Followed by Radical Prostatectomy in Patients With High Risk Localized Prostate Cancer Start of enrollment: 2001 Jan 01
Completed
Phase 2
Effects of Two Doses of MPX Capsules on Rising Prostate-specific Antigen Levels in Men Following Initial Therapy for Prostate Cancer Start of enrollment: 2011 Jul 01
Completed
Phase 1, Phase 2
A 2 Part, Phase 2 Trial of Galeterone in the Treatment of Castration Resistant Prostate Cancer Start of enrollment: 2012 Dec 01
Terminated
Phase 2
BKM120+Abiraterone Acetate for Metastatic CRPC Start of enrollment: 2012 Nov 01
Terminated
Phase 1
Study of Enzalutamide in Patients With Castration-resistant Prostate Cancer Start of enrollment: 2013 Sep 13
Completed
Phase 2
Enzalutamide + External Beam Rt For Prostate Start of enrollment: 2014 Feb 01
Completed
Phase 2
A Study of Docetaxel + ARN-509 in Castration-Resistant Prostate Cancer Start of enrollment: 2017 Jun 23
Terminated
Phase 2
Study Evaluating the Addition of Pembrolizumab to Radium-223 in mCRPC Start of enrollment: 2017 Jun 09
Active, not recruiting
Phase 2
Nivolumab Combined With Ipilimumab for Patients With Advanced Rare Genitourinary Tumors Start of enrollment: 2017 Dec 28
Active, not recruiting
Phase 2
INTREPId (INTermediate Risk Erection PreservatIon Trial) Start of enrollment: 2020 Jun 01
Recruiting
Phase 2
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Publications & Presentations

PubMed

Randomized Phase II Study Evaluating the Addition of Pembrolizumab to Radium-223 in Metastatic Castration-resistant Prostate Cancer.
Atish D Choudhury, Lucia Kwak, Alexander Cheung, Kathryn M Allaire, Jaqueline Marquez, David D Yang, Abhishek Tripathi, Jacqueline M Kilar, Meredith Flynn, Brianna May...> ;Cancer Immunology Research. 2024 Mar 29
1 citations
Postradical prostatectomy prostate-specific antigen outcomes after 6 versus 18 months of perioperative androgen-deprivation therapy in men with localized, unfavorable ...
Rana R McKay, Wanling Xie, Xiaoyu Yang, Andres Acosta, Dana Rathkopf, Vincent P Laudone, Glenn J Bubley, David J Einstein, Peter Chang, Andrew A Wagner, Christopher J ...> ;Cancer. 2024 May 1
Adjuvant and salvage radiotherapy after neoadjuvant therapy and radical prostatectomy for high-risk localized prostate cancer.
Praful Ravi, Lucia Kwak, Wout Devlies, Wanling Xie, Fallon Chipidza, Xiaoyu Yang, Glenn Bubley, Irving Kaplan, Adam S Kibel, Paul Nguyen, Mary-Ellen Taplin> ;The Prostate. 2024 Mar 1
14 citations
Randomized Trial of Olaparib With or Without Cediranib for Metastatic Castration-Resistant Prostate Cancer: The Results From National Cancer Institute 9984.
Joseph W Kim, Rana R McKay, Marc R Radke, Shilin Zhao, Mary-Ellen Taplin, Nancy B Davis, Paul Monk, Leonard J Appleman, Primo N Lara Jr, Ulka N Vaishampayan, Jingsong ...> ;Journal of Clinical Oncology. 2023 Feb 1
14 citations
Radiation and Androgen Deprivation Therapy With or Without Docetaxel in the Management of Nonmetastatic Unfavorable-Risk Prostate Cancer: A Prospective Randomized Trial.
Anthony V. D'Amico, Wanling Xie, Elizabeth McMahon, Marian Loffredo, Shana Medeiros, David Joseph, James W. Denham, Parvesh Kumar, Glenn J. Bubley, Molly Sullivan, Ric...> ;Journal of Clinical Oncology. 2021 Jul 1
29 citations
Prospective Evaluation of Clinical Outcomes Using a Multiplex Liquid Biopsy Targeting Diverse Resistance Mechanisms in Metastatic Prostate Cancer.
Jamie M. Sperger, Hamid Emamekhoo, Rana R. McKay, Charlotte N. Stahlfeld, Anupama Singh, Xinyi E. Chen, Lucia Kwak, Cole Gilsdorf, Serena K. Wolfe, Xiao X. Wei, Rebecc...> ;Journal of Clinical Oncology. 2021 Jul 1
4 citations
The impact of pretreatment PSA on risk stratification in men with Gleason 6 prostate cancer: Implications for active surveillance.
Sina Monfared, Aaron Fleishman, Ruslan Korets, Peter Chang, Andrew A. Wagner, Glenn J. Bubley, Irving D. Kaplan, Aria F. Olumi, Boris Gershman> ;Urologic Oncology. 2021 Nov 1
3 citations
An up-to-date evaluation of abiraterone for the treatment of prostate cancer
Jason Shpilsky, Julia S Stevens, Glenn J. Bubley> ;Expert Opinion on Pharmacotherapy. 2021 Apr 27
10 citations
Phase II Multicenter Study of Enzalutamide in Metastatic Castration-Resistant Prostate Cancer to Identify Mechanisms Driving Resistance.
Rana R. McKay, Lucia Kwak, Jett Crowdis, Jamie M. Sperger, Shuang G. Zhao, Wanling Xie, Lillian Werner, Rosina T. Lis, Zhenwei Zhang, Xiao X. Wei, Joshua M. Lang, Elie...> ;Clinical Cancer Research. 2021 Apr 13
31 citations
Results of a Randomized Phase II Trial of Intense Androgen Deprivation Therapy prior to Radical Prostatectomy in Men with High-Risk Localized Prostate Cancer
Rana R. McKay, Wanling Xie, Huihui Ye, Fiona M. Fennessy, Zhenwei Zhang, Rosina T. Lis, Carla Calagua, Dana E. Rathkopf, Vincent P. Laudone, Glenn J. Bubley, David J. ...> ;The Journal of Urology. 2021 Mar 8
6 citations
Enzalutamide With Radiation Therapy for Intermediate-Risk Prostate Cancer: A Phase 2 Study.
Irving D. Kaplan, Glenn J. Bubley, Rupal S. Bhatt, Mary-Ellen Taplin, Shanna Dowling, Kathleen M. Mahoney, E. Werner, Paul L. Nguyen> ;International Journal of Radiation Oncology, Biology, Physics. 2021 Feb 23
24 citations
Outcomes of Post-Neoadjuvant Intense Hormone Therapy and Surgery for High Risk Localized Prostate Cancer: Results of a Pooled Analysis of Contemporary Clinical Trials.
Rana R. McKay, Jacob E. Berchuck, Lucia Kwak, Wanling Xie, Rebecca Silver, Glenn J. Bubley, Peter Chang, Andrew A. Wagner, Zhenwei Zhang, Adam S. Kibel, Mary-Ellen Taplin> ;The Journal of Urology. 2021 Jan 27
46 citations
Results of a multicenter, phase 2 study of nivolumab and ipilimumab for patients with advanced rare genitourinary malignancies
Bradley Alexander McGregor, Matthew T. Campbell, Wanling Xie, Subrina Farah, Mehmet Asim Bilen, Andrew Schmidt, Guru Sonpavde, Kerry L. Kilbridge, Atish D. Choudhury, ...> ;Cancer. 2021 Mar 15
1 citations
Author Correction: A co-clinical approach identifies mechanisms and potential therapies for androgen deprivation resistance in prostate cancer.
Andrea Lunardi, Ugo Ala, Mirjam T. Epping, Leonardo Salmena, John G. Clohessy, Kaitlyn A. Webster, Guocan Wang, Roberta Mazzucchelli, Maristella Bianconi, Edward C. St...> ;Nature Genetics. 2020 Sep 3
24 citations
Taxane resistance in prostate cancer is mediated by decreased drug-target engagement
Ada Gjyrezi, Fang Xie, Olga Voznesensky, Prateek Khanna, Carla Calagua, Yang Bai, Justin W. Kung, Jim S. Wu, Eva Corey, Bruce Montgomery, Sandrine Mace, Diego A. Giano...> ;The Journal of Clinical Investigation. 2020 Jun 1
2 citations
TRA-1-60-positive/CD45low cells found in the peripheral blood of prostate cancer patients with metastatic disease - A proof-of-concept study.
Claudia Schäfer, Yawen Ju, Tak Youngbin, Cesar Vazquez, Sangyoon J. Han, Tan Edwin Saavedra, Jerry W. Shay, Holmqvist Mats Harald, Gaudenz Danuser, Schopperle William ...> ;Heliyon. 2020 Jan 1
Enzalutamide in Metastatic Prostate Cancer.
Varkaris, A., Bubley, G.> ;The New England journal of medicine. 2019 Oct 10
34 citations
Low Abundance of Circulating Tumor DNA in Localized Prostate Cancer.
S. Thomas Hennigan, Shana Y. Trostel, Nicholas T. Terrigino, Olga Voznesensky, Rachel J. Schaefer, Nichelle C. Whitlock, Scott Wilkinson, Nicole V. Carrabba, Rayann At...> ;JCO Precision Oncology. 2019 Sep 9
1 citations
Repurposed Drugs for Prostate Cancer.
Wenxin Xu, Glenn J. Bubley> ;Cancer Journal. 2019 Mar 1
70 citations
Evaluation of Intense Androgen Deprivation Before Prostatectomy: A Randomized Phase II Trial of Enzalutamide and Leuprolide With or Without Abiraterone
Rana R. McKay, Huihui Ye, Wanling Xie, Rosina T. Lis, Carla Calagua, Zhenwei Zhang, Quoc-Dien Trinh, Steven L. Chang, Lauren C. Harshman, Ashley E. Ross, Kenneth J. Pi...> ;Journal of Clinical Oncology. 2019 Feb 27
113 citations
A Pan-Cancer Analysis Reveals High-Frequency Genetic Alterations in Mediators of Signaling by the TGF-β Superfamily
Rai, K., Anil Korkut, Sobia Zaidi, Rupa S. Kanchi, Shuyun Rao, Nancy R. Gough, Andre Schultz, Xubin Li, Philip L. Lorenzi, Ashton C. Berger, Gordon Robertson, Lawrence...> ;Cell Systems. 2018 Oct 24
43 citations
Post prostatectomy outcomes of patients with high-risk prostate cancer treated with neoadjuvant androgen blockade
Rana R. McKay, Bruce Montgomery, Wanling Xie, Zhenwei Zhang, Glenn J. Bubley, David W. Lin, Mark A. Preston, Quoc-Dien Trinh, Peter Chang, Andrew A. Wagner, Elahe A. M...> ;Prostate Cancer and Prostatic Diseases. 2018 Sep 1
45 citations
Neoadjuvant-Intensive Androgen Deprivation Therapy Selects for Prostate Tumor Foci with Diverse Subclonal Oncogenic Alterations
Adam G. Sowalsky, Huihui Ye, Manoj Bhasin, Eliezer M. Van Allen, Massimo Loda, Rosina T. Lis, Laleh Montaser-Kouhsari, Carla Calagua, Fen Ma, Joshua W. Russo, Rachel J...> ;Cancer Research. 2018 Aug 15
1272 citations
Cell-of-Origin Patterns Dominate the Molecular Classification of 10,000 Tumors from 33 Types of Cancer.
Rai, K., Katherine A Hoadley, Christina Yau, Toshinori Hinoue, Denise M. Wolf, Alexander J. Lazar, Esther Drill, Ronglai Shen, Alison M. Taylor, Andrew D. Cherniack, V...> ;Cell. 2018 Apr 5
221 citations
Pan-cancer Alterations of the MYC Oncogene and Its Proximal Network across the Cancer Genome Atlas
Rai, K., Franz X. Schaub, Varsha Dhankani, Ashton C. Berger, Mihir Trivedi, Anne B. Richardson, Reid Shaw, Wei Zhao, Xiaoyang Zhang, Andrea Ventura, Yuexin Liu, Donald...> ;Cell Systems. 2018 Mar 28
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Other

Effects of cytotoxic agents on gonadal function in adult men
Bubley GJ, Hayes FJ
http://www.uptodate.com/contents/effects-of-cytotoxic-agents-on-gonadal-function-in-adult-men
UpToDate, Wolters Kluwer Health - 2013-01-04

Press Mentions

Promising Clinical Trials Coming in 2016 for IBD, Prostate Cancer and Spinal Cord InjuriesDecember 15th, 2015
Testing Prostate Cancer Therapies Using a Co-Clinical TrialNovember 16th, 2015
Upcoming Webinar to Provide an Overview and Guide to Clinical Trial Endpoint AdjudicationOctober 27th, 2015