GowthamiArepallyMD

PubMed

• Inhibition of the C1s Protease and the Classical Complement Pathway by 6-(4-Phenylpiperazin-1-yl)Pyridine-3-Carboximidamide and Chemical Analogs.
  Xu, X., Herdendorf, T., Duan, H., Rohlik, D., Roy, S., Zhou, H., Alkhateeb, H., Khandelwal, S., Zhou, Q., Li, P., Walker, J., Garcia, B., Geisbrecht, B., Arepally, G.> ;Journal of Immunology. 2024 Feb 15
• 2 citations
  Deciphering and disrupting PIEZO1-TMEM16F interplay in hereditary xerocytosis.
  Pengfei Liang, Yang Zhang, Shang Ma, Ping Dong, Augustus J Lowry, Samuel J Francis, Sanjay Khandelwal, Martha Delahunty, Marilyn J Telen, John J Strouse, Gowthami M Ar...> ;Blood. 2024 Jan 25
• 1 citations
  Treatment of thrombocytopenia and thrombosis in HIT in mice using deglycosylated KKO: a novel therapeutic?
  Amrita Sarkar, Sanjay Khandelwal, Gavin T Koma, Hyunjun Kim, Yves Gruel, Jerome Rollin, Freda Passam, Geoffrey D Wool, Gowthami M Arepally, Douglas B Cines, Lubica Rau...> ;Blood Advances. 2023 Aug 8
• Clot Imaging Using Photostable Nanodiamond.
  Samuel J Francis, Marco D Torelli, Nicholas A Nunn, Gowthami M Arepally, Olga A Shenderova> ;Nanomaterials. 2023 Mar 7
• 2 citations
  Modulation of ultralarge immune complexes in heparin-induced thrombocytopenia.
  Zheng Cai, Khalil Bdeir, Serge V Yarovoi, Lubica Rauova, Gowthami M Arepally, Sanjay Khandelwal, Jerome Rollin, Yves Gruel, Sergei Zaitsev, Mortimer Poncz, Mark I Gree...> ;Journal of Thrombosis and Haemostasis. 2023 Mar 1
• 1 citations
  Minimal role for the alternative pathway in complement activation by HIT immune complexes.
  Ayiesha P Barnes, Sanjay Khandelwal, Simone Sartoretto, Sooho Myoung, Samuel J Francis, Grace M Lee, Lubica Rauova, Douglas B Cines, Jon T Skare, Charles E Booth Jr, B...> ;Journal of Thrombosis and Haemostasis. 2022 Nov 1
• 2 citations
  Neutrophil functional heterogeneity is a fixed phenotype and is associated with distinct gene expression profiles.
  Stacey A Maskarinec, Margaret McKelvy, Kimberly Boyle, Halie Hotchkiss, Madelaine E Duarte, Bechtler Addison, Nicholas Amato, Sanjay Khandelwal, Gowthami M Arepally, G...> ;Journal of Leukocyte Biology. 2022 Dec 1
• 1 citations
  The Predictive Value of the 4Ts and HEP Score at Recommended Cutoffs in Patients With Mechanical Circulatory Support Devices.
  Shawn J Kram, Arzo Hamidi, Bridgette L Kram, Gowthami Arepally, Jerrold H Levy> ;Journal of Cardiothoracic and Vascular Anesthesia. 2022 Jul 1
• 4 citations
  Aptamer-based factor IXa inhibition preserves hemostasis and prevents thrombosis in a piglet model of ECMO.
  Christopher R Reed, Desiree Bonadonna, James C Otto, Charles Griffin McDaniel, Charlene Vongai Chabata, Maragatha Kuchibhatla, James Frederiksen, Juliana M Layzer, Gow...> ;Molecular Therapy. Nucleic Acids. 2022 Mar 8
• 1 citations
  COVID-19 and VITT: same or different?
  Gowthami M. Arepally> ;Blood. 2021 Oct 7
• 24 citations
  C3 complement inhibition prevents antibody-mediated rejection and prolongs renal allograft survival in sensitized non-human primates.
  Robin Schmitz, Zachary W. Fitch, Paul M. Schroder, Ashley Y. Choi, Miriam Manook, Janghoon Yoon, Mingqing Song, John S. Yi, Sanjay Khandelwal, Gowthami M. Arepally, Al...> ;Nature Communications. 2021 Sep 15
• 56 citations
  Vaccine-induced immune thrombotic thrombocytopenia: what we know and do not know.
  Gowthami M Arepally, Thomas L Ortel> ;Blood. 2021 Jul 29
• 15 citations
  Complement mediates binding and procoagulant effects of ultralarge HIT immune complexes.
  Sanjay Khandelwal, Ayiesha Barnes, Lubica Rauova, Amrita Sarkar, Ann H. Rux, Serge Yarovoi, Sergei Zaitsev, John D. Lambris, Sooho Samuel Myoung, Alexandra Johnson, Gr...> ;Blood. 2021 Nov 25
• Vaccine-Induced Immune Thrombotic Thrombocytopenia (VITT): What We Know and Don't Know.
  Gowthami M. Arepally, Thomas L. Ortel> ;Blood. 2021 Jun 1
• 10 citations
  Thrombocytopenia and splanchnic thrombosis after Ad26.COV2.S vaccination successfully treated with transjugular intrahepatic portosystemic shunting and thrombectomy.
  Roshni Dhoot, Aman Kansal, Chauncy B Handran, Tarek Haykal, James Ronald, Matthew R. Kappus, Gowthami M. Arepally, Mark L. Graham, John J. Strouse> ;American Journal of Hematology. 2021 May 31
• 11 citations
  Heparin-Induced Thrombocytopenia: A Focus on Thrombosis.
  Gowthami M. Arepally, Anand Padmanabhan> ;Arteriosclerosis, Thrombosis, and Vascular Biology. 2020 Dec 3
• 19 citations
  The Developing Balance of Thrombosis and Hemorrhage in Pediatric Surgery: Clinical Implications of Age-Related Changes in Hemostasis:
  Meredith A. Achey, Uttara Nag, Victoria Robinson, Christopher R. Reed, Gowthami M. Arepally, Jerrold H. Levy, Elisabeth T. Tracy> ;Clinical and Applied Thrombosis/hemostasis. 2020 Jun 25
• 39 citations
  Pathogenesis of heparin-induced thrombocytopenia.
  Gowthami M. Arepally, Douglas B. Cines> ;Translational Research. 2020 May 15
• 40 citations
  Recognition of PF4-VWF complexes by heparin-induced thrombocytopenia antibodies contributes to thrombus propagation.
  Ian Johnston, Amrita Sarkar, Vincent Hayes, Gavin T. Koma, Gowthami M. Arepally, Junmei Chen, Dominic W. Chung, José A. López, Douglas B. Cines, Lubica Rauova, Mortime...> ;Blood. 2020 Apr 9
• 28 citations
  Fc-modified HIT-like monoclonal antibody as a novel treatment for sepsis.
  Kandace Gollomp, Amrita Sarkar, Sanjiv Harikumar, Steven H. Seeholzer, Gowthami M. Arepally, Kristin M. Hudock, Lubica Rauova, M. Anna Kowalska, Mortimer Poncz> ;Blood. 2020 Mar 5
• Understanding How Fc-Modification Transforms a Pathogenic Heparin-Induced Thrombocytopenia (HIT)-like Monoclonal Antibody into a Novel Treatment for Sepsis
  Kandace Gollomp, Amrita Sarkar, Gowthami M. Arepally, Douglas B. Cines, M. Anna Kowalska, Lubica Rauova, Mortimer Poncz> ;Blood. 2019 Nov 13
• 9 citations
  Heterogeneity in neutrophil responses to immune complexes
  Madelaine Duarte, Maragatha Kuchibhatla, Sanjay Khandelwal, Gowthami M. Arepally, Grace M. Lee> ;Blood Advances. 2019 Oct 8
• 29 citations
  The risk of major bleeding in patients with suspected heparin-induced thrombocytopenia
  Allyson M. Pishko, Daniel S. Lefler, Phyllis A. Gimotty, Koosha Paydary, Gowthami M. Arepally, Mark Crowther, Lawrence Rice, Rolando Vega, Douglas B. Cines, James P. G...> ;Journal of Thrombosis and Haemostasis. 2019 Aug 12
• 16 citations
  Bad weed: synthetic cannabinoid-associated coagulopathy.
  Gowthami M. Arepally, Thomas L. Ortel> ;Blood. 2019 Feb 28
• 17 citations
  Plastic-based acoustofluidic devices for high-throughput, biocompatible platelet separation
  Yuyang Gu, Chuyi Chen, Zeyu Wang, Po-Hsun Huang, Hai Fu, Lin Wang, Mengxi Wu, Yuchao Chen, Tieyu Gao, Jianying Gong, Jean Kwun, Gowthami M. Arepally, Tony Jun Huang> ;Lab on a Chip. 2019 Jan 29
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Journal Articles

• Polyreactive IgM Initiates Complement Activation by PF4/heparin Complexes Through the Classical Pathway  
  Grace M Lee, Michael Frank, Mortimer Poncz, Jennifer B Gilner, Douglas B Cines, Gowthami M Arepally, Blood

Abstracts/Posters

• Transfusion-Dependent Anemia and Coagulopathy in a Porcine Model of Pediatric Extracorporeal Membrane Oxygenation (ECMO)
  Gowthami Arepally, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/7/2019

Lectures

• Adult Clinical Non-Malignant Hematology 
  61st Annual American Society of Hematology Meeting - Orlando, FL - 12/7/2019
• Evaluation and Treatment of Complement-Mediated Blood Disorders in Women of Childbearing Age 
  60th American Society of Hematology Annual Meeting - 11/30/2018