RobertCFlaumenhaftMD

PubMed

• Protocol to identify flavonoid antagonists of the SARS-CoV-2 main protease.
  Moua Yang, Lin Lin, Robert Flaumenhaft> ;STAR Protocols. 2024 Apr 6
• Interferons prime the endothelium for toll-like receptor-mediated thrombin generation.
  Kelsey D Sack, Nathan Eaton, Maneli Doroudian Tehrani, Robert Flaumenhaft> ;Journal of Thrombosis and Haemostasis. 2024 Apr 1
• 6 citations
  Sulfenylation links oxidative stress to protein disulfide isomerase oxidase activity and thrombus formation.
  Moua Yang, Joyce Chiu, Christina Scartelli, Nathan Ponzar, Sachin Patel, Anika Patel, Renan B Ferreira, Robert F Keyes, Kate S Carroll, Nicola Pozzi, Philip J Hogg, Br...> ;Journal of Thrombosis and Haemostasis. 2023 Aug 1
• 9 citations
  Reduction of protein disulfide isomerase results in open conformations and stimulates dynamic exchange between structural ensembles.
  Mathivanan Chinnaraj, Robert Flaumenhaft, Nicola Pozzi> ;The Journal of Biological Chemistry. 2022 Aug 1
• 6 citations
  Vascular thiol isomerases: Structures, regulatory mechanisms, and inhibitor development.
  Chenghui Liang, Robert Flaumenhaft, Cai Yuan, Mingdong Huang> ;Drug Discovery Today. 2021 Oct 29
• 17 citations
  Tie2 activation protects against prothrombotic endothelial dysfunction in COVID-19.
  Alec A. Schmaier, Gabriel M. Pajares Hurtado, Zachary Manickas-Hill, Kelsey Sack, Siyu M. Chen, Victoria Bhambhani, Juweria Quadir, Anjali K. Nath, Ai-ris Y. Collier, ...> ;JCI Insight. 2021 Oct 22
• 5 citations
  Circulating Protein Disulfide Isomerase Is Associated with Increased Risk of Thrombosis in JAK2-Mutated Myeloproliferative Neoplasms.
  Anish V. Sharda, Thomas Bogue, Alexandra M. Barr, Lourdes M. Mendez, Robert Flaumenhaft, Jeffrey I. Zwicker> ;Clinical Cancer Research. 2021 Aug 16
• 4 citations
  Microvesicles, but not platelets, bud off from mouse bone marrow megakaryocytes
  Joseph E. Italiano, Markus Bender, Glenn Merrill-Skoloff, Cedric Ghevaert, Bernhard Nieswandt, Robert Flaumenhaft> ;Blood. 2021 Nov 18
• 4 citations
  Enhanced Thrombotic Responses Are Associated With Striatin Deficiency and Aldosterone
  Anna Gromotowicz‐Poplawska, Robert Flaumenhaft, Shadi K Gholami, Glenn Merrill-Skoloff, Ewa Chabielska, Gordon H. Williams, Jose R. Romero> ;Journal of the American Heart Association. 2021 Nov 3
• 7 citations
  Oxidative Cysteine Modification of Thiol Isomerases in Thrombotic Disease: A Hypothesis.
  Moua Yang, Robert Flaumenhaft> ;Antioxidants & Redox Signaling. 2021 Jun 13
• 19 citations
  Tie2 activation protects against prothrombotic endothelial dysfunction in COVID-19
  Alec A. Schmaier, Gabriel M. Pajares Hurtado, Zachary Manickas-Hill, Kelsey Sack, Siyu M. Chen, Victoria Bhambhani, Juweria Quadir, Anjali K. Nath, Ai-ris M Collier, D...> ;Medrxiv. 2021 May 17
• 10 citations
  Bioorthogonal Chemistry Enables Single-Molecule FRET Measurements of Catalytically Active Protein Disulfide Isomerase
  Mathivanan Chinnaraj, David A. Barrios, Carl Frieden, Tomasz Heyduk, Robert Flaumenhaft, Nicola Pozzi> ;Chembiochem. 2021 Jan 5
• 10 citations
  VWF maturation and release are controlled by 2 regulators of Weibel-Palade body biogenesis: exocyst and BLOC-2
  Anish V. Sharda, Alexandra M. Barr, Joshua Harrison, Adrian R. Wilkie, Chao Fang, Lourdes M. Mendez, Ionita Ghiran, Joseph E. Italiano, Robert Flaumenhaft> ;Blood. 2020 Dec 10
• 5 citations
  The Secreted Tyrosine Kinase Vlk Is Essential for Normal Platelet Activation and Thrombus Formation
  Leila Denise Revollo, Glenn Merrill-Skoloff, Karen De Ceunynck, James R. Dilks, Shihui Guo, Mattia Renato Bordoli, Christian G. Peters, Leila Noetzli, Andreia M. Iones...> ;Blood. 2020 Nov 5
• 4 citations
  Injury measurements improve interpretation of thrombus formation data in the cremaster arteriole laser-induced injury model of thrombosis.
  Steven P. Grover, Pavan K. Bendapudi, Moua Yang, Glenn Merrill-Skoloff, Vijay Govindarajan, Alexander Y Mitrophanov, Robert Flaumenhaft> ;Journal of Thrombosis and Haemostasis. 2020 Oct 29
• 9 citations
  A coagulation defect arising from heterozygous premature termination of tissue factor
  Sol Schulman, Emale El-Darzi, Mary H.C. Florido, Max Friesen, Glenn Merrill-Skoloff, Marisa A Brake, Calvin R. Schuster, Lin Lin, Randal J. Westrick, Chad A. Cowan, Ro...> ;The Journal of Clinical Investigation. 2020 Oct 1
• 17 citations
  Cysteine sulfenylation by CD36 signaling promotes arterial thrombosis in dyslipidemia.
  Moua Yang, Wei Li, Wenjing Chen, Hong Yue, Renan B. Ferreira, Sarah L. Wynia-Smith, Kate S. Carroll, Jacek Zielonka, Robert Flaumenhaft, Roy L. Silverstein, Brian C. S...> ;Blood Advances. 2020 Sep 22
• 3 citations
  Route exploration and synthesis of the reported pyridone-based PDI inhibitor STK076545.
  Eric Greve, Sergey V. Lindeman, Christina Scartelli, Lin Lin, Robert Flaumenhaft, Chris Dockendorff> ;Organic & Biomolecular Chemistry. 2020 Sep 2
• 23 citations
  Platelet Dysfunction and Thrombosis in JAK2 V617F -Mutated Primary Myelofibrotic Mice.
  Shinobu Matsuura, Cristal Reyna Thompson, Mostafa Belghasem, Roelof H. Bekendam, Andrew Piasecki, Orly Leiva, Anjana Ray, Joseph E. Italiano, Moua Yang, Glenn Merill-S...> ;Arteriosclerosis, Thrombosis, and Vascular Biology. 2020 Aug 20
• 2 citations
  Injury Length and Arteriole Constriction Shape Clot Growth and Blood-Flow Acceleration in a Mouse Model of Thrombosis
  Alexander Y. Mitrophanov, Glenn Merrill-Skoloff, Steven P. Grover, Vijay Govindarajan, Arun V. Kolanjiyil, Daniel S. Hariprasad, Ginu Unnikrishnan, Robert Flaumenhaft,...> ;Arteriosclerosis, Thrombosis, and Vascular Biology. 2020 Jul 9
• 40 citations
  A polymer-based systemic hemostatic agent.
  Yongsheng Gao, Apoorva Sarode, Nikolaos Kokoroskos, Anvay Ukidve, Zongmin Zhao, Shihui Guo, Robert Flaumenhaft, Anirban Sen Gupta, Noelle Saillant, Samir Mitragotri> ;Science Advances. 2020 Jul 1
• 9 citations
  Cationic zinc is required for factor XII recruitment and activation by stimulated platelets and for thrombus formation in vivo.
  Sharjeel A. Chaudhry, Matthew Serrata, Lindsay Tomczak, Sarah J. Higgins, Justine H. Ryu, Dylan Laprise, Keiichi Enjyoji, Roelof H. Bekendam, Virendar K. Kaushik, Robe...> ;Journal of Thrombosis and Haemostasis. 2020 Sep 1
• 1 citations
  VWF Exocytosis and Biogenesis of Weibel Palade Bodies in Endothelial Cells Are Differentially Controlled By Interactions between Bloc-2 and the Exocyst Complex
  Anish V. Sharda, Joshua Harrison, Adrian R. Wilkie, Chao Fang, Lourdes M. Mendez, Joseph E. Italiano, Robert Flaumenhaft> ;Blood. 2019 Nov 13
• 29 citations
  Gain-of-function CEBPE mutation causes noncanonical autoinflammatory inflammasomopathy
  Helka Göös, Christopher L. Fogarty, Biswajyoti Sahu, Vincent Plagnol, Kristiina Rajamäki, Katariina Nurmi, Xiaonan Liu, Elisabet Einarsdottir, Annukka Jouppila, Tom Pe...> ;The Journal of Allergy and Clinical Immunology. 2019 Nov 1
• 34 citations
  Megakaryocytes package contents into separate α-granules that are differentially distributed in platelets.
  Elisabeth M. Battinelli, Jonathan N. Thon, Ross Okazaki, Christian G. Peters, Prakrith Vijey, Adrian R. Wilkie, Leila J. Noetzli, Robert Flaumenhaft, Joseph E. Italiano> ;Blood Advances. 2019 Oct 22
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Abstracts/Posters

• The Effects of Antiplatelet Agents on Endocytosis
  Robert C. Flaumenhaft, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/7/2019
• The Effects of Antiplatelet Agents on Endocytosis
  Robert C. Flaumenhaft, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/9/2019